WILLIAM WIMLEY

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc Describing the mechanism of antimicrobial peptide action with the interfacial activity model
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    ACS Chem Biol 5:905-17. 2010
  2. pmc Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1
    Sibnarayan Datta
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA
    Virol J 8:351. 2011
  3. pmc Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein
    Joshua M Costin
    Biotechnology Research Group, Department of Biology, Florida Gulf Coast University, 10501 FGCU Blvd S, Fort Myers, FL 33965, USA
    Virol J 4:123. 2007
  4. pmc Antimicrobial peptides: successes, challenges and unanswered questions
    William C Wimley
    Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    J Membr Biol 239:27-34. 2011
  5. ncbi request reprint Energetics of peptide and protein binding to lipid membranes
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Adv Exp Med Biol 677:14-23. 2010
  6. pmc Toward genomic identification of beta-barrel membrane proteins: composition and architecture of known structures
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Protein Sci 11:301-12. 2002
  7. ncbi request reprint The versatile beta-barrel membrane protein
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Curr Opin Struct Biol 13:404-11. 2003
  8. doi request reprint Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa
    Samantha L Gerlach
    Department of Ecology and Evolutionary Biology, Tulane University, 2863 St Charles Avenue, 400 Boggs Center for Energy and Biotechnology, New Orleans, LA 70118, USA
    Biopolymers 94:617-25. 2010
  9. pmc Reversible unfolding of beta-sheets in membranes: a calorimetric study
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    J Mol Biol 342:703-11. 2004
  10. pmc Biomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranes
    Ramesh Rathinakumar
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    J Am Chem Soc 130:9849-58. 2008

Research Grants

  1. Folding and design of beta sheets in membranes
    WILLIAM WIMLEY; Fiscal Year: 2009
  2. Folding and design of beta sheets in membranes
    WILLIAM WIMLEY; Fiscal Year: 2006
  3. Folding and design of beta sheets in membranes
    William C Wimley; Fiscal Year: 2010

Collaborators

  • Robert Garry
  • Kalina Hristova
  • Stephen H White
  • William F Walkenhorst
  • Michael Wiener
  • THOMAS CONNOR BISHOP
  • Ramesh Rathinakumar
  • Joshua M Rausch
  • Bruno Sainz
  • William R Gallaher
  • Sibnarayan Datta
  • Samantha L Gerlach
  • Thomas C Freeman
  • Xue Han
  • Joshua M Costin
  • Anjali Naresh
  • Jessica R Marks
  • Min You
  • Cynthia Paul
  • Arun K Mohanty
  • Bret Poat
  • Maria Samara
  • Sidhartha Hazari
  • Christophe Lamaze
  • Mario Köster
  • Srikanta Dash
  • Feyza Gunduz
  • Luis A Balart
  • Partha K Chandra
  • Hansjorg Hauser
  • Ulf Goransson
  • Steven P Darwin
  • Geetika Chakravarty
  • Debasis Mondal
  • C J Peters
  • Luis Marrero
  • Sian Tovey
  • Timothy G Cooke
  • Frank E Jones
  • Eric C Mossel
  • Gregory A Vidal
  • Russell B Wilson
  • John M S Bartlett
  • Weiwen Long
  • Carolyn I Sartor
  • Edwin Li
  • Paul H Axelsen
  • Robin M Hochstrasser
  • Jianping Wang
  • Christopher M Bishop

Detail Information

Publications23

  1. pmc Describing the mechanism of antimicrobial peptide action with the interfacial activity model
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    ACS Chem Biol 5:905-17. 2010
    ..The interfacial activity model may be useful in driving engineering and design of novel AMPs...
  2. pmc Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1
    Sibnarayan Datta
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA
    Virol J 8:351. 2011
    ..The results of this study suggest that expression of cell surface IFNAR1 is critical for the response of HCV to exogenous IFN-α...
  3. pmc Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein
    Joshua M Costin
    Biotechnology Research Group, Department of Biology, Florida Gulf Coast University, 10501 FGCU Blvd S, Fort Myers, FL 33965, USA
    Virol J 4:123. 2007
    ..These sequences have been dubbed lentiviral lytic peptides (LLP) -1, -2, and -3...
  4. pmc Antimicrobial peptides: successes, challenges and unanswered questions
    William C Wimley
    Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    J Membr Biol 239:27-34. 2011
    ..Here, we discuss the state of the field and pose some questions that, if answered, could speed the discovery of clinically useful peptide antibiotics...
  5. ncbi request reprint Energetics of peptide and protein binding to lipid membranes
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Adv Exp Med Biol 677:14-23. 2010
    ..The thermodynamic and structural principles of polypeptide-membrane interactions are described in this chapter...
  6. pmc Toward genomic identification of beta-barrel membrane proteins: composition and architecture of known structures
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Protein Sci 11:301-12. 2002
    ....
  7. ncbi request reprint The versatile beta-barrel membrane protein
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Curr Opin Struct Biol 13:404-11. 2003
    ..New research is revealing the variety of beta-barrel structures and the variety of functions performed by these versatile proteins...
  8. doi request reprint Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa
    Samantha L Gerlach
    Department of Ecology and Evolutionary Biology, Tulane University, 2863 St Charles Avenue, 400 Boggs Center for Energy and Biotechnology, New Orleans, LA 70118, USA
    Biopolymers 94:617-25. 2010
    ..39-0.76 microM). This study documents several cyclotides with robust cytotoxicity that may be promising chemosensitizing agents against drug resistant breast cancer...
  9. pmc Reversible unfolding of beta-sheets in membranes: a calorimetric study
    William C Wimley
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    J Mol Biol 342:703-11. 2004
    ..The enthalpy for thermal unfolding of AcWL(5) beta-sheets in the membrane was found to be about 8(+/-1)kcal mol(-1), or about 1.3(+/-0.2)kcal mol(-1) per residue...
  10. pmc Biomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranes
    Ramesh Rathinakumar
    Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    J Am Chem Soc 130:9849-58. 2008
    ..We demonstrate here that composition-space peptide libraries coupled with function-based high-throughput screens can lead to the discovery of diverse, soluble, and highly potent membrane-permeabilizing peptides...
  11. ncbi request reprint The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells
    Anjali Naresh
    Department of Biochemistry, Tulane University Health Sciences Center, Tulane Cancer Center, LA 70112 2699, USA
    Cancer Res 66:6412-20. 2006
    ..Thus, we propose that ligand-induced mitochondrial accumulation of 4ICD represents a unique mechanism of action for transmembrane receptors, directly coupling a cell surface signal to the tumor cell mitochondrial apoptotic pathway...
  12. pmc A highly accurate statistical approach for the prediction of transmembrane beta-barrels
    Thomas C Freeman
    Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Bioinformatics 26:1965-74. 2010
    ..However, membrane proteins, such as TMBBs, are notoriously difficult to identify and characterize using traditional experimental approaches and current prediction methods are still unreliable...
  13. pmc Rational combinatorial design of pore-forming beta-sheet peptides
    Joshua M Rausch
    Department of Biochemistry and Interdisciplinary Program in Molecular and Cellular Biology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Proc Natl Acad Sci U S A 102:10511-5. 2005
    ..These methods provide a powerful means for selecting and engineering novel pore-forming sequences and will open prospects for designing peptide antibiotics, biosensors, and new membrane protein structures...
  14. pmc Polar residues in transmembrane helices can decrease electrophoretic mobility in polyacrylamide gels without causing helix dimerization
    William F Walkenhorst
    Department of Chemistry, Loyola University, New Orleans, LA 70118, USA
    Biochim Biophys Acta 1788:1321-31. 2009
    ....
  15. pmc Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike protein
    Bruno Sainz
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL 43, New Orleans, LA 70112, USA
    J Virol 79:7195-206. 2005
    ..Based on the activity of SARS(WW-I), we propose that the hydrophobic stretch of 19 aa corresponding to residues 770 to 788 is a fusion peptide of the SARS-CoV S2 subunit...
  16. pmc High-throughput discovery of broad-spectrum peptide antibiotics
    Ramesh Rathinakumar
    Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    FASEB J 24:3232-8. 2010
    ....
  17. pmc Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein
    Bruno Sainz
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Virus Res 120:146-55. 2006
    ..The antiviral activity of the CoV peptides tested provides an attractive basis for the development of new fusion peptide inhibitors corresponding to regions outside the fusion protein heptad repeat regions...
  18. pmc Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes
    Joshua M Rausch
    Department of Biochemistry, Tulane University Health Sciences Center, New Orleans Louisiana 70112 2699, USA
    Biochemistry 46:12124-39. 2007
    ....
  19. ncbi request reprint The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: putative role during viral entry
    Bruno Sainz
    Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Biochemistry 44:947-58. 2005
    ....
  20. ncbi request reprint Enzymatic E-colicins bind to their target receptor BtuB by presentation of a small binding epitope on a coiled-coil scaffold
    Arun K Mohanty
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908 0736, USA
    J Biol Chem 278:40953-8. 2003
    ..We conclude that the BtuB binding sites for cobalamins and enzymatic E-colicins are overlapping but inequivalent and that the distal loop and (possibly) the short alpha-helical flanking regions are sufficient for high affinity binding...
  21. pmc Vibrational coupling, isotopic editing, and beta-sheet structure in a membrane-bound polypeptide
    Cynthia Paul
    Department of Pharmacology, The Johnson Foundation for Molecular Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Chem Soc 126:5843-50. 2004
    ....
  22. pmc Forster resonance energy transfer in liposomes: measurements of transmembrane helix dimerization in the native bilayer environment
    Min You
    Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Anal Biochem 340:154-64. 2005
    ..e., on the protein-to-lipid ratio), thereby yielding thermodynamic parameters that are directly relevant to processes in biological membranes...
  23. pmc Protein folding in membranes: insights from neutron diffraction studies of a membrane beta-sheet oligomer
    Xue Han
    The Johns Hopkins University, Department of Materials Science and Engineering, Baltimore, Maryland 21218, USA
    Biophys J 94:492-505. 2008
    ....

Research Grants12

  1. Folding and design of beta sheets in membranes
    WILLIAM WIMLEY; Fiscal Year: 2009
    ..This information will be used to create a public database of potential outer membrane proteins ..
  2. Folding and design of beta sheets in membranes
    WILLIAM WIMLEY; Fiscal Year: 2006
    ....
  3. Folding and design of beta sheets in membranes
    William C Wimley; Fiscal Year: 2010
    ..This information will be used to create a public database of potential outer membrane proteins ..