D V Goeddel

Summary

Affiliation: Tularik Inc
Country: USA

Publications

  1. ncbi request reprint TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Immunity 4:387-96. 1996
  2. ncbi request reprint TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90
    Guoqing Chen
    Tularik, Incorporated, Two Corporate Drive, South San Francisco, CA 94080, USA
    Mol Cell 9:401-10. 2002
  3. ncbi request reprint TNF-R1 signaling: a beautiful pathway
    Guoqing Chen
    Tularik Inc, Two Corporate Drive, South San Francisco, CA 94080, USA
    Science 296:1634-5. 2002
  4. pmc T6BP, a TRAF6-interacting protein involved in IL-1 signaling
    L Ling
    Tularik Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 97:9567-72. 2000
  5. ncbi request reprint Casper is a FADD- and caspase-related inducer of apoptosis
    H B Shu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Immunity 6:751-63. 1997
  6. pmc The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
    H B Shu
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:13973-8. 1996
  7. pmc I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction
    M Rothe
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:8241-6. 1996
  8. ncbi request reprint TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 84:299-308. 1996
  9. pmc Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
    H Y Song
    Tularik, Two Corporate Drive, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 94:9792-6. 1997
  10. ncbi request reprint IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
    J D Woronicz
    Tularik, Two Corporate Drive, South San Francisco, CA 94080, USA
    Science 278:866-9. 1997

Collaborators

Detail Information

Publications29

  1. ncbi request reprint TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Immunity 4:387-96. 1996
    ..These results suggest that distinct domains of RIP participate in the TNF signaling cascades leading to apoptosis and NF-kappa B activation...
  2. ncbi request reprint TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90
    Guoqing Chen
    Tularik, Incorporated, Two Corporate Drive, South San Francisco, CA 94080, USA
    Mol Cell 9:401-10. 2002
    ..Therefore, heterocomplex formation with Cdc37/Hsp90 is a prerequisite for TNF-induced activation and trafficking of IKK from the cytoplasm to the membrane...
  3. ncbi request reprint TNF-R1 signaling: a beautiful pathway
    Guoqing Chen
    Tularik Inc, Two Corporate Drive, South San Francisco, CA 94080, USA
    Science 296:1634-5. 2002
    ..We provide an overview of current knowledge of TNF signaling and introduce an STKE Connections Map that depicts a canonical view of this process...
  4. pmc T6BP, a TRAF6-interacting protein involved in IL-1 signaling
    L Ling
    Tularik Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 97:9567-72. 2000
    ..T6BP does not seem to play a direct role in activation of IkappaB kinases or Jun N-terminal kinase...
  5. ncbi request reprint Casper is a FADD- and caspase-related inducer of apoptosis
    H B Shu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Immunity 6:751-63. 1997
    ..When overexpressed in mammalian cells, Casper potently induces apoptosis. A C-terminal deletion mutant of Casper inhibits TNF- and Fas-induced cell death, suggesting that Casper is involved in these apoptotic pathways...
  6. pmc The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
    H B Shu
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:13973-8. 1996
    ..These data establish the physiological involvement of TRAF2 and c-IAP1 in TNF-R1 signaling and help provide a molecular explanation for both the overlapping and distinct signals generated by the two TNF receptors...
  7. pmc I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction
    M Rothe
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:8241-6. 1996
    ..Overexpression of I-TRAF inhibits TRAF2-mediated NF-kappa B activation signaled by CD40 and both TNF receptors. Thus, I-TRAF appears as a natural regulator of TRAF function that may act by maintaining TRAFs in a latent state...
  8. ncbi request reprint TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 84:299-308. 1996
    ..Thus, these two TNFR1-TRADD signaling cascades appear to bifurcate at TRADD...
  9. pmc Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
    H Y Song
    Tularik, Two Corporate Drive, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 94:9792-6. 1997
    ..Thus, TRAF2 is the bifurcation point of two kinase cascades leading to activation of NF-kappaB and JNK, respectively...
  10. ncbi request reprint IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK
    J D Woronicz
    Tularik, Two Corporate Drive, South San Francisco, CA 94080, USA
    Science 278:866-9. 1997
    ..Overexpression of a catalytically inactive form of IKK-beta blocked cytokine-induced NF-kappaB activation. Thus, an active IkappaB kinase complex may require three distinct protein kinases...
  11. ncbi request reprint Prevention of constitutive TNF receptor 1 signaling by silencer of death domains
    Y Jiang
    Tularik, Two Corporate Drive, South San Francisco, CA 94080, USA
    Science 283:543-6. 1999
    ..Thus, SODD association may be representative of a general mechanism for preventing spontaneous signaling by death domain-containing receptors...
  12. ncbi request reprint Sequence, genomic organization, and chromosome localization of the mouse TRADD gene
    M G Pan
    Department of Molecular Biology, Tularik, Inc, South San Francisco, CA 94080, USA
    J Inflamm 46:168-75. 1995
    ..The mTRADD gene contains four exons, with the fourth exon encoding all of the death domain. The mouse TRADD gene was localized to the distal region of chromosome 8...
  13. ncbi request reprint MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network
    L Ling
    Tularik Inc, South San Francisco, California 94080, USA
    J Biol Chem 275:23852-60. 2000
    ..MIP-T3 complex and recruited to the CD40 receptor upon CD40 ligand stimulation. MIP-T3 may provide a novel mechanism in sequestering TRAF3 to the cytoskeletal network...
  14. pmc NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
    L Ling
    Tularik, Inc, Two Corporate Drive, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 95:3792-7. 1998
    ..Conversely, a mutant form of IKK-alpha containing glutamic acid at residue 176 is constitutively active. Thus, the phosphorylation of IKK-alpha on Ser-176 by NIK may be required for cytokine-mediated NF-kappaB activation...
  15. pmc The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
    H Y Song
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:6721-5. 1996
    ..Our findings suggest a possible molecular mechanism that could explain A20's ability to negatively regulate its own TNF-inducible expression...
  16. ncbi request reprint The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
    M Rothe
    Department of Molecular Biology Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 83:1243-52. 1995
    ..The recruitment of c-IAP1 or c-IAP2 to the TNFR2 signaling complex requires a TRAF2-TRAF1 heterocomplex...
  17. ncbi request reprint Identification and characterization of an IkappaB kinase
    C H Regnier
    Tularik, Inc, South San Francisco, California 94080, USA
    Cell 90:373-83. 1997
    ..This phosphorylation of IkappaB-alpha is greatly enhanced by NIK costimulation. Thus, CHUK is a NIK-activated IkappaB-alpha kinase that links TNF- and IL-1-induced kinase cascades to NF-kappaB activation...
  18. ncbi request reprint Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice
    M Tanaka
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Immunity 10:421-9. 1999
    ..These results indicate that IKK-beta is crucial for liver development and regulation of NF-kappaB activity and that IKK-alpha can only partially compensate for the loss of IKK-beta...
  19. ncbi request reprint TRAF6 is a signal transducer for interleukin-1
    Z Cao
    Tularik Inc, South San Francisco, California 94080, USA
    Nature 383:443-6. 1996
    ..These findings indicate that TRAF proteins may function as signal transducers for distinct receptor families and that TRAF6 participates in IL-1 signalling...
  20. ncbi request reprint The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    H Hsu
    Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 81:495-504. 1995
    ..However, NF-kappa B activation by TRADD is not inhibited by crmA expression, demonstrating that the signaling pathways for TNF-induced cell death and NF-kappa B activation are distinct...
  21. pmc Human atrial natriuretic peptide receptor defines a new paradigm for second messenger signal transduction
    D G Lowe
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    EMBO J 8:1377-84. 1989
    ..These data demonstrate a new paradigm of cellular signal transduction where extracellular ligand binding allosterically regulates cyclic nucleotide second-messenger production by a receptor cytoplasmic catalytic domain...
  22. pmc Primary structure and mRNA localization of protein F1, a growth-related protein kinase C substrate associated with synaptic plasticity
    A Rosenthal
    Genentech, Inc, Department of Molecular Biology, South San Francisco, CA 94080
    EMBO J 6:3641-6. 1987
    ..In cerebellum, granule cells contained protein F1 mRNA, while Purkinje cells did not. Co-localization of protein F1 with protein kinase C-II [PKC-II (beta)], rather than PKC-I (gamma) suggests that PKC-II may phosphorylate protein F1...
  23. ncbi request reprint Genomic cloning and heterologous expression of human differentiation-stimulating factor
    D G Lowe
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    DNA 8:351-9. 1989
    ....
  24. ncbi request reprint TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
    M Rothe
    Molecular Biology Department, Tularik, Inc, South San Francisco, CA 94080, USA
    Science 269:1424-7. 1995
    ..A truncated derivative of TRAF2 lacking an amino-terminal RING finger domain was a dominant-negative inhibitor of NF-kappa B activation mediated by TNF-R2 and CD40. Thus, TRAF2 is a common mediator of TNF-R2 and CD40 signaling...
  25. ncbi request reprint Vascular endothelial growth factor is a secreted angiogenic mitogen
    D W Leung
    Department of Molecular Biology, Genetech, South San Francisco, CA 94080
    Science 246:1306-9. 1989
    ..Human 293 cells transfected with an expression vector containing a bovine or human VEGF cDNA insert secrete an endothelial cell mitogen that behaves like native VEGF...
  26. pmc Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific
    M Lewis
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 88:2830-4. 1991
    ..This result suggests that the various activities of human tumor necrosis factor alpha reported in mice or in murine cell lines are probably mediated by mTNF-R1...
  27. pmc cDNA sequence of the human atrial natriuretic peptide clearance receptor
    D G Lowe
    Department of Molecular Biology, Genentech Inc, South San Francisco, CA 94080
    Nucleic Acids Res 18:3412. 1990
  28. pmc The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis
    Deborah Veis Novack
    Washington University School of Medicine, 660 S Euclid Ave, Box 8301, St Louis, MO 63110, USA
    J Exp Med 198:771-81. 2003
    ..These data demonstrate a novel, biologically relevant means of regulating NF-kappaB signaling, with upstream control and kinetics distinct from the classical IkappaBalpha pathway...
  29. pmc Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo
    Dietrich B Conze
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 3002, Bethesda, MD 20892, USA
    Mol Cell Biol 25:3348-56. 2005
    ..Thus, the c-IAPs represent a pair of TNFR-associated ubiquitin protein ligases in which one regulates the expression of the other by a posttranscriptional and E3-dependent mechanism...