Juliann G Kiang

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Ciprofloxacin as a potential radio-sensitizer to tumor cells and a radio-protectant for normal cells: differential effects on γ-H2AX formation, p53 phosphorylation, Bcl-2 production, and cell death
    Juliann G Kiang
    Radiation Combined Injury Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD, 20889 5603, USA
    Mol Cell Biochem 393:133-43. 2014
  2. pmc Ciprofloxacin modulates cytokine/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma
    Risaku Fukumoto
    Radiation Combined Injury Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58389. 2013
  3. pmc Ciprofloxacin enhances stress erythropoiesis in spleen and increases survival after whole-body irradiation combined with skin-wound trauma
    Risaku Fukumoto
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, United States of America
    PLoS ONE 9:e90448. 2014
  4. pmc Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation
    Shaw Wei D Tsen
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biomed Sci 19:62. 2012
  5. pmc Wound trauma alters ionizing radiation dose assessment
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Cell Biosci 2:20. 2012
  6. doi request reprint Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 173:319-32. 2010
  7. pmc Pegylated G-CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole-body ionizing irradiation but not after irradiation combined with burn
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA Department of Radiation Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Oxid Med Cell Longev 2014:481392. 2014
  8. pmc Ciprofloxacin increases survival after ionizing irradiation combined injury: γ-H2AX formation, cytokine/chemokine, and red blood cells
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute Department of Radiation Biology Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD
    Health Phys 106:720-6. 2014
  9. pmc Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E 2 after whole-body reactor-produced mixed field (n + γ-photons) irradiation
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA Department of Radiation Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Oxid Med Cell Longev 2013:821541. 2013
  10. pmc Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis
    Nikolai V Gorbunov
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 1402, USA
    Oxid Med Cell Longev 2013:186795. 2013

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Ciprofloxacin as a potential radio-sensitizer to tumor cells and a radio-protectant for normal cells: differential effects on γ-H2AX formation, p53 phosphorylation, Bcl-2 production, and cell death
    Juliann G Kiang
    Radiation Combined Injury Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD, 20889 5603, USA
    Mol Cell Biochem 393:133-43. 2014
    ..Our data are the first to support the view that CIP may be effective to protect normal tissue cells from radiation injury, while enhancing cancer cell death in radiation therapy...
  2. pmc Ciprofloxacin modulates cytokine/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma
    Risaku Fukumoto
    Radiation Combined Injury Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58389. 2013
    ..CIP treatment led to LD(0/10) compared to LD(20/10) for vehicle-treated group after CI. Given the multiple beneficial activities of CIP shown in our experiments, CIP may prove to be a useful therapeutic drug for CI...
  3. pmc Ciprofloxacin enhances stress erythropoiesis in spleen and increases survival after whole-body irradiation combined with skin-wound trauma
    Risaku Fukumoto
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, United States of America
    PLoS ONE 9:e90448. 2014
    ..Splenocytes from CIP-treated CI mice formed CD71⁺ colony-forming unit-erythroid significantly better than those from controls. Thus, CIP-mediated BMP4-dependent stress erythropoiesis may play a role in improving survival after CI...
  4. pmc Prospects for a novel ultrashort pulsed laser technology for pathogen inactivation
    Shaw Wei D Tsen
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biomed Sci 19:62. 2012
    ....
  5. pmc Wound trauma alters ionizing radiation dose assessment
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Cell Biosci 2:20. 2012
    ..abstract:..
  6. doi request reprint Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 173:319-32. 2010
    ..Agents that inhibit these responses may prove to be therapeutic for combined injury and may reduce related mortality...
  7. pmc Pegylated G-CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole-body ionizing irradiation but not after irradiation combined with burn
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA Department of Radiation Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Oxid Med Cell Longev 2014:481392. 2014
    ..The results suggest that pegylated G-CSF effectively sustained animal survival by mitigating radiation-induced cytopenia, thrombopenia, erythropenia, and anemia...
  8. pmc Ciprofloxacin increases survival after ionizing irradiation combined injury: γ-H2AX formation, cytokine/chemokine, and red blood cells
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute Department of Radiation Biology Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD
    Health Phys 106:720-6. 2014
    ..At day 30, CIP treatment increased 45% survival after CI (i.e., 2.3-fold increase over vehicle treatment). The results suggest that CIP may prove to be an effective therapeutic drug for CI...
  9. pmc Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E 2 after whole-body reactor-produced mixed field (n + γ-photons) irradiation
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA Department of Radiation Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Oxid Med Cell Longev 2013:821541. 2013
    ..Agents inhibiting these responses may prove to be therapeutic for RCI and improve related survival. ..
  10. pmc Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis
    Nikolai V Gorbunov
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 1402, USA
    Oxid Med Cell Longev 2013:186795. 2013
    ..We propose that the above prosurvival pathways activated in MSCs in vitro could be a part of adaptive responses employed by stromal cells under septic conditions...
  11. doi request reprint Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation
    Nikolai V Gorbunov
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    J Pathol 219:242-52. 2009
    ..129P2-NOS2(tm1Lau)/J mice subjected to the same treatments. We postulate that the observed up-regulation of mAG in the irradiated small intestine is at least in part mediated by the iNOS signalling mechanism...
  12. pmc Small-molecule antioxidant proteome-shields in Deinococcus radiodurans
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12570. 2010
    ....
  13. pmc Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation
    Risaku Fukumoto
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Radiat Res 176:333-45. 2011
    ..Hsp90 inhibitors such as 17-DMAG may prove useful with radiation-based cancer therapy as well as for general radioprotection...