Research Topics
| Radha K MaheshwariSummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
| Collaborators
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Detail Information
Publications
Hemorrhagic shock induces differential gene expression and apoptosis in mouse liverShirin V Sundar
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Biochem Biophys Res Commun 332:688-96. 2005..Our findings show that oxidative stress causes immediate upregulation of genes involved in a variety of cellular defense pathways. Complex interactions among them might determine the ultimate fate of the cell...- Multiple biological activities of curcumin: a short reviewRadha K Maheshwari
Department of Pathology, Uniformed Services University of the Life Sciences, Center for Combat Casualty and Life Sustainment Research, Bethesda, Maryland 20814, USA
Life Sci 78:2081-7. 2006..This review summarizes the most interesting in vitro and in vivo studies on the biological effects of curcumin... - Picroliv accelerates epithelialization and angiogenesis in rat woundsAnoop K Singh
Center for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Life Sciences, Bethesda, Maryland 20814, USA
Planta Med 73:251-6. 2007..These findings suggest that picroliv could be developed as a therapeutic angiogenic agent for the restoration of the blood supply in diseases involving inadequate blood supply such as limb ischemia, ischemic myocardium and wound healing... - Picroliv modulates antioxidant status and down-regulates AP1 transcription factor after hemorrhage and resuscitationPankaj Seth
Center for Combat Casualty Care and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814, USA
Shock 19:169-75. 2003..These findings suggest that picroliv has the potential to be developed as a protective agent against H/R injury... - Homeopathic medicines do not alter growth and gene expression in prostate and breast cancer cells in vitroRajesh L Thangapazham
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Integr Cancer Ther 5:356-61. 2006..CONCLUSIONS: The results demonstrate that the highly diluted homeopathic remedies used by homeopathic practitioners for cancer show no measurable effects on cell growth or gene expression in vitro using currently available methodologies... - Androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptomeRajesh L Thangapazham
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Cancer Biol Ther 7:1427-35. 2008..Importantly, new gene-networks identified here further delineate molecular mechanism(s) of action of curcumin in prostate cancer cells... - Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissuesRajesh L Thangapazham
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Integr Cancer Ther 5:350-5. 2006..Future research should explore subtle modulations in the expression of multiple genes in different biological pathways... - Inhibition of tumor angiogenesis by Brahma Rasayana (BR)Rajesh L Thangapazham
Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
J Exp Ther Oncol 6:13-21. 2006..These findings suggest the possible mechanism(s) of action of BR in the reduction of tumor growth and metastatic spread... 
Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cellsRajesh L Thangapazham
Center for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences USUHS, Bethesda, MD 20814, USA
Int J Oncol 32:1119-23. 2008..We are currently developing liposome formulations with targeting ability to further improve the efficacy of curcumin in vivo...- Green tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cellsRajesh L Thangapazham
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Cancer Biol Ther 6:1938-43. 2007..For the first time we report the connection of beta-catenin and AKT modulation by GTP and EGCG as a possible mechanism for the induction of apoptosis in human breast cancer cells and also inhibition in their invasive capacity... - Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivoRajesh L Thangapazham
Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Cancer Lett 245:232-41. 2007..Our results suggest that GTP and EGCG treatment inhibits proliferation and induce apoptosis of MDA-MB-231 cells in-vitro and in-vivo. All together, these data sustain our contention that GTP and EGCG have anti-tumor properties... - Differential regulation of angiogenic genes in diabetic wound healingAnuj Sharma
Department of Pathology, Center for Combat Casualty and Life Sustainment Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Invest Dermatol 126:2323-31. 2006..This finding suggests that OPN might be playing a crucial role in the early events of the wound healing and its delayed expression may be in part responsible for the delayed healing of wounds in diabetic mice... - Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cellsRajesh L Thangapazham
Center for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Front Biosci 13:561-8. 2008..SA treatment also resulted in induction of caspase-3 activity. The results suggest the involvement of bcl2 and Caspase-3 in SA induced apoptosis of human U937 cells... - Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brainAnuj Sharma
Centre for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
BMC Genomics 9:289. 2008..Changes in gene expression were correlated with histological changes in the brain. In addition, a molecular framework of changes in gene expression associated with progression of the disease was studied... - Beneficial role of curcumin in skin diseasesRajesh L Thangapazham
Uniformed Services University of Health Sciences, Bethesda, MD, USA
Adv Exp Med Biol 595:343-57. 2007..These studies suggest the beneficial effects of curcumin and the potential of this compound to be developed as a potent nontoxic agent for treating skin diseases... - Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitationJaya P Gaddipati
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Shock 19:150-6. 2003..These results suggest that protection against hemorrhage/resuscitation injury by curcumin pretreatment may result from the inactivation of transcription factors involved and regulation of cytokines to beneficial levels... 
Oligonucleotide array analysis of Toll-like receptors and associated signalling genes in Venezuelan equine encephalitis virus-infected mouse brainAnuj Sharma
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Gen Virol 90:1836-47. 2009..These results demonstrate the upregulation of TLRs and associated signalling genes following VEEV infection of the brain, with important implications for how VEEV induces inflammation and neurodegeneration...- Multiple molecular targets in cancer chemoprevention by curcuminRajesh L Thangapazham
Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
AAPS J 8:E443-9. 2006..This review summarizes the inhibition of NF-kappaB by curcumin and describes the recently identified molecular targets of curcumin. It is hoped that continued research will lead to development of curcumin as an anticancer agent... - Safety and protective efficacy of INA-inactivated Venezuelan equine encephalitis virus: implication in vaccine developmentAnuj Sharma
Centre for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Vaccine 29:953-9. 2011..Results suggest that inactivation of enveloped viruses by INA may occur by two independent mechanisms and the INA-inactivated VEEV elicit a protective antibody response in mice... - Preserving immunogenicity of lethally irradiated viral and bacterial vaccine epitopes using a radio- protective Mn2+-Peptide complex from DeinococcusElena K Gaidamakova
Department of Pathology, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Cell Host Microbe 12:117-24. 2012..This approach could expedite vaccine production for emerging and established pathogens for which no protective vaccines exist... - Role of adhesion molecules and inflammation in Venezuelan equine encephalitis virus infected mouse brainAnuj Sharma
Dept of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Virol J 8:197. 2011..In this study, we evaluated the expression of extracellular matrix and adhesion molecules genes in the brain of VEEV infected mice... - Complete inactivation of Venezuelan equine encephalitis virus by 1,5-iodonaphthylazideAnuj Sharma
Centre for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Biochem Biophys Res Commun 358:392-8. 2007..This data suggest that such inactivation strategies can be used for developing vaccine candidates for VEEV and other enveloped viruses... - Protective effect of a polyherbal preparation, Brahma rasayana against tumor growth and lung metastasis in rat prostate model systemJaya P Gaddipati
Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
J Exp Ther Oncol 4:203-12. 2004..These are inexpensive preparations that have little or no adverse side effects with a potential as lead chemopreventive compounds and which might prove useful for the treatment of disorders such as human prostate cancer... - Early onset of virus infection and up-regulation of cytokines in mice treated with cadmium and manganesePankaj Seth
Center for Combat Casualty Care and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences (USUHS, Bethesda, MD-20814, USA
Biometals 16:359-68. 2003.... - MicroRNA let-7i is a promising serum biomarker for blast-induced traumatic brain injuryNagaraja Balakathiresan
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Neurotrauma 29:1379-87. 2012..The presence of microRNA in both serum and cerebrospinal fluid immediately after injury makes microRNA let-7i an ideal candidate for further studies of biomarkers in TBI... - Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healingHaresh Mani
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Biofactors 16:29-43. 2002..The study indicates an enhancement in dexamethasone impaired wound repair by topical curcumin and its differential regulatory effect on TGF-beta1, it's receptors and iNOS in this cutaneous wound-healing model... - Can homeopathic treatment slow prostate cancer growth?Wayne B Jonas
Samueli Institute, 1700 Diagonal Road, Suite 400, Alexandria, VA 22314, USA
Integr Cancer Ther 5:343-9. 2006..Therefore, the authors conducted a series of carefully controlled laboratory studies evaluating the effects of commonly used homeopathic remedies in cell and animal models of prostate cancer...