Thomas P Flagg

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. pmc Muscle KATP channels: recent insights to energy sensing and myoprotection
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Rev 90:799-829. 2010
  2. pmc Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 103:1458-65. 2008
  3. pmc Differential K(ATP) channel pharmacology in intact mouse heart
    Alexey V Glukhov
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Mol Cell Cardiol 48:152-60. 2010
  4. ncbi request reprint Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP)
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Avenue, Box 8228, St Louis, MO 63110, USA
    J Mol Cell Cardiol 39:647-56. 2005
  5. doi request reprint Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy
    Thomas P Flagg
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 104:95-103. 2009
  6. ncbi request reprint Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[DeltaN30,K185Q] in the heart
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 293:H836-45. 2007
  7. pmc Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!
    Haixia Zhang
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Mol Cell Cardiol 48:71-5. 2010
  8. ncbi request reprint Random assembly of SUR subunits in K(ATP) channel complexes
    Wayland W L Cheng
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Channels (Austin) 2:34-8. 2008
  9. ncbi request reprint Role of the sarcolemmal adenosine triphosphate-sensitive potassium channel in hyperkalemic cardioplegia-induced myocyte swelling and reduced contractility
    Sandip M Prasad
    Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 81:148-53. 2006
  10. ncbi request reprint Sarcolemmal K(ATP) channels: what do we really know?
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Cell Cardiol 39:61-70. 2005

Collaborators

Detail Information

Publications13

  1. pmc Muscle KATP channels: recent insights to energy sensing and myoprotection
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Rev 90:799-829. 2010
    ..As yet, few human diseases have been correlated with altered muscle K(ATP) activity, but genetically modified animals give important insights to likely pathological roles of aberrant channel activity in different muscle types...
  2. pmc Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 103:1458-65. 2008
    ....
  3. pmc Differential K(ATP) channel pharmacology in intact mouse heart
    Alexey V Glukhov
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Mol Cell Cardiol 48:152-60. 2010
    ....
  4. ncbi request reprint Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP)
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Avenue, Box 8228, St Louis, MO 63110, USA
    J Mol Cell Cardiol 39:647-56. 2005
    ..2 suppresses the functional expression of K(ATP) from optimized dimeric SUR1-Kir6.2. Thus, the graded effect of SUR1 expression in the intact heart appears to demonstrate an in vivo requirement for 1:1 expression ratio of Kir6.2 and SURx...
  5. doi request reprint Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic cardiomyopathy
    Thomas P Flagg
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 104:95-103. 2009
    ....
  6. ncbi request reprint Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[DeltaN30,K185Q] in the heart
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 293:H836-45. 2007
    ..2[DeltaN30,K185Q] in the myocardium specifically, the results highlight the critical differential activation of SUR1 versus SUR2A, and indicate that expression of hyperactive K(ATP) in the heart is likely to be proarrhythmic...
  7. pmc Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!
    Haixia Zhang
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Mol Cell Cardiol 48:71-5. 2010
    ..This topical review focuses on these new findings and considers their implications...
  8. ncbi request reprint Random assembly of SUR subunits in K(ATP) channel complexes
    Wayland W L Cheng
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Channels (Austin) 2:34-8. 2008
    ..The data demonstrate clearly that SUR1 and SUR2A subunits associate randomly, and suggest that heteromeric channels will occur in native tissues...
  9. ncbi request reprint Role of the sarcolemmal adenosine triphosphate-sensitive potassium channel in hyperkalemic cardioplegia-induced myocyte swelling and reduced contractility
    Sandip M Prasad
    Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 81:148-53. 2006
    ..To examine whether the mitochondrial or sarcolemmal KATP channel might be involved, volume and contractility in isolated myocytes from wild-type mice and mice lacking the sarcolemmal KATP channel (Kir6.2-/-) were evaluated...
  10. ncbi request reprint Sarcolemmal K(ATP) channels: what do we really know?
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Cell Cardiol 39:61-70. 2005
    ..However, the true physiological determinants of sarcolemmal K(ATP) activity remain elusive, we still await full illumination of the role of the channel in the intact heart...
  11. pmc Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice
    Paul J Schaeffer
    Departments of Medicine, Washington University School of Medicine, Center for Cardiovascular Research, St Louis, Missouri, USA
    Am J Physiol Heart Circ Physiol 297:H1263-73. 2009
    ..These results define a novel mouse model of cardiac-specific Cn deficiency and demonstrate novel links between Cn signaling, postnatal growth of the heart, pathological ventricular remodeling, and excitation-contraction coupling...
  12. pmc Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy
    Celine Marionneau
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 102:1406-15. 2008
    ..Functional changes in repolarizing K(+) currents with LVH, therefore, result from distinct cellular (cardiomyocyte enlargement) and molecular (alterations in the numbers of functional channels) mechanisms...
  13. ncbi request reprint Remodeling of excitation-contraction coupling in transgenic mice expressing ATP-insensitive sarcolemmal KATP channels
    Thomas P Flagg
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 286:H1361-9. 2004
    ..Collectively, the data demonstrate that a compensatory increase in I(Ca) counteracts a mild activation of ATP-insensitive K(ATP) channels to maintain the action potential duration and elevate the inotropic state of TG hearts...