EDWARD E MITRE

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. pmc Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response
    Rommy Teran
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Clin Immunol 138:299-310. 2011
  2. pmc Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study
    Philip J Cooper
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    BMC Infect Dis 11:184. 2011
  3. ncbi request reprint IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 117:939-45. 2006
  4. doi request reprint CD4(+) (and not CD25+) T cells are the predominant interleukin-10-producing cells in the circulation of filaria-infected patients
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 197:94-101. 2008
  5. ncbi request reprint Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:2439-45. 2004
  6. pmc Induction of type 2 responses by schistosome worms during prepatent infection
    Lucia Alves de Oliveira Fraga
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Infect Dis 201:464-72. 2010
  7. pmc Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures
    Marc P Hübner
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Vaccine 28:1746-57. 2010
  8. pmc Litomosoides sigmodontis: a simple method to infect mice with L3 larvae obtained from the pleural space of recently infected jirds (Meriones unguiculatus)
    Marc P Hübner
    Dept of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Exp Parasitol 123:95-8. 2009
  9. pmc Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cells
    Marc P Hübner
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Immunology 127:512-22. 2009
  10. pmc Microfilariae of the filarial nematode Litomosoides sigmodontis exacerbate the course of lipopolysaccharide-induced sepsis in mice
    Marc P Hübner
    Institute of Tropical Medicine, University of Tubingen, 72074 Tubingen, Germany
    Infect Immun 76:1668-77. 2008

Collaborators

Detail Information

Publications14

  1. pmc Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response
    Rommy Teran
    Laboratorio de Investigaciones FEPIS, Quininde, Esmeraldas Province, Ecuador
    Clin Immunol 138:299-310. 2011
    ..Enhanced innate immunity in early life may be important for host defense against pathogens but may increase the risk of immunopathology...
  2. pmc Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study
    Philip J Cooper
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    BMC Infect Dis 11:184. 2011
    ....
  3. ncbi request reprint IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 117:939-45. 2006
    ..Although it is well established that IgG humoral immunity can persist for years, as yet there have been no longitudinal studies of antigen-specific IgE responses to helminth infection in the absence of re-exposure to pathogen...
  4. doi request reprint CD4(+) (and not CD25+) T cells are the predominant interleukin-10-producing cells in the circulation of filaria-infected patients
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 197:94-101. 2008
    ..Interleukin (IL)-10 plays an important role in down-regulating the immune response to filarial parasites. The goal of this study was to characterize the predominant cellular source of IL-10 in human filarial infections...
  5. ncbi request reprint Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:2439-45. 2004
    ....
  6. pmc Induction of type 2 responses by schistosome worms during prepatent infection
    Lucia Alves de Oliveira Fraga
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Infect Dis 201:464-72. 2010
    ....
  7. pmc Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures
    Marc P Hübner
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Vaccine 28:1746-57. 2010
    ..These results demonstrate that vaccines which induce type 2 immune responses can maintain their efficacy in the setting of repeated parasite exposures...
  8. pmc Litomosoides sigmodontis: a simple method to infect mice with L3 larvae obtained from the pleural space of recently infected jirds (Meriones unguiculatus)
    Marc P Hübner
    Dept of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Exp Parasitol 123:95-8. 2009
    ..Additionally, this method allows for geographical separation of the facility maintaining the L. sigmodontis life cycle from the institution at which mice are infected...
  9. pmc Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cells
    Marc P Hübner
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Immunology 127:512-22. 2009
    ..This protection is associated with a Th2 shift, as demonstrated by cytokine and antibody production, and with an increase in CD4(+) CD25(+) FoxP3(+) regulatory T cells...
  10. pmc Microfilariae of the filarial nematode Litomosoides sigmodontis exacerbate the course of lipopolysaccharide-induced sepsis in mice
    Marc P Hübner
    Institute of Tropical Medicine, University of Tubingen, 72074 Tubingen, Germany
    Infect Immun 76:1668-77. 2008
    ....
  11. pmc Saturation of immunoglobulin E (IgE) binding sites by polyclonal IgE does not explain the protective effect of helminth infections against atopy
    Edward Mitre
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 4 Center Lane, Room 4 126, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 73:4106-11. 2005
    ....
  12. ncbi request reprint Basophils, basophilia and helminth infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Chem Immunol Allergy 90:141-56. 2006
    ....
  13. ncbi request reprint Lack of basophilia in human parasitic infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 69:87-91. 2003
    ..Thus, basophilia occurs only rarely in human parasitic infections and is consequently not a useful clinical marker in the evaluation of suspected parasitic disease...
  14. ncbi request reprint Majority of interferon-gamma-producing CD4+ cells in patients infected with human T cell lymphotrophic virus do not express tax protein
    Edward Mitre
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 188:428-32. 2003
    ..In the patients with HTLV-1 with detectable Tax, the majority of CD4(+) cells making IFN-gamma did not express Tax...

Research Grants6

  1. Role of basophils in the immune response to filariae
    Edward Mitre; Fiscal Year: 2007
    ..Specific Aim 3: To determine the role basophils play in driving naive T cells toward a type 2 phenotype. ..
  2. Role of basophils in the immune response to filariae
    Edward Mitre; Fiscal Year: 2007
    ..Specific Aim 3: To determine the role basophils play in driving naive T cells toward a type 2 phenotype. ..
  3. Role of basophils and IgE in the immune response to Litomosoides
    EDWARD E MITRE; Fiscal Year: 2010
    ..Information gained from these studies has the potential to lead to advances in I) helminth vaccine development, 2) mechanisms of inducing immune modulation, and 3) prevention and treatment of allergy and asthma. of ..