K Sree Kumar

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Inhibition of LPS-induced nitric oxide production in RAW cells by radioprotective thiols
    K Sree Kumar
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, Maryland 20889 5603, USA
    Exp Mol Pathol 74:68-73. 2003
  2. ncbi request reprint Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol
    K Sree Kumar
    Radiation Casualty Management Team and Veterinary Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Life Sci 78:2099-104. 2006
  3. ncbi request reprint High-dose antibiotic therapy is superior to a 3-drug combination of prostanoids and lipid A derivative in protecting irradiated canines
    K Sree Kumar
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA
    J Radiat Res 43:361-70. 2002
  4. doi request reprint Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation
    Shilpa Kulkarni
    a Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA
    Radiat Res 173:738-47. 2010
  5. pmc Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    J Radiat Res 53:526-36. 2012
  6. doi request reprint Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor
    Shilpa S Kulkarni
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, United States
    Int Immunopharmacol 14:495-503. 2012
  7. doi request reprint Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, USA
    Int J Radiat Biol 85:598-606. 2009
  8. ncbi request reprint Hematological targets of radiation damage
    Shilpa Kulkarni
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Curr Drug Targets 11:1375-85. 2010
  9. ncbi request reprint Induction of cytokines by radioprotective tocopherol analogs
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Exp Mol Pathol 81:55-61. 2006
  10. doi request reprint Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, Maryland 20889 5603, USA
    Radiat Res 171:173-9. 2009

Detail Information

Publications15

  1. ncbi request reprint Inhibition of LPS-induced nitric oxide production in RAW cells by radioprotective thiols
    K Sree Kumar
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, Maryland 20889 5603, USA
    Exp Mol Pathol 74:68-73. 2003
    ....
  2. ncbi request reprint Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol
    K Sree Kumar
    Radiation Casualty Management Team and Veterinary Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Life Sci 78:2099-104. 2006
    ..Liver tissue was protected in the short-term from radiation-induced lipid peroxidation. These studies indicate that the radiotherapy efficacy of prostate cancer can be increased with GT and a pro-oxidant if the kidneys can be shielded...
  3. ncbi request reprint High-dose antibiotic therapy is superior to a 3-drug combination of prostanoids and lipid A derivative in protecting irradiated canines
    K Sree Kumar
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA
    J Radiat Res 43:361-70. 2002
    ..Although blood transfusion correlated with survival of 3-DC treated canines, there were no additional survivors with 3-DC treated canines than the controls...
  4. doi request reprint Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation
    Shilpa Kulkarni
    a Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA
    Radiat Res 173:738-47. 2010
    ..Our results demonstrate that GT3 protected hematopoietic tissue by preserving the HSCs and HPCs and by preventing persistent DNA damage...
  5. pmc Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    J Radiat Res 53:526-36. 2012
    ..The results demonstrated that Ex-RAD ameliorates radiation-induced peripheral blood cell depletion, promotes bone marrow recovery, reduces p53 signaling in spleen and protects intestine from radiation injury...
  6. doi request reprint Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor
    Shilpa S Kulkarni
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, United States
    Int Immunopharmacol 14:495-503. 2012
    ..These results also suggest a possible role of GT3-induced G-CSF stimulation in protecting mice from radiation-induced neutropenia and thrombocytopenia...
  7. doi request reprint Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, USA
    Int J Radiat Biol 85:598-606. 2009
    ..To assess the radioprotective potential of gamma-tocotrienol...
  8. ncbi request reprint Hematological targets of radiation damage
    Shilpa Kulkarni
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Curr Drug Targets 11:1375-85. 2010
    ....
  9. ncbi request reprint Induction of cytokines by radioprotective tocopherol analogs
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Exp Mol Pathol 81:55-61. 2006
    ..These studies may indicate that alpha-tocopherol succinate can be used as an adjunct in cancer chemotherapy, where neutropenia is a serious problem with threatening infectious complications...
  10. doi request reprint Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, Maryland 20889 5603, USA
    Radiat Res 171:173-9. 2009
    ..In conclusion, it appears that Ex-Rad's radioprotective mechanisms involve prevention of p53-dependent and independent radiation-induced apoptosis...
  11. pmc Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    Mol Biosyst 9:723-31. 2013
    ..Post-radiation GI injury is a critical determinant of survival after exposure to IR. Our results show a distinct dose and time dependent response to GI tissue injury...
  12. doi request reprint Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a promising radiation countermeasure
    Sugata Ray
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    Int Immunopharmacol 15:557-64. 2013
    ..Mobilization of progenitor cells in peripheral blood by GT3 indicates that GT3 can be used as an alternative to G-CSF and VGEF to mobilize HPCs and EPCs...
  13. ncbi request reprint Determination of WR-1065 and WR-33278 by liquid chromatography with electrochemical detection
    James A Pendergrass
    Armed Forces Radiobiology Research Institute, Radiation Medicine Department, Bethesda, MD 20889 5603, USA
    J AOAC Int 85:551-4. 2002
    ..Within- and between-day determinations of measurement Vision and accuracy for both compounds validated the suitability of this assay method...
  14. ncbi request reprint Protection against gamma-irradiation with 5-androstenediol
    Mark H Whitnall
    Radiation Casualty Management Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Mil Med 167:64-5. 2002
    ..Clinical chemistry, histopathology, and behavioral assays showed no evidence of toxicity. We conclude that AED and related steroids are attractive candidates to explore as countermeasures to high- and low-level ionizing radiation...
  15. ncbi request reprint Nutritional approaches to radioprotection: vitamin E
    K Sree Kumar
    Radiation Casualty Management Research Team, Department of Radiation Medicine, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Besthesda, MD 20889 5603, USA
    Mil Med 167:57-9. 2002
    ..Vitamin E was more efficacious when given subcutaneously than when given orally...