Research Topics
| Hasan B AlamSummaryAffiliation: Uniformed Services University of the Health Sciences Country: USA Publications
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Detail Information
Publications
Hypertonic saline: intraosseous infusion causes myonecrosis in a dehydrated swine model of uncontrolled hemorrhagic shockHasan B Alam
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Trauma 52:18-25. 2002..5% hypertonic saline (HTS) for combat casualties in shock. We tested the safety and efficacy of this recommendation in a long-term survival model of uncontrolled hemorrhagic shock using dehydrated swine...- The rate of induction of hypothermic arrest determines the outcome in a Swine model of lethal hemorrhageHasan B Alam
Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Trauma 57:961-9. 2004..However, the optimal rate for the induction of hypothermic metabolic arrest following uncontrolled lethal hemorrhage (ULH) is unknown... - Profound hypothermia protects neurons and astrocytes, and preserves cognitive functions in a Swine model of lethal hemorrhageHasan B Alam
Trauma Research and Readiness Institute for Surgery, Bethesda, Maryland, USA
J Surg Res 126:172-81. 2005..Furthermore, our goal was to correlate the histological changes in the brain with neurological outcome, and the levels of circulating brain specific markers... - Application of a zeolite hemostatic agent achieves 100% survival in a lethal model of complex groin injury in SwineHasan B Alam
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
J Trauma 56:974-83. 2004..We tested ZH with increasing RM against controls and other hemostatic agents in a swine model of battlefield injury... - Effect of different resuscitation strategies on neutrophil activation in a swine model of hemorrhagic shockHasan B Alam
Department of Surgery, Uniformed Services University of the Health Sciences, USUHS, Room A 3021, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Resuscitation 60:91-9. 2004..These findings suggest that the type of resuscitation fluid and method of infusion can influence neutrophil function... - Combat casualty care research: from bench to the battlefieldHasan B Alam
Trauma Research and Readiness Institute for Surgery, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
World J Surg 29:S7-11. 2005..The impact of these basic science research findings on changes in military medical care and outcome of injured soldiers is also described... - Comparative analysis of hemostatic agents in a swine model of lethal groin injuryHasan B Alam
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Trauma 54:1077-82. 2003..A large-animal model of lethal, uncontrolled hemorrhage was developed to test whether the use of various hemostatic agents would decrease bleeding and improve early survival... - Hemorrhage control in the battlefield: role of new hemostatic agentsHasan B Alam
Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Mil Med 170:63-9. 2005..The purpose of this article is to summarize the background information regarding these hemostatic agents, indications and rationale for their use, and characteristics of these products that may impact effectiveness... - cDNA array analysis of gene expression following hemorrhagic shock and resuscitation in ratsHasan B Alam
Department of Surgery, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Resuscitation 54:195-206. 2002..The aim of this study was to characterize gene expression following hemorrhagic shock and resuscitation with emphasis on the differences between various resuscitation strategies... - Alterations in gene expression after induction of profound hypothermia for the treatment of lethal hemorrhageHasan B Alam
Division of Trauma, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
J Trauma 68:1084-98. 2010..However, the precise mechanisms have not been well defined. The aim of this high-throughput study was to investigate the impact of profound hypothermia on gene expression profiles... - Surviving lethal septic shock without fluid resuscitation in a rodent modelYongqing Li
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
Surgery 148:246-54. 2010..The purpose of the present study was to determine whether SAHA treatment would attenuate LPS-induced shock and improve survival when given postinsult in a rodent model... - Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humansElizabeth A Sailhamer
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Surgery 144:204-16. 2008..Correction of this imbalance with histone deacetylase inhibitors (HDACI) improves survival. We aimed to identify whether this was due to modulation of the post-shock immune response... - Impact of resuscitation strategies on the acetylation status of cardiac histones in a swine model of hemorrhageHasan B Alam
Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Resuscitation 76:299-310. 2008.... - Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liverTom Lin
Department of Surgery, Washington Hospital Center, Washington, DC, USA
Surgery 141:784-94. 2007.... - Surviving blood loss without blood transfusion in a swine poly-trauma modelHasan B Alam
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Surgery 146:325-33. 2009..This study investigated whether VPA treatment would improve survival in a clinically relevant large animal model of poly-trauma/hemorrhagic shock, and whether the protective effects are executed through the Akt survival pathway... - Cell protective mechanism of valproic acid in lethal hemorrhagic shockYongqing Li
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Surgery 144:217-24. 2008..This study investigated whether VPA treatment works through the beta-catenin survival pathways... - Induction of profound hypothermia modulates the immune/inflammatory response in a swine model of lethal hemorrhageZhang Chen
Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Resuscitation 66:209-16. 2005..05, MC versus NC). CONCLUSIONS:Profound hypothermia modulates the post-shock immune/inflammatory system by attenuating the pro-inflammatory IL-6, increasing anti-inflammatory IL-10 and augmenting the protective heat shock responses... - Hepatic and pulmonary apoptosis after hemorrhagic shock in swine can be reduced through modifications of conventional Ringer's solutionEduardo C Ayuste
Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
J Trauma 60:52-63. 2006..This effect can be prevented by simple elimination of D-lactate from the Ringer's solution... - Testing of modified zeolite hemostatic dressings in a large animal model of lethal groin injuryNaresh Ahuja
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
J Trauma 61:1312-20. 2006..CONCLUSIONS: The use of zeolite hemostat can control hemorrhage and dramatically reduce mortality from a lethal groin wound. Modifications of zeolite hemostat can decrease the exothermic reaction and attenuate tissue damage... - Hypoxic "second hit" in leukocytes from trauma patients: Modulation of the immune response by histone deacetylase inhibitionElizabeth A Sailhamer
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cytokine 49:303-11. 2010..The current experiments were designed to study the effects of HDACI after hemorrhage and severe hypoxia... - Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibitionYongqing Li
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
J Trauma 64:863-70; discussion 870-1. 2008..In the present study, neurons were subjected to severe hypoxic condition in vitro to test whether VPA would prevent hypoxia-induced apoptosis, and to explore the possible mechanisms... - Learning and memory is preserved after induced asanguineous hyperkalemic hypothermic arrest in a swine model of traumatic exsanguinationHasan B Alam
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Surgery 132:278-88. 2002.... - Treatment with histone deacetylase inhibitor attenuates MAP kinase mediated liver injury in a lethal model of septic shockRobert A Finkelstein
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
J Surg Res 163:146-54. 2010..The purpose of this study was to assess the effect of SAHA treatment on MAP kinases and associated inflammatory markers in murine liver after LPS-induced injury... - D-lactate increases pulmonary apoptosis by restricting phosphorylation of bad and eNOS in a rat model of hemorrhagic shockAmin Jaskille
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Trauma 57:262-69; discussion 269-70. 2004..These modified solutions however alter the function of apoptotic proteins through an unknown mechanism. We postulated that DL-LR induces apoptosis by restricting the phosphorylation of key apoptotic proteins... - Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodentsYongqing Li
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Shock 32:517-23. 2009..We report for the first time that administration of SAHA (50 mg/kg) significantly attenuates a variety of inflammatory markers and improves long-term survival after a lethal LPS insult... - Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shockMuhammad U Butt
Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
J Surg Res 156:290-6. 2009..This study investigated whether VPA treatment works through the c-Jun N-terminal kinase (JNK)/Caspase-3 survival pathways... - Pharmacologic resuscitation decreases circulating cytokine-induced neutrophil chemoattractant-1 levels and attenuates hemorrhage-induced acute lung injuryEugene Y Fukudome
Department of Surgery, Division of Trauma, Emergency Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
Surgery 152:254-61. 2012..Herein, we have investigated the effects of HS and VPA treatment on ALI and circulating cytokines that may serve as biomarkers for the development of organ injury... - Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatmentYongqing Li
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Surg Res 159:474-81. 2010..Treatment with valproic acid (VPA) has been shown to up-regulate various survival pathways and improve outcome. Here we determine whether these changes would result in altered serum biomarkers... - Surviving blood loss without fluid resuscitationChristian Shults
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
J Trauma 64:629-38; discussion 638-40. 2008..The current experiment was done to test whether administration of HDACI after lethal hemorrhage, without fluid resuscitation, would improve outcome by creating a pro-survival phenotype... 
Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shockYongqing Li
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
Surgery 150:442-51. 2011..The present study was designed to confirm these findings and to test whether the pro-survival phenotype could be detected by an early alteration in serum biomarkers...- Identification of expression patterns associated with hemorrhage and resuscitation: integrated approach to data analysisHuazhen Chen
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
J Trauma 60:701-23; discussion 723-4. 2006..Gene expression in various organs is affected differentially by HS, which can be further modulated by the choice of resuscitation strategy... - Differential effect of resuscitation on Toll-like receptors in a model of hemorrhagic shock without a septic challengeHuazhen Chen
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
Resuscitation 74:526-37. 2007..This study was conducted to measure the impact of different resuscitation strategies on TLR expression and downstream signaling in key organs... - Does the rate of rewarming from profound hypothermic arrest influence the outcome in a swine model of lethal hemorrhage?Hasan B Alam
Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
J Trauma 60:134-46. 2006..The optimal rate for re-warming from a state of profound hypothermia is unknown. This experiment was designed to test the impact of different warming rates on outcome in a swine model of lethal hemorrhage from complex vascular injuries... - Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusionKyuseok Kim
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA Department of Emergency Medicine, Seoul National University Bungdang Hospital, Seoul, Republic of Korea
Resuscitation 83:243-8. 2012..The purpose of this study was to investigate whether VPA could affect survival and development of ALI in a rat model of intestinal I/R... - Effects of lactated Ringer's solutions on human leukocytesElena Koustova
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Trauma 52:872-8. 2002..The aim of this study was to investigate whether racemic LR solution (containing both isomers, dl-LR) differs from LR containing L-isomer only (L-LR)... - Profound hypothermia is superior to ultraprofound hypothermia in improving survival in a swine model of lethal injuriesHasan B Alam
Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, USA
Surgery 140:307-14. 2006..The depth of hypothermia influences survival, with a better outcome associated with a core temperature of 10 degrees C compared with 5 degrees C... - Histone Deacetylase Inhibitor Treatment Attenuates MAP Kinase Pathway Activation and Pulmonary Inflammation Following Hemorrhagic Shock in a Rodent ModelAshley R Kochanek
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts
J Surg Res 176:185-94. 2012..The aim of the current study was to examine whether these protective effects were due to attenuation of mitogen activated protein kinase (MAPK) signaling pathways, which are known to promote inflammation and apoptosis... - Development and testing of low-volume hyperoncotic, hyperosmotic spray-dried plasma for the treatment of trauma-associated coagulopathyFahad Shuja
Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
J Trauma 70:664-71. 2011..To enhance the logistical advantage (lower volume and weight), we developed and tested a hyperoncotic, hyperosmotic spray-dried plasma (SDP) product in a multiple injuries/hemorrhagic shock swine model... - Hepatic apoptosis after hemorrhagic shock in rats can be reduced through modifications of conventional Ringer's solutionAmin Jaskille
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
J Am Coll Surg 202:25-35. 2006..Apoptosis is reduced even more when lactate is substituted with beta-hydroxybutyrate or pyruvate. The beneficial effects are not through improvements in the energy status or activation of the PI3K/Akt pathway... - Creating a "pro-survival" phenotype through epigenetic modulationYongqing Li
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Surgery 152:455-64. 2012..The precise mechanisms, however, have not been well-defined. The aim of this study was to investigate the impact of SAHA treatment on gene expression profiles at an early stage of shock... - Traumatic brain injury and hemorrhagic shock: evaluation of different resuscitation strategies in a large animal model of combined insultsGuang Jin
Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Shock 38:49-56. 2012..Early administration of FFP reduces the size of brain lesion and associated swelling in a large animal model of TBI + HS. In contrast, artificial colloid (Hex) decreases swelling without reducing the actual size of the brain lesion... - Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-regulated kinase 1/2Eugene Y Fukudome
Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
J Surg Res 163:118-26. 2010..Here we have investigated the effects of VPA treatment on extracellular signal-regulated kinase 1/2 (ERK) activation, as ERK is well known to modulate cell death, gene expression, and inflammation... - Ketone and pyruvate Ringer's solutions decrease pulmonary apoptosis in a rat model of severe hemorrhagic shock and resuscitationElena Koustova
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Surgery 134:267-74. 2003..Therefore, metabolic modulation is unlikely to be the major mechanism by which BHB exerts its protective effects during reperfusion... - Histone deacetylase inhibitors prevent apoptosis following lethal hemorrhagic shock in rodent kidney cellsNikolaos Zacharias
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Resuscitation 82:105-9. 2011..These agents are known to acetylate insulin receptor substrate-I (IRS-I), which in turn activates the Akt survival pathway. This study investigated whether HDACI exert their beneficial effects through the Akt survival pathway... - Human polymorphonuclear cell death after exposure to resuscitation fluids in vitro: apoptosis versus necrosisKathleen Stanton
Department of Surgery, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814, USA
J Trauma 54:1065-74; discussion 1075-6. 2003..CONCLUSION: Hypertonic fluids and dextran decrease human polymorphonuclear cell survival through necrotic and apoptotic pathways, respectively... - Abdominal insufflation for control of bleeding after severe splenic injuryGeorge C Velmahos
Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Surgery, The Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Trauma 63:285-8; discussion 288-90. 2007..This model represents a clinically relevant scenario of continuous bleeding, which does not kill the patient immediately but may ultimately result in death if not managed early... - Valproic acid prevents hemorrhage-associated lethality and affects the acetylation pattern of cardiac histonesEarl Gonzales
Department of Surgery, Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Shock 25:395-401. 2006..Our results reveal that VPA offers considerable protection in the hemorrhagic shock model and suggest a role for HDAC inhibition in mediating VPA actions... - Cardiac histones are substrates of histone deacetylase activity in hemorrhagic shock and resuscitationTom Lin
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
Surgery 139:365-76. 2006..Shock-induced changes can be reversed through the infusion of pharmacologic HDAC inhibitor, even when it is administered after the insult for a limited period of time... - Differential expression of extracellular matrix remodeling genes in rat model of hemorrhagic shock and resuscitationHuazhen Chen
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Surg Res 123:235-44. 2005..CONCLUSION: Expression of MMP and TIMP in lung and spleen following hemorrhage is modulated by the resuscitation strategy... - Development and testing of portable pump for the induction of profound hypothermia in a Swine model of lethal vascular injuriesHasan B Alam
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
J Trauma 61:1321-9. 2006..In this experiment, a portable prototype pump was tested and its performance was compared with the regular roller pump in a swine model of lethal vascular injuries... - Administration of recombinant interleukin-11 improves the hemodynamic functions and decreases third space fluid loss in a porcine model of hemorrhagic shock and resuscitationKaneatsu Honma
Department of Medicine, Uniformed Services University of the Health Sciences, F. Edward Hebert School of Medicine, Bethesda, Maryland 20814-4799, USA
Shock 23:539-42. 2005..This strategy also significantly reduced the extent of third space fluid losses while also having a favorable impact on the intravascular volume status as evidenced by the improved urine output... - New developments in fluid resuscitationHasan B Alam
Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, WHT 1, Boston, MA 02114, USA
Surg Clin North Am 87:55-72, vi. 2007..This article summarizes a number of studies that have evaluated the cellular toxicities of commonly used resuscitation fluids, to highlight the need for the development of new fluids... - Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic studyWei Chong
Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital, 165 Cambridge St, Boston, MA 02114, USA
J Trauma Acute Care Surg 72:347-53; discussion 353-4. 2012.... - Energy substrate-supplemented resuscitation affects brain monocarboxylate transporter levels and gliosis in a rat model of hemorrhagic shockTom Lin
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
J Trauma 59:1191-202; discussion 1202. 2005..Enhanced MC trafficking could be an essential route for energy supply to neurons under adverse circulatory conditions... - Searching for the optimal resuscitation method: recommendations for the initial fluid resuscitation of combat casualtiesPeter Rhee
Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Trauma 54:S52-62. 2003..Finally, because of the uniqueness of combat care, a set of new recommendations for initial fluid resuscitation of combat casualties is proposed... - A portable handpump is effective in the evacuation of hemothorax in a swine model of penetrating chest injuryAmin Jaskille
Department of Surgery, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
J Trauma 55:864-8. 2003..The use of an endotracheal instead of a conventional pleural tube had no adverse impact on efficacy of the pump in evacuating blood from the chest cavity... - cDNA profiling in leukocytes exposed to hypertonic resuscitation fluidsVadim Gushchin
Department of Surgery, Washington Hospital Center, Washington, DC, USA
J Am Coll Surg 197:426-32. 2003..CONCLUSIONS: Hypertonic resuscitation fluids diminish the expression of immune activation-associated genes. Hypertonic component of HTD determines the leukocyte gene expression profile... - Fluid resuscitation: past, present, and the futureHeena P Santry
Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Shock 33:229-41. 2010..Thus, we describe how some novel resuscitation strategies aimed at preventing or ameliorating cellular injury may become clinically available in the future... - Fulminant Clostridium difficile colitis: patterns of care and predictors of mortalityElizabeth A Sailhamer
Department of Surgery, Division of Trauma, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Arch Surg 144:433-9; discussion 439-40. 2009..There exist predictors of mortality and the need for colectomy among patients with fulminant Clostridium difficile colitis... - Cytokine expression profiling in human leukocytes after exposure to hypertonic and isotonic fluidsVadim Gushchin
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
J Trauma 52:867-71. 2002..CONCLUSION: Exposure of human leukocytes to resuscitation fluids causes an increase in cytokine gene expressions compared with undiluted blood. This expression profile is largely independent of the type of fluid used... - Making sense of the preclinical literature on advanced hemostatic productsAnthony E Pusateri
US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, and the Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
J Trauma 60:674-82. 2006..Mission and training requirements will dictate the use of these products by military and civilian prehospital care providers... - Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shockYongqing Li
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, 165 Cambridge Street, Suite 810, Boston, MA 02114, USA
J Biomed Biotechnol 2011:523481. 2011..This paper highlights the emerging roles of HDACIs as acetylation modulators in models of hemorrhagic and septic shock and explains some contradictions encountered in previous studies... - Hypothermia in bleeding trauma: a friend or a foe?Tareq Kheirbek
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
Scand J Trauma Resusc Emerg Med 17:65. 2009..While many of the advantageous molecular and physiological effects of induced hypothermia have been outlined in animal models, rigorous clinical investigations are needed to translate these promising findings into clinical practice... - Hypothermia in multisystem traumaEugene Y Fukudome
Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Crit Care Med 37:S265-72. 2009..Hypothermia may be an effective therapeutic approach for otherwise lethal traumatic hemorrhage, and a clinical trial to determine its utility is warranted... - Is upper extremity deep venous thrombosis underdiagnosed in trauma patients?Konstantinos Spaniolas
Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am Surg 74:124-8. 2008..UEDVT is an uncommon event with unclear significance in trauma. Aggressive screening did not result in a higher rate of UEDVT diagnosis, nor an opportunity to prevent PE... - Creating a Pro-survival and Anti-inflammatory Phenotype by Modulation of Acetylation in Models of Hemorrhagic and Septic ShockYongqing Li
Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
Adv Exp Med Biol 710:107-33. 2012.... - Diazoxide increases liver and kidney HSP25 and HSP70 after shock and strokeJoseph C O'Sullivan
Graduate Program in Neuroscience, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
J Surg Res 149:120-30. 2008..Our team tested the hypothesis that pharmacological induction of ischemic preconditioning with DZ can offer cytoprotection and preserve vital tissues after hemorrhagic shock and stroke... - Alterations of cullin-5 mRNA levels in the rat central nervous system following hemorrhagic shockThomas E Ceremuga
Graduate Program in Neuroscience, Department of Surgery, F Edmund Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Neurol Res 25:211-6. 2003..This is the first report of cul-5 mRNA regulation by hemorrhagic shock. Evidence indicates this protein may have a regulatory role in ubiquitin-proteasomal protein degradation in response to hemorrhagic shock... - Long-term outcome of acellular dermal matrix when used for large traumatic open abdomenMarc A de Moya
Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
J Trauma 65:349-53. 2008..Previous studies have not examined the long-term outcomes in trauma patients with abdominal wall reconstructions... - Abdominal insufflation decreases blood loss without worsening the inflammatory response: implications for prehospital control of internal bleedingGeorge C Velmahos
Division of Trauma, Emergency Surgery, and Surgical Critical Care, The Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Am Surg 74:297-301. 2008..Our conclusion is that AI reduces blood loss from splenic injury without a measurable effect on the early inflammatory response in a clinically relevant animal model... - Host-guest composites for induced hemostasis and therapeutic healing in traumatic injuriesTodd A Ostomel
Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, 93106, USA
J Thromb Thrombolysis 22:55-67. 2006..A method for incorporating antibacterial activity against gram negative P. aeruginosa into the Ag-exchanged formulation of zeolite LTA-5A has been described and substantiated... - Putting life on hold-for how long? Profound hypothermic cardiopulmonary bypass in a Swine model of complex vascular injuriesHasan B Alam
Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Trauma 64:912-22. 2008..5 degrees C/min) for best results. However, the maximum duration of hypothermic arrest in a clinically relevant trauma model remains unknown... - Profound hypothermic cardiopulmonary bypass facilitates survival without a high complication rate in a swine model of complex vascular, splenic, and colon injuriesElizabeth A Sailhamer
Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
J Am Coll Surg 204:642-53. 2007.... - Dose-dependent effects of recombinant human interleukin-11 on the systemic hemodynamic function and urinationKaneatsu Honma
Division of Operative Management, Koga Hospital 21, Kurume, Japan
Kurume Med J 54:73-6. 2007..05). In conclusion, even a low dose of rhIL-11 improved the hemodynamic functions dose-dependently in a porcine model of hemorrhagic shock, although the relationship did not demonstrate a simple linearity... - Bedside placement of removable vena cava filters guided by intravascular ultrasound in the critically injuredKonstantinos Spaniolas
Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 810, Boston, MA 02114, USA
World J Surg 32:1438-43. 2008..Intravascular ultrasound (IVUS) eliminates such problems. The objective of the present study was to analyze the safety and feasibility of IVUS-guided bedside RVCF placement in critically injured patients... - Just do itHasan B Alam
Crit Care Med 36:2456-7. 2008 - Routine repeat head CT for minimal head injury is unnecessaryGeorge C Velmahos
Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Neurosurgery, and Biostatistics Center (DJD, Massachusetts General Hospital, Harvard School of Medicine, Boston, MA 02114, USA
J Trauma 60:494-9; discussion 499-501. 2006..CONCLUSIONS: RRHCT is unnecessary in patients with MHI. Clinical examination identifies accurately the few who will show significant evolution and require intervention...