Bin Shan

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition
    Bin Shan
    Department of Medicine and Tulane Cancer Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Biol Chem 283:21065-73. 2008
  2. pmc Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen
    Yan Zhuang
    Department of Medicine and Pathology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    J Hematol Oncol 6:35. 2013
  3. pmc Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture
    Hong T Nguyen
    Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Cancer Cell Int 13:16. 2013
  4. pmc Epstein - Barr virus Latent Membrane Protein 1 suppresses reporter activity through modulation of promyelocytic leukemia protein-nuclear bodies
    Mark D Sides
    Department of Medicine, Section of Pulmonary Disease and Critical Care, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Virol J 8:461. 2011
  5. doi The microRNA expression associated with morphogenesis of breast cancer cells in three-dimensional organotypic culture
    Hong T Nguyen
    Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Oncol Rep 28:117-26. 2012
  6. pmc Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance
    James W Antoon
    Departments of Pharmacology, Tulane University School of Medicine, Tulane Avenue, New Orleans, LA, USA
    Sci Rep 2:539. 2012
  7. pmc The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--β1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells
    Mark D Sides
    Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Respir Cell Mol Biol 44:852-62. 2011
  8. pmc Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase
    Bin Shan
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 5:e11662. 2010
  9. pmc Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells
    Mark D Sides
    Department of Medicine, Section of Pulmonary Disease and Critical Care, Tulane University School of Medicine, New Orleans, LA, USA
    Virology 416:86-97. 2011
  10. pmc MEK5/ERK5 Signaling Suppresses Estrogen Receptor Expression and Promotes Hormone-Independent Tumorigenesis
    James W Antoon
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
    PLoS ONE 8:e69291. 2013

Collaborators

Detail Information

Publications23

  1. pmc Requirement of HDAC6 for transforming growth factor-beta1-induced epithelial-mesenchymal transition
    Bin Shan
    Department of Medicine and Tulane Cancer Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Biol Chem 283:21065-73. 2008
    ..Our results identify HDAC6 as a critical regulator of EMT and a potential therapeutic target against pathological EMT, a key event for tumor progression and fibrogenesis...
  2. pmc Induction of long intergenic non-coding RNA HOTAIR in lung cancer cells by type I collagen
    Yan Zhuang
    Department of Medicine and Pathology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    J Hematol Oncol 6:35. 2013
    ..Long intergenic non-coding RNAs (lincRNA) are a new family of regulatory RNAs that modulate fundamental cellular processes via diverse mechanisms...
  3. pmc Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture
    Hong T Nguyen
    Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Cancer Cell Int 13:16. 2013
    ..These findings also indicate that rBM 3-D culture can serve as an ideal platform for swift and cost-effective screening of therapeutic candidates at the interface of the tumor and its microenvironment...
  4. pmc Epstein - Barr virus Latent Membrane Protein 1 suppresses reporter activity through modulation of promyelocytic leukemia protein-nuclear bodies
    Mark D Sides
    Department of Medicine, Section of Pulmonary Disease and Critical Care, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Virol J 8:461. 2011
    ..These data offer an explanation for previously conflicting data on LMP1 signaling and calls attention to the possibility of false-positives and false-negatives when using reporter assays as a research tool in cells expressing LMP1...
  5. doi The microRNA expression associated with morphogenesis of breast cancer cells in three-dimensional organotypic culture
    Hong T Nguyen
    Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Oncol Rep 28:117-26. 2012
    ..In summary, we provide the first miRNA signatures of morphogenesis of human breast cancer cells in rBM 3-D culture and warrant further utilization of rBM 3-D culture in investigation of miRNAs in breast cancer...
  6. pmc Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance
    James W Antoon
    Departments of Pharmacology, Tulane University School of Medicine, Tulane Avenue, New Orleans, LA, USA
    Sci Rep 2:539. 2012
    ..This first report identifying specific mechanisms underlying acquired resistance to TNF could lead to a better understanding of the progression of breast cancer in response to chemotherapy treatment...
  7. pmc The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--β1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells
    Mark D Sides
    Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Respir Cell Mol Biol 44:852-62. 2011
    ..Our in vitro data may help to explain the observation that patients with IPF demonstrating positive staining for LMP1 in lung epithelial cells have a more rapid demise than patients in whom LMP1 is not detected...
  8. pmc Thy-1 attenuates TNF-alpha-activated gene expression in mouse embryonic fibroblasts via Src family kinase
    Bin Shan
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America
    PLoS ONE 5:e11662. 2010
    ..The current study provides a novel mechanistic insight to the distinct roles of fibroblast Thy-1 subsets in inflammation...
  9. pmc Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells
    Mark D Sides
    Department of Medicine, Section of Pulmonary Disease and Critical Care, Tulane University School of Medicine, New Orleans, LA, USA
    Virology 416:86-97. 2011
    ..This study introduces an effective modality to induce susceptibility to ganciclovir in epithelial cells with implications for the treatment of EBV associated pathologies...
  10. pmc MEK5/ERK5 Signaling Suppresses Estrogen Receptor Expression and Promotes Hormone-Independent Tumorigenesis
    James W Antoon
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
    PLoS ONE 8:e69291. 2013
    ..Given the need for new clinical therapeutic targets, our results demonstrate the therapeutic potential of targeting the MEK5-ERK5 pathway in breast cancer. ..
  11. pmc Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation
    Yan Zhuang
    Department of Medicine, Tulane School of Medicine, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 392:608-13. 2010
    ..Taken together, our results implicate that expression and function of hHDAC6p114 is differentially regulated when compared to hHDAC6p131...
  12. doi KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer
    Muralidharan Anbalagan
    Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Breast Cancer Res Treat 132:391-409. 2012
    ..Combinations of KX-01 with endocrine therapy present a promising new strategy for clinical management of ERα positive breast cancer...
  13. pmc Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition
    Weichao Guo
    Biomedical Sciences Program, 1430 Tulane Ave SL 9, Tulane Medical School, New Orleans, LA 70112, USA
    Am J Physiol Lung Cell Mol Physiol 297:L864-70. 2009
    ..Together, these data demonstrate that the differentiation of NHLFs to myofibroblasts is HDAC4 dependent and requires phosphorylation of Akt...
  14. pmc Modulation of lung inflammation by the Epstein-Barr virus protein Zta
    James F Guenther
    Dept of Pathology, Tulane Univ Health Sciences Center, New Orleans, LA 70112, USA
    Am J Physiol Lung Cell Mol Physiol 299:L771-84. 2010
    ..These observations indicate that the EBV lytic transactivator protein Zta displays activity consistent with a pathogenic role in pulmonary fibrosis associated with herpesvirus infection...
  15. pmc Circadian gating of epithelial-to-mesenchymal transition in breast cancer cells via melatonin-regulation of GSK3β
    Lulu Mao
    Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Mol Endocrinol 26:1808-20. 2012
    ....
  16. pmc Human cytomegalovirus infection dysregulates the canonical Wnt/β-catenin signaling pathway
    Magdalena Angelova
    Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    PLoS Pathog 8:e1002959. 2012
    ..Given the critical role of Wnt/β-catenin signaling in cellular processes, these findings represent a novel and important mechanism whereby HCMV disrupts normal cellular function...
  17. ncbi Activation of proMMP-2 and Src by HHV8 vGPCR in human pulmonary arterial endothelial cells
    Bin Shan
    Department of Medicine, Pulmonary Section, Department of Microbiology, Tulane Cancer Center and Program in Lung Biology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    J Mol Cell Cardiol 42:517-25. 2007
    ..The current study implicates vGPCR as an etiological agent in iPAH and identifies Src and MMP-2 as potential therapeutic targets in HHV8 associated KS and iPAH...
  18. pmc Pharmacological inhibition of HDAC6 attenuates endothelial barrier dysfunction induced by thrombin
    Shigeki Saito
    Department of Medicine, Tulane Medical School, New Orleans, LA, USA
    Biochem Biophys Res Commun 408:630-4. 2011
    ..Histone deacetylase 6 (HDAC6) deacetylates α-tubulin, and thereby destabilizes microtubules. This study investigates a role for HDAC6 in EBD...
  19. ncbi Over-expression of PDGF-C using a lung specific promoter results in abnormal lung development
    Ying Zhuo
    Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Transgenic Res 15:543-55. 2006
    ..These results suggest that PDGF-C is activated during lung development and is a potent growth factor for mesenchymal cells in vivo...
  20. ncbi Binding sequence-dependent regulation of the human proliferating cell nuclear antigen promoter by p53
    Bin Shan
    Program in Molecular and Cellular Biology, Department of Pathology, Tulane Cancer Center and Tulane Xavier Center for Bioenvironmental Research, Tulane University Health Sciences Center, SL 79, 1430 Tulane Avenue, New Orleans, LA 70112 2699, USA
    Exp Cell Res 305:10-22. 2005
    ..Limited activation of the PCNA promoter by p53 and its modified forms would restrict the amount of PCNA made available for DNA repair...
  21. ncbi Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cells
    Bin Shan
    Pulmonary and Critical Care Section, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 280:1103-11. 2005
    ..Our findings indicate that CDK9 mediates TNF-alpha-induced MMP-9 transcription. Disruption of TNF-alpha signaling using CDK9 inhibitors could serve as a potential therapeutic strategy against tumor invasion and metastasis...
  22. pmc Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype
    Changhua Zhou
    Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA
    Breast Cancer Res 10:R105. 2008
    ....
  23. pmc Molecular recognition and enhancement of aqueous solubility and bioactivity of CD437 by β-cyclodextrin
    Robert J Mishur
    Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, United States
    Bioorg Med Chem Lett 21:857-60. 2011
    ....