Regina Day

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. pmc Hepatocyte growth factor inhibits apoptosis by the profibrotic factor angiotensin II via extracellular signal-regulated kinase 1/2 in endothelial cells and tissue explants
    Young H Lee
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Mol Biol Cell 21:4240-50. 2010
  2. pmc Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms
    Regina M Day
    Dept of Pharmacology, Uniformed Services Univ of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 301:L772-81. 2011
  3. pmc A tandem repeat of a fragment of Listeria monocytogenes internalin B protein induces cell survival and proliferation
    Ognoon Mungunsukh
    Dept of Pharmacology, Uniformed Services University of the Health Sciences, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 299:L905-14. 2010
  4. pmc Plasma levels of retinoids, carotenoids and tocopherols in patients with mild obstructive sleep apnoea
    Regina M Day
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Respirology 14:1134-42. 2009
  5. pmc Cell proliferation, reactive oxygen and cellular glutathione
    Regina M Day
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Dose Response 3:425-42. 2005
  6. pmc Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation
    Regina M Day
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    J Radiat Res 49:361-72. 2008
  7. pmc Serotonin induces pulmonary artery smooth muscle cell migration
    Regina M Day
    Department of Pharmacology, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Biochem Pharmacol 71:386-97. 2006
  8. pmc Regulation of Bcl-xL expression in lung vascular smooth muscle
    Yuichiro J Suzuki
    Department of Pharmacology, Georgetown University Medical Center, NW403 Medical Dental Building, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Am J Respir Cell Mol Biol 36:678-87. 2007
  9. pmc Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells
    Young H Lee
    Department of Pharmacology, C2023, 4301 Jones Bridge Road, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Cell Sci 123:1634-43. 2010
  10. pmc Retinoic acid inhibits airway smooth muscle cell migration
    Regina M Day
    Department of Pharmacology, Georgetown University Medical Center, NW403 Medical Dental Building, Washington, DC 20057, USA
    Am J Respir Cell Mol Biol 34:695-703. 2006

Research Grants

  1. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2004
  2. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2005
  3. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2004
  4. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2006
  5. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2007

Collaborators

Detail Information

Publications23

  1. pmc Hepatocyte growth factor inhibits apoptosis by the profibrotic factor angiotensin II via extracellular signal-regulated kinase 1/2 in endothelial cells and tissue explants
    Young H Lee
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Mol Biol Cell 21:4240-50. 2010
    ..HGF also blocked Ang II-induced caspase-3 activation and lactate dehydrogenase release in tissue explants in an ERK-dependent manner...
  2. pmc Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanisms
    Regina M Day
    Dept of Pharmacology, Uniformed Services Univ of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 301:L772-81. 2011
    ..These are the first findings demonstrating that AMPK is activated by Ang II to produce ATP required for apoptosis. Our data also indicate that AMPK plays an energy-independent role by mediating SHP-2 activation...
  3. pmc A tandem repeat of a fragment of Listeria monocytogenes internalin B protein induces cell survival and proliferation
    Ognoon Mungunsukh
    Dept of Pharmacology, Uniformed Services University of the Health Sciences, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 299:L905-14. 2010
    ..The ease of large-scale production and capacity of 2×InlB₃₆₋₃₂₁ to mimic HGF make it a potential candidate as a pharmaceutical agent for tissue repair...
  4. pmc Plasma levels of retinoids, carotenoids and tocopherols in patients with mild obstructive sleep apnoea
    Regina M Day
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Respirology 14:1134-42. 2009
    ..The present study tested the hypothesis that plasmas from OSA patients contain altered levels of retinoids, carotenoids and tocopherols...
  5. pmc Cell proliferation, reactive oxygen and cellular glutathione
    Regina M Day
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Dose Response 3:425-42. 2005
    ..The modulation of the cellular redox environment, through the regulation of cellular glutathione levels, may be a part of the hormetic effect shown by ROS on cell growth...
  6. pmc Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation
    Regina M Day
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    J Radiat Res 49:361-72. 2008
    ..These data suggest that genistein is protective against a range of radiation injuries...
  7. pmc Serotonin induces pulmonary artery smooth muscle cell migration
    Regina M Day
    Department of Pharmacology, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Biochem Pharmacol 71:386-97. 2006
    ..We conclude that 5-HT stimulates PASMC migration and associated cytoskeletal reorganization through the 5-HT4 receptor and cAMP activation of a chloride channel...
  8. pmc Regulation of Bcl-xL expression in lung vascular smooth muscle
    Yuichiro J Suzuki
    Department of Pharmacology, Georgetown University Medical Center, NW403 Medical Dental Building, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Am J Respir Cell Mol Biol 36:678-87. 2007
    ..Thus, inducers of pulmonary hypertension enhance anti-apoptotic Bcl-x(L) gene transcription, which can be suppressed by targeting gata4 gene transcription...
  9. pmc Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells
    Young H Lee
    Department of Pharmacology, C2023, 4301 Jones Bridge Road, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Cell Sci 123:1634-43. 2010
    ....
  10. pmc Retinoic acid inhibits airway smooth muscle cell migration
    Regina M Day
    Department of Pharmacology, Georgetown University Medical Center, NW403 Medical Dental Building, Washington, DC 20057, USA
    Am J Respir Cell Mol Biol 34:695-703. 2006
    ..RAR was found to form protein-protein interactions with the p85 PI3K subunit. These results suggest that retinoic acid inhibits airway SMC migration through the modulation of the PI3K/Akt pathway...
  11. pmc Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases
    Yuichiro J Suzuki
    Department of Pharmacology, Georgetown University Medical Center, Room NW403, Medical Dental Building, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Free Radic Biol Med 40:1683-92. 2006
    ..This review summarizes currently available information on the evidence for and against the occurrence of oxidative stress in OSA and the role of reactive oxygen species in cardiovascular changes associated with OSA...
  12. pmc Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation
    Thomas A Davis
    Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD, USA
    Exp Hematol 38:270-81. 2010
    ..We investigated the consequences of different regimens of the ACE inhibitor captopril on radiation-induced hematopoietic injury...
  13. ncbi request reprint Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta
    Feng Liu
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    FASEB J 16:950-62. 2002
    ....
  14. pmc Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells
    Ognoon Mungunsukh
    Dept of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Am J Physiol Lung Cell Mol Physiol 298:L696-703. 2010
    ..Apoptosis was also abrogated by caspase-8 inhibition, but only slightly reduced by caspase-3 inhibition. Together, these data suggest that bleomycin initiates apoptosis via the extrinsic pathway...
  15. doi request reprint Characterization of the bovine angiotensin converting enzyme promoter: essential roles of Egr-1, ATF-2 and Ets-1 in the regulation by phorbol ester
    Ognoon Mungunsukh
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
    Gene 421:81-8. 2008
    ..The bovine and human ACE promoters share similarities in binding sites for transcription factors and PMA regulation within the core regions but contain significant differences in the distal promoter regions...
  16. pmc Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src
    Young H Lee
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Am J Respir Cell Mol Biol 37:485-93. 2007
    ..Together, these results suggest that TGF-beta1-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src-dependent and -independent pathways...
  17. ncbi request reprint Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells
    Yuichiro J Suzuki
    Department of Medicine, Tufts University, Boston, Massachusetts 02111, USA
    J Biol Chem 278:17525-31. 2003
    ..Thus, GATA-4 mediates 5-HT-induced growth of PASMC and may be an important therapeutic target for the prevention of pulmonary hypertension...
  18. ncbi request reprint Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin
    Yinglin Liu
    Tufts New England Medical Center, Pulmonary, Critical Care and Sleep Division, Tupper Research Institute, Boston, Mass 02111, USA
    Circ Res 95:579-86. 2004
    ....
  19. ncbi request reprint Regulation of glutathione by oxidative stress in bovine pulmonary artery endothelial cells
    Regina M Day
    Pulmonary, Critical Care and Sleep Division, Tufts New England Medical Center, Tupper Research Institute, Department of Medicine, Tufts University, Boston, MA 02111, USA
    Antioxid Redox Signal 5:699-704. 2003
    ..H(2)O(2)-mediated increase in glutathione and activation of ARE binding may play important roles in growth and death of pulmonary artery endothelial cells...
  20. ncbi request reprint Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase
    Victor J Thannickal
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 278:12384-9. 2003
    ....
  21. ncbi request reprint 5-HT induction of c-fos gene expression requires reactive oxygen species and Rac1 and Ras GTPases
    Amy R Simon
    Tufts, New England Medical Center, Tupper Research Institute, Pulmonary, Critical Care and Sleep Division, 750 Washington Street, NEMC number 257, Boston, MA 02111, USA
    Cell Biochem Biophys 42:263-76. 2005
    ..Nuclear factor-kappaB, which can also regulate cyclin D1, was not activated. We conclude that 5-HT stimulates c-fos and cyclin D1 expression through a ROS-dependent mechanism that requires Ras, Rac1, and MAPK...
  22. pmc Hepatocyte growth factor regulates angiotensin converting enzyme expression
    Regina M Day
    New England Medical Center, Tupper Research Institute, Pulmonary and Critical Care Division, Boston, Massachusetts 02111, USA
    J Biol Chem 279:8792-801. 2004
    ..These results show that HGF transiently increases gene transcription of ACE via activation of Egr-1, whereas PMA regulation involves Egr-1 and additional factor(s)...
  23. ncbi request reprint Bleomycin upregulates expression of gamma-glutamylcysteine synthetase in pulmonary artery endothelial cells
    Regina M Day
    Pulmonary and Critical Care Division, Tupper Research Institute, New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1349-57. 2002
    ..NAC and U-0126 both inhibit bleomycin-induced upregulation of gamma-GCS expression. These data suggest that bleomycin can activate oxidative stress response pathways and upregulate cellular GSH...

Research Grants5

  1. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2004
    ..In addition, it is expected that the results will fundamentally advance the field of lung cell biology. ..
  2. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2005
    ..In addition, it is expected that the results will fundamentally advance the field of lung cell biology. ..
  3. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2004
    ..In addition, it is expected that the results will fundamentally advance the field of lung cell biology. ..
  4. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2006
    ..In addition, it is expected that the results will fundamentally advance the field of lung cell biology. ..
  5. HGF Signaling in Pulmonary Remodeling
    Regina Day; Fiscal Year: 2007
    ..In addition, it is expected that the results will fundamentally advance the field of lung cell biology. ..