Kimberly R Byrnes
Affiliation: Uniformed Services University of the Health Sciences
Yauger Y, Bermudez S, Moritz K, Glaser E, Stoica B, Byrnes K. Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro. J Neuroinflammation. 2019;16:41 pubmed publisher
..Further, this study highlights both NOX2 and NOX4 as potential therapeutic targets in the treatment of iron-induced microglia-related inflammation and neurotoxicity. ..
Jaiswal S, Hockenbury N, Pan H, Knutsen A, Dardzinski B, Byrnes K. Alteration of FDG uptake by performing novel object recognition task in a rat model of Traumatic Brain Injury. Neuroimage. 2019;188:419-426 pubmed publisher
..Overall, these data suggest that cognitive activity during FDG uptake affects the regional uptake pattern in the brain, increasing uptake at baseline and suppressing the effects of injury. ..
von Leden R, Moritz K, Bermudez S, Jaiswal S, Wilson C, Dardzinski B, et al
. Aging alters glucose uptake in the naïve and injured rodent spinal cord. Neurosci Lett. 2019;690:23-28 pubmed publisher
Khayrullina G, Bermudez S, Byrnes K. Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury. J Neuroinflammation. 2015;12:172 pubmed publisher
..NOX2 inhibition may therefore have true potential as a therapy after SCI. ..
von Leden R, Selwyn R, Jaiswal S, Wilson C, Khayrullina G, Byrnes K. (18)F-FDG-PET imaging of rat spinal cord demonstrates altered glucose uptake acutely after contusion injury. Neurosci Lett. 2016;621:126-132 pubmed publisher
..This acute and sub-acute uptake, which is dependent on cellular responses, may represent a therapeutic target. ..
Bermudez S, Khayrullina G, Zhao Y, Byrnes K. NADPH oxidase isoform expression is temporally regulated and may contribute to microglial/macrophage polarization after spinal cord injury. Mol Cell Neurosci. 2016;77:53-64 pubmed publisher
..These data can contribute to the therapeutic targeting of NOX as a therapy for SCI. ..