Juliann G Kiang

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi Inactivation of viruses by coherent excitations with a low power visible femtosecond laser
    K T Tsen
    Department of Physics, Arizona State University, Tempe, AZ 85287, USA
    Virol J 4:50. 2007
  2. ncbi Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Appl Physiol 102:933-41. 2007
  3. ncbi Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase
    Juliann G Kiang
    Scientific Research Department, Armed Forces Radiobiology Research Institute, BLDG 46, Rm 2423, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Appl Physiol 103:1045-55. 2007
  4. ncbi Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells
    Juliann G Kiang
    Department of Radiation Biology, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 172:321-30. 2009
  5. ncbi Inhibition of inducible nitric-oxide synthase protects human T cells from hypoxia-induced apoptosis
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, BLDG 46, Room 2423, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Mol Pharmacol 73:738-47. 2008
  6. ncbi Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 173:319-32. 2010
  7. ncbi Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006
  8. ncbi Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 97:564-9. 2004
  9. ncbi NaCN-induced chemical hypoxia is associated with altered gene expression
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 254:211-6. 2003
  10. ncbi Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human T cells: role of [Ca2+]i and tyrosine phosphorylation
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 1N07, Silver Spring, MD 20910 7500, USA
    J Cell Biochem 89:1030-43. 2003

Collaborators

Detail Information

Publications25

  1. ncbi Inactivation of viruses by coherent excitations with a low power visible femtosecond laser
    K T Tsen
    Department of Physics, Arizona State University, Tempe, AZ 85287, USA
    Virol J 4:50. 2007
    ..We demonstrate for the first time that, by using a visible femtosecond laser, it is effective to inactivate viruses such as bacteriophage M13 through impulsive stimulated Raman scattering...
  2. ncbi Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Appl Physiol 102:933-41. 2007
    ..AED can potentially be a useful adjuvant for limiting liver apoptosis following T-H shock...
  3. ncbi Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase
    Juliann G Kiang
    Scientific Research Department, Armed Forces Radiobiology Research Institute, BLDG 46, Rm 2423, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Appl Physiol 103:1045-55. 2007
    ..Geldanamycin, therefore, may prove useful as an adjuvant in fluids used to treat patients suffering blood loss...
  4. ncbi Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells
    Juliann G Kiang
    Department of Radiation Biology, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 172:321-30. 2009
    ..Control of iNOS expression may represent a useful approach for protecting T cells from radiation injury...
  5. ncbi Inhibition of inducible nitric-oxide synthase protects human T cells from hypoxia-induced apoptosis
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, BLDG 46, Room 2423, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Mol Pharmacol 73:738-47. 2008
    ..These data suggest iNOS-mediated NO produced endogenously in the T cell alters overall T-cell function and results in apoptosis. Proper control of iNOS expressed in the T cell may represent a useful approach to immunomodulation...
  6. ncbi Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 173:319-32. 2010
    ..Agents that inhibit these responses may prove to be therapeutic for combined injury and may reduce related mortality...
  7. ncbi Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006
    ..We conclude that agents able to increase the expression of HSP70 and PDH may be of value in reducing pathology resulting from hemorrhage-associated ATP loss...
  8. ncbi Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 97:564-9. 2004
    ..These results suggest that GA may be therapeutically useful for reducing hemorrhage-induced injury when used as a presurgical treatment or when added to resuscitation fluids...
  9. ncbi NaCN-induced chemical hypoxia is associated with altered gene expression
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 254:211-6. 2003
    ....
  10. ncbi Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human T cells: role of [Ca2+]i and tyrosine phosphorylation
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 1N07, Silver Spring, MD 20910 7500, USA
    J Cell Biochem 89:1030-43. 2003
    ..This process is related to increased expression of Fas/CD95 on the cell surface, which might explain the apoptotic diathesis of lymphocytes after heat stress...
  11. ncbi Biology of hypoxia
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Chin J Physiol 49:223-33. 2006
    ..Therefore, iNOS inhibition may be a novel mechanism for protection from hypoxia-induced injury and cell death...
  12. ncbi Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhage
    Juliann G Kiang
    Division of Military Casualty Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Rm 1N07, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 98:550-6. 2005
    ..Our results demonstrate that resuscitation with LR can reverse the expression of genes and their products that are thought to contribute to hemorrhage-induced lung injury...
  13. ncbi Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells
    Sandeep Krishnan
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910-7500, USA
    J Immunol 175:3417-23. 2005
    ..We conclude that caspase-3 inhibitors can normalize SLE T cell function by limiting the excessive digestion of CD3zeta-chain and suggest that such molecules can be considered in the treatment of this disease...
  14. ncbi Genistein inhibits herbimycin A-induced over-expression of inducible heat shock protein 70 kDa
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 245:191-9. 2003
    ..The herbimycin A-induced increase in HSP-70i protected cells from hypoxia injury...
  15. ncbi External bioenergy-induced increases in intracellular free calcium concentrations are mediated by Na+/Ca2+ exchanger and L-type calcium channel
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 1N07, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 271:51-9. 2005
    ..The increase in [Ca2+]i is mediated by activation of Na+/Ca2+ exchangers and opening of L-type voltage-gated Ca2+ channels...
  16. ncbi N(omega)-nitro-L-arginine inhibits inducible HSP-70 via Ca(2+), PKC, and PKA in human intestinal epithelial T84 cells
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 282:G415-23. 2002
    ..These results suggest that L-NNA inhibits HSP-70i by reducing [Ca(2+)](i) and decreasing PKC and PKA activity, thereby blocking HSF1 translocation from the cytosol to the nucleus...
  17. ncbi Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Cell Res 14:450-9. 2004
    ..HSP-70i is found to couple to iNOS and its transcription factor. Therefore, the complex formation between HSP-70i and iNOS may be a novel mechanism for protection from hemorrhage/resuscitation-induced injury...
  18. ncbi Ciprofloxacin modulates cytokine/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma
    Risaku Fukumoto
    Radiation Combined Injury Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58389. 2013
    ..CIP treatment led to LD(0/10) compared to LD(20/10) for vehicle-treated group after CI. Given the multiple beneficial activities of CIP shown in our experiments, CIP may prove to be a useful therapeutic drug for CI...
  19. ncbi Wound trauma alters ionizing radiation dose assessment
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Cell Biosci 2:20. 2012
    ..abstract:..
  20. ncbi Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat
    James L Atkins
    Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Shock 30:411-6. 2008
    ....
  21. ncbi Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation
    Nikolai V Gorbunov
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    J Pathol 219:242-52. 2009
    ..129P2-NOS2(tm1Lau)/J mice subjected to the same treatments. We postulate that the observed up-regulation of mAG in the irradiated small intestine is at least in part mediated by the iNOS signalling mechanism...
  22. ncbi Heat stress protection against mesenteric I/R-induced alterations in intestinal mucosa in rats
    Sherry D Fleming
    Department of Cellular Injury, Walter Reed Army Medical Institute of Research, Silver Spring, Maryland, USA
    J Appl Physiol 92:2600-7. 2002
    ..Thus induction of heat shock protein 70 is associated with the preservation of mucosal architecture and attenuation of some specific functional alterations induced by I/R...
  23. ncbi Small-molecule antioxidant proteome-shields in Deinococcus radiodurans
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12570. 2010
    ....
  24. ncbi Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation
    Risaku Fukumoto
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Radiat Res 176:333-45. 2011
    ..Hsp90 inhibitors such as 17-DMAG may prove useful with radiation-based cancer therapy as well as for general radioprotection...
  25. ncbi External bioenergy increases intracellular free calcium concentration and reduces cellular response to heat stress
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Investig Med 50:38-45. 2002
    ....