Research Topics
| Sanchita P GhoshSummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
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Detail Information
Publications
Gamma-tocotrienol, a tocol antioxidant as a potent radioprotectorSanchita P Ghosh
Armed Forces Radiobiology Research Institute, USUHS, Bethesda, USA
Int J Radiat Biol 85:598-606. 2009..To assess the radioprotective potential of gamma-tocotrienol...
Amelioration of radiation-induced hematopoietic and gastrointestinal damage by Ex-RAD(R) in miceSanchita P Ghosh
Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
J Radiat Res 53:526-36. 2012..The results demonstrated that Ex-RAD ameliorates radiation-induced peripheral blood cell depletion, promotes bone marrow recovery, reduces p53 signaling in spleen and protects intestine from radiation injury...
Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanismsSanchita P Ghosh
Armed Forces Radiobiology Research Institute, USUHS, Bethesda, Maryland 20889 5603, USA
Radiat Res 171:173-9. 2009..In conclusion, it appears that Ex-Rad's radioprotective mechanisms involve prevention of p53-dependent and independent radiation-induced apoptosis...
Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiationShilpa Kulkarni
a Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA
Radiat Res 173:738-47. 2010..Our results demonstrate that GT3 protected hematopoietic tissue by preserving the HSCs and HPCs and by preventing persistent DNA damage...
Hematological targets of radiation damageShilpa Kulkarni
Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA
Curr Drug Targets 11:1375-85. 2010....
Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a promising radiation countermeasureSugata Ray
Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
Int Immunopharmacol 15:557-64. 2013..Mobilization of progenitor cells in peripheral blood by GT3 indicates that GT3 can be used as an alternative to G-CSF and VGEF to mobilize HPCs and EPCs...
Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine modelSanchita P Ghosh
Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, USA
Mol Biosyst 9:723-31. 2013..Post-radiation GI injury is a critical determinant of survival after exposure to IR. Our results show a distinct dose and time dependent response to GI tissue injury...
Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factorShilpa S Kulkarni
Armed Forces Radiobiology Research Institute, USUHS, Bethesda, MD 20889 5603, United States
Int Immunopharmacol 14:495-503. 2012..These results also suggest a possible role of GT3-induced G-CSF stimulation in protecting mice from radiation-induced neutropenia and thrombocytopenia...
Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform δ-TocotrienolMerriline M Satyamitra
Armed Forces Radiobiology Research Institute AFRRI, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA
Radiat Res 175:736-45. 2011..05). The large therapeutic potential of and multi-lineage hematopoietic recovery for DT3 warrants further studies...
Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasureShilpa Kulkarni
Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Cytokine 62:278-85. 2013..Our results suggest that induction of high levels of G-CSF by GT3 administration is responsible for its protective efficacy against radiation injury...
