D Merrell

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. pmc A single nucleotide change affects fur-dependent regulation of sodB in H. pylori
    Beth M Carpenter
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    PLoS ONE 4:e5369. 2009
  2. pmc A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease
    Kathleen R Jones
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences Bethesda, MD, USA
    Front Microbiol 1:115. 2010
  3. pmc The geographic origin of Helicobacter pylori influences the association of the homB gene with gastric cancer
    Jieun Kang
    Department of Oral Biology, Oral Science Research Center, BK21 Project, Research Center for Orofacial Hard Tissue Regeneration, Yonsei University College of Dentistry, Seoul, South Korea
    J Clin Microbiol 50:1082-5. 2012
  4. pmc Microarray analysis of Shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition
    Christina S Faherty
    Department of Microbiology and Immunology, F, Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    BMC Genomics 11:272. 2010
  5. pmc Enterobacterial common antigen mutants of Salmonella enterica serovar Typhimurium establish a persistent infection and provide protection against subsequent lethal challenge
    Jeremy J Gilbreath
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Infect Immun 80:441-50. 2012
  6. ncbi request reprint Frontal and stealth attack strategies in microbial pathogenesis
    D Scott Merrell
    Uniformed Services University of the Health Sciences, Department of Microbiology and Immunology, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
    Nature 430:250-6. 2004
  7. pmc The oligo-acyl lysyl antimicrobial peptide C₁₂K-2β₁₂ exhibits a dual mechanism of action and demonstrates strong in vivo efficacy against Helicobacter pylori
    Morris O Makobongo
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Antimicrob Agents Chemother 56:378-90. 2012
  8. pmc Mutagenesis of conserved amino acids of Helicobacter pylori fur reveals residues important for function
    Beth M Carpenter
    Department of Microbiology and Immunology, Uniformed Services University of the Heath Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    J Bacteriol 192:5037-52. 2010
  9. pmc Detailed in vivo analysis of the role of Helicobacter pylori Fur in colonization and disease
    Shana Miles
    Department of Microbiology and Immunology, Uniformed Services University of the Heath Sciences, Bethesda, Maryland 20814, USA
    Infect Immun 78:3073-82. 2010
  10. pmc Diet synergistically affects helicobacter pylori-induced gastric carcinogenesis in nonhuman primates
    Hui Liu
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    Gastroenterology 137:1367-79.e1-6. 2009

Research Grants

  1. Regulatory Networks of Helicobacter pylori
    D Merrell; Fiscal Year: 2007
  2. Regulatory Networks of Helicobacter pylori
    D Merrell; Fiscal Year: 2009
  3. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2010
  4. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2011

Collaborators

  • ANDRE T DUBOIS
  • Anne Mueller
  • Lucinda J Thompson
  • Robert Maier
  • Richard Peek
  • P Correa
  • Hanan Gancz
  • Beth M Carpenter
  • Kathleen R Jones
  • Jeannette M Whitmire
  • Morris O Makobongo
  • Shana Miles
  • Cara H Olsen
  • Cristina Semino-Mora
  • Jeremy J Gilbreath
  • Jieun Kang
  • Yun Jung Yoo
  • Jeong Heon Cha
  • Sungil Jang
  • Christina S Faherty
  • Sarah L J Michel
  • Hui Liu
  • Stefano Censini
  • Sahar H El-Etr
  • Eleanor S Metcalf
  • Dennis P McDaniel
  • Paul D Rick
  • Mark J Soloski
  • Jennifer Colvocoresses Dodds
  • Sarah Evans
  • Anthony T Maurelli
  • M Blanca Piazuelo
  • Stéphane L Benoit
  • Aishwarya V Ramaswamy
  • Mary Kay Washington
  • Arifur Rahman
  • Young Min Joo
  • Tchelet Kovachi
  • Hak Sung Lee
  • Amram Mor
  • Steven Mog
  • Reyda P Gonzalez-Nieves
  • Abby L West
  • Matthew Goldman
  • In Sik Chung
  • Silvia Guidotti
  • Timothy K McDaniel
  • Stanley Falkow
  • Lucy S Tompkins

Detail Information

Publications23

  1. pmc A single nucleotide change affects fur-dependent regulation of sodB in H. pylori
    Beth M Carpenter
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    PLoS ONE 4:e5369. 2009
    ..Taken together these data indicate that this nucleotide residue is important for direct apo-Fur binding to the sodB promoter...
  2. pmc A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease
    Kathleen R Jones
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences Bethesda, MD, USA
    Front Microbiol 1:115. 2010
    ..Herein we highlight the diverse types of cellular pathways and processes targeted by these important toxins...
  3. pmc The geographic origin of Helicobacter pylori influences the association of the homB gene with gastric cancer
    Jieun Kang
    Department of Oral Biology, Oral Science Research Center, BK21 Project, Research Center for Orofacial Hard Tissue Regeneration, Yonsei University College of Dentistry, Seoul, South Korea
    J Clin Microbiol 50:1082-5. 2012
    ..Uniquely, several East Asian strains carried multiple copies of the hom genes...
  4. pmc Microarray analysis of Shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition
    Christina S Faherty
    Department of Microbiology and Immunology, F, Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    BMC Genomics 11:272. 2010
    ..The goal of this research was to identify host factors that contribute to apoptosis inhibition in infected cells...
  5. pmc Enterobacterial common antigen mutants of Salmonella enterica serovar Typhimurium establish a persistent infection and provide protection against subsequent lethal challenge
    Jeremy J Gilbreath
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Infect Immun 80:441-50. 2012
    ..Typhimurium. Thus, wecA mutant (ECA-negative) strains of Salmonella may be useful as live attenuated vaccine strains or as vehicles for heterologous antigen expression...
  6. ncbi request reprint Frontal and stealth attack strategies in microbial pathogenesis
    D Scott Merrell
    Uniformed Services University of the Health Sciences, Department of Microbiology and Immunology, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
    Nature 430:250-6. 2004
    ..This highlights the relevance of continuing to probe the mechanisms used by microorganisms to cause disease, and emphasizes the need for new model systems to advance our understanding of host-pathogen interactions...
  7. pmc The oligo-acyl lysyl antimicrobial peptide C₁₂K-2β₁₂ exhibits a dual mechanism of action and demonstrates strong in vivo efficacy against Helicobacter pylori
    Morris O Makobongo
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Antimicrob Agents Chemother 56:378-90. 2012
    ..pylori when used as monotherapy. Therefore, OAK peptides may be a valuable resource for therapeutic treatment of H. pylori infection...
  8. pmc Mutagenesis of conserved amino acids of Helicobacter pylori fur reveals residues important for function
    Beth M Carpenter
    Department of Microbiology and Immunology, Uniformed Services University of the Heath Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    J Bacteriol 192:5037-52. 2010
    ..This study is the first for H. pylori to analyze the roles of specific amino acid residues of Fur in function and continues to highlight the complexity of Fur regulation in this organism...
  9. pmc Detailed in vivo analysis of the role of Helicobacter pylori Fur in colonization and disease
    Shana Miles
    Department of Microbiology and Immunology, Uniformed Services University of the Heath Sciences, Bethesda, Maryland 20814, USA
    Infect Immun 78:3073-82. 2010
    ..pylori Fur is most important at early stages of infection and illustrate the importance of the ability of H. pylori to adapt to its constantly fluctuating environment when it is establishing infection, inflammation, and disease...
  10. pmc Diet synergistically affects helicobacter pylori-induced gastric carcinogenesis in nonhuman primates
    Hui Liu
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    Gastroenterology 137:1367-79.e1-6. 2009
    ..Because the role of these factors in gastric carcinogenesis cannot be determined readily in human beings, the present study examined the role of an oral carcinogen and H pylori infection in rhesus monkeys...
  11. pmc In vitro antibacterial activity of acyl-lysyl oligomers against Helicobacter pylori
    Morris O Makobongo
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, Maryland 20814, USA
    Antimicrob Agents Chemother 53:4231-9. 2009
    ..Our results show a significant in vitro effect of C12K-2beta12 against H. pylori and suggest that OAKs may be a valuable resource for the treatment of H. pylori infection...
  12. pmc Helicobacter pylori apo-Fur regulation appears unconserved across species
    Shana Miles
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Microbiol 48:378-86. 2010
    ..These data suggest that despite the conservation among bacterial Fur proteins, H. pylori Fur contains unique structure/function features that make it novel in comparison to Fur from other species...
  13. pmc Polymorphism in the CagA EPIYA motif impacts development of gastric cancer
    Kathleen R Jones
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Marylan 20814, USA
    J Clin Microbiol 47:959-68. 2009
    ....
  14. pmc pH-regulated gene expression of the gastric pathogen Helicobacter pylori
    D Scott Merrell
    Department of Microbiology and Immunology, Stanford School of Medicine, California 94305, USA
    Infect Immun 71:3529-39. 2003
    ..Furthermore, this transcriptional repression was reflected at the level of protein accumulation in the H. pylori cell...
  15. pmc Growth phase-dependent response of Helicobacter pylori to iron starvation
    D Scott Merrell
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA
    Infect Immun 71:6510-25. 2003
    ..Finally, bioinformatic analysis of the predicted promoter regions of the differentially regulated genes led to identification of several putative Fur boxes, suggesting a direct role for Fur in iron-dependent regulation of these genes...
  16. ncbi request reprint Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers
    Sahar H El-Etr
    Department of Microbiology and Immunology, Stanford University Medical School, Stanford, California 94305, USA
    J Infect Dis 190:1516-23. 2004
    ..These data suggest the presence of distinct functional domains within the CagA protein that play essential roles in protein targeting and alteration of host-cell signaling pathways...
  17. ncbi request reprint Profiling of microdissected gastric epithelial cells reveals a cell type-specific response to Helicobacter pylori infection
    Anne Mueller
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Gastroenterology 127:1446-62. 2004
    ..We have explored the transcriptional response of the epithelium globally by applying a whole-genome approach to a murine model of infection...
  18. pmc Iron and pH homeostasis intersect at the level of Fur regulation in the gastric pathogen Helicobacter pylori
    Hanan Gancz
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Infect Immun 74:602-14. 2006
    ..This fact likely explains the requirement for this regulator for growth and colonization in the stomach...
  19. ncbi request reprint Balancing the double-edged sword: metal ion homeostasis and the ulcer bug
    Jeannette M Whitmire
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Curr Med Chem 14:469-78. 2007
    ..pylori colonization and disease and the possibility that these metal homeostasis cascade components may serve as good targets for rational drug design to eradicate H. pylori infection...
  20. pmc Expanding the Helicobacter pylori genetic toolbox: modification of an endogenous plasmid for use as a transcriptional reporter and complementation vector
    Beth M Carpenter
    Department of Microbiology and Immunology, Uniformed Services University of the Heath Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Appl Environ Microbiol 73:7506-14. 2007
    ..These studies show the potential of pTM117 as a molecular tool for genetic analysis of H. pylori...
  21. pmc Sodium chloride affects Helicobacter pylori growth and gene expression
    Hanan Gancz
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    J Bacteriol 190:4100-5. 2008
    ..Here we characterize the response of H. pylori to temporal changes in sodium chloride concentration and show that growth, cell morphology, survival, and virulence factor expression are all altered by increased salt concentration...
  22. ncbi request reprint Acid tolerance of gastrointestinal pathogens
    D Scott Merrell
    Stanford University School of Medicine, Department of Microbiology and Immunology, 299 Campus Drive, Stanford, CA 94305, USA
    Curr Opin Microbiol 5:51-5. 2002
    ..Here, we review recent work on four gastrointestinal pathogens, focusing on studies that reveal both acid-inducible resistance systems and inherent (basal state) acid-resistance systems...
  23. pmc Gene expression profiling of Helicobacter pylori reveals a growth-phase-dependent switch in virulence gene expression
    Lucinda J Thompson
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia
    Infect Immun 71:2643-55. 2003
    ....

Research Grants5

  1. Regulatory Networks of Helicobacter pylori
    D Merrell; Fiscal Year: 2007
    ..Our studies will help to shed light on genes involved in the process of surviving in the human body and should provide novel targets for vaccine and therapeutic design. ..
  2. Regulatory Networks of Helicobacter pylori
    D Merrell; Fiscal Year: 2009
    ..Our studies will help to shed light on genes involved in the process of surviving in the human body and should provide novel targets for vaccine and therapeutic design. ..
  3. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2010
    ..Our studies will help to shed light on genes involved in the process of surviving in the human body and should provide novel targets for vaccine and therapeutic design. ..
  4. Regulatory Networks of Helicobacter pylori
    D Scott Merrell; Fiscal Year: 2011
    ..Our studies will help to shed light on genes involved in the process of surviving in the human body and should provide novel targets for vaccine and therapeutic design. ..