Genomes and Genes
Affiliation: Tularik Inc
- Transcriptional repressor of vasoactive intestinal peptide receptor mediates repression through interactions with TFIIB and TFIIEbetaL Pei
Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, 8700 Beverly Boulevard, Los Angeles, CA 90048, U S A
Biochem J 360:633-8. 2001..My results indicate that VIPR-RP mediates transcriptional repression through direct interactions with the general transcription machinery...
- Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel functionLin Pei
Tularik Inc, 1120 Veterans Boulevard, South San Francisco, CA 94080, USA
Proc Natl Acad Sci U S A 100:7803-7. 2003..These results establish a direct link between the potassium channel activity of TASK3 and its oncogenic functions and imply that blockers for this potassium channel may have therapeutic potential for the treatment of cancers...
- Genomic amplification and oncogenic properties of the KCNK9 potassium channel geneDavid Mu
Tularik Inc, Genomics Division, 266 E Pulaski Road, Greenlawn, NY 11740, USA
Cancer Cell 3:297-302. 2003....
- PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancerLin Pei
Tularik Inc, South San Francisco, California 94080, USA
Cancer Res 62:5420-4. 2002..The potent oncogenic activity of PRC17 is likely to influence the tumorigenic phenotype of these prostate cancers...
- G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclaseNatalie Lavine
Centre for Addiction and Mental Health, Department of Pharmacology, Institute of Medical Science, University of Toronto, Ontario M5T 1R8, Canada
J Biol Chem 277:46010-9. 2002..The observation that several G protein-coupled receptors form stable complexes with their effectors suggests that this arrangement might be a general feature of G protein-coupled signal transduction...
- Control of synaptic strength, a novel function of AktQinghua Wang
Programme in Brain and Behaviour Research, Research Institute of the Hospital for Sick Children, University of Toronto, 555 University Avenue, M5G 1X8, Toronto, Ontario, Canada
Neuron 38:915-28. 2003..This work also provides evidence for the rapid regulation of neurotransmitter receptor numbers in the postsynaptic domain by direct receptor phosphorylation as an important means of producing synaptic plasticity...
- Regulation of dopamine D1 receptor function by physical interaction with the NMDA receptorsLin Pei
Department of Neuroscience, Centre for Addiction and Mental Health, Clarke Division, Toronto, Ontario, M5T 1R8 Canada
J Neurosci 24:1149-58. 2004....