Radha K Maheshwari

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Hemorrhagic shock induces differential gene expression and apoptosis in mouse liver
    Shirin V Sundar
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Biochem Biophys Res Commun 332:688-96. 2005
  2. ncbi request reprint Multiple biological activities of curcumin: a short review
    Radha K Maheshwari
    Department of Pathology, Uniformed Services University of the Life Sciences, Center for Combat Casualty and Life Sustainment Research, Bethesda, Maryland 20814, USA
    Life Sci 78:2081-7. 2006
  3. ncbi request reprint Picroliv accelerates epithelialization and angiogenesis in rat wounds
    Anoop K Singh
    Center for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Life Sciences, Bethesda, Maryland 20814, USA
    Planta Med 73:251-6. 2007
  4. ncbi request reprint Homeopathic medicines do not alter growth and gene expression in prostate and breast cancer cells in vitro
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Integr Cancer Ther 5:356-61. 2006
  5. ncbi request reprint Picroliv modulates antioxidant status and down-regulates AP1 transcription factor after hemorrhage and resuscitation
    Pankaj Seth
    Center for Combat Casualty Care and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814, USA
    Shock 19:169-75. 2003
  6. ncbi request reprint Androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptome
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Cancer Biol Ther 7:1427-35. 2008
  7. ncbi request reprint Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Integr Cancer Ther 5:350-5. 2006
  8. ncbi request reprint Green tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cells
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Cancer Biol Ther 6:1938-43. 2007
  9. pmc Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells
    Rajesh L Thangapazham
    Center for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences USUHS, Bethesda, MD 20814, USA
    Int J Oncol 32:1119-23. 2008
  10. ncbi request reprint Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cancer Lett 245:232-41. 2007

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Hemorrhagic shock induces differential gene expression and apoptosis in mouse liver
    Shirin V Sundar
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Biochem Biophys Res Commun 332:688-96. 2005
    ..Our findings show that oxidative stress causes immediate upregulation of genes involved in a variety of cellular defense pathways. Complex interactions among them might determine the ultimate fate of the cell...
  2. ncbi request reprint Multiple biological activities of curcumin: a short review
    Radha K Maheshwari
    Department of Pathology, Uniformed Services University of the Life Sciences, Center for Combat Casualty and Life Sustainment Research, Bethesda, Maryland 20814, USA
    Life Sci 78:2081-7. 2006
    ..This review summarizes the most interesting in vitro and in vivo studies on the biological effects of curcumin...
  3. ncbi request reprint Picroliv accelerates epithelialization and angiogenesis in rat wounds
    Anoop K Singh
    Center for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Life Sciences, Bethesda, Maryland 20814, USA
    Planta Med 73:251-6. 2007
    ..These findings suggest that picroliv could be developed as a therapeutic angiogenic agent for the restoration of the blood supply in diseases involving inadequate blood supply such as limb ischemia, ischemic myocardium and wound healing...
  4. ncbi request reprint Homeopathic medicines do not alter growth and gene expression in prostate and breast cancer cells in vitro
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Integr Cancer Ther 5:356-61. 2006
    ..In this study, the authors investigate the effect of selected homeopathic remedies often used to treat prostate and breast cancer. Materials and..
  5. ncbi request reprint Picroliv modulates antioxidant status and down-regulates AP1 transcription factor after hemorrhage and resuscitation
    Pankaj Seth
    Center for Combat Casualty Care and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20814, USA
    Shock 19:169-75. 2003
    ..These findings suggest that picroliv has the potential to be developed as a protective agent against H/R injury...
  6. ncbi request reprint Androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptome
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Cancer Biol Ther 7:1427-35. 2008
    ..Importantly, new gene-networks identified here further delineate molecular mechanism(s) of action of curcumin in prostate cancer cells...
  7. ncbi request reprint Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Integr Cancer Ther 5:350-5. 2006
    ..In a recent study, the authors found that certain homeopathic treatments produced anticancer effects in an animal model. In this study, the authors examined the immunomodulating and apoptotic effects of these remedies. Materials and..
  8. ncbi request reprint Green tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cells
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Cancer Biol Ther 6:1938-43. 2007
    ..For the first time we report the connection of beta-catenin and AKT modulation by GTP and EGCG as a possible mechanism for the induction of apoptosis in human breast cancer cells and also inhibition in their invasive capacity...
  9. pmc Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells
    Rajesh L Thangapazham
    Center for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences USUHS, Bethesda, MD 20814, USA
    Int J Oncol 32:1119-23. 2008
    ..We are currently developing liposome formulations with targeting ability to further improve the efficacy of curcumin in vivo...
  10. ncbi request reprint Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cancer Lett 245:232-41. 2007
    ..Our results suggest that GTP and EGCG treatment inhibits proliferation and induce apoptosis of MDA-MB-231 cells in-vitro and in-vivo. All together, these data sustain our contention that GTP and EGCG have anti-tumor properties...
  11. ncbi request reprint Inhibition of tumor angiogenesis by Brahma Rasayana (BR)
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    J Exp Ther Oncol 6:13-21. 2006
    ..These findings suggest the possible mechanism(s) of action of BR in the reduction of tumor growth and metastatic spread...
  12. ncbi request reprint Differential regulation of angiogenic genes in diabetic wound healing
    Anuj Sharma
    Department of Pathology, Center for Combat Casualty and Life Sustainment Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Invest Dermatol 126:2323-31. 2006
    ..This finding suggests that OPN might be playing a crucial role in the early events of the wound healing and its delayed expression may be in part responsible for the delayed healing of wounds in diabetic mice...
  13. ncbi request reprint Artificial microRNAs can effectively inhibit replication of Venezuelan equine encephalitis virus
    Manish Bhomia
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India
    Antiviral Res 100:429-34. 2013
    ..In conclusion, we have shown that RNAi through artificial microRNAs effectively inhibits VEEV replication and is significantly less toxic in comparison to siRNAs. ..
  14. ncbi request reprint Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cells
    Rajesh L Thangapazham
    Center for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Front Biosci 13:561-8. 2008
    ..SA treatment also resulted in induction of caspase-3 activity. The results suggest the involvement of bcl2 and Caspase-3 in SA induced apoptosis of human U937 cells...
  15. pmc Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brain
    Anuj Sharma
    Centre for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    BMC Genomics 9:289. 2008
    ..Changes in gene expression were correlated with histological changes in the brain. In addition, a molecular framework of changes in gene expression associated with progression of the disease was studied...
  16. ncbi request reprint Skin regenerative potentials of curcumin
    Rajesh L Thangapazham
    Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Biofactors 39:141-9. 2013
    ..Recent clinical trials pertaining to the use of curcumin in skin diseases establishes its benefits and also the need for additional clinical trials in other diseases are discussed...
  17. pmc Multiple molecular targets in cancer chemoprevention by curcumin
    Rajesh L Thangapazham
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    AAPS J 8:E443-9. 2006
    ..This review summarizes the inhibition of NF-kappaB by curcumin and describes the recently identified molecular targets of curcumin. It is hoped that continued research will lead to development of curcumin as an anticancer agent...
  18. doi request reprint Oligonucleotide array analysis of Toll-like receptors and associated signalling genes in Venezuelan equine encephalitis virus-infected mouse brain
    Anuj Sharma
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Gen Virol 90:1836-47. 2009
    ..These results demonstrate the upregulation of TLRs and associated signalling genes following VEEV infection of the brain, with important implications for how VEEV induces inflammation and neurodegeneration...
  19. ncbi request reprint Beneficial role of curcumin in skin diseases
    Rajesh L Thangapazham
    Uniformed Services University of Health Sciences, Bethesda, MD, USA
    Adv Exp Med Biol 595:343-57. 2007
    ..These studies suggest the beneficial effects of curcumin and the potential of this compound to be developed as a potent nontoxic agent for treating skin diseases...
  20. ncbi request reprint Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation
    Jaya P Gaddipati
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Shock 19:150-6. 2003
    ..These results suggest that protection against hemorrhage/resuscitation injury by curcumin pretreatment may result from the inactivation of transcription factors involved and regulation of cytokines to beneficial levels...
  21. pmc Inactivation of Chikungunya virus by 1,5 iodonapthyl azide
    Anuj Sharma
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Virol J 9:301. 2012
    ..A live attenuated strain of CHIKV, CHIK181/25, was previously demonstrated to be highly immunogenic in humans, however, it showed residual virulence causing transient arthralgia...
  22. doi request reprint Safety and protective efficacy of INA-inactivated Venezuelan equine encephalitis virus: implication in vaccine development
    Anuj Sharma
    Centre for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Vaccine 29:953-9. 2011
    ..Results suggest that inactivation of enveloped viruses by INA may occur by two independent mechanisms and the INA-inactivated VEEV elicit a protective antibody response in mice...
  23. pmc Preserving immunogenicity of lethally irradiated viral and bacterial vaccine epitopes using a radio- protective Mn2+-Peptide complex from Deinococcus
    Elena K Gaidamakova
    Department of Pathology, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Cell Host Microbe 12:117-24. 2012
    ..This approach could expedite vaccine production for emerging and established pathogens for which no protective vaccines exist...
  24. pmc Role of adhesion molecules and inflammation in Venezuelan equine encephalitis virus infected mouse brain
    Anuj Sharma
    Dept of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Virol J 8:197. 2011
    ..In this study, we evaluated the expression of extracellular matrix and adhesion molecules genes in the brain of VEEV infected mice...
  25. ncbi request reprint Complete inactivation of Venezuelan equine encephalitis virus by 1,5-iodonaphthylazide
    Anuj Sharma
    Centre for Combat Casualty and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Biochem Biophys Res Commun 358:392-8. 2007
    ..This data suggest that such inactivation strategies can be used for developing vaccine candidates for VEEV and other enveloped viruses...
  26. ncbi request reprint Protective effect of a polyherbal preparation, Brahma rasayana against tumor growth and lung metastasis in rat prostate model system
    Jaya P Gaddipati
    Department of Pathology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    J Exp Ther Oncol 4:203-12. 2004
    ..These are inexpensive preparations that have little or no adverse side effects with a potential as lead chemopreventive compounds and which might prove useful for the treatment of disorders such as human prostate cancer...
  27. ncbi request reprint Early onset of virus infection and up-regulation of cytokines in mice treated with cadmium and manganese
    Pankaj Seth
    Center for Combat Casualty Care and Life Sustainment Research, Department of Pathology, Uniformed Services University of the Health Sciences USUHS, Bethesda, MD 20814, USA
    Biometals 16:359-68. 2003
    ....
  28. pmc MicroRNA let-7i is a promising serum biomarker for blast-induced traumatic brain injury
    Nagaraja Balakathiresan
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurotrauma 29:1379-87. 2012
    ..The presence of microRNA in both serum and cerebrospinal fluid immediately after injury makes microRNA let-7i an ideal candidate for further studies of biomarkers in TBI...
  29. ncbi request reprint Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing
    Haresh Mani
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Biofactors 16:29-43. 2002
    ..The study indicates an enhancement in dexamethasone impaired wound repair by topical curcumin and its differential regulatory effect on TGF-beta1, it's receptors and iNOS in this cutaneous wound-healing model...
  30. ncbi request reprint Can homeopathic treatment slow prostate cancer growth?
    Wayne B Jonas
    Samueli Institute, 1700 Diagonal Road, Suite 400, Alexandria, VA 22314, USA
    Integr Cancer Ther 5:343-9. 2006
    ..Therefore, the authors conducted a series of carefully controlled laboratory studies evaluating the effects of commonly used homeopathic remedies in cell and animal models of prostate cancer...