Alexandra C Miller

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pellets
    A C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Mutagenesis 13:643-8. 1998
  2. ncbi request reprint Proto-oncogene expression: a predictive assay for radiation biodosimetry applications
    A C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Radiat Prot Dosimetry 99:295-302. 2002
  3. ncbi request reprint Observation of radiation-specific damage in human cells exposed to depleted uranium: dicentric frequency and neoplastic transformation as endpoints
    A C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Radiat Prot Dosimetry 99:275-8. 2002
  4. ncbi request reprint Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decay
    Alexandra C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Inorg Biochem 91:246-52. 2002
  5. ncbi request reprint Genomic instability in human osteoblast cells after exposure to depleted uranium: delayed lethality and micronuclei formation
    Alexandra C Miller
    Applied Cellular Radiobiology Department Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    J Environ Radioact 64:247-59. 2003
  6. doi request reprint Preconceptional paternal exposure to depleted uranium: transmission of genetic damage to offspring
    Alexandra C Miller
    Scientific Research Department, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Health Phys 99:371-9. 2010
  7. ncbi request reprint Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uranium
    Alexandra C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research, Institute, Bethesda, Maryland 20889 5603, USA
    Mol Cell Biochem 279:97-104. 2005
  8. ncbi request reprint Effect of the militarily-relevant heavy metals, depleted uranium and heavy metal tungsten-alloy on gene expression in human liver carcinoma cells (HepG2)
    Alexandra C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Mol Cell Biochem 255:247-56. 2004
  9. doi request reprint Radioprotection by the histone deacetylase inhibitor phenylbutyrate
    Alexandra C Miller
    Scientific Research Department, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Radiat Environ Biophys 50:585-96. 2011
  10. ncbi request reprint Potential late health effects of depleted uranium and tungsten used in armor-piercing munitions: comparison of neoplastic transformation and genotoxicity with the known carcinogen nickel
    Alexandra C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Mil Med 167:120-2. 2002

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pellets
    A C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Mutagenesis 13:643-8. 1998
    ..The results suggest that uranium content in the urine is correlated with urine mutagenicity and that urinary mutagenicity might be used as a biomarker to detect exposure to internalized uranium...
  2. ncbi request reprint Proto-oncogene expression: a predictive assay for radiation biodosimetry applications
    A C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Radiat Prot Dosimetry 99:295-302. 2002
    ..The use of real-time PCR technologies to quantify gene expression changes will also be discussed...
  3. ncbi request reprint Observation of radiation-specific damage in human cells exposed to depleted uranium: dicentric frequency and neoplastic transformation as endpoints
    A C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Radiat Prot Dosimetry 99:275-8. 2002
    ..Taken together these data suggest that radiation can play a role in DU-induced biological effects in vitro...
  4. ncbi request reprint Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decay
    Alexandra C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Inorg Biochem 91:246-52. 2002
    ..g. oxidative DNA lesions, through interaction with a cellular oxygen species...
  5. ncbi request reprint Genomic instability in human osteoblast cells after exposure to depleted uranium: delayed lethality and micronuclei formation
    Alexandra C Miller
    Applied Cellular Radiobiology Department Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    J Environ Radioact 64:247-59. 2003
    ..These studies demonstrate that DU exposure in vitro results in genomic instability manifested as delayed reproductive death and micronuclei formation...
  6. doi request reprint Preconceptional paternal exposure to depleted uranium: transmission of genetic damage to offspring
    Alexandra C Miller
    Scientific Research Department, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Health Phys 99:371-9. 2010
    ..Regardless of the question of DU-radiation vs. DU-chemical effects, the data indicate that there exists a route for transgenerational transmission of factor(s) leading to genomic instability in F1 progeny from DU-exposed fathers...
  7. ncbi request reprint Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uranium
    Alexandra C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research, Institute, Bethesda, Maryland 20889 5603, USA
    Mol Cell Biochem 279:97-104. 2005
    ..These results demonstrated that a DU altered in vivo environment may be involved in the pathogenesis of DU induced leukemia in an animal model...
  8. ncbi request reprint Effect of the militarily-relevant heavy metals, depleted uranium and heavy metal tungsten-alloy on gene expression in human liver carcinoma cells (HepG2)
    Alexandra C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Mol Cell Biochem 255:247-56. 2004
    ..Our data show for the first time that DU and rWNiCo can activate gene expression through several signal transduction pathways that may be involved in the toxicity and tumorigenicity of both DU and HMTAs...
  9. doi request reprint Radioprotection by the histone deacetylase inhibitor phenylbutyrate
    Alexandra C Miller
    Scientific Research Department, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Radiat Environ Biophys 50:585-96. 2011
    ..These results indicate that an HDAC inhibitor like PB has potential as a radiation protector and that mechanisms of action include attenuation of DNA damage and inhibition of apoptosis...
  10. ncbi request reprint Potential late health effects of depleted uranium and tungsten used in armor-piercing munitions: comparison of neoplastic transformation and genotoxicity with the known carcinogen nickel
    Alexandra C Miller
    Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Mil Med 167:120-2. 2002
    ..These results suggest that long-term exposure to DU or tungsten alloys could be critical to the development of neoplastic disease in humans and that additional studies are needed...
  11. ncbi request reprint A review of depleted uranium biological effects: in vitro and in vivo studies
    Alexandra C Miller
    Uniformed Services University of the Health Sciences, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Building 42, Bethesda, MD 20889 5603, USA
    Rev Environ Health 22:75-89. 2007
    ..Until issues of concern are resolved with further research, the use of depleted uranium by the military will continue to be controversial...
  12. ncbi request reprint Nucleic acid molecular biomarkers for diagnostic biodosimetry applications: use of the fluorogenic 5'-nuclease polymerase chain reaction assay
    William F Blakely
    Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Mil Med 167:16-9. 2002
    ..Our research shows that the analysis of multitarget nucleic acid biomarkers, using the multiplex fluorogenic 5'-nuclease PCR assay, has beneficial applications in radiation epidemiology, radiation therapy, and biodosimetry...
  13. doi request reprint DNA methylation during depleted uranium-induced leukemia
    Alexandra C Miller
    Scientific Research Department, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, MD 20889 5603, USA
    Biochimie 91:1328-30. 2009
    ..The radioactive heavy metal depleted uranium (DU) is used in kinetic-energy penetrators in military applications. The objective of this study was to determine involvement of DNA methylation in DU-induced leukemia...
  14. pmc Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 rats
    John F Kalinich
    Heavy Metals Research Team, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Environ Health Perspect 113:729-34. 2005
    ..These results point out the need for further studies investigating the health effects of tungsten and tungsten-based alloys...
  15. ncbi request reprint Development of chemopreventive strategies for radiation-induced cancer: targeting radiation-induced genetic alterations
    Alexandra C Miller
    Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Mil Med 167:54-6. 2002
    ..Furthermore, this strategy to target LLR-induced preneoplastic alterations may be an effective means of developing modulators of LLR-induced cancers...
  16. ncbi request reprint Health effects of embedded depleted uranium
    David E McClain
    Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Mil Med 167:117-9. 2002
    ..Preliminary data also indicate decreased rodent litter size when animals are bred 6 months or longer after DU implantation...