Research Topics
| Alexandra C MillerSummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
| Collaborators
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Detail Information
Publications
Urinary and serum mutagenicity studies with rats implanted with depleted uranium or tantalum pelletsA C Miller
Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
Mutagenesis 13:643-8. 1998..The results suggest that uranium content in the urine is correlated with urine mutagenicity and that urinary mutagenicity might be used as a biomarker to detect exposure to internalized uranium...- Proto-oncogene expression: a predictive assay for radiation biodosimetry applicationsA C Miller
Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
Radiat Prot Dosimetry 99:295-302. 2002..The use of real-time PCR technologies to quantify gene expression changes will also be discussed... - Observation of radiation-specific damage in human cells exposed to depleted uranium: dicentric frequency and neoplastic transformation as endpointsA C Miller
Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
Radiat Prot Dosimetry 99:275-8. 2002..Taken together these data suggest that radiation can play a role in DU-induced biological effects in vitro... - Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decayAlexandra C Miller
Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
J Inorg Biochem 91:246-52. 2002..g. oxidative DNA lesions, through interaction with a cellular oxygen species... - Genomic instability in human osteoblast cells after exposure to depleted uranium: delayed lethality and micronuclei formationAlexandra C Miller
Applied Cellular Radiobiology Department Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5603, USA
J Environ Radioact 64:247-59. 2003..These studies demonstrate that DU exposure in vitro results in genomic instability manifested as delayed reproductive death and micronuclei formation... 
Preconceptional paternal exposure to depleted uranium: transmission of genetic damage to offspringAlexandra C Miller
Scientific Research Department, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, MD 20889 5603, USA
Health Phys 99:371-9. 2010..Regardless of the question of DU-radiation vs. DU-chemical effects, the data indicate that there exists a route for transgenerational transmission of factor(s) leading to genomic instability in F1 progeny from DU-exposed fathers...- Leukemic transformation of hematopoietic cells in mice internally exposed to depleted uraniumAlexandra C Miller
Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research, Institute, Bethesda, Maryland 20889 5603, USA
Mol Cell Biochem 279:97-104. 2005..These results demonstrated that a DU altered in vivo environment may be involved in the pathogenesis of DU induced leukemia in an animal model... - Effect of the militarily-relevant heavy metals, depleted uranium and heavy metal tungsten-alloy on gene expression in human liver carcinoma cells (HepG2)Alexandra C Miller
Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
Mol Cell Biochem 255:247-56. 2004..Our data show for the first time that DU and rWNiCo can activate gene expression through several signal transduction pathways that may be involved in the toxicity and tumorigenicity of both DU and HMTAs... - Radioprotection by the histone deacetylase inhibitor phenylbutyrateAlexandra C Miller
Scientific Research Department, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, MD 20889 5603, USA
Radiat Environ Biophys 50:585-96. 2011..These results indicate that an HDAC inhibitor like PB has potential as a radiation protector and that mechanisms of action include attenuation of DNA damage and inhibition of apoptosis... - Potential late health effects of depleted uranium and tungsten used in armor-piercing munitions: comparison of neoplastic transformation and genotoxicity with the known carcinogen nickelAlexandra C Miller
Applied Cellular Radiobiology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA
Mil Med 167:120-2. 2002..These results suggest that long-term exposure to DU or tungsten alloys could be critical to the development of neoplastic disease in humans and that additional studies are needed... - A review of depleted uranium biological effects: in vitro and in vivo studiesAlexandra C Miller
Uniformed Services University of the Health Sciences, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Building 42, Bethesda, MD 20889 5603, USA
Rev Environ Health 22:75-89. 2007..Until issues of concern are resolved with further research, the use of depleted uranium by the military will continue to be controversial... - Nucleic acid molecular biomarkers for diagnostic biodosimetry applications: use of the fluorogenic 5'-nuclease polymerase chain reaction assayWilliam F Blakely
Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA
Mil Med 167:16-9. 2002..Our research shows that the analysis of multitarget nucleic acid biomarkers, using the multiplex fluorogenic 5'-nuclease PCR assay, has beneficial applications in radiation epidemiology, radiation therapy, and biodosimetry... - DNA methylation during depleted uranium-induced leukemiaAlexandra C Miller
Scientific Research Department, Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University, Bethesda, MD 20889 5603, USA
Biochimie 91:1328-30. 2009..The radioactive heavy metal depleted uranium (DU) is used in kinetic-energy penetrators in military applications. The objective of this study was to determine involvement of DNA methylation in DU-induced leukemia... 
Embedded weapons-grade tungsten alloy shrapnel rapidly induces metastatic high-grade rhabdomyosarcomas in F344 ratsJohn F Kalinich
Heavy Metals Research Team, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
Environ Health Perspect 113:729-34. 2005..These results point out the need for further studies investigating the health effects of tungsten and tungsten-based alloys...- Development of chemopreventive strategies for radiation-induced cancer: targeting radiation-induced genetic alterationsAlexandra C Miller
Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA
Mil Med 167:54-6. 2002..Furthermore, this strategy to target LLR-induced preneoplastic alterations may be an effective means of developing modulators of LLR-induced cancers... - Health effects of embedded depleted uraniumDavid E McClain
Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA
Mil Med 167:117-9. 2002..Preliminary data also indicate decreased rodent litter size when animals are bred 6 months or longer after DU implantation...