David Mu

Summary

Affiliation: Tularik Inc
Country: USA

Publications

  1. pmc Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model
    Jiangyong Miao
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA
    Int J Cancer 123:2041-7. 2008
  2. ncbi Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene
    David Mu
    Tularik Inc, Genomics Division, 266 E Pulaski Road, Greenlawn, NY 11740, USA
    Cancer Cell 3:297-302. 2003
  3. pmc Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function
    Lin Pei
    Tularik Inc, 1120 Veterans Boulevard, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 100:7803-7. 2003
  4. ncbi The gene encoding the splicing factor SF2/ASF is a proto-oncogene
    Rotem Karni
    Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA
    Nat Struct Mol Biol 14:185-93. 2007
  5. ncbi A microRNA polycistron as a potential human oncogene
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 435:828-33. 2005
  6. pmc Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    Lars Zender
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 125:1253-67. 2006
  7. pmc Identification of alterations in DNA copy number in host stromal cells during tumor progression
    Robert J Pelham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 103:19848-53. 2006
  8. pmc Role of the chromobox protein CBX7 in lymphomagenesis
    Clare L Scott
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 104:5389-94. 2007
  9. pmc Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer
    Jude Kendall
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 104:16663-8. 2007

Collaborators

Detail Information

Publications9

  1. pmc Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model
    Jiangyong Miao
    Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA
    Int J Cancer 123:2041-7. 2008
    ..The ability of ectopic hepsin to induce tumor growth in mice is abrogated by the mutation of 3 critical residues in the catalytic domain, thus implicating the enzymatic activity of hepsin in promoting tumor progression...
  2. ncbi Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene
    David Mu
    Tularik Inc, Genomics Division, 266 E Pulaski Road, Greenlawn, NY 11740, USA
    Cancer Cell 3:297-302. 2003
    ....
  3. pmc Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function
    Lin Pei
    Tularik Inc, 1120 Veterans Boulevard, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 100:7803-7. 2003
    ..These results establish a direct link between the potassium channel activity of TASK3 and its oncogenic functions and imply that blockers for this potassium channel may have therapeutic potential for the treatment of cancers...
  4. ncbi The gene encoding the splicing factor SF2/ASF is a proto-oncogene
    Rotem Karni
    Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA
    Nat Struct Mol Biol 14:185-93. 2007
    ..Knockdown of either SF2/ASF or isoform-2 of S6K1 is sufficient to reverse transformation caused by the overexpression of SF2/ASF in vitro and in vivo. Thus, SF2/ASF can act as an oncoprotein and is a potential target for cancer therapy...
  5. ncbi A microRNA polycistron as a potential human oncogene
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 435:828-33. 2005
    ..Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene...
  6. pmc Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    Lars Zender
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 125:1253-67. 2006
    ..Our results establish a tractable model of liver cancer, identify two oncogenes that cooperate by virtue of their coamplification in the same genomic locus, and suggest an efficient strategy for the annotation of human cancer genes...
  7. pmc Identification of alterations in DNA copy number in host stromal cells during tumor progression
    Robert J Pelham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 103:19848-53. 2006
    ..We show that numerous amplifications and deletions are found within the host stromal microenvironment, suggesting that alterations in host DNA copy number can occur and may play a significant role in modifying tumor-stromal interactions...
  8. pmc Role of the chromobox protein CBX7 in lymphomagenesis
    Clare L Scott
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 104:5389-94. 2007
    ..These data identify CBX7 as a chromobox protein causally linked to cancer development and may help explain the low frequency of INK4a/ARF mutations observed in human follicular lymphoma...
  9. pmc Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer
    Jude Kendall
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 104:16663-8. 2007
    ....