W Zou

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells
    W Zou
    Tulane Medical School, Section of Hematology and Medical Oncology, New Orleans, Louisiana, USA
    Nat Med 7:1339-46. 2001
  2. ncbi request reprint Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection
    W Zou
    Tulane Medical School, New Orleans, LA 70112, USA
    Eur J Immunol 31:3833-9. 2001
  3. ncbi request reprint Immunosuppressive networks in the tumour environment and their therapeutic relevance
    Weiping Zou
    Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue, New Orleans, Louisiana 70112 2699, USA
    Nat Rev Cancer 5:263-74. 2005
  4. ncbi request reprint Interferons alpha, beta, gamma each inhibit hepatitis C virus replication at the level of internal ribosome entry site-mediated translation
    Srikanta Dash
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Liver Int 25:580-94. 2005
  5. ncbi request reprint Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana, USA
    Nat Med 9:562-7. 2003
  6. ncbi request reprint Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines
    Jens Ruter
    Department of Medicine, Hematology and Medical Oncology, Tulane University School of Medicine, 1430 Tulane Avenue SL 78, New Orleans, LA 70112, USA
    Front Biosci (Landmark Ed) 14:1761-70. 2009
  7. ncbi request reprint Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004
  8. ncbi request reprint Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Cancer Res 64:5535-8. 2004
  9. ncbi request reprint Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma
    Shuang Wei
    Tulane University Health Science Center, New Orleans, Louisiana 70112 2699, USA
    Cancer Res 65:5020-6. 2005
  10. ncbi request reprint Regulatory T cells in ovarian cancer: biology and therapeutic potential
    Brian Barnett
    Department of Medicine Hematology and Medical Oncology, Tulane Medical School, New Orleans, LA 70112, USA
    Am J Reprod Immunol 54:369-77. 2005

Collaborators

  • George Coukos
  • Tyler Curiel
  • Lieping Chen
  • Keith Knutson
  • D Emilie
  • R Krzysiek
  • D T Curiel
  • Ramesh Prabhu
  • Disis L Mary
  • Haidong Dong
  • Peter Carmeliet
  • A E Chang
  • Jens Ruter
  • Evan Keller
  • Ilona Kryczek
  • Shuang Wei
  • Linhua Zou
  • Pui Cheng
  • Peter Mottram
  • Wojciech Szeliga
  • Gefeng Zhu
  • Brian G Barnett
  • Rebecca Liu
  • Haifa Hamdi
  • Leann Myers
  • Brian Barnett
  • Srikanta Dash
  • Christiane Stahl-Hennig
  • Nobuhiro Takeshita
  • Andrew B Shreiner
  • Pui Joan Cheng
  • Benjamin J Daniel
  • Michael J Brumlik
  • Robert P Edwards
  • François M Lemoine
  • Bruce Redman
  • Marie Christine Maillot
  • Mousumi Banerjee
  • Jay Kolls
  • June Escara-Wilke
  • Maria Victoria Prejean
  • Ronald B Herberman
  • Nicolas Cohen
  • Marilyn Cost
  • Veronique Godot
  • Linhua Vatan
  • Saleh Altuwaijri
  • Huanbin Xu
  • Paulo Rodriguez
  • Andrew Lackner
  • Xavier Alvarez
  • Augusto Ochoa
  • Michael Brumlik
  • Salima Haque
  • Sidhartha Hazari
  • Robert Garry
  • Fredric G Regenstein
  • Swan N Thung
  • Virendra Joshi
  • Frank Bastian
  • Andrzej Lange
  • Ben Daniel
  • Jonathan Heeney
  • Klaus Uberla
  • Björn R Gundlach
  • Sieghart Sopper
  • Peter ten Haaft
  • Ulf Dittmer
  • Jay Radke
  • Jozef Borvak
  • Jacqueline Channon
  • Florentina Marches
  • Michael White
  • Marie France Cesbron-Delauw

Detail Information

Publications25

  1. ncbi request reprint Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells
    W Zou
    Tulane Medical School, Section of Hematology and Medical Oncology, New Orleans, Louisiana, USA
    Nat Med 7:1339-46. 2001
    ..Myeloid precursor DCs (preDC1s) were not detected. Tumors may weaken immunity by attracting preDC2s and protecting them from the harsh microenvironment, and by altering preDC1 distribution...
  2. ncbi request reprint Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection
    W Zou
    Tulane Medical School, New Orleans, LA 70112, USA
    Eur J Immunol 31:3833-9. 2001
    ..Such reciprocal regulation of potentially opposing influences may help modulate anti-pathogen immunity...
  3. ncbi request reprint Immunosuppressive networks in the tumour environment and their therapeutic relevance
    Weiping Zou
    Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue, New Orleans, Louisiana 70112 2699, USA
    Nat Rev Cancer 5:263-74. 2005
    ..Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity...
  4. ncbi request reprint Interferons alpha, beta, gamma each inhibit hepatitis C virus replication at the level of internal ribosome entry site-mediated translation
    Srikanta Dash
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Liver Int 25:580-94. 2005
    ..Results of this in vitro study suggest that selective inhibition of IRES-mediated translation of viral polyprotein is a general mechanism by which IFNs inhibits HCV replication...
  5. ncbi request reprint Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana, USA
    Nat Med 9:562-7. 2003
    ..Therefore, upregulation of B7-H1 on MDCs in the tumor microenvironment downregulates T-cell immunity. Blockade of B7-H1 represents one approach for cancer immunotherapy...
  6. ncbi request reprint Altering regulatory T cell function in cancer immunotherapy: a novel means to boost the efficacy of cancer vaccines
    Jens Ruter
    Department of Medicine, Hematology and Medical Oncology, Tulane University School of Medicine, 1430 Tulane Avenue SL 78, New Orleans, LA 70112, USA
    Front Biosci (Landmark Ed) 14:1761-70. 2009
    ..We discuss specific strategies to block Treg activity and present some of our preliminary data in this area. Combining Treg depletion with active vaccination and other approaches poses additional challenges that are discussed...
  7. ncbi request reprint Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Nat Med 10:942-9. 2004
    ..This specific recruitment of T(reg) cells represents a mechanism by which tumors may foster immune privilege. Thus, blocking T(reg) cell migration or function may help to defeat human cancer...
  8. ncbi request reprint Dendritic cell subsets differentially regulate angiogenesis in human ovarian cancer
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana 70112, USA
    Cancer Res 64:5535-8. 2004
    ..Because dendritic cells (DCs) have long been known to affect tumor immunity, our data also implicate DCs in regulation of tumor neoangiogenesis, suggesting a novel role of DCs in tumor pathology...
  9. ncbi request reprint Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma
    Shuang Wei
    Tulane University Health Science Center, New Orleans, Louisiana 70112 2699, USA
    Cancer Res 65:5020-6. 2005
    ..The data are relevant to understanding tumor immunopathology as well as reevaluating tumor immunotherapeutic strategies...
  10. ncbi request reprint Regulatory T cells in ovarian cancer: biology and therapeutic potential
    Brian Barnett
    Department of Medicine Hematology and Medical Oncology, Tulane Medical School, New Orleans, LA 70112, USA
    Am J Reprod Immunol 54:369-77. 2005
    ..We discuss Tregs in this regard in human ovarian cancer and present evidence that depleting Treg in human cancer, including ovarian cancer, using denileukin diftitox (Ontak), improves immunity and may be therapeutic...
  11. pmc Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta
    Shuang Wei
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA
    Cancer Res 68:5432-8. 2008
    ..These results show a major role for the B7-H1/PD-1 axis and TGF-beta as synergistic suppressive mechanisms in cTDLN. Our data have clinical relevance in the generation of effector T cells in the tumor-bearing host...
  12. doi request reprint Inhibitory B7-family molecules in the tumour microenvironment
    Weiping Zou
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Immunol 8:467-77. 2008
    ..We also discuss novel therapeutic strategies that target these inhibitory B7 molecules and their signalling pathways to treat human cancer...
  13. pmc B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Exp Med 203:871-81. 2006
    ..Blocking B7-H4 or depleting B7-H4+ tumor macrophages may represent novel strategies to enhance T cell tumor immunity in cancer...
  14. ncbi request reprint Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells
    Ilona Kryczek
    Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    J Immunol 177:40-4. 2006
    ..Altogether, our data provide a novel cellular and molecular mechanism for Treg cell-mediated immunosuppression at the level of APCs, and suggest a plausible mechanism for the suppressive effect of IL-10 in Treg cell-mediated suppression...
  15. pmc Toxoplasma gondii-infected human myeloid dendritic cells induce T-lymphocyte dysfunction and contact-dependent apoptosis
    Shuang Wei
    Baylor Institute for Immunology Research, Dallas, Texas 75205, USA
    Infect Immun 70:1750-60. 2002
    ..Thus, regulation of host cell and bystander cell apoptosis by viable T. gondii may be significant components of a strategy to evade immunity and enhance intracellular parasite survival...
  16. ncbi request reprint Regulatory T cells, tumour immunity and immunotherapy
    Weiping Zou
    Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 0346, USA
    Nat Rev Immunol 6:295-307. 2006
    ..Strategies for therapeutic targeting of regulatory T cells and the effect of regulatory T cells on current immunotherapeutic and vaccine regimens are discussed...
  17. ncbi request reprint Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis
    Ilona Kryczek
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109 0669, USA
    Am J Physiol Cell Physiol 292:C987-95. 2007
    ..In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed...
  18. ncbi request reprint Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma
    Christiane Stahl-Hennig
    Deutsches Primatenzentrum, Gottingen, Germany
    Virology 305:473-85. 2003
    ..However, SIV-IL4 and SIV-IFN induced protection against a homologous challenge virus. Subsequent challenge with an SIV-HIV-1 hybrid virus (SHIV) also revealed protection in the absence of neutralizing antibodies...
  19. doi request reprint Inhibitory B7 family members in human ovarian carcinoma
    Shuang Wei
    Center for Research on the Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia 19104, USA
    Adv Exp Med Biol 622:261-71. 2008
  20. doi request reprint Regulatory T cells: a new frontier in cancer immunotherapy
    Brian G Barnett
    Center for Research on the Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia 19104, USA
    Adv Exp Med Biol 622:255-60. 2008
  21. ncbi request reprint Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 67:8900-5. 2007
    ..Altogether, our data support the concept that there is a mechanistic interaction between Treg cells and macrophage, and that Treg cells may convey the suppressive activity to APCs through B7-H4 induction in human ovarian cancer...
  22. ncbi request reprint Interleukin-2 administration alters the CD4+FOXP3+ T-cell pool and tumor trafficking in patients with ovarian carcinoma
    Shuang Wei
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 67:7487-94. 2007
    ..These data provide an important insight in evaluating the clinical benefit and therapeutic prediction of IL-2 treatment in patients with cancer...
  23. ncbi request reprint Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression
    Ilona Kryczek
    Department of Surgery, University of Mechigan, Ann Arbor, MI 48109, USA
    J Immunol 179:1423-6. 2007
    ..Thus, the IL-17(+) T cell pool may be controlled by the local cytokine profile in the microenvironment...
  24. ncbi request reprint Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 178:6730-3. 2007
    ....
  25. pmc Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper
    Haifa Hamdi
    Institut National de la Sante et de la Recherche Medicale, Clamart, France
    Blood 110:211-9. 2007
    ..Therefore, GILZ is critical for commitment of DCs to differentiate into regulatory DCs and to the generation of antigen-specific Tregs. This mechanism may contribute to the therapeutic effects of glucocorticoids...