Ying Hong Feng

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. pmc Functional diversity of AT2 receptor orthologues in closely related species
    Ying Hong Feng
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Kidney Int 67:1731-8. 2005
  2. pmc Single mutations at Asn295 and Leu305 in the cytoplasmic half of transmembrane alpha-helix domain 7 of the AT1 receptor induce promiscuous agonist specificity for angiotensin II fragments: a pseudo-constitutive activity
    Ying Hong Feng
    Department of Pharmacology, C2021, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Mol Pharmacol 68:347-55. 2005
  3. pmc Unconventional homologous internalization of the angiotensin II type-1 receptor induced by G-protein-independent signals
    Ying Hong Feng
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Hypertension 46:419-25. 2005
  4. pmc Epidermal growth factor facilitates epinephrine inhibition of P2X7-receptor-mediated pore formation and apoptosis: a novel signaling network
    Liqin Wang
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Endocrinology 146:164-74. 2005
  5. pmc Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms
    Regina M Day
    Dept of Pharmacology, Uniformed Services Univ of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 301:L772-81. 2011
  6. pmc ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor
    Ying Hong Feng
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Am J Physiol Cell Physiol 288:C1342-56. 2005
  7. pmc Gbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1
    Ying Hong Feng
    Department of Medicine, Case Western Reserve University School of Medicine, and University Hospital of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106 4982, USA
    Proc Natl Acad Sci U S A 99:12049-54. 2002

Research Grants

Detail Information

Publications7

  1. pmc Functional diversity of AT2 receptor orthologues in closely related species
    Ying Hong Feng
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Kidney Int 67:1731-8. 2005
    ..The present study investigated the properties of AT(2) receptors in closely related species...
  2. pmc Single mutations at Asn295 and Leu305 in the cytoplasmic half of transmembrane alpha-helix domain 7 of the AT1 receptor induce promiscuous agonist specificity for angiotensin II fragments: a pseudo-constitutive activity
    Ying Hong Feng
    Department of Pharmacology, C2021, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Mol Pharmacol 68:347-55. 2005
    ....
  3. pmc Unconventional homologous internalization of the angiotensin II type-1 receptor induced by G-protein-independent signals
    Ying Hong Feng
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Hypertension 46:419-25. 2005
    ..This may represent a general mechanism for triggering GPCR internalization...
  4. pmc Epidermal growth factor facilitates epinephrine inhibition of P2X7-receptor-mediated pore formation and apoptosis: a novel signaling network
    Liqin Wang
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Endocrinology 146:164-74. 2005
    ..These findings underscore a novel signaling network of communication between the receptor tyrosine kinases, the G protein-coupled receptors, and the purinergic P2X7 receptor...
  5. pmc Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms
    Regina M Day
    Dept of Pharmacology, Uniformed Services Univ of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 301:L772-81. 2011
    ..These are the first findings demonstrating that AMPK is activated by Ang II to produce ATP required for apoptosis. Our data also indicate that AMPK plays an energy-independent role by mediating SHP-2 activation...
  6. pmc ATP stimulates GRK-3 phosphorylation and beta-arrestin-2-dependent internalization of P2X7 receptor
    Ying Hong Feng
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Am J Physiol Cell Physiol 288:C1342-56. 2005
    ....
  7. pmc Gbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1
    Ying Hong Feng
    Department of Medicine, Case Western Reserve University School of Medicine, and University Hospital of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106 4982, USA
    Proc Natl Acad Sci U S A 99:12049-54. 2002
    ..The AT(2)-mediated ITIM-independent activation of SHP-1 that is distinct from the conventional mode of activation, may represent a general paradigm for activation of SHP-1/2-class tyrosine phosphatases by G protein-coupled receptors...

Research Grants4

  1. Inhibitory AT2 Receptor:Activation/Signaling Mechanisms
    Ying Hong Feng; Fiscal Year: 2002
    ..This proposal has the potential to open up novel avenues for therapy of hypertrophy and fibrosis. ..
  2. Inhibitory AT2 Receptor:Activation/Signaling Mechanisms
    Ying Hong Feng; Fiscal Year: 2003
    ..This proposal has the potential to open up novel avenues for therapy of hypertrophy and fibrosis. ..
  3. Inhibitory AT2 Receptor:Activation/Signaling Mechanisms
    Ying Hong Feng; Fiscal Year: 2004
    ..This proposal has the potential to open up novel avenues for therapy of hypertrophy and fibrosis. ..
  4. Inhibitory AT2 Receptor:Activation/Signaling Mechanisms
    Ying Hong Feng; Fiscal Year: 2005
    ..This proposal has the potential to open up novel avenues for therapy of hypertrophy and fibrosis. ..