Li chun Sun

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice
    Lichun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112 2699, USA
    Anticancer Res 24:179-86. 2004
  2. ncbi Effects of camptothecin conjugated to a somatostatin analog vector on growth of tumor cell lines in culture and related tumors in rodents
    Lichun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, Tulane University School of Medicine, New Orleans, Louisiana 70112 2699, USA
    Drug Deliv 11:231-8. 2004
  3. pmc Targeted chemotherapy using a cytotoxic somatostatin conjugate to inhibit tumor growth and metastasis in nude mice
    Li chun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA 70112 2699, U S A
    Clin Med Oncol 2:491-9. 2008
  4. pmc Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture
    Hong T Nguyen
    Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Cancer Cell Int 13:16. 2013
  5. pmc Notch1-mediated tumor suppression in cervical cancer with the involvement of SST signaling and its application in enhanced SSTR-targeted therapeutics
    Laura G Franko-Tobin
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, Louisiana 70112, USA
    Oncologist 17:220-32. 2012
  6. ncbi A conjugate of camptothecin and a somatostatin analog against prostate cancer cell invasion via a possible signaling pathway involving PI3K/Akt, alphaVbeta3/alphaVbeta5 and MMP-2/-9
    Li chun Sun
    Peptide Research Laboratories, Department of Medicine, Tulane Health Sciences Center, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
    Cancer Lett 246:157-66. 2007
  7. doi Investigation of cancer cell lines for peptide receptor-targeted drug development
    Lichun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA 70112 2699, USA
    J Drug Target 19:719-30. 2011
  8. doi Application of human pancreatic carcinoid BON cells for receptor-targeted drug development
    Lichun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA 70112 2699, USA
    J Drug Target 19:666-74. 2011
  9. ncbi Effects of camptothecin on tumor cell proliferation and angiogenesis when coupled to a bombesin analog used as a targeted delivery vector
    Li chun Sun
    Peptide Research Laboratories, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Anticancer Drugs 18:341-8. 2007
  10. ncbi Somatostatin receptor-targeted anti-cancer therapy
    Li chun Sun
    Peptide Research Laboratories, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Curr Drug Deliv 8:2-10. 2011

Collaborators

Detail Information

Publications16

  1. ncbi Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice
    Lichun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112 2699, USA
    Anticancer Res 24:179-86. 2004
    ..These analogs appear to offer a valuable tool for CA-4 research because of their extremely facile synthesis from readily available starting materials...
  2. ncbi Effects of camptothecin conjugated to a somatostatin analog vector on growth of tumor cell lines in culture and related tumors in rodents
    Lichun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, Tulane University School of Medicine, New Orleans, Louisiana 70112 2699, USA
    Drug Deliv 11:231-8. 2004
    ....
  3. pmc Targeted chemotherapy using a cytotoxic somatostatin conjugate to inhibit tumor growth and metastasis in nude mice
    Li chun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA 70112 2699, U S A
    Clin Med Oncol 2:491-9. 2008
    ....
  4. pmc Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture
    Hong T Nguyen
    Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Cancer Cell Int 13:16. 2013
    ..These findings also indicate that rBM 3-D culture can serve as an ideal platform for swift and cost-effective screening of therapeutic candidates at the interface of the tumor and its microenvironment...
  5. pmc Notch1-mediated tumor suppression in cervical cancer with the involvement of SST signaling and its application in enhanced SSTR-targeted therapeutics
    Laura G Franko-Tobin
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, Louisiana 70112, USA
    Oncologist 17:220-32. 2012
    ..Our findings thus provide us with a promising clinical opportunity for enhanced cancer therapy using combinations of Notch1-activating agents and SSTR2-targeting agents...
  6. ncbi A conjugate of camptothecin and a somatostatin analog against prostate cancer cell invasion via a possible signaling pathway involving PI3K/Akt, alphaVbeta3/alphaVbeta5 and MMP-2/-9
    Li chun Sun
    Peptide Research Laboratories, Department of Medicine, Tulane Health Sciences Center, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
    Cancer Lett 246:157-66. 2007
    ....
  7. doi Investigation of cancer cell lines for peptide receptor-targeted drug development
    Lichun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA 70112 2699, USA
    J Drug Target 19:719-30. 2011
    ..Furthermore, the in vivo antitumor assay showed that the cytotoxic conjugate CPT-SST targeting all SSTR subtypes displayed a potent tumor-suppressive ability to BON tumors expressing multiple SSTR subtypes...
  8. doi Application of human pancreatic carcinoid BON cells for receptor-targeted drug development
    Lichun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA 70112 2699, USA
    J Drug Target 19:666-74. 2011
    ..Our findings suggest that appropriately defined tumor cell lines may provide physiologically relevant cell-based evaluations of novel peptide analogs and receptor-targeted chemotherapeutics...
  9. ncbi Effects of camptothecin on tumor cell proliferation and angiogenesis when coupled to a bombesin analog used as a targeted delivery vector
    Li chun Sun
    Peptide Research Laboratories, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Anticancer Drugs 18:341-8. 2007
    ..By binding to bombesin receptor-expressing sites, this bombesin analog, consisting of 11 amino acids, is potentially a novel delivery vector for nonspecific cytotoxic agents...
  10. ncbi Somatostatin receptor-targeted anti-cancer therapy
    Li chun Sun
    Peptide Research Laboratories, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Curr Drug Deliv 8:2-10. 2011
    ..These and other peptide conjugates may possibly represent a newer generation of receptor-targeted cancer therapeutics. This review discusses the progress with reference to SST-based and SSTR-selective cytotoxic cancer therapy...
  11. ncbi An adjustable release rate linking strategy for cytotoxin-peptide conjugates
    Joseph A Fuselier
    Peptide Research Laboratories, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Bioorg Med Chem Lett 13:799-803. 2003
    ....
  12. ncbi Antisense peptide nucleic acids conjugated to somatostatin analogs and targeted at the n-myc oncogene display enhanced cytotoxity to human neuroblastoma IMR32 cells expressing somatostatin receptors
    Lichun Sun
    Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112 2699, USA
    Peptides 23:1557-65. 2002
    ....
  13. ncbi Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design
    Lichun Sun
    Department of Medicine, Tulane University, Health Sciences Center, New Orleans, LA 70112, USA
    Bioorg Med Chem Lett 14:2041-6. 2004
    ..Further studies on this interesting group of compounds as anti-cancer agents appear warranted...
  14. ncbi In vitro and in vivo antitumor effects of cytotoxic camptothecin-bombesin conjugates are mediated by specific interaction with cellular bombesin receptors
    Terry W Moody
    Department of Health and Human Services, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Pharmacol Exp Ther 318:1265-72. 2006
    ..Because many tumors overexpress Bn receptors, these results also demonstrate that CPT-L2-BA3 will be a useful agent for delivering receptor-mediated cytotoxicity to many different human tumors...
  15. ncbi Downregulation of MDM2 expression by RNAi inhibits LoVo human colorectal adenocarcinoma cells growth and the treatment of LoVo cells with mdm2siRNA3 enhances the sensitivity to cisplatin
    Yan Yu
    Department of Internal Medicine, Cancer Hospital of Harbin Medical University, Harbin 150040, People s Republic of China
    Biochem Biophys Res Commun 339:71-8. 2006
    ..It also could be a therapeutic target in colorectal carcinoma. The synergistic activation of RNAi and cell toxicity agents indicated that the combination of chemotherapy and gene therapy will be a promising approach in the future...
  16. ncbi [Enhancement of HER-2 degradation by carbamazepine in breast cancer SKBR-3 cell line]
    Qing Wei Meng
    Fourth Department of Medical Oncology, Affiliated Tumor Hospital, Harbin Medical University, Harbin 150040, China
    Zhonghua Zhong Liu Za Zhi 28:503-6. 2006
    ..To investigate the anti-tumor effect and the mechanism of down-regulation of HER - 2 by cabamazepine in SKBR - 3 cells , a breast cancer cell line with HER - 2 over - expression...