Sanchita P Ghosh

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. doi request reprint Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, USA
    Int J Radiat Biol 85:598-606. 2009
  2. pmc Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    J Radiat Res 53:526-36. 2012
  3. doi request reprint Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, Maryland 20889 5603, USA
    Radiat Res 171:173-9. 2009
  4. doi request reprint Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation
    Shilpa Kulkarni
    a Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA
    Radiat Res 173:738-47. 2010
  5. doi request reprint Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a promising radiation countermeasure
    Sugata Ray
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    Int Immunopharmacol 15:557-64. 2013
  6. pmc Delta-Tocotrienol Suppresses Radiation-Induced MicroRNA-30 and Protects Mice and Human CD34+ Cells from Radiation Injury
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America
    PLoS ONE 10:e0122258. 2015
  7. doi request reprint Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor
    Shilpa S Kulkarni
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, United States
    Int Immunopharmacol 14:495-503. 2012
  8. ncbi request reprint Hematological targets of radiation damage
    Shilpa Kulkarni
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Curr Drug Targets 11:1375-85. 2010
  9. doi request reprint Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure
    Shilpa Kulkarni
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of Health Sciences, Bethesda, MD 20889 5603, USA
    Cytokine 62:278-85. 2013
  10. pmc Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    Mol Biosyst 9:723-31. 2013

Collaborators

Detail Information

Publications13

  1. doi request reprint Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, USA
    Int J Radiat Biol 85:598-606. 2009
    ..To assess the radioprotective potential of gamma-tocotrienol...
  2. pmc Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in mice
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    J Radiat Res 53:526-36. 2012
    ..The results demonstrated that Ex-RAD ameliorates radiation-induced peripheral blood cell depletion, promotes bone marrow recovery, reduces p53 signaling in spleen and protects intestine from radiation injury...
  3. doi request reprint Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, Maryland 20889 5603, USA
    Radiat Res 171:173-9. 2009
    ..In conclusion, it appears that Ex-Rad's radioprotective mechanisms involve prevention of p53-dependent and independent radiation-induced apoptosis...
  4. doi request reprint Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation
    Shilpa Kulkarni
    a Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA
    Radiat Res 173:738-47. 2010
    ..Our results demonstrate that GT3 protected hematopoietic tissue by preserving the HSCs and HPCs and by preventing persistent DNA damage...
  5. doi request reprint Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a promising radiation countermeasure
    Sugata Ray
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    Int Immunopharmacol 15:557-64. 2013
    ..Mobilization of progenitor cells in peripheral blood by GT3 indicates that GT3 can be used as an alternative to G-CSF and VGEF to mobilize HPCs and EPCs...
  6. pmc Delta-Tocotrienol Suppresses Radiation-Induced MicroRNA-30 and Protects Mice and Human CD34+ Cells from Radiation Injury
    Xiang Hong Li
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America
    PLoS ONE 10:e0122258. 2015
    ..Our data suggest that DT3 protects human and mouse cells from radiation damage may through suppression of IL-1β-induced NFκB/miR-30 signaling. ..
  7. doi request reprint Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor
    Shilpa S Kulkarni
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, United States
    Int Immunopharmacol 14:495-503. 2012
    ..These results also suggest a possible role of GT3-induced G-CSF stimulation in protecting mice from radiation-induced neutropenia and thrombocytopenia...
  8. ncbi request reprint Hematological targets of radiation damage
    Shilpa Kulkarni
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
    Curr Drug Targets 11:1375-85. 2010
    ....
  9. doi request reprint Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure
    Shilpa Kulkarni
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of Health Sciences, Bethesda, MD 20889 5603, USA
    Cytokine 62:278-85. 2013
    ..Our results suggest that induction of high levels of G-CSF by GT3 administration is responsible for its protective efficacy against radiation injury...
  10. pmc Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model
    Sanchita P Ghosh
    Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
    Mol Biosyst 9:723-31. 2013
    ..Post-radiation GI injury is a critical determinant of survival after exposure to IR. Our results show a distinct dose and time dependent response to GI tissue injury...
  11. doi request reprint Acute toxicity of subcutaneously administered vitamin E isomers delta- and gamma-tocotrienol in mice
    Sibyl N Swift
    Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Int J Toxicol 33:450-8. 2014
    ..At this dose, a mild skin irritation occurred at the injection site that recovered completely by the end of the experimental period. At a dose of 300 mg/kg of DT3 or GT3, no adverse effects were observed in any tissues or organs. ..
  12. doi request reprint Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury
    Xiang Hong Li
    a Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    Radiat Res 180:649-57. 2013
    ..Our data demonstrate that administration of DT3 protected mice from radiation-induced gastrointestinal system damage. ..
  13. doi request reprint Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform δ-Tocotrienol
    Merriline M Satyamitra
    Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA
    Radiat Res 175:736-45. 2011
    ..05). The large therapeutic potential of and multi-lineage hematopoietic recovery for DT3 warrants further studies...