Research Topics
| Regina DaySummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
Research Grants
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Detail Information
Publications
Angiotensin II activates AMPK for execution of apoptosis through energy-dependent and -independent mechanismsRegina M Day
Dept of Pharmacology, Uniformed Services Univ of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 4799, USA
Am J Physiol Lung Cell Mol Physiol 301:L772-81. 2011..These are the first findings demonstrating that AMPK is activated by Ang II to produce ATP required for apoptosis. Our data also indicate that AMPK plays an energy-independent role by mediating SHP-2 activation...- A tandem repeat of a fragment of Listeria monocytogenes internalin B protein induces cell survival and proliferationOgnoon Mungunsukh
Dept of Pharmacology, Uniformed Services University of the Health Sciences, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
Am J Physiol Lung Cell Mol Physiol 299:L905-14. 2010..The ease of large-scale production and capacity of 2×InlB₃₆₋₃₂₁ to mimic HGF make it a potential candidate as a pharmaceutical agent for tissue repair... - Plasma levels of retinoids, carotenoids and tocopherols in patients with mild obstructive sleep apnoeaRegina M Day
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
Respirology 14:1134-42. 2009..The present study tested the hypothesis that plasmas from OSA patients contain altered levels of retinoids, carotenoids and tocopherols... - Cell proliferation, reactive oxygen and cellular glutathioneRegina M Day
Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
Dose Response 3:425-42. 2005..The modulation of the cellular redox environment, through the regulation of cellular glutathione levels, may be a part of the hormetic effect shown by ROS on cell growth... - Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiationRegina M Day
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
J Radiat Res 49:361-72. 2008..These data suggest that genistein is protective against a range of radiation injuries... - Serotonin induces pulmonary artery smooth muscle cell migrationRegina M Day
Department of Pharmacology, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
Biochem Pharmacol 71:386-97. 2006..We conclude that 5-HT stimulates PASMC migration and associated cytoskeletal reorganization through the 5-HT4 receptor and cAMP activation of a chloride channel... - Regulation of Bcl-xL expression in lung vascular smooth muscleYuichiro J Suzuki
Department of Pharmacology, Georgetown University Medical Center, NW403 Medical Dental Building, 3900 Reservoir Road NW, Washington, DC 20057, USA
Am J Respir Cell Mol Biol 36:678-87. 2007..Thus, inducers of pulmonary hypertension enhance anti-apoptotic Bcl-x(L) gene transcription, which can be suppressed by targeting gata4 gene transcription... - Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiationThomas A Davis
Department of Regenerative Medicine, Naval Medical Research Center, Silver Spring, MD, USA
Exp Hematol 38:270-81. 2010..We investigated the consequences of different regimens of the ACE inhibitor captopril on radiation-induced hematopoietic injury... - Retinoic acid inhibits airway smooth muscle cell migrationRegina M Day
Department of Pharmacology, Georgetown University Medical Center, NW403 Medical-Dental Building, Washington, DC 20057, USA
Am J Respir Cell Mol Biol 34:695-703. 2006..RAR was found to form protein-protein interactions with the p85 PI3K subunit. These results suggest that retinoic acid inhibits airway SMC migration through the modulation of the PI3K/Akt pathway... - Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseasesYuichiro J Suzuki
Department of Pharmacology, Georgetown University Medical Center, Room NW403, Medical Dental Building, 3900 Reservoir Road NW, Washington, DC 20057, USA
Free Radic Biol Med 40:1683-92. 2006..This review summarizes currently available information on the evidence for and against the occurrence of oxidative stress in OSA and the role of reactive oxygen species in cardiovascular changes associated with OSA... 
Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3betaFeng Liu
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
FASEB J 16:950-62. 2002....- Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cellsYoung H Lee
Department of Pharmacology, C2023, 4301 Jones Bridge Road, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Cell Sci 123:1634-43. 2010.... - Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cellsOgnoon Mungunsukh
Dept of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
Am J Physiol Lung Cell Mol Physiol 298:L696-703. 2010..Apoptosis was also abrogated by caspase-8 inhibition, but only slightly reduced by caspase-3 inhibition. Together, these data suggest that bleomycin initiates apoptosis via the extrinsic pathway... - Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/SrcYoung H Lee
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
Am J Respir Cell Mol Biol 37:485-93. 2007..Together, these results suggest that TGF-beta1-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK/Src-dependent and -independent pathways... 
Characterization of the bovine angiotensin converting enzyme promoter: essential roles of Egr-1, ATF-2 and Ets-1 in the regulation by phorbol esterOgnoon Mungunsukh
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, USA
Gene 421:81-8. 2008..The bovine and human ACE promoters share similarities in binding sites for transcription factors and PMA regulation within the core regions but contain significant differences in the distal promoter regions...- Regulation of glutathione by oxidative stress in bovine pulmonary artery endothelial cellsRegina M Day
Pulmonary, Critical Care and Sleep Division, Tufts New England Medical Center, Tupper Research Institute, Department of Medicine, Tufts University, Boston, MA 02111, USA
Antioxid Redox Signal 5:699-704. 2003..H(2)O(2)-mediated increase in glutathione and activation of ARE binding may play important roles in growth and death of pulmonary artery endothelial cells... - Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cellsYuichiro J Suzuki
Department of Medicine, Tufts University, Boston, Massachusetts 02111, USA
J Biol Chem 278:17525-31. 2003..Thus, GATA-4 mediates 5-HT-induced growth of PASMC and may be an important therapeutic target for the prevention of pulmonary hypertension... - Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotoninYinglin Liu
Tufts New England Medical Center, Pulmonary, Critical Care and Sleep Division, Tupper Research Institute, Boston, Mass 02111, USA
Circ Res 95:579-86. 2004.... - Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinaseVictor J Thannickal
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
J Biol Chem 278:12384-9. 2003.... - 5-HT induction of c-fos gene expression requires reactive oxygen species and Rac1 and Ras GTPasesAmy R Simon
Tufts, New England Medical Center, Tupper Research Institute, Pulmonary, Critical Care and Sleep Division, 750 Washington Street, NEMC number 257, Boston, MA 02111, USA
Cell Biochem Biophys 42:263-76. 2005..Nuclear factor-kappaB, which can also regulate cyclin D1, was not activated. We conclude that 5-HT stimulates c-fos and cyclin D1 expression through a ROS-dependent mechanism that requires Ras, Rac1, and MAPK... - Hepatocyte growth factor regulates angiotensin converting enzyme expressionRegina M Day
New England Medical Center, Tupper Research Institute, Pulmonary and Critical Care Division, Boston, Massachusetts 02111, USA
J Biol Chem 279:8792-801. 2004..These results show that HGF transiently increases gene transcription of ACE via activation of Egr-1, whereas PMA regulation involves Egr-1 and additional factor(s)... - Bleomycin upregulates expression of gamma-glutamylcysteine synthetase in pulmonary artery endothelial cellsRegina M Day
Pulmonary and Critical Care Division, Tupper Research Institute, New England Medical Center, Boston, Massachusetts 02111, USA
Am J Physiol Lung Cell Mol Physiol 282:L1349-57. 2002..NAC and U-0126 both inhibit bleomycin-induced upregulation of gamma-GCS expression. These data suggest that bleomycin can activate oxidative stress response pathways and upregulate cellular GSH...
Research Grants
- HGF Signaling in Pulmonary RemodelingRegina Day; Fiscal Year: 2007..In addition, it is expected that the results will fundamentally advance the field of lung cell biology. ..