James E Zadina

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint Isolation and distribution of endomorphins in the central nervous system
    James E Zadina
    Department of Medicine, Tulane University School of Medicine and Department of Veterans Affairs Medical Center, New Orleans, LA 70112 1262, USA
    Jpn J Pharmacol 89:203-8. 2002
  2. ncbi request reprint Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine
    Marc A Czapla
    Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70118, USA
    Brain Res 1059:159-66. 2005
  3. ncbi request reprint Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells
    Kristen A Horner
    Neuroscience Program, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Brain Res 1028:121-32. 2004
  4. ncbi request reprint Colocalization and shared distribution of endomorphins with substance P, calcitonin gene-related peptide, gamma-aminobutyric acid, and the mu opioid receptor
    Thomas N Greenwell
    Neuroscience Program, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Comp Neurol 503:319-33. 2007
  5. ncbi request reprint Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells
    Aniko Somogyvari-Vigh
    Tulane University Department of Medicine and VA Medical Center, 1601 Perdido Street, 8F165, New Orleans, LA 70112, USA
    Exp Brain Res 156:224-30. 2004
  6. ncbi request reprint Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice
    R Denis Soignier
    Louisiana State University, School of Medicine, 533 Bolivar St, Room 324, New Orleans, LA 70112, USA
    Neurosci Lett 366:211-4. 2004
  7. ncbi request reprint Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system
    Abba J Kastin
    Veterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, Louisiana 70112 1262, USA
    Drug Metab Dispos 30:231-4. 2002
  8. ncbi request reprint Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area
    Thomas N Greenwell
    Neuroscience Program, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Comp Neurol 454:320-8. 2002
  9. ncbi request reprint Endomorphin-2 axon terminals contact mu-opioid receptor-containing dendrites in trigeminal dorsal horn
    Sue A Aicher
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 977:190-8. 2003
  10. ncbi request reprint Morphological studies of the endomorphinergic neurons in the central nervous system
    Qing Ping Wang
    Department of Anatomy, Showa University School of Medicine, Tokyo, Japan
    Jpn J Pharmacol 89:209-15. 2002

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Isolation and distribution of endomorphins in the central nervous system
    James E Zadina
    Department of Medicine, Tulane University School of Medicine and Department of Veterans Affairs Medical Center, New Orleans, LA 70112 1262, USA
    Jpn J Pharmacol 89:203-8. 2002
    ..Thus, the pharmacology and distribution of EMs provide new avenues both for therapeutic development and for understanding the neurobiology of opioids...
  2. ncbi request reprint Reduced suppression of CO2-induced ventilatory stimulation by endomorphins relative to morphine
    Marc A Czapla
    Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70118, USA
    Brain Res 1059:159-66. 2005
    ..4 mg/kg i.v.). It was concluded that the endomorphins attenuated the HCVR only in large doses, well beyond the analgesic threshold, and did so through a centrally mediated mu-opioid mechanism...
  3. ncbi request reprint Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells
    Kristen A Horner
    Neuroscience Program, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Brain Res 1028:121-32. 2004
    ..These results may help elucidate the ability of mu agonists to regulate the number and responsiveness of their receptors...
  4. ncbi request reprint Colocalization and shared distribution of endomorphins with substance P, calcitonin gene-related peptide, gamma-aminobutyric acid, and the mu opioid receptor
    Thomas N Greenwell
    Neuroscience Program, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Comp Neurol 503:319-33. 2007
    ..Several areas in which EM1 and EM2 showed extensive shared distributions, but no detectable colocalization with other signaling molecules, are also described...
  5. ncbi request reprint Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells
    Aniko Somogyvari-Vigh
    Tulane University Department of Medicine and VA Medical Center, 1601 Perdido Street, 8F165, New Orleans, LA 70112, USA
    Exp Brain Res 156:224-30. 2004
    ..As endormorphins are mainly produced in the CNS, the presence of the efflux system at the BBB could play an important role in pain modulation and neuroendocrine control...
  6. ncbi request reprint Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice
    R Denis Soignier
    Louisiana State University, School of Medicine, 533 Bolivar St, Room 324, New Orleans, LA 70112, USA
    Neurosci Lett 366:211-4. 2004
    ..These results demonstrate a time-course and extent of tolerance similar to morphine, and support a common mechanism of action through the mu-opioid receptor...
  7. ncbi request reprint Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system
    Abba J Kastin
    Veterans Affairs Medical Center and Tulane University School of Medicine, New Orleans, Louisiana 70112 1262, USA
    Drug Metab Dispos 30:231-4. 2002
    ..This demonstrates that unlike endorphin and morphine, P-gp does not seem to be required for the brain-to-blood transport of the endomorphins, Met-enkephalin, or Tyr-MIF-1 across the BBB...
  8. ncbi request reprint Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area
    Thomas N Greenwell
    Neuroscience Program, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Comp Neurol 454:320-8. 2002
    ..The results support the idea that some endomorphin-containing neurons in the hypothalamus project to the VTA, where they may modulate reward and locomotor circuitry...
  9. ncbi request reprint Endomorphin-2 axon terminals contact mu-opioid receptor-containing dendrites in trigeminal dorsal horn
    Sue A Aicher
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 977:190-8. 2003
    ..These anatomical data support the hypothesis that endomorphin-2 is a ligand for MORs in the trigeminal dorsal horn, particularly at postsynaptic sites...
  10. ncbi request reprint Morphological studies of the endomorphinergic neurons in the central nervous system
    Qing Ping Wang
    Department of Anatomy, Showa University School of Medicine, Tokyo, Japan
    Jpn J Pharmacol 89:209-15. 2002
    ..We also discuss the possible coexistence of EM with other neurotransmitters. Finally, we introduce some new results regarding the ultrastructure and synaptic relationships of EM-2 obtained by the immunoelectron microscopic method...
  11. ncbi request reprint Rewarding and psychomotor stimulant effects of endomorphin-1: anteroposterior differences within the ventral tegmental area and lack of effect in nucleus accumbens
    Abraham Zangen
    National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 22:7225-33. 2002
    ..The present findings implicate the posterior VTA as a highly specific and sensitive site for opioid reward and suggest a role for EM-1-containing projections to the posterior VTA in the rewarding effects of other reinforcers...
  12. ncbi request reprint Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone
    Shinobu Sakurada
    Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Sendai, Japan
    Peptides 23:895-901. 2002
    ..v. Our results indicate that the antinociception induced by endomorphin-2 is mediated by the stimulation of subtypes of mu-opioid receptor, which is different from that of mu-opioid receptor subtype stimulation by endomorphin-1 and DAMGO...
  13. ncbi request reprint Morphological evidence of endomorphin as an agonist for the mu-opioid receptor in the rat spinal cord
    Qing Ping Wang
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    Neurosci Lett 341:107-10. 2003
    ..The results support the idea that endomorphin 2 is an endogenous ligand for the mu-opioid receptor. Furthermore, the results indicate that such a role is mediated at least in part through synaptic relationships...