Research Topics
Genomes and Genes | WILLIAM WIMLEYSummaryAffiliation: Tulane University Country: USA Publications
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Publications
Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1Sibnarayan Datta
Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA
Virol J 8:351. 2011..The results of this study suggest that expression of cell surface IFNAR1 is critical for the response of HCV to exogenous IFN-α...- Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 proteinJoshua M Costin
Biotechnology Research Group, Department of Biology, Florida Gulf Coast University, 10501 FGCU Blvd S, Fort Myers, FL 33965, USA
Virol J 4:123. 2007..These sequences have been dubbed lentiviral lytic peptides (LLP) -1, -2, and -3... - Antimicrobial peptides: successes, challenges and unanswered questionsWilliam C Wimley
Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
J Membr Biol 239:27-34. 2011..Here, we discuss the state of the field and pose some questions that, if answered, could speed the discovery of clinically useful peptide antibiotics... - Describing the mechanism of antimicrobial peptide action with the interfacial activity modelWilliam C Wimley
Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
ACS Chem Biol 5:905-17. 2010..The interfacial activity model may be useful in driving engineering and design of novel AMPs... 
Energetics of peptide and protein binding to lipid membranesWilliam C Wimley
Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
Adv Exp Med Biol 677:14-23. 2010..The thermodynamic and structural principles of polypeptide-membrane interactions are described in this chapter...- Toward genomic identification of beta-barrel membrane proteins: composition and architecture of known structuresWilliam C Wimley
Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
Protein Sci 11:301-12. 2002.... - The versatile beta-barrel membrane proteinWilliam C Wimley
Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
Curr Opin Struct Biol 13:404-11. 2003..New research is revealing the variety of beta-barrel structures and the variety of functions performed by these versatile proteins... 
Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsaSamantha L Gerlach
Department of Ecology and Evolutionary Biology, Tulane University, 2863 St Charles Avenue, 400 Boggs Center for Energy and Biotechnology, New Orleans, LA 70118, USA
Biopolymers 94:617-25. 2010..39-0.76 microM). This study documents several cyclotides with robust cytotoxicity that may be promising chemosensitizing agents against drug resistant breast cancer...- Reversible unfolding of beta-sheets in membranes: a calorimetric studyWilliam C Wimley
Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
J Mol Biol 342:703-11. 2004..The enthalpy for thermal unfolding of AcWL(5) beta-sheets in the membrane was found to be about 8(+/-1)kcal mol(-1), or about 1.3(+/-0.2)kcal mol(-1) per residue... - Biomolecular engineering by combinatorial design and high-throughput screening: small, soluble peptides that permeabilize membranesRamesh Rathinakumar
Department of Biochemistry SL43, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
J Am Chem Soc 130:9849-58. 2008..We demonstrate here that composition-space peptide libraries coupled with function-based high-throughput screens can lead to the discovery of diverse, soluble, and highly potent membrane-permeabilizing peptides... - The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cellsAnjali Naresh
Department of Biochemistry, Tulane University Health Sciences Center, Tulane Cancer Center, LA 70112 2699, USA
Cancer Res 66:6412-20. 2006..Thus, we propose that ligand-induced mitochondrial accumulation of 4ICD represents a unique mechanism of action for transmembrane receptors, directly coupling a cell surface signal to the tumor cell mitochondrial apoptotic pathway... - A highly accurate statistical approach for the prediction of transmembrane beta-barrelsThomas C Freeman
Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Bioinformatics 26:1965-74. 2010..However, membrane proteins, such as TMBBs, are notoriously difficult to identify and characterize using traditional experimental approaches and current prediction methods are still unreliable... - Rational combinatorial design of pore-forming beta-sheet peptidesJoshua M Rausch
Department of Biochemistry and Interdisciplinary Program in Molecular and Cellular Biology, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, USA
Proc Natl Acad Sci U S A 102:10511-5. 2005..These methods provide a powerful means for selecting and engineering novel pore-forming sequences and will open prospects for designing peptide antibiotics, biosensors, and new membrane protein structures... - Polar residues in transmembrane helices can decrease electrophoretic mobility in polyacrylamide gels without causing helix dimerizationWilliam F Walkenhorst
Department of Chemistry, Loyola University, New Orleans, LA 70118, USA
Biochim Biophys Acta 1788:1321-31. 2009.... - Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike proteinBruno Sainz
Department of Microbiology and Immunology, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL 43, New Orleans, LA 70112, USA
J Virol 79:7195-206. 2005..Based on the activity of SARS(WW-I), we propose that the hydrophobic stretch of 19 aa corresponding to residues 770 to 788 is a fusion peptide of the SARS-CoV S2 subunit... - High-throughput discovery of broad-spectrum peptide antibioticsRamesh Rathinakumar
Department of Biochemistry, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
FASEB J 24:3232-8. 2010.... - Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike proteinBruno Sainz
Department of Microbiology and Immunology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Virus Res 120:146-55. 2006..The antiviral activity of the CoV peptides tested provides an attractive basis for the development of new fusion peptide inhibitors corresponding to regions outside the fusion protein heptad repeat regions... - Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranesJoshua M Rausch
Department of Biochemistry, Tulane University Health Sciences Center, New Orleans Louisiana 70112 2699, USA
Biochemistry 46:12124-39. 2007.... - The aromatic domain of the coronavirus class I viral fusion protein induces membrane permeabilization: putative role during viral entryBruno Sainz
Department of Microbiology and Immunology, Program in Molecular Pathogenesis and Immunity, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Biochemistry 44:947-58. 2005.... - Enzymatic E-colicins bind to their target receptor BtuB by presentation of a small binding epitope on a coiled-coil scaffoldArun K Mohanty
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908 0736, USA
J Biol Chem 278:40953-8. 2003..We conclude that the BtuB binding sites for cobalamins and enzymatic E-colicins are overlapping but inequivalent and that the distal loop and (possibly) the short alpha-helical flanking regions are sufficient for high affinity binding... - Vibrational coupling, isotopic editing, and beta-sheet structure in a membrane-bound polypeptideCynthia Paul
Department of Pharmacology, The Johnson Foundation for Molecular Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Am Chem Soc 126:5843-50. 2004.... - Forster resonance energy transfer in liposomes: measurements of transmembrane helix dimerization in the native bilayer environmentMin You
Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
Anal Biochem 340:154-64. 2005..e., on the protein-to-lipid ratio), thereby yielding thermodynamic parameters that are directly relevant to processes in biological membranes... - Protein folding in membranes: insights from neutron diffraction studies of a membrane beta-sheet oligomerXue Han
The Johns Hopkins University, Department of Materials Science and Engineering, Baltimore, Maryland 21218, USA
Biophys J 94:492-505. 2008....
Research Grants
- Folding and design of beta sheets in membranesWILLIAM WIMLEY; Fiscal Year: 2009..This information will be used to create a public database of potential outer membrane proteins ..
- Folding and design of beta sheets in membranesWILLIAM WIMLEY; Fiscal Year: 2006....
- Folding and design of beta sheets in membranesWilliam C Wimley; Fiscal Year: 2010..This information will be used to create a public database of potential outer membrane proteins ..