Thomas B Elliott

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. doi request reprint Combined injury: factors with potential to impact radiation dose assessments
    G David Ledney
    Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Health Phys 98:145-52. 2010
  2. ncbi request reprint Antimicrobial therapies for pulmonary Klebsiella pneumoniae infection in B6D2F1/J mice immunocompromised by use of sublethal irradiation
    David E Bentzel
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
    Comp Med 54:185-92. 2004
  3. doi request reprint Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Int J Radiat Biol 89:334-45. 2013
  4. ncbi request reprint Management of postirradiation infection: lessons learned from animal models
    Itzhak Brook
    Radiation Medicine Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Mil Med 169:194-7. 2004
  5. ncbi request reprint Comparison of clarithromycin and ciprofloxacin therapy for Bacillus anthracis Sterne infection in mice with or without (60)Co gamma-photon irradiation
    Itzhak Brook
    Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    J Med Microbiol 54:1157-62. 2005
  6. doi request reprint Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury
    Xiang Hong Li
    a Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    Radiat Res 180:649-57. 2013
  7. ncbi request reprint Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: early hematological changes and systemic inflammatory response syndrome in minipig
    Maria Moroni
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda
    Int J Radiat Biol 90:363-72. 2014
  8. ncbi request reprint Susceptibility of irradiated B6D2F1/J mice to Klebsiella pneumoniae administered intratracheally: a pulmonary infection model in an immunocompromised host
    Christopher E Keller
    Center of Laboratory Animal Medicine, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814 4799, USA
    Comp Med 53:397-403. 2003
  9. pmc Pegylated G-CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole-body ionizing irradiation but not after irradiation combined with burn
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA Department of Radiation Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Oxid Med Cell Longev 2014:481392. 2014
  10. pmc Wound trauma alters ionizing radiation dose assessment
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Cell Biosci 2:20. 2012

Collaborators

Detail Information

Publications14

  1. doi request reprint Combined injury: factors with potential to impact radiation dose assessments
    G David Ledney
    Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Health Phys 98:145-52. 2010
    ..Because trauma to irradiated personnel and medical countermeasures may affect biodosimetric measurements, it will be necessary to quickly determine radiation dose in order to implement appropriate therapy...
  2. ncbi request reprint Antimicrobial therapies for pulmonary Klebsiella pneumoniae infection in B6D2F1/J mice immunocompromised by use of sublethal irradiation
    David E Bentzel
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
    Comp Med 54:185-92. 2004
    ..pneumoniae pneumonia using a third-generation cephalosporin, with or without an aminoglycoside...
  3. doi request reprint Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation
    Vijay K Singh
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Int J Radiat Biol 89:334-45. 2013
    ..The objective of this study was to elucidate the action of α-tocopherol succinate (TS)- and AMD3100-mobilized progenitors in mitigating radiation-induced injuries...
  4. ncbi request reprint Management of postirradiation infection: lessons learned from animal models
    Itzhak Brook
    Radiation Medicine Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Mil Med 169:194-7. 2004
    ..Based on these findings, antimicrobial agents recommended for therapy of infection after exposure to irradiation are: ciprofloxacin, levofloxacin, ceftriaxone, cefepime, gentamicin +/- amoxicillin, or vancomycin...
  5. ncbi request reprint Comparison of clarithromycin and ciprofloxacin therapy for Bacillus anthracis Sterne infection in mice with or without (60)Co gamma-photon irradiation
    Itzhak Brook
    Scientific Research Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    J Med Microbiol 54:1157-62. 2005
    ..B. anthracis Sterne only was isolated from 25-50 % of treated mice with or without irradiation. Mixed infections with B. anthracis Sterne were present in 50-71 % of gamma-irradiated mice but only in 5-10 % of mice without irradiation...
  6. doi request reprint Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury
    Xiang Hong Li
    a Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    Radiat Res 180:649-57. 2013
    ..Our data demonstrate that administration of DT3 protected mice from radiation-induced gastrointestinal system damage. ..
  7. ncbi request reprint Accelerated hematopoietic syndrome after radiation doses bridging hematopoietic (H-ARS) and gastrointestinal (GI-ARS) acute radiation syndrome: early hematological changes and systemic inflammatory response syndrome in minipig
    Maria Moroni
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda
    Int J Radiat Biol 90:363-72. 2014
    ..To characterize acute radiation syndrome (ARS) sequelae at doses intermediate between the bone marrow (H-ARS) and full gastrointestinal (GI-ARS) syndrome...
  8. ncbi request reprint Susceptibility of irradiated B6D2F1/J mice to Klebsiella pneumoniae administered intratracheally: a pulmonary infection model in an immunocompromised host
    Christopher E Keller
    Center of Laboratory Animal Medicine, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814 4799, USA
    Comp Med 53:397-403. 2003
    ..001). These results demonstrate that 7-Gy 60Co gamma-photon radiation in combination with intratracheal K. pneumoniae challenge induces a valid pulmonary infection model in immunocompromised female B6D2F1/J mice...
  9. pmc Pegylated G-CSF inhibits blood cell depletion, increases platelets, blocks splenomegaly, and improves survival after whole-body ionizing irradiation but not after irradiation combined with burn
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889, USA Department of Radiation Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Oxid Med Cell Longev 2014:481392. 2014
    ..The results suggest that pegylated G-CSF effectively sustained animal survival by mitigating radiation-induced cytopenia, thrombopenia, erythropenia, and anemia...
  10. pmc Wound trauma alters ionizing radiation dose assessment
    Juliann G Kiang
    Radiation Combined Injury Program, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    Cell Biosci 2:20. 2012
    ..abstract:..
  11. ncbi request reprint α-Tocopherol succinate protects mice against radiation-induced gastrointestinal injury
    Pankaj K Singh
    Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Ave, Bethesda, MD 20889 5603, USA
    Radiat Res 177:133-45. 2012
    ..Our data suggest that α-TS protects mice from radiation-induced gastrointestinal damage by inhibiting apoptosis, promoting regeneration of crypt cells, and inhibiting translocation of gut bacteria...
  12. doi request reprint Wound trauma increases radiation-induced mortality by activation of iNOS pathway and elevation of cytokine concentrations and bacterial infection
    Juliann G Kiang
    Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889 5603, USA
    Radiat Res 173:319-32. 2010
    ..Agents that inhibit these responses may prove to be therapeutic for combined injury and may reduce related mortality...
  13. pmc Antimicrobial therapy for bacillus anthracis-induced polymicrobial infection in (60)Co gamma-irradiated mice
    Thomas B Elliott
    Nuclear, Biological, and Chemical Interactions and Countermeasures Research Team, Radiation Medicine Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889 5603, USA
    Antimicrob Agents Chemother 46:3463-71. 2002
    ..To limit mortality following nonlethal irradiation and challenge with B. anthracis spores, antimicrobial therapy needs to be initiated within a few hours after challenge and continued for up to 21 days...
  14. ncbi request reprint Nuclear, biological, and chemical combined injuries and countermeasures on the battlefield
    Gregory B Knudson
    Nuclear Biological Chemical Interactions and Countermeasures Research Team, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Mil Med 167:95-7. 2002
    ..armed forces to accomplish military operations in NBC environments while optimizing both survival and military performance. Preserving combatants' health in an NBC environment will improve warfighting operations and mission capabilities...