N Arispe

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site
    George Lee
    Laboratory of Cell Biology and Biochemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Peptides 23:1249-63. 2002
  2. doi request reprint Polyhistidine peptide inhibitor of the Abeta calcium channel potently blocks the Abeta-induced calcium response in cells. Theoretical modeling suggests a cooperative binding process
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Biochemistry 49:7847-53. 2010
  3. ncbi request reprint ATP and ADP modulate a cation channel formed by Hsc70 in acidic phospholipid membranes
    N Arispe
    Department of Anatomy and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 275:30839-43. 2000
  4. pmc Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Biophys J 95:4879-89. 2008
  5. ncbi request reprint Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, USUHS, 4301 Jones Bridge Rd Bethesda, MD 20814, USA
    Biochim Biophys Acta 1768:1952-65. 2007
  6. ncbi request reprint Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    FASEB J 18:1636-45. 2004
  7. ncbi request reprint Architecture of the Alzheimer's A beta P ion channel pore
    N Arispe
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services, University School of Medicine, USUHS, Bethesda, MD, 20814, USA
    J Membr Biol 197:33-48. 2004
  8. pmc Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cell Stress Chaperones 7:330-8. 2002
  9. ncbi request reprint Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, USUHS, Bethesda, Maryland 20814, USA
    FASEB J 16:1526-36. 2002
  10. ncbi request reprint Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer's disease Abeta ion channel and cytotoxicity
    Juan Carlos Diaz
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, Maryland 20814, USA
    Biol Res 39:447-60. 2006

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site
    George Lee
    Laboratory of Cell Biology and Biochemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Peptides 23:1249-63. 2002
    ..These results also provide a biochemical mechanism by which the apoE varepsilon2 allele, but not apoE varepsilon4, can be protective towards the incidence and progression of Alzheimer's disease...
  2. doi request reprint Polyhistidine peptide inhibitor of the Abeta calcium channel potently blocks the Abeta-induced calcium response in cells. Theoretical modeling suggests a cooperative binding process
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Biochemistry 49:7847-53. 2010
    ..We have modeled how up to four NAHis04 peptides may block these types of pores by binding to side chains of Abeta residues Glu 11, His 13, and His 14...
  3. ncbi request reprint ATP and ADP modulate a cation channel formed by Hsc70 in acidic phospholipid membranes
    N Arispe
    Department of Anatomy and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Biol Chem 275:30839-43. 2000
    ..The Hsc70 channel activity is ATP-dependent and is reversibly blocked by ADP. This channel has cationic selectivity. Thus, Hsc70 can directly interact with lipid membranes to create functionally stable ATP-dependent cationic pathways...
  4. pmc Efficiency of histidine-associating compounds for blocking the alzheimer's Abeta channel activity and cytotoxicity
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Biophys J 95:4879-89. 2008
    ..These data reinforce the premise that His residues within the Abeta channel sequence are in the pathway of ion flow. Additionally, the data confirm the contribution of the Abeta channel to the cytotoxicity of exogenous Abeta...
  5. ncbi request reprint Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, USUHS, 4301 Jones Bridge Rd Bethesda, MD 20814, USA
    Biochim Biophys Acta 1768:1952-65. 2007
    ....
  6. ncbi request reprint Hsc70 and Hsp70 interact with phosphatidylserine on the surface of PC12 cells resulting in a decrease of viability
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    FASEB J 18:1636-45. 2004
    ..These findings may also explain the toxicity observed in cells overexpressing Hsp70s and provide a rational for the tight regulation of Hsp70 expression...
  7. ncbi request reprint Architecture of the Alzheimer's A beta P ion channel pore
    N Arispe
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services, University School of Medicine, USUHS, Bethesda, MD, 20814, USA
    J Membr Biol 197:33-48. 2004
    ..The results also provide additional evidence for the asymmetric insertion of the A beta P molecules into lipid membranes, and give support to the concept that rings of histidines line the entry to one side of the A beta P pore...
  8. pmc Lipid interaction differentiates the constitutive and stress-induced heat shock proteins Hsc70 and Hsp70
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Cell Stress Chaperones 7:330-8. 2002
    ..It is possible that the interaction of Hsp70s with lipids may play a role in the folding of membrane proteins and the translocation of polypeptides across membranes...
  9. ncbi request reprint Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides
    Nelson Arispe
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, USUHS, Bethesda, Maryland 20814, USA
    FASEB J 16:1526-36. 2002
    ..This idea is supported by our finding that the enhanced cytotoxicity generated by lowering the membrane cholesterol content can be reversed by AbetaP calcium channel blockers Zn2+ and tromethamine...
  10. ncbi request reprint Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer's disease Abeta ion channel and cytotoxicity
    Juan Carlos Diaz
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, Maryland 20814, USA
    Biol Res 39:447-60. 2006
    ..These data also emphasize the potential value in using inhibition of Abeta ion channel activity as an end point for Alzheimer's disease drug discovery...
  11. pmc Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity
    Juan Carlos Diaz
    Department of Anatomy, Physiology and Genetics, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 106:3348-53. 2009
    ..However, we find that inhibition by MRS2481 is easily reversible, whereas inhibition by MRS2485 is virtually irreversible. We suggest that both species deserve consideration as candidates for Alzheimer's disease drug discovery...
  12. pmc Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels
    Nelson Arispe
    Department of Anatomy, Physiology, and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 105:2610-5. 2008
    ..We propose that these digitoxin calcium channels may be part of the mechanism by which digitoxin and other active cardiac glycosides, such as digoxin, exert system-wide actions at and above the therapeutic concentration range...
  13. ncbi request reprint Aggregation of liposomes induced by the toxic peptides Alzheimer's Abetas, human amylin and prion (106-126): facilitation by membrane-bound GM1 ganglioside
    Boris Kurganov
    Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Peptides 25:217-32. 2004
    ....
  14. ncbi request reprint Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages
    Virginia L Vega
    Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 180:4299-307. 2008
    ..These observations suggest that Hsp70 translocates into the plasma membrane after stress and is released within membranous structures from intact cells, which could act as a danger signal to activate the immune system...
  15. ncbi request reprint Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B
    Catharina Gross
    University Hospital Regensburg, Department of Hematology, 93053 Regensburg, Germany
    J Biol Chem 278:41173-81. 2003
    ..Taken together we propose a novel perforin-independent, granzyme B-mediated apoptosis pathway for Hsp70 membrane-positive tumor cells...