J Tasker

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids and stress
    Benjamin H Levy
    Neuroscience Program, Tulane University, New Orleans, LA, USA
    Front Cell Neurosci 6:24. 2012
  2. doi request reprint Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis
    Jeffrey G Tasker
    Department of Cell and Molecular Biology and Neuroscience Program, Tulane University, New Orleans, LA 70118, USA
    Stress 14:398-406. 2011
  3. ncbi request reprint Rapid glucocorticoid actions in the hypothalamus as a mechanism of homeostatic integration
    Jeffrey G Tasker
    Neurobiology Division, Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, New Orleans, LA 70118, USA
    Obesity (Silver Spring) 14:259S-265S. 2006
  4. pmc Minireview: rapid glucocorticoid signaling via membrane-associated receptors
    Jeffrey G Tasker
    Department of Cell and Molecular Biology, Tulane University, 6400 Freret Street, New Orleans, Louisiana 70118, USA
    Endocrinology 147:5549-56. 2006
  5. ncbi request reprint Coregulation of ion channels by neurosteroids and phosphorylation
    J Tasker
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA, USA
    Sci STKE 2000:pe1. 2000
  6. ncbi request reprint Teaching resources. Regulation of GABA receptor activity by neurosteroids and phosphorylation
    Jeffrey Tasker
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Sci STKE 2004:tr4. 2004
  7. ncbi request reprint Functional synaptic plasticity in hypothalamic magnocellular neurons
    Jeffrey G Tasker
    Department of Cell and Molecular Biology, Neurobiology Division, 2000 Percival Stern Hall, Tulane University, New Orleans, LA 70118, USA
    Prog Brain Res 139:113-9. 2002
  8. pmc Glucocorticoids shift arachidonic acid metabolism toward endocannabinoid synthesis: a non-genomic anti-inflammatory switch
    Renato Malcher-Lopes
    Center for Genetic Resources, and Biotechnology, EMBRAPA, Brasilia, DF, Brazil
    Eur J Pharmacol 583:322-39. 2008
  9. pmc Somato-dendritic mechanisms underlying the electrophysiological properties of hypothalamic magnocellular neuroendocrine cells: a multicompartmental model study
    Alexander O Komendantov
    Center for Computational Science, Tulane University, New Orleans, LA 70118, USA
    J Comput Neurosci 23:143-68. 2007
  10. ncbi request reprint Role of the paraventricular nucleus microenvironment in stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Eur J Neurosci 16:381-5. 2002

Research Grants

  1. HYPOTHALAMIC SYNCHRONIZATION BY LOCAL GLUTAMATE CIRCUITS
    Jeffrey Tasker; Fiscal Year: 2000
  2. Cellular Plasticity and HPA Axis Dysfunction
    Jeffrey Tasker; Fiscal Year: 2009
  3. Acute Corticosteriod Actions in the Hypothalamus
    Jeffrey Tasker; Fiscal Year: 2009
  4. Synaptic Plasticity of Hypothalamic Neurons
    Jeffrey Tasker; Fiscal Year: 2007
  5. Acute Corticosteriod Actions in the Hypothalamus
    Jeffrey Tasker; Fiscal Year: 2005
  6. Synaptic Plasticity of Hypothalamic Neurons
    Jeffrey Tasker; Fiscal Year: 2004
  7. Cellular Plasticity and HPA Axis Dysfunction
    Jeffrey Tasker; Fiscal Year: 2004
  8. HYPOTHALAMIC SYNCHRONIZATION BY LOCAL GLUTAMATE CIRCUITS
    Jeffrey Tasker; Fiscal Year: 2001
  9. HYPOTHALAMIC SYNCHRONIZATION BY LOCAL GLUTAMATE CIRCUITS
    Jeffrey Tasker; Fiscal Year: 2002
  10. Synaptic Plasticity of Hypothalamic Neurons
    Jeffrey Tasker; Fiscal Year: 2003

Collaborators

Detail Information

Publications18

  1. pmc Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids and stress
    Benjamin H Levy
    Neuroscience Program, Tulane University, New Orleans, LA, USA
    Front Cell Neurosci 6:24. 2012
    ....
  2. doi request reprint Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis
    Jeffrey G Tasker
    Department of Cell and Molecular Biology and Neuroscience Program, Tulane University, New Orleans, LA 70118, USA
    Stress 14:398-406. 2011
    ....
  3. ncbi request reprint Rapid glucocorticoid actions in the hypothalamus as a mechanism of homeostatic integration
    Jeffrey G Tasker
    Neurobiology Division, Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, New Orleans, LA 70118, USA
    Obesity (Silver Spring) 14:259S-265S. 2006
    ..This represents a means by which the regulation of stress and feeding may interface in the PVN, thus providing a possible mechanism for the integration of multiple homeostatic functions...
  4. pmc Minireview: rapid glucocorticoid signaling via membrane-associated receptors
    Jeffrey G Tasker
    Department of Cell and Molecular Biology, Tulane University, 6400 Freret Street, New Orleans, Louisiana 70118, USA
    Endocrinology 147:5549-56. 2006
    ..We also discuss the possibility that membrane-initiated actions of glucocorticoids may provide an additional mechanism for the regulation of gene transcription...
  5. ncbi request reprint Coregulation of ion channels by neurosteroids and phosphorylation
    J Tasker
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA, USA
    Sci STKE 2000:pe1. 2000
    ..The dual regulation of gamma-aminobutyric acid type A (GABA(A)) receptors and voltage-gated calcium channels by phosphorylation and neurosteroids is the focus of this Perspective...
  6. ncbi request reprint Teaching resources. Regulation of GABA receptor activity by neurosteroids and phosphorylation
    Jeffrey Tasker
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Sci STKE 2004:tr4. 2004
    ..These animations would be useful in teaching how allosteric modulators (neurosteroids) and covalent modulators (kinases) can work together as regulators of protein activity...
  7. ncbi request reprint Functional synaptic plasticity in hypothalamic magnocellular neurons
    Jeffrey G Tasker
    Department of Cell and Molecular Biology, Neurobiology Division, 2000 Percival Stern Hall, Tulane University, New Orleans, LA 70118, USA
    Prog Brain Res 139:113-9. 2002
    ....
  8. pmc Glucocorticoids shift arachidonic acid metabolism toward endocannabinoid synthesis: a non-genomic anti-inflammatory switch
    Renato Malcher-Lopes
    Center for Genetic Resources, and Biotechnology, EMBRAPA, Brasilia, DF, Brazil
    Eur J Pharmacol 583:322-39. 2008
    ..In the central nervous system (CNS) this may represent a major neuroprotective system, which may cross-talk with leptin signaling in the hypothalamus allowing for the coordination between energy homeostasis and the inflammatory response...
  9. pmc Somato-dendritic mechanisms underlying the electrophysiological properties of hypothalamic magnocellular neuroendocrine cells: a multicompartmental model study
    Alexander O Komendantov
    Center for Computational Science, Tulane University, New Orleans, LA 70118, USA
    J Comput Neurosci 23:143-68. 2007
    ....
  10. ncbi request reprint Role of the paraventricular nucleus microenvironment in stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Eur J Neurosci 16:381-5. 2002
    ..The current state of knowledge reveals the paraventricular nucleus to be a dynamic entity, capable of integrating diverse classes of signals into control of adrenocortical activation...
  11. ncbi request reprint Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism
    Shi Di
    Division of Neurobiology, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118 5698, USA
    J Neurosci 23:4850-7. 2003
    ....
  12. ncbi request reprint Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release
    Renato Malcher-Lopes
    Neuroscience Program, Tulane University, New Orleans, Louisiana 70118, USA
    J Neurosci 26:6643-50. 2006
    ....
  13. ncbi request reprint Intranuclear coupling of hypothalamic magnocellular nuclei by glutamate synaptic circuits
    Cherif Boudaba
    Neurobiology Division, Department of Cell and Molecular Biology, Tulane Unversity, New Orleans, Louisiana 70118, USA
    Am J Physiol Regul Integr Comp Physiol 291:R102-11. 2006
    ..These internuclear glutamatergic circuits may provide the functional architecture to support burst generation and/or burst synchronization in hypothalamic magnocellular neurons under conditions of activation...
  14. ncbi request reprint Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons
    Shi Di
    Division of Neurobiology, Tulane University, New Orleans, Louisiana 70118 5698, USA
    Endocrinology 146:4292-301. 2005
    ....
  15. ncbi request reprint Dehydration-induced synaptic plasticity in magnocellular neurons of the hypothalamic supraoptic nucleus
    Shi Di
    Department of Cell and Molecular Biology, 2000 Percival Stern Hall, Tulane University, New Orleans, Louisiana 70118 5698, USA
    Endocrinology 145:5141-9. 2004
    ..This synaptic plasticity would be expected to increase the excitability of the magnocellular neurons and support the enhanced bursting capacity and facilitated hormone secretion observed in vivo with chronic dehydration...
  16. pmc Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus
    Shi Di
    Department of Cell and Molecular Biology, 2000 Percival Stern Hall, Tulane University, New Orleans, LA 70118 5698, USA
    J Physiol 569:751-60. 2005
    ..This activity-dependent regulation of excitatory synaptic input by endocannabinoids may play a role in determining spiking patterns characteristic of magnocellular neurones under stimulated conditions...
  17. pmc Increased tonic activation of presynaptic metabotropic glutamate receptors in the rat supraoptic nucleus following chronic dehydration
    Cherif Boudaba
    Department of Cell and Molecular Biology and Neuroscience Program, Tulane University, New Orleans, LA 70118, USA
    J Physiol 551:815-23. 2003
    ..The resulting reduction in glutamate release probability may compensate for the increase in glutamate release sites that occurs during dehydration...
  18. ncbi request reprint Local circuit regulation of paraventricular nucleus stress integration: glutamate-GABA connections
    James P Herman
    Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Avenue, Cincinnati, OH 45267 0559, USA
    Pharmacol Biochem Behav 71:457-68. 2002
    ..Local circuits are likely the primary integrators of anticipatory stress responses, and may indeed be the focus of HPA dysfunction seen with aging or affective disease...

Research Grants23

  1. HYPOTHALAMIC SYNCHRONIZATION BY LOCAL GLUTAMATE CIRCUITS
    Jeffrey Tasker; Fiscal Year: 2000
    ..This proposal should make a substantial contribution to understanding the mechanisms of burst generation in hypothalamic neuroendocrine cells. ..
  2. Cellular Plasticity and HPA Axis Dysfunction
    Jeffrey Tasker; Fiscal Year: 2009
    ....
  3. Acute Corticosteriod Actions in the Hypothalamus
    Jeffrey Tasker; Fiscal Year: 2009
    ..abstract_text> ..
  4. Synaptic Plasticity of Hypothalamic Neurons
    Jeffrey Tasker; Fiscal Year: 2007
    ..abstract_text> ..
  5. Acute Corticosteriod Actions in the Hypothalamus
    Jeffrey Tasker; Fiscal Year: 2005
    ..Furthermore, the glucocorticoid-endocannabinoid link opens interesting possibilities for interactions between hypothalamic function and the cannabinoids. ..
  6. Synaptic Plasticity of Hypothalamic Neurons
    Jeffrey Tasker; Fiscal Year: 2004
    ..The successful completion of these studies will reveal the physiological significance of anatomical changes observed under conditions of dehydration, and will provide insight into the molecular mechanisms responsible for these changes. ..
  7. Cellular Plasticity and HPA Axis Dysfunction
    Jeffrey Tasker; Fiscal Year: 2004
    ....
  8. HYPOTHALAMIC SYNCHRONIZATION BY LOCAL GLUTAMATE CIRCUITS
    Jeffrey Tasker; Fiscal Year: 2001
    ..This proposal should make a substantial contribution to understanding the mechanisms of burst generation in hypothalamic neuroendocrine cells. ..
  9. HYPOTHALAMIC SYNCHRONIZATION BY LOCAL GLUTAMATE CIRCUITS
    Jeffrey Tasker; Fiscal Year: 2002
    ..This proposal should make a substantial contribution to understanding the mechanisms of burst generation in hypothalamic neuroendocrine cells. ..
  10. Synaptic Plasticity of Hypothalamic Neurons
    Jeffrey Tasker; Fiscal Year: 2003
    ..The successful completion of these studies will reveal the physiological significance of anatomical changes observed under conditions of dehydration, and will provide insight into the molecular mechanisms responsible for these changes. ..
  11. Acute Corticosteriod Actions in the Hypothalamus
    Jeffrey G Tasker; Fiscal Year: 2010
    ..abstract_text> ..
  12. Acute Corticosteriod Actions in the Hypothalamus
    Jeffrey Tasker; Fiscal Year: 2003
    ..Furthermore, the glucocorticoid-endocannabinoid link opens interesting possibilities for interactions between hypothalamic function and the cannabinoids. ..
  13. Synaptic Plasticity of Hypothalamic Neurons
    Jeffrey Tasker; Fiscal Year: 2007
    ..The successful completion of these studies will reveal the physiological significance of anatomical changes observed under conditions of dehydration, and will provide insight into the molecular mechanisms responsible for these changes. ..
  14. Acute Corticosteriod Actions in the Hypothalamus
    Jeffrey Tasker; Fiscal Year: 2004
    ..Furthermore, the glucocorticoid-endocannabinoid link opens interesting possibilities for interactions between hypothalamic function and the cannabinoids. ..
  15. Synaptic Plasticity of Hypothalamic Neurons
    Jeffrey Tasker; Fiscal Year: 2005
    ..The successful completion of these studies will reveal the physiological significance of anatomical changes observed under conditions of dehydration, and will provide insight into the molecular mechanisms responsible for these changes. ..
  16. Cellular Plasticity and HPA Axis Dysfunction
    Jeffrey Tasker; Fiscal Year: 2005
    ....
  17. HYPOTHALAMIC SYNCHRONIZATION BY LOCAL GLUTAMATE CIRCUITS
    Jeffrey Tasker; Fiscal Year: 2003
    ..This proposal should make a substantial contribution to understanding the mechanisms of burst generation in hypothalamic neuroendocrine cells. ..
  18. Cellular Plasticity and HPA Axis Dysfunction
    Jeffrey Tasker; Fiscal Year: 2007
    ....
  19. Acute Corticosteriod Actions in the Hypothalamus
    Jeffrey Tasker; Fiscal Year: 2006
    ..Furthermore, the glucocorticoid-endocannabinoid link opens interesting possibilities for interactions between hypothalamic function and the cannabinoids. ..
  20. Cellular Plasticity and HPA Axis Dysfunction
    Jeffrey Tasker; Fiscal Year: 2006
    ....
  21. Synaptic Plasticity of Hypothalamic Neurons
    Jeffrey Tasker; Fiscal Year: 2006
    ..The successful completion of these studies will reveal the physiological significance of anatomical changes observed under conditions of dehydration, and will provide insight into the molecular mechanisms responsible for these changes. ..