S C Sikka

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint Endocrine disruptors and estrogenic effects on male reproductive axis
    Suresh C Sikka
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Asian J Androl 10:134-45. 2008
  2. ncbi request reprint Role of oxidative stress and antioxidants in andrology and assisted reproductive technology
    Suresh C Sikka
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Androl 25:5-18. 2004
  3. ncbi request reprint Role of oxidative stress response elements and antioxidants in prostate cancer pathobiology and chemoprevention--a mechanistic approach
    Suresh C Sikka
    Department of Urology, Faculty of Molecular and Cellular Biology MCB, Tulane Cancer Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL 42, New Orleans, Louisiana 70112 2699, USA
    Curr Med Chem 10:2679-92. 2003
  4. ncbi request reprint Relative impact of oxidative stress on male reproductive function
    S C Sikka
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112 2699, USA
    Curr Med Chem 8:851-62. 2001
  5. ncbi request reprint Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa
    S C Sikka
    Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
    Int J Androl 24:136-41. 2001
  6. ncbi request reprint Role of oxidative stress and antioxidants in Peyronie's disease
    S C Sikka
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Lousiana 70112 2699, USA
    Int J Impot Res 14:353-60. 2002
  7. ncbi request reprint Oxidative stress and role of antioxidants in normal and abnormal sperm function
    S C Sikka
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Front Biosci 1:e78-86. 1996
  8. ncbi request reprint Nitric oxide induces oxidative stress and mediates cytotoxicity to human cavernosal cells in culture
    M Rajasekaran
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112-2699, USA
    J Androl 22:34-9. 2001
  9. ncbi request reprint Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers
    Wayne J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 176:1529-33. 2006
  10. ncbi request reprint Single-blind, multicenter, placebo controlled, parallel study to assess the safety and efficacy of intralesional interferon alpha-2B for minimally invasive treatment for Peyronie's disease
    Wayne J G Hellstrom
    Department of Urology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Urol 176:394-8. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Endocrine disruptors and estrogenic effects on male reproductive axis
    Suresh C Sikka
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Asian J Androl 10:134-45. 2008
    ....
  2. ncbi request reprint Role of oxidative stress and antioxidants in andrology and assisted reproductive technology
    Suresh C Sikka
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Androl 25:5-18. 2004
  3. ncbi request reprint Role of oxidative stress response elements and antioxidants in prostate cancer pathobiology and chemoprevention--a mechanistic approach
    Suresh C Sikka
    Department of Urology, Faculty of Molecular and Cellular Biology MCB, Tulane Cancer Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL 42, New Orleans, Louisiana 70112 2699, USA
    Curr Med Chem 10:2679-92. 2003
    ....
  4. ncbi request reprint Relative impact of oxidative stress on male reproductive function
    S C Sikka
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112 2699, USA
    Curr Med Chem 8:851-62. 2001
    ..Such assessment of oxidative stress status (OSS) may help in designing newer modes of male factor infertility treatment by suitable antioxidants...
  5. ncbi request reprint Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa
    S C Sikka
    Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
    Int J Androl 24:136-41. 2001
    ..These data suggest that the combination of LPS and IFN-gamma is detrimental to human spermatozoa and may contribute to male factor infertility in patients with chronic GUI...
  6. ncbi request reprint Role of oxidative stress and antioxidants in Peyronie's disease
    S C Sikka
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Lousiana 70112 2699, USA
    Int J Impot Res 14:353-60. 2002
  7. ncbi request reprint Oxidative stress and role of antioxidants in normal and abnormal sperm function
    S C Sikka
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Front Biosci 1:e78-86. 1996
    ..Assessment of such oxidative stress status (OSS) may help in the medical treatment of this male factor infertility by suitable antioxidants...
  8. ncbi request reprint Nitric oxide induces oxidative stress and mediates cytotoxicity to human cavernosal cells in culture
    M Rajasekaran
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112-2699, USA
    J Androl 22:34-9. 2001
    ..These findings suggest that the NO released by SNP (>0.8 mM) exhibited a significant cytotoxicity to HCSMC, mediated by increased oxidative stress to these cells...
  9. ncbi request reprint Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers
    Wayne J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 176:1529-33. 2006
    ..We assessed the effect of acute administration of tamsulosin, alfuzosin and placebo on ejaculate volume and sperm concentration in post-ejaculate urine, and addressed the mechanism of action of tamsulosin and alfuzosin on ejaculation...
  10. ncbi request reprint Single-blind, multicenter, placebo controlled, parallel study to assess the safety and efficacy of intralesional interferon alpha-2B for minimally invasive treatment for Peyronie's disease
    Wayne J G Hellstrom
    Department of Urology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Urol 176:394-8. 2006
    ..We investigated the efficacy and safety of intralesional interferon alpha-2b for the treatment of Peyronie's disease...
  11. ncbi request reprint Semen and sperm reference ranges for men 45 years of age and older
    Wayne J G Hellstrom
    Department of Urology, SL 42, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, Louisiana 70112, USA
    J Androl 27:421-8. 2006
    ..The observation that less than half the men in this study met all 4 WHO reference values for measured semen and sperm parameters underscores the need for age-specific reference ranges...
  12. doi request reprint Effects of alfuzosin and tamsulosin on sperm parameters in healthy men: results of a short-term, randomized, double-blind, placebo-controlled, crossover study
    Wayne J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, 1430 Tulane Avenue SL 42, New Orleans, LA 70112, USA
    J Androl 30:469-74. 2009
    ..The results suggest that tamsulosin has a negative effect on sperm in healthy men. Studies on the effects of alpha(1)-adrenergic blockers on sperm in men with BPH are warranted...
  13. doi request reprint Adipose tissue-derived stem cell therapy for prevention and treatment of erectile dysfunction in a rat model of Peyronie's disease
    A Gokce
    Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA
    Andrology 2:244-51. 2014
    ..This study documents the preventive and therapeutic benefits of ADSC on penile fibrosis and erectile function in an animal model of PD...
  14. pmc Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation
    X Zeng
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Prostate Cancer Prostatic Dis 13:195-201. 2010
    ..We conclude that TRPM2 is essential for prostate cancer cell proliferation and may be a potential target for the selective treatment of prostate cancer...
  15. ncbi request reprint Evaluation of nitric oxide synthase and arginase in the induction of a Peyronie's-like condition in the rat
    T J Bivalacqua
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    J Androl 22:497-506. 2001
    ..These results suggest that iNOS is the key control element for peroxynitrite formation, arginase II expression, and eNOS down-regulation in the induction of a Peyronie's-like condition in the rat...
  16. doi request reprint Alfuzosin attenuates erectile dysfunction in rats with partial bladder outlet obstruction
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    BJU Int 102:1651-7. 2008
    ....
  17. ncbi request reprint Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress
    Serap Gur
    Tulane University Health Sciences Center, Department of Urology, 1430 Tulane Avenue, SL 42, New Orleans, LA 70112, USA
    Expert Opin Investig Drugs 17:855-64. 2008
    ..The phophodiesterase-5 (PDE5) inhibitors still remain ineffective in 15 - 57% of impotent men...
  18. ncbi request reprint The impact of intralesional interferon alpha-2b injection therapy on penile hemodynamics in men with Peyronie's disease
    Muammer Kendirci
    Department of Urology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Sex Med 2:709-15. 2005
    ..PDDU may be used to monitor objectively changes in penile vascular parameters in men who undergo treatment for Peyronie's disease (PD), including intralesional interferon alpha-2b (IFN alpha-2b)...
  19. ncbi request reprint Diabetes mellitus is associated with severe Peyronie's disease
    Muammer Kendirci
    Tulane University, Urology, New Orleans, LA, USA
    BJU Int 99:383-6. 2007
    ..To evaluate the severity of penile deformity and penile blood flow variables in men with Peyronie's disease (PD) and diabetes mellitus (DM), and those with no risk factors...
  20. ncbi request reprint The relationship between the type of penile abnormality and penile vascular status in patients with peyronie's disease
    Muammer Kendirci
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 174:632-5; discussion 635. 2005
    ..We evaluated penile vascular status using penile duplex Doppler ultrasound (PDDU) according to the type of abnormality in men with Peyronie's disease (PD)...
  21. doi request reprint Management of erectile function by penile purinergic p2 receptors in the diabetic rat
    Serap Gur
    Department of Urology and Pharmacology, Tulane Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 181:2375-82. 2009
    ..We determined the role of purine and pyrimidine nucleotides in erectile function in diabetic rats...
  22. ncbi request reprint Stratification of penile vascular pathologies in patients with Peyronie's disease and in men with erectile dysfunction according to age: a comparative study
    Mustafa F Usta
    Section of Andrology, Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Urol 172:259-62. 2004
    ..Erectile dysfunction (ED) occurs in 20% to 54% of men with Peyronie's disease (PD). We investigated the role of vascular status in the pathophysiology of ED in patients with PD...
  23. ncbi request reprint Chronic inhibition of nitric-oxide synthase induces hypertension and erectile dysfunction in the rat that is not reversed by sildenafil
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    BJU Int 106:78-83. 2010
    ....
  24. ncbi request reprint DNA profiling of azoospermic semen samples from vasectomized males by using Y-PLEX 6 amplification kit
    Jaiprakash G Shewale
    ReliaGene Technologies, Inc, 5525 Mounes St, Suite 101, New Orleans, LA 70123, USA
    J Forensic Sci 48:127-9. 2003
    ..DNA profiles of these vasectomized males were obtained for all six Y-STR loci, namely DYS393, DYS 19, DYS389II, DYS390, DYS391, and DYS385 amplified by using the Y-PLEX 6...
  25. ncbi request reprint The effect of vascular risk factors on penile vascular status in men with erectile dysfunction
    Muammer Kendirci
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Urol 178:2516-20; discussion 2520. 2007
    ..This study evaluates the relationship between penile hemodynamic parameters and vascular risk factors in men with erectile dysfunction...
  26. ncbi request reprint Relationship between the severity of penile curvature and the presence of comorbidities in men with Peyronie's disease
    Mustafa F Usta
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Urol 171:775-9. 2004
    ..We investigated the relationship between penile curvature severity and co-morbidities in men with Peyronie's disease (PD) and assessed whether the severity of curvature had an impact on penile vascular status and/or erectile function...
  27. ncbi request reprint T-type (alpha1G) low voltage-activated calcium channel interactions with nitric oxide-cyclic guanosine monophosphate pathway and regulation of calcium homeostasis in human cavernosal cells
    Xiangbin Zeng
    Department of Urology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Sex Med 2:620-30; discussion 630-3. 2005
    ....
  28. ncbi request reprint Functional androgen receptor confers sensitization of androgen-independent prostate cancer cells to anticancer therapy via caspase activation
    Rodney Davis
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Biochem Biophys Res Commun 309:937-45. 2003
    ....
  29. ncbi request reprint Oxidant stress and blood pressure responses to angiotensin II administration in rats fed varying salt diets
    Vladimir Pech
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Hypertens 19:534-40. 2006
    ....
  30. ncbi request reprint Gene therapy for erectile dysfunction
    Muammer Kendirci
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Front Biosci 10:2758-69. 2005
    ..Varieties of other gene therapy trials have also been undertaken for the treatment of ED and are the focus of this review...
  31. ncbi request reprint Human sperm superoxide anion generation and correlation with semen quality in patients with male infertility
    Tamer M Said
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute and Department of Obstetrics and Gynecology, The Cleveland Clinic Foundation, OH 44195, USA
    Fertil Steril 82:871-7. 2004
    ..generation in infertile men and determine whether sperm quality is correlated with levels of ROS triggered by the exogenous reduced form of beta nicotinamide adenine dinucleotide phosphate (NADPH)...
  32. ncbi request reprint Characterization of oxidative stress status by evaluation of reactive oxygen species levels in whole semen and isolated spermatozoa
    Shyam S R Allamaneni
    Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute and Department of Obstetrics Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 83:800-3. 2005
    ..The reference values of ROS in neat semen and mature spermatozoa can be used to define the pathologic levels of ROS in infertile men and may guide in therapeutic interventions...
  33. ncbi request reprint Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele
    Ramadan A Saleh
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 80:1431-6. 2003
    ..To examine levels of sperm DNA damage and oxidative stress (OS) in infertile men with varicocele...
  34. ncbi request reprint Reactive oxygen species as an independent marker of male factor infertility
    Ashok Agarwal
    Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute and Department of Obstetrics Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 86:878-85. 2006
    ..To determine the abnormal patterns of reactive oxygen species (ROS) production in male factor infertility (MFI) patients and to define the ROS reference values in such patients...
  35. ncbi request reprint Seminal characteristics and sexual behavior in men of different age groups: is there an aging effect?
    Panayiotis M Zavos
    Andrology Institute of America, P O Box 23777, Lexington, Kentucky 40523, USA
    Asian J Androl 8:337-41. 2006
    ..To assess the seminal characteristics as well as the sexual behavior of men of various age groups to establish the presence of an aging effect on those characteristics...
  36. ncbi request reprint Impact of clinical varicocele and testis size on seminal reactive oxygen species levels in a fertile population: a prospective controlled study
    Marcello Cocuzza
    Department of Urology, University of Sao Paulo, Sao Paulo, Brazil
    Fertil Steril 90:1103-8. 2008
    ....
  37. ncbi request reprint Clinical relevance of oxidative stress and sperm chromatin damage in male infertility: an evidence based analysis
    Marcello Cocuzza
    Reproductive Research Center, Glickman Urological and Kidney Institute, Department of Obstetrics Gynecology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Int Braz J Urol 33:603-21. 2007
    ..Thus evaluation of seminal ROS levels and extent of sperm DNA damage especially in an infertile male may help develop new therapeutic strategies and improve success of assisted reproductive techniques (ART)...
  38. ncbi request reprint Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility
    Xia Wang
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Department of Obsterics and Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 80:531-5. 2003
    ....
  39. ncbi request reprint Enhanced chemiluminescence assay vs colorimetric assay for measurement of the total antioxidant capacity of human seminal plasma
    Tamer M Said
    Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Androl 24:676-80. 2003
    ..98% +/- 4.1%. In conclusion, we found that the colorimetric assay is a reliable and accurate method to evaluate seminal TAC, and it could be used as a simpler, rapid, and cheaper alternative to the chemiluminescence assay...
  40. ncbi request reprint Impact of sperm morphology on DNA damage caused by oxidative stress induced by beta-nicotinamide adenine dinucleotide phosphate
    Tamer M Said
    Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, The Cleveland Clinic Foundation, Ohio 44195, USA
    Fertil Steril 83:95-103. 2005
    ..To investigate the role of DNA damage induced by beta-nicotinamide adenine dinucleotide phosphate (NADPH) in human spermatozoa...