Regina M Day

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. pmc Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence
    Ronald Allan M Panganiban
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 8:e78589. 2013
  2. doi request reprint Enhanced hematopoietic protection from radiation by the combination of genistein and captopril
    R M Day
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Int Immunopharmacol 15:348-56. 2013
  3. ncbi request reprint Mechanism of erythropoietin regulation by angiotensin II
    Yong Chul Kim
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland Y C K, O M, E A M, P J R, R M D and Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania D K Y
    Mol Pharmacol 85:898-908. 2014
  4. pmc Transforming growth factor-β1 selectively inhibits hepatocyte growth factor expression via a micro-RNA-199-dependent posttranscriptional mechanism
    Ognoon Mungunsukh
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Mol Biol Cell 24:2088-97. 2013
  5. doi request reprint Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation
    Michal Barshishat-Kupper
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20892, USA
    Exp Hematol 39:293-304. 2011
  6. doi request reprint X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells
    Ronald Allan M Panganiban
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Int J Radiat Biol 89:656-67. 2013
  7. pmc Angiotensin II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPKβ1/2 and Cdk4
    Yong Chul Kim
    Department of Pharmacology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 303:L228-38. 2012
  8. pmc Hepatocyte growth factor inhibits apoptosis by the profibrotic factor angiotensin II via extracellular signal-regulated kinase 1/2 in endothelial cells and tissue explants
    Young H Lee
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Mol Biol Cell 21:4240-50. 2010
  9. pmc Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells
    Ognoon Mungunsukh
    Dept of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 298:L696-703. 2010
  10. pmc Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms
    Regina M Day
    Dept of Pharmacology, Uniformed Services Univ of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 301:L772-81. 2011

Collaborators

Detail Information

Publications14

  1. pmc Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence
    Ronald Allan M Panganiban
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 8:e78589. 2013
    ..Together these findings suggest that IGF-1R is a key regulator of IR-induced accelerated senescence in a pathway that requires intact mTOR activity upstream of both p53 and p21/waf1. ..
  2. doi request reprint Enhanced hematopoietic protection from radiation by the combination of genistein and captopril
    R M Day
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Int Immunopharmacol 15:348-56. 2013
    ..These data suggest that genistein and captopril protect the hematopoietic system from radiation injury via independent mechanisms...
  3. ncbi request reprint Mechanism of erythropoietin regulation by angiotensin II
    Yong Chul Kim
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland Y C K, O M, E A M, P J R, R M D and Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania D K Y
    Mol Pharmacol 85:898-908. 2014
    ..Our current data suggest that Ang II, in addition to regulating blood volume and pressure, may be a master regulator of erythropoiesis. ..
  4. pmc Transforming growth factor-β1 selectively inhibits hepatocyte growth factor expression via a micro-RNA-199-dependent posttranscriptional mechanism
    Ognoon Mungunsukh
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Mol Biol Cell 24:2088-97. 2013
    ..Taken together, these findings demonstrate that HGF is distinctly regulated at the posttranscriptional level from its antagonist NK2. ..
  5. doi request reprint Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation
    Michal Barshishat-Kupper
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20892, USA
    Exp Hematol 39:293-304. 2011
    ..Here we investigate captopril and radiation regulation of erythropoietin (EPO) and thrombopoietin (TPO), key effectors of erythroid progenitor proliferation and differentiation...
  6. doi request reprint X-irradiation induces ER stress, apoptosis, and senescence in pulmonary artery endothelial cells
    Ronald Allan M Panganiban
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Int J Radiat Biol 89:656-67. 2013
    ..The use of clinical radiation for cancer treatment is limited by damage to underlying normal tissue including to the vascular endothelium. We investigated the mechanisms of X-ray-induced cell damage to endothelial cells...
  7. pmc Angiotensin II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPKβ1/2 and Cdk4
    Yong Chul Kim
    Department of Pharmacology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 303:L228-38. 2012
    ..Together these findings illuminate a novel proapoptotic signaling pathway in endothelial cells, whereby Ang II triggers E2F1-mediated transcriptional upregulation of Bim via activation of AMPKβ1/2 and Cdk4...
  8. pmc Hepatocyte growth factor inhibits apoptosis by the profibrotic factor angiotensin II via extracellular signal-regulated kinase 1/2 in endothelial cells and tissue explants
    Young H Lee
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Mol Biol Cell 21:4240-50. 2010
    ..HGF also blocked Ang II-induced caspase-3 activation and lactate dehydrogenase release in tissue explants in an ERK-dependent manner...
  9. pmc Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells
    Ognoon Mungunsukh
    Dept of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 298:L696-703. 2010
    ..Apoptosis was also abrogated by caspase-8 inhibition, but only slightly reduced by caspase-3 inhibition. Together, these data suggest that bleomycin initiates apoptosis via the extrinsic pathway...
  10. pmc Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms
    Regina M Day
    Dept of Pharmacology, Uniformed Services Univ of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 301:L772-81. 2011
    ..These are the first findings demonstrating that AMPK is activated by Ang II to produce ATP required for apoptosis. Our data also indicate that AMPK plays an energy-independent role by mediating SHP-2 activation...
  11. doi request reprint Hepatocyte growth factor in lung repair and pulmonary fibrosis
    Ronald Allan M Panganiban
    Department of Pharmacology, Uniformed Services University of Health Sciences, Bethesda, MD 20852, USA
    Acta Pharmacol Sin 32:12-20. 2011
    ....
  12. pmc Mechanisms of radiation toxicity in transformed and non-transformed cells
    Ronald Allan M Panganiban
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Int J Mol Sci 14:15931-58. 2013
    ..Understanding the molecular mechanisms of radiation toxicity is critical for the development of radiation countermeasures as well as for the improvement of clinical radiation in cancer treatment. ..
  13. pmc A tandem repeat of a fragment of Listeria monocytogenes internalin B protein induces cell survival and proliferation
    Ognoon Mungunsukh
    Dept of Pharmacology, Uniformed Services University of the Health Sciences, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 299:L905-14. 2010
    ..The ease of large-scale production and capacity of 2×InlB₃₆₋₃₂₁ to mimic HGF make it a potential candidate as a pharmaceutical agent for tissue repair...
  14. pmc Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation
    Thomas A Davis
    Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD, USA
    Exp Hematol 38:270-81. 2010
    ..We investigated the consequences of different regimens of the ACE inhibitor captopril on radiation-induced hematopoietic injury...