Juliann G Kiang

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. pmc Inactivation of viruses by coherent excitations with a low power visible femtosecond laser
    K T Tsen
    Department of Physics, Arizona State University, Tempe, AZ 85287, USA
    Virol J 4:50. 2007
  2. doi request reprint Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 173:319-32. 2010
  3. doi request reprint Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells
    Juliann G Kiang
    Department of Radiation Biology, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 172:321-30. 2009
  4. ncbi request reprint Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase
    Juliann G Kiang
    Scientific Research Department, Armed Forces Radiobiology Research Institute, BLDG 46, Rm 2423, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Appl Physiol (1985) 103:1045-55. 2007
  5. ncbi request reprint Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Appl Physiol (1985) 102:933-41. 2007
  6. ncbi request reprint Inhibition of inducible nitric-oxide synthase protects human T cells from hypoxia-induced apoptosis
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, BLDG 46, Room 2423, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Mol Pharmacol 73:738-47. 2008
  7. ncbi request reprint Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006
  8. ncbi request reprint Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol (1985) 97:564-9. 2004
  9. ncbi request reprint NaCN-induced chemical hypoxia is associated with altered gene expression
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 254:211-6. 2003
  10. ncbi request reprint Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human T cells: role of [Ca2+]i and tyrosine phosphorylation
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 1N07, Silver Spring, MD 20910 7500, USA
    J Cell Biochem 89:1030-43. 2003

Collaborators

Detail Information

Publications32

  1. pmc Inactivation of viruses by coherent excitations with a low power visible femtosecond laser
    K T Tsen
    Department of Physics, Arizona State University, Tempe, AZ 85287, USA
    Virol J 4:50. 2007
    ..We demonstrate for the first time that, by using a visible femtosecond laser, it is effective to inactivate viruses such as bacteriophage M13 through impulsive stimulated Raman scattering...
  2. doi request reprint Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 173:319-32. 2010
    ..Agents that inhibit these responses may prove to be therapeutic for combined injury and may reduce related mortality...
  3. doi request reprint Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells
    Juliann G Kiang
    Department of Radiation Biology, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 172:321-30. 2009
    ..Control of iNOS expression may represent a useful approach for protecting T cells from radiation injury...
  4. ncbi request reprint Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase
    Juliann G Kiang
    Scientific Research Department, Armed Forces Radiobiology Research Institute, BLDG 46, Rm 2423, Uniformed Services University of the Health Sciences, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    J Appl Physiol (1985) 103:1045-55. 2007
    ..Geldanamycin, therefore, may prove useful as an adjuvant in fluids used to treat patients suffering blood loss...
  5. ncbi request reprint Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Appl Physiol (1985) 102:933-41. 2007
    ..AED can potentially be a useful adjuvant for limiting liver apoptosis following T-H shock...
  6. ncbi request reprint Inhibition of inducible nitric-oxide synthase protects human T cells from hypoxia-induced apoptosis
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, BLDG 46, Room 2423, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Mol Pharmacol 73:738-47. 2008
    ..These data suggest iNOS-mediated NO produced endogenously in the T cell alters overall T-cell function and results in apoptosis. Proper control of iNOS expressed in the T cell may represent a useful approach to immunomodulation...
  7. ncbi request reprint Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006
    ..We conclude that agents able to increase the expression of HSP70 and PDH may be of value in reducing pathology resulting from hemorrhage-associated ATP loss...
  8. ncbi request reprint Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol (1985) 97:564-9. 2004
    ..These results suggest that GA may be therapeutically useful for reducing hemorrhage-induced injury when used as a presurgical treatment or when added to resuscitation fluids...
  9. ncbi request reprint NaCN-induced chemical hypoxia is associated with altered gene expression
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 254:211-6. 2003
    ....
  10. ncbi request reprint Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human T cells: role of [Ca2+]i and tyrosine phosphorylation
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 1N07, Silver Spring, MD 20910 7500, USA
    J Cell Biochem 89:1030-43. 2003
    ..This process is related to increased expression of Fas/CD95 on the cell surface, which might explain the apoptotic diathesis of lymphocytes after heat stress...
  11. pmc Ciprofloxacin modulates cytokine/chemokine profile in serum, improves bone marrow repopulation, and limits apoptosis and autophagy in ileum after whole body ionizing irradiation combined with skin-wound trauma
    Risaku Fukumoto
    Radiation Combined Injury Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 8:e58389. 2013
    ..CIP treatment led to LD(0/10) compared to LD(20/10) for vehicle-treated group after CI. Given the multiple beneficial activities of CIP shown in our experiments, CIP may prove to be a useful therapeutic drug for CI...
  12. ncbi request reprint Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhage
    Juliann G Kiang
    Division of Military Casualty Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Rm 1N07, Silver Spring, MD 20910 7500, USA
    J Appl Physiol (1985) 98:550-6. 2005
    ..Our results demonstrate that resuscitation with LR can reverse the expression of genes and their products that are thought to contribute to hemorrhage-induced lung injury...
  13. ncbi request reprint Biology of hypoxia
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Chin J Physiol 49:223-33. 2006
    ..Therefore, iNOS inhibition may be a novel mechanism for protection from hypoxia-induced injury and cell death...
  14. ncbi request reprint Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells
    Sandeep Krishnan
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Immunol 175:3417-23. 2005
    ..We conclude that caspase-3 inhibitors can normalize SLE T cell function by limiting the excessive digestion of CD3zeta-chain and suggest that such molecules can be considered in the treatment of this disease...
  15. ncbi request reprint Genistein inhibits herbimycin A-induced over-expression of inducible heat shock protein 70 kDa
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 245:191-9. 2003
    ..The herbimycin A-induced increase in HSP-70i protected cells from hypoxia injury...
  16. ncbi request reprint External bioenergy-induced increases in intracellular free calcium concentrations are mediated by Na+/Ca2+ exchanger and L-type calcium channel
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 1N07, Silver Spring, MD 20910 7500, USA
    Mol Cell Biochem 271:51-9. 2005
    ..The increase in [Ca2+]i is mediated by activation of Na+/Ca2+ exchangers and opening of L-type voltage-gated Ca2+ channels...
  17. ncbi request reprint Inducible heat shock protein 70 kD and inducible nitric oxide synthase in hemorrhage/resuscitation-induced injury
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Cell Res 14:450-9. 2004
    ..HSP-70i is found to couple to iNOS and its transcription factor. Therefore, the complex formation between HSP-70i and iNOS may be a novel mechanism for protection from hemorrhage/resuscitation-induced injury...
  18. ncbi request reprint N(omega)-nitro-L-arginine inhibits inducible HSP-70 via Ca(2+), PKC, and PKA in human intestinal epithelial T84 cells
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 282:G415-23. 2002
    ..These results suggest that L-NNA inhibits HSP-70i by reducing [Ca(2+)](i) and decreasing PKC and PKA activity, thereby blocking HSF1 translocation from the cytosol to the nucleus...
  19. pmc Pegylated G-CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole-body ionizing irradiation but not after irradiation combined with burn
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA Department of Radiation Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Oxid Med Cell Longev 2014:481392. 2014
    ..The results suggest that pegylated G-CSF effectively sustained animal survival by mitigating radiation-induced cytopenia, thrombopenia, erythropenia, and anemia...
  20. pmc Wound trauma alters ionizing radiation dose assessment
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Cell Biosci 2:20. 2012
    ..abstract:..
  21. pmc Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E 2 after whole-body reactor-produced mixed field (n + γ-photons) irradiation
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA Department of Radiation Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Oxid Med Cell Longev 2013:821541. 2013
    ..Agents inhibiting these responses may prove to be therapeutic for RCI and improve related survival. ..
  22. pmc Ciprofloxacin increases survival after ionizing irradiation combined injury: γ-H2AX formation, cytokine/chemokine, and red blood cells
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute Department of Radiation Biology Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD
    Health Phys 106:720-6. 2014
    ..At day 30, CIP treatment increased 45% survival after CI (i.e., 2.3-fold increase over vehicle treatment). The results suggest that CIP may prove to be an effective therapeutic drug for CI...
  23. ncbi request reprint Ciprofloxacin as a potential radio-sensitizer to tumor cells and a radio-protectant for normal cells: differential effects on γ-H2AX formation, p53 phosphorylation, Bcl-2 production, and cell death
    Juliann G Kiang
    Radiation Combined Injury Program, Scientific Research Department, Armed Forces Radiobiology Research Institute, Bethesda, MD, 20889 5603, USA
    Mol Cell Biochem 393:133-43. 2014
    ..Our data are the first to support the view that CIP may be effective to protect normal tissue cells from radiation injury, while enhancing cancer cell death in radiation therapy. ..
  24. pmc Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis
    Nikolai V Gorbunov
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 1402, USA
    Oxid Med Cell Longev 2013:186795. 2013
    ..We propose that the above prosurvival pathways activated in MSCs in vitro could be a part of adaptive responses employed by stromal cells under septic conditions...
  25. doi request reprint Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation
    Nikolai V Gorbunov
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    J Pathol 219:242-52. 2009
    ..129P2-NOS2(tm1Lau)/J mice subjected to the same treatments. We postulate that the observed up-regulation of mAG in the irradiated small intestine is at least in part mediated by the iNOS signalling mechanism...
  26. doi request reprint Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat
    James L Atkins
    Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Shock 30:411-6. 2008
    ....
  27. pmc Ciprofloxacin enhances stress erythropoiesis in spleen and increases survival after whole-body irradiation combined with skin-wound trauma
    Risaku Fukumoto
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, United States of America
    PLoS ONE 9:e90448. 2014
    ..Splenocytes from CIP-treated CI mice formed CD71⁺ colony-forming unit-erythroid significantly better than those from controls. Thus, CIP-mediated BMP4-dependent stress erythropoiesis may play a role in improving survival after CI...
  28. pmc Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation
    Risaku Fukumoto
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Radiat Res 176:333-45. 2011
    ..Hsp90 inhibitors such as 17-DMAG may prove useful with radiation-based cancer therapy as well as for general radioprotection...
  29. pmc Small-molecule antioxidant proteome-shields in Deinococcus radiodurans
    Michael J Daly
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 5:e12570. 2010
    ....
  30. ncbi request reprint Heat stress protection against mesenteric I/R-induced alterations in intestinal mucosa in rats
    Sherry D Fleming
    Department of Cellular Injury, Walter Reed Army Medical Institute of Research, Silver Spring, Maryland, USA
    J Appl Physiol 92:2600-7. 2002
    ..Thus induction of heat shock protein 70 is associated with the preservation of mucosal architecture and attenuation of some specific functional alterations induced by I/R...
  31. ncbi request reprint External bioenergy increases intracellular free calcium concentration and reduces cellular response to heat stress
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Investig Med 50:38-45. 2002
    ....