Ihor V Yosypiv

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi Renin-angiotensin system-growth factor cross-talk: a novel mechanism for ureteric bud morphogenesis
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA, USA
    Pediatr Nephrol 24:1113-20. 2009
  2. ncbi A role for angiotensin II AT1 receptors in ureteric bud cell branching
    Igor V Iosipiv
    Section of Pediatric Nephrology, Department of Pediatrics, Tulane University Health Sciences, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 285:F199-207. 2003
  3. ncbi Role of the renin-angiotensin system in the development of the ureteric bud and renal collecting system
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Pediatr Nephrol 20:1219-29. 2005
  4. ncbi Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis
    Ihor V Yosypiv
    Department of Pediatrics, Tulane University Health Sciences Center, SL 37, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Am Soc Nephrol 17:1005-14. 2006
  5. ncbi Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Kidney Int 74:1287-93. 2008
  6. ncbi A new role for the renin-angiotensin system in the development of the ureteric bud and renal collecting system
    Ihor V Yosypiv
    Division of Pediatric Nephrology, Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Keio J Med 57:184-9. 2008
  7. ncbi Renin-angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, SL 37 Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Pediatr Nephrol 26:1499-512. 2011
  8. ncbi Histone deacetylases are critical regulators of the renin-angiotensin system during ureteric bud branching morphogenesis
    Renfang Song
    Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Pediatr Res 67:573-8. 2010
  9. ncbi Angiotensin II regulates growth of the developing papillas ex vivo
    Renfang Song
    Division of Pediatric Nephrology, Department of Pediatrics, Hypertension, and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 302:F1112-20. 2012
  10. ncbi Angiotensin II AT2 receptor regulates ureteric bud morphogenesis
    Renfang Song
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 298:F807-17. 2010

Research Grants

  1. Renin-ANG System in Morphogenesis of Renal Medulla
    Ihor V Yosypiv; Fiscal Year: 2010
  2. Renin-ANG System in Morphogenesis of Renal Medulla
    Ihor V Yosypiv; Fiscal Year: 2010

Collaborators

  • Samir S El-Dahr
  • Renfang Song
  • Graeme Preston
  • Melissa Spera
  • Colleen Garrett
  • Igor V Iosipiv
  • Ali Khalili
  • Thomas Van Buren
  • Mercedes Schroeder

Detail Information

Publications16

  1. ncbi Renin-angiotensin system-growth factor cross-talk: a novel mechanism for ureteric bud morphogenesis
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA, USA
    Pediatr Nephrol 24:1113-20. 2009
    ....
  2. ncbi A role for angiotensin II AT1 receptors in ureteric bud cell branching
    Igor V Iosipiv
    Section of Pediatric Nephrology, Department of Pediatrics, Tulane University Health Sciences, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 285:F199-207. 2003
    ..The presence of Ao in the stroma and AT1 on UB cells supports the notion that cross talk between stroma and epithelial cells is crucial to epithelial branching morphogenesis in the developing kidney...
  3. ncbi Role of the renin-angiotensin system in the development of the ureteric bud and renal collecting system
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Pediatr Nephrol 20:1219-29. 2005
    ....
  4. ncbi Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis
    Ihor V Yosypiv
    Department of Pediatrics, Tulane University Health Sciences Center, SL 37, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Am Soc Nephrol 17:1005-14. 2006
    ..This process depends on tyrosine phosphorylation of the EGFR. Cooperation of AT(1)R and EGFR signaling therefore is important in the development of the renal collecting system...
  5. ncbi Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Kidney Int 74:1287-93. 2008
    ..Enhanced Wnt11 expression induces GDNF in adjacent mesenchyme causing focal bursts of ureteric bud tip cell proliferation, decreased tip cell apoptosis and branching...
  6. ncbi A new role for the renin-angiotensin system in the development of the ureteric bud and renal collecting system
    Ihor V Yosypiv
    Division of Pediatric Nephrology, Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Keio J Med 57:184-9. 2008
    ..Together, these data indicate that cooperation of AT1R and EGFR signaling performs essential functions during renal collecting system development via control of UB branching morphogenesis...
  7. ncbi Renin-angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, SL 37 Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Pediatr Nephrol 26:1499-512. 2011
    ..This review describes the role of the RAS in UB branching morphogenesis and highlights emerging insights into the cellular and molecular mechanisms whereby RAS regulates this critical morphogenetic process...
  8. ncbi Histone deacetylases are critical regulators of the renin-angiotensin system during ureteric bud branching morphogenesis
    Renfang Song
    Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Pediatr Res 67:573-8. 2010
    ..We conclude that intact RAS is critical in structural integrity of the renal collecting system and that UB morphogenetic program genes, such as AGT, renin, ACE, AT1R, or Spry1, are epigenetically controlled via HDACs...
  9. ncbi Angiotensin II regulates growth of the developing papillas ex vivo
    Renfang Song
    Division of Pediatric Nephrology, Department of Pediatrics, Hypertension, and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 302:F1112-20. 2012
    ..We conclude that AT(1)R prevents shrinkage of the developing papillas observed ex vivo via control of Wnt7b, FGF7, β-catenin, calcineurin B1, and α3 integrin gene expression, collecting duct cell proliferation, and survival...
  10. ncbi Angiotensin II AT2 receptor regulates ureteric bud morphogenesis
    Renfang Song
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 298:F807-17. 2010
    ..We conclude that AT2R performs essential functions during UB branching morphogenesis via control of the GDNF/c-Ret/Wnt11 signaling pathway, UB cell proliferation, and survival...
  11. ncbi Angiotensin II-induced activation of c-Ret signaling is critical in ureteric bud branching morphogenesis
    Renfang Song
    Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Mech Dev 127:21-7. 2010
    ..These data demonstrate that Ang II-induced UB branching depends on activation of Akt and ERK1/2. We conclude that cross-talk between the RAS and c-Ret signaling plays an important role in the development of the renal collecting system...
  12. ncbi Angiotensin II stimulates in vitro branching morphogenesis of the isolated ureteric bud
    Renfang Song
    Division of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Mech Dev 128:359-67. 2011
    ..We conclude that Ang II-regulated genes in the iUB may be important mediators of Ang II-induced UB branching. We hypothesize that Ang II-dependent cell movements play an important role in UB branching morphogenesis...
  13. ncbi Genetics of congenital anomalies of the kidney and urinary tract
    Renfang Song
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Pediatr Nephrol 26:353-64. 2011
    ..Integrated understanding of how morphogenetic process disruptions are linked to CAKUT will enable improved diagnosis, treatment, and prevention of congenital renal system anomalies and their consequences...
  14. ncbi Development of the kidney medulla
    Renfang Song
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, LA, USA
    Organogenesis 8:10-7. 2012
    ....
  15. ncbi Ontogeny of angiotensin-converting enzyme 2
    Renfang Song
    Department of Pediatrics, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Pediatr Res 71:13-9. 2012
    ..This study examined the temporal expression of angiotensin (Ang)-converting enzyme 2 (ACE2) during renal, heart, lung, and brain organogenesis in the mouse...
  16. ncbi Receptor tyrosine kinases in kidney development
    Renfang Song
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Signal Transduct 2011:869281. 2011
    ..Here, we review the current understanding of role of RTKs and their downstream signaling pathways in the pathogenesis of CAKUT...

Research Grants6

  1. Renin-ANG System in Morphogenesis of Renal Medulla
    Ihor V Yosypiv; Fiscal Year: 2010
    ..Such information can be utilized for the design of interventional strategies aimed at the prevention and treatment of CAKUT. ..
  2. Renin-ANG System in Morphogenesis of Renal Medulla
    Ihor V Yosypiv; Fiscal Year: 2010
    ..Such information can be utilized for the design of interventional strategies aimed at the prevention and treatment of CAKUT. ..