Juliann G Kiang

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. pmc Inactivation of viruses by coherent excitations with a low power visible femtosecond laser
    K T Tsen
    Department of Physics, Arizona State University, Tempe, AZ 85287, USA
    Virol J 4:50. 2007
  2. doi request reprint Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells
    Juliann G Kiang
    Department of Radiation Biology, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 172:321-30. 2009
  3. doi request reprint Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 173:319-32. 2010
  4. ncbi request reprint Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Appl Physiol 102:933-41. 2007
  5. ncbi request reprint Inhibition of inducible nitric-oxide synthase protects human T cells from hypoxia-induced apoptosis
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, BLDG 46, Room 2423, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Mol Pharmacol 73:738-47. 2008
  6. ncbi request reprint Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase
    Juliann G Kiang
    Scientific Research Department, Armed Forces Radiobiology Research Institute, BLDG 46, Rm 2423, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Appl Physiol 103:1045-55. 2007
  7. ncbi request reprint Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006
  8. ncbi request reprint Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 97:564-9. 2004
  9. ncbi request reprint NaCN-induced chemical hypoxia is associated with altered gene expression
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 254:211-6. 2003
  10. ncbi request reprint Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human T cells: role of [Ca2+]i and tyrosine phosphorylation
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 1N07, Silver Spring, MD 20910 7500, USA
    J Cell Biochem 89:1030-43. 2003

Collaborators

Detail Information

Publications26

  1. pmc Inactivation of viruses by coherent excitations with a low power visible femtosecond laser
    K T Tsen
    Department of Physics, Arizona State University, Tempe, AZ 85287, USA
    Virol J 4:50. 2007
    ..We demonstrate for the first time that, by using a visible femtosecond laser, it is effective to inactivate viruses such as bacteriophage M13 through impulsive stimulated Raman scattering...
  2. doi request reprint Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells
    Juliann G Kiang
    Department of Radiation Biology, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 172:321-30. 2009
    ..Control of iNOS expression may represent a useful approach for protecting T cells from radiation injury...
  3. doi request reprint Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 173:319-32. 2010
    ..Agents that inhibit these responses may prove to be therapeutic for combined injury and may reduce related mortality...
  4. ncbi request reprint Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Appl Physiol 102:933-41. 2007
    ..AED can potentially be a useful adjuvant for limiting liver apoptosis following T-H shock...
  5. ncbi request reprint Inhibition of inducible nitric-oxide synthase protects human T cells from hypoxia-induced apoptosis
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, BLDG 46, Room 2423, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Mol Pharmacol 73:738-47. 2008
    ..These data suggest iNOS-mediated NO produced endogenously in the T cell alters overall T-cell function and results in apoptosis. Proper control of iNOS expressed in the T cell may represent a useful approach to immunomodulation...
  6. ncbi request reprint Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase
    Juliann G Kiang
    Scientific Research Department, Armed Forces Radiobiology Research Institute, BLDG 46, Rm 2423, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Appl Physiol 103:1045-55. 2007
    ..Geldanamycin, therefore, may prove useful as an adjuvant in fluids used to treat patients suffering blood loss...
  7. ncbi request reprint Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006
    ..We conclude that agents able to increase the expression of HSP70 and PDH may be of value in reducing pathology resulting from hemorrhage-associated ATP loss...
  8. ncbi request reprint Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 97:564-9. 2004
    ..These results suggest that GA may be therapeutically useful for reducing hemorrhage-induced injury when used as a presurgical treatment or when added to resuscitation fluids...
  9. ncbi request reprint NaCN-induced chemical hypoxia is associated with altered gene expression
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 254:211-6. 2003
    ....
  10. ncbi request reprint Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human T cells: role of [Ca2+]i and tyrosine phosphorylation
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 1N07, Silver Spring, MD 20910 7500, USA
    J Cell Biochem 89:1030-43. 2003
    ..This process is related to increased expression of Fas/CD95 on the cell surface, which might explain the apoptotic diathesis of lymphocytes after heat stress...
  11. pmc Ciprofloxacin modulates cytokine/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma
    Risaku Fukumoto
    Radiation Combined Injury Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58389. 2013
    ..CIP treatment led to LD(0/10) compared to LD(20/10) for vehicle-treated group after CI. Given the multiple beneficial activities of CIP shown in our experiments, CIP may prove to be a useful therapeutic drug for CI...
  12. ncbi request reprint Biology of hypoxia
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Chin J Physiol 49:223-33. 2006
    ..Therefore, iNOS inhibition may be a novel mechanism for protection from hypoxia-induced injury and cell death...
  13. ncbi request reprint Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhage
    Juliann G Kiang
    Division of Military Casualty Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Rm 1N07, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 98:550-6. 2005
    ..Our results demonstrate that resuscitation with LR can reverse the expression of genes and their products that are thought to contribute to hemorrhage-induced lung injury...
  14. ncbi request reprint Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells
    Sandeep Krishnan
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Immunol 175:3417-23. 2005
    ..We conclude that caspase-3 inhibitors can normalize SLE T cell function by limiting the excessive digestion of CD3zeta-chain and suggest that such molecules can be considered in the treatment of this disease...
  15. ncbi request reprint Genistein inhibits herbimycin A-induced over-expression of inducible heat shock protein 70 kDa
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 245:191-9. 2003
    ..The herbimycin A-induced increase in HSP-70i protected cells from hypoxia injury...
  16. ncbi request reprint External bioenergy-induced increases in intracellular free calcium concentrations are mediated by Na+/Ca2+ exchanger and L-type calcium channel
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 1N07, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 271:51-9. 2005
    ..The increase in [Ca2+]i is mediated by activation of Na+/Ca2+ exchangers and opening of L-type voltage-gated Ca2+ channels...
  17. ncbi request reprint Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Cell Res 14:450-9. 2004
    ..HSP-70i is found to couple to iNOS and its transcription factor. Therefore, the complex formation between HSP-70i and iNOS may be a novel mechanism for protection from hemorrhage/resuscitation-induced injury...
  18. ncbi request reprint N(omega)-nitro-L-arginine inhibits inducible HSP-70 via Ca(2+), PKC, and PKA in human intestinal epithelial T84 cells
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 282:G415-23. 2002
    ..These results suggest that L-NNA inhibits HSP-70i by reducing [Ca(2+)](i) and decreasing PKC and PKA activity, thereby blocking HSF1 translocation from the cytosol to the nucleus...
  19. pmc Wound trauma alters ionizing radiation dose assessment
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Cell Biosci 2:20. 2012
    ..abstract:..
  20. pmc Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis
    Nikolai V Gorbunov
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 1402, USA
    Oxid Med Cell Longev 2013:186795. 2013
    ..We propose that the above prosurvival pathways activated in MSCs in vitro could be a part of adaptive responses employed by stromal cells under septic conditions...
  21. doi request reprint Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation
    Nikolai V Gorbunov
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    J Pathol 219:242-52. 2009
    ..129P2-NOS2(tm1Lau)/J mice subjected to the same treatments. We postulate that the observed up-regulation of mAG in the irradiated small intestine is at least in part mediated by the iNOS signalling mechanism...
  22. doi request reprint Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat
    James L Atkins
    Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Shock 30:411-6. 2008
    ....
  23. pmc Small-molecule antioxidant proteome-shields in Deinococcus radiodurans
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12570. 2010
    ....
  24. ncbi request reprint Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation
    Risaku Fukumoto
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Radiat Res 176:333-45. 2011
    ..Hsp90 inhibitors such as 17-DMAG may prove useful with radiation-based cancer therapy as well as for general radioprotection...
  25. ncbi request reprint Heat stress protection against mesenteric I/R-induced alterations in intestinal mucosa in rats
    Sherry D Fleming
    Department of Cellular Injury, Walter Reed Army Medical Institute of Research, Silver Spring, Maryland, USA
    J Appl Physiol 92:2600-7. 2002
    ..Thus induction of heat shock protein 70 is associated with the preservation of mucosal architecture and attenuation of some specific functional alterations induced by I/R...
  26. ncbi request reprint External bioenergy increases intracellular free calcium concentration and reduces cellular response to heat stress
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Investig Med 50:38-45. 2002
    ....