ANN JERSE

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. pmc Phenotypic and genotypic analyses of Neisseria gonorrhoeae isolates that express frequently recovered PorB PIA variable region types suggest that certain P1a porin sequences confer a selective advantage for urogenital tract infection
    Lotisha E Garvin
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20853 4799, USA
    Infect Immun 76:3700-9. 2008
  2. pmc Growth of Neisseria gonorrhoeae in the female mouse genital tract does not require the gonococcal transferrin or hemoglobin receptors and may be enhanced by commensal lactobacilli
    Ann E Jerse
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, USA
    Infect Immun 70:2549-58. 2002
  3. pmc A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection
    Ann E Jerse
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Infect Immun 71:5576-82. 2003
  4. pmc Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
    Douglas M Warner
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University, Bethesda, MD, USA
    Mol Microbiol 70:462-78. 2008
  5. ncbi request reprint Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae
    Douglas M Warner
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20853, USA
    J Infect Dis 196:1804-12. 2007
  6. pmc Hydrogen peroxide-producing lactobacilli inhibit gonococci in vitro but not during experimental genital tract infection
    Dawn F Muench
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Infect Dis 199:1369-78. 2009
  7. ncbi request reprint Inhibition of Neisseria gonorrhoeae genital tract infection by leading-candidate topical microbicides in a mouse model
    Steven E Spencer
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland 20814, USA
    J Infect Dis 189:410-9. 2004
  8. pmc Opacity proteins increase Neisseria gonorrhoeae fitness in the female genital tract due to a factor under ovarian control
    Jessica G Cole
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Infect Immun 78:1629-41. 2010
  9. pmc In vivo selection for Neisseria gonorrhoeae opacity protein expression in the absence of human carcinoembryonic antigen cell adhesion molecules
    Amy N Simms
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Infect Immun 74:2965-74. 2006
  10. pmc Neisseria gonorrhoeae catalase is not required for experimental genital tract infection despite the induction of a localized neutrophil response
    Angel A Soler-García
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Infect Immun 75:2225-33. 2007

Collaborators

  • Sunita Gulati
  • William Shafer
  • Margaret C Bash
  • Steven E Spencer
  • S Ram
  • C N Cornelissen
  • ROBIN INGALLS
  • H Jarva
  • Harry Smith
  • T Darville
  • Hong Wu
  • Angel A Soler-García
  • Douglas M Warner
  • Jessica G Cole
  • Rachel A Vonck
  • Mathanraj Packiam
  • Sandra J Veit
  • Dawn F Muench
  • Lotisha E Garvin
  • Rachel M Exley
  • Laura Serino
  • Amy N Simms
  • Jutamas Ngampasutadol
  • Diane C St Amant
  • C M O'Connell
  • Nanette B Fulcher
  • Deborah J Anderson
  • Marie Eve Pelletier
  • David J Kuch
  • Afrin A Begum
  • Christine Keys
  • Brian T Mocca
  • Muriel C Schneider
  • Barbara Nesta
  • Christoph M Tang
  • Elisabetta Monaci
  • Maria Rita Fontana
  • Mariagrazia Pizza
  • Jason P Folster
  • Rosanna Leuzzi
  • Jonathan Shaw
  • Elena Cartocci
  • Vega Masignani
  • Rino Rappuoli
  • Peter A Rice
  • Anna M Blom
  • Egil Lien
  • Jon Goguen
  • Iris E Valentin-Bon

Detail Information

Publications20

  1. pmc Phenotypic and genotypic analyses of Neisseria gonorrhoeae isolates that express frequently recovered PorB PIA variable region types suggest that certain P1a porin sequences confer a selective advantage for urogenital tract infection
    Lotisha E Garvin
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20853 4799, USA
    Infect Immun 76:3700-9. 2008
    ..The capacity of some porin types to evade a porin-specific adaptive immune response must also be considered...
  2. pmc Growth of Neisseria gonorrhoeae in the female mouse genital tract does not require the gonococcal transferrin or hemoglobin receptors and may be enhanced by commensal lactobacilli
    Ann E Jerse
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, USA
    Infect Immun 70:2549-58. 2002
    ..In summary, these studies support the potential role of nontransferrin, nonhemoglobin iron sources during gonococcal infection of the female genital tract...
  3. pmc A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection
    Ann E Jerse
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Infect Immun 71:5576-82. 2003
    ..However, hormonally regulated factors rather than progesterone itself may be responsible for the more rapid clearance of mtr-deficient gonococci from intact mice...
  4. pmc Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness
    Douglas M Warner
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University, Bethesda, MD, USA
    Mol Microbiol 70:462-78. 2008
    ..These studies establish a hierarchy of mtrR locus mutations with regard to regulation of pump efflux, and suggest selection for more derepressed mutants may occur during mixed infections...
  5. ncbi request reprint Regulation of the MtrC-MtrD-MtrE efflux-pump system modulates the in vivo fitness of Neisseria gonorrhoeae
    Douglas M Warner
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20853, USA
    J Infect Dis 196:1804-12. 2007
    ....
  6. pmc Hydrogen peroxide-producing lactobacilli inhibit gonococci in vitro but not during experimental genital tract infection
    Dawn F Muench
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Infect Dis 199:1369-78. 2009
    ..gonorrhoeae balances the detrimental effects of H(2)O(2) during infection. We conclude that the association between lactobacilli and gonococci is complex and may be subject to factors that have not been reproduced in vitro...
  7. ncbi request reprint Inhibition of Neisseria gonorrhoeae genital tract infection by leading-candidate topical microbicides in a mouse model
    Steven E Spencer
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland 20814, USA
    J Infect Dis 189:410-9. 2004
    ..The findings of the present study suggest that topical agents may effectively reduce N. gonorrhoeae infection and that further evaluation is warranted...
  8. pmc Opacity proteins increase Neisseria gonorrhoeae fitness in the female genital tract due to a factor under ovarian control
    Jessica G Cole
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Infect Immun 78:1629-41. 2010
    ..This work revealed an intimate interaction between pathogen and host and provides evidence that hormonally related factors shape bacterial adaptation...
  9. pmc In vivo selection for Neisseria gonorrhoeae opacity protein expression in the absence of human carcinoembryonic antigen cell adhesion molecules
    Amy N Simms
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Infect Immun 74:2965-74. 2006
    ....
  10. pmc Neisseria gonorrhoeae catalase is not required for experimental genital tract infection despite the induction of a localized neutrophil response
    Angel A Soler-García
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Infect Immun 75:2225-33. 2007
    ..gonorrhoeae is not significantly challenged by H2O2 produced by PMNs in the murine lower genital tract; alternatively, redundant defense mechanisms may protect the gonococcus from reactive oxygen species during infection...
  11. pmc Mouse strain-dependent differences in susceptibility to Neisseria gonorrhoeae infection and induction of innate immune responses
    Mathanraj Packiam
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Infect Immun 78:433-40. 2010
    ..gonorrhoeae infection, and this resistance is not due to an overwhelming inflammatory response to infection. Host genetic factors can therefore impact susceptibility and the immune response to N. gonorrhoeae...
  12. pmc A strain-specific catalase mutation and mutation of the metal-binding transporter gene mntC attenuate Neisseria gonorrhoeae in vivo but not by increasing susceptibility to oxidative killing by phagocytes
    Hong Wu
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
    Infect Immun 77:1091-102. 2009
    ..Finally, we also showed that an msrA mutant of strain MS11 demonstrated delayed attenuation in BALB/c but not C57BL/6 mice. Therefore, MsrA/B also appears to play a role in infection that is dependent on host genetic background...
  13. pmc Inhibition of Neisseria gonorrhoeae by Lactobacillus species that are commonly isolated from the female genital tract
    Diane C St Amant
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University, Bethesda, Maryland 20814 4799, USA
    Infect Immun 70:7169-71. 2002
    ..Inhibition was neutralized by bovine catalase, suggesting that H(2)O(2) is the primary mediator of inhibition...
  14. pmc Functional characterization of antibodies against Neisseria gonorrhoeae opacity protein loops
    Jessica G Cole
    Department of Microbiology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 4:e8108. 2009
    ..Here we compared antibodies to linear (Ab(linear)) and cyclic (Ab(cyclic)) peptides that correspond to the SV and 4L loops and selected hypervariable (HV(2)) loops for surface-binding and protective activity in vitro and in vivo...
  15. pmc Alpha-2,3-sialyltransferase enhances Neisseria gonorrhoeae survival during experimental murine genital tract infection
    Hong Wu
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Infect Immun 74:4094-103. 2006
    ..gonorrhoeae pathogenesis in an in vivo model. This study also validates the use of experimental murine infection to study certain aspects of gonococcal pathogenesis...
  16. pmc Chlamydial infection increases gonococcal colonization in a novel murine coinfection model
    Rachel A Vonck
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Infect Immun 79:1566-77. 2011
    ..We conclude that female mice can be successfully infected with both C. muridarum and N. gonorrhoeae and that chlamydia-induced alterations in host innate responses may enhance gonococcal infection...
  17. ncbi request reprint A Neisseria gonorrhoeae catalase mutant is more sensitive to hydrogen peroxide and paraquat, an inducer of toxic oxygen radicals
    Angel A Soler-García
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Microb Pathog 37:55-63. 2004
    ..gonorrhoeae. Additionally, we showed a 262 base pair region upstream of the kat gene is required for expression in E. coli and a putative fumarate-nitrate regulator (FNR) binding site is located in this region...
  18. pmc Lactate acquisition promotes successful colonization of the murine genital tract by Neisseria gonorrhoeae
    Rachel M Exley
    The Centre for Molecular Microbiology and Infection, Department of Infectious Diseases, Flowers Building, Imperial College London, Armstrong Road, London SW7 2AZ, United Kingdom
    Infect Immun 75:1318-24. 2007
    ..Lactate is a micronutrient in the genital tract that contributes to the survival of the gonococcus...
  19. ncbi request reprint Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization
    Laura Serino
    Research Centre, Novartis Vaccines, Via Fiorentina, 1, 53100 Siena, Italy
    Mol Microbiol 64:1391-403. 2007
    ..All together, these data suggest that the newly identified surface exposed protein Ng-OmpA represents a novel virulence factor of gonococcus...
  20. pmc Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection
    Jutamas Ngampasutadol
    Section of Infectious Diseases, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 102:17142-7. 2005
    ..Our findings may lead to the development of better animal models for gonorrhea and may also have implications in the choice of complement sources to evaluate neisserial vaccine candidates...

Research Grants11

  1. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    ANN JERSE; Fiscal Year: 2007
    ....
  2. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    ANN JERSE; Fiscal Year: 2003
    ....
  3. GONOCOCCAL INFECTION AND GENE EXPRESSION IN FEMALE MICE
    Ann E Jerse; Fiscal Year: 2010
    ..Identifying how this pathogen capitalizes or evades the host immune system may lead to new therapeutic or prophylactic strategies, which could prevent or reduce the incidence of gonorrhea and associated morbidity and mortality. ..