K Sestak

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi Evaluation of rotavirus dsRNA load in specimens and body fluids from experimentally infected juvenile macaques by real-time PCR
    Wei Zhao
    Tulane National Primate Research Center, Covington, LA 70433, USA
    Virology 341:248-56. 2005
  2. ncbi Experimental inoculation of juvenile rhesus macaques with primate enteric caliciviruses
    Karol Sestak
    Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 7:e37973. 2012
  3. ncbi Improved xenobiotic metabolism and reduced susceptibility to cancer in gluten-sensitive macaques upon introduction of a gluten-free diet
    Karol Sestak
    Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 6:e18648. 2011
  4. ncbi Identification of anti-human CD antibodies reactive with rhesus macaque peripheral blood cells
    Karol Sestak
    Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Vet Immunol Immunopathol 119:21-6. 2007
  5. ncbi Defining T-cell-mediated immune responses in rotavirus-infected juvenile rhesus macaques
    K Sestak
    Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    J Virol 78:10258-64. 2004
  6. ncbi Chronic diarrhea and AIDS: insights into studies with non-human primates
    Karol Sestak
    Division of Microbiology and Immunology, Tulane National Primate Research Center, Covington, LA, and Tulane University Health Sciences Center, New Orleans, LA 70433, USA
    Curr HIV Res 3:199-205. 2005
  7. ncbi Variability among Cryptosporidium parvum genotype 1 and 2 immunodominant surface glycoproteins
    K Sestak
    Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA, USA
    Parasite Immunol 24:213-9. 2002
  8. ncbi Quantitative evaluation of Enterocytozoon bieneusi infection in simian immunodeficiency virus-infected rhesus monkeys
    K Sestak
    Tufts University School of Veterinary Medicine, North Grafton, MA, USA
    J Med Primatol 32:74-81. 2003
  9. ncbi Epidemiology of microsporidiosis: sources and modes of transmission
    E S Didier
    Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Vet Parasitol 126:145-66. 2004
  10. ncbi Visualizing cytokine-secreting cells in situ in the rhesus macaque model of chronic gut inflammation
    Geeta Ramesh
    Division of Comparative Pathology, Tulane National Primate Research Center and Tulane University Health Science Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    Clin Diagn Lab Immunol 12:192-7. 2005

Research Grants

  1. HIV and the Mucosal Immune System:New Vaccine Strategies
    Karol Sestak; Fiscal Year: 2006
  2. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2010
  3. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2009
  4. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. ncbi Evaluation of rotavirus dsRNA load in specimens and body fluids from experimentally infected juvenile macaques by real-time PCR
    Wei Zhao
    Tulane National Primate Research Center, Covington, LA 70433, USA
    Virology 341:248-56. 2005
    ..Thus, the rhesus model of rotavirus infection can be exploited further in studies with vaccine candidates designed to prevent or abrogate rotavirus infection...
  2. ncbi Experimental inoculation of juvenile rhesus macaques with primate enteric caliciviruses
    Karol Sestak
    Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 7:e37973. 2012
    ..CONCLUSIONS/SIGNIFICANCE: Taken together, our results show that ReCVs represent an alternative cell culture and animal model to study enteric calicivirus replication, pathogenesis and immunity...
  3. ncbi Improved xenobiotic metabolism and reduced susceptibility to cancer in gluten-sensitive macaques upon introduction of a gluten-free diet
    Karol Sestak
    Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 6:e18648. 2011
    ..A non-human primate (NHP) model of gluten sensitivity was employed to study the gene perturbations associated with dietary gluten changes in small intestinal tissues from gluten-sensitive rhesus macaques (Macaca mulatta)...
  4. ncbi Identification of anti-human CD antibodies reactive with rhesus macaque peripheral blood cells
    Karol Sestak
    Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Vet Immunol Immunopathol 119:21-6. 2007
    ..In addition, reference reagents known to react with rhesus macaque CD3, CD20 and CD56 were used to further characterization of the reactivity of the selected 57 mAb on peripheral blood cells...
  5. ncbi Defining T-cell-mediated immune responses in rotavirus-infected juvenile rhesus macaques
    K Sestak
    Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    J Virol 78:10258-64. 2004
    ..Further exploration of rhesus macaques in vaccine trials with human rotavirus vaccine candidates is the major objective of future studies...
  6. ncbi Chronic diarrhea and AIDS: insights into studies with non-human primates
    Karol Sestak
    Division of Microbiology and Immunology, Tulane National Primate Research Center, Covington, LA, and Tulane University Health Sciences Center, New Orleans, LA 70433, USA
    Curr HIV Res 3:199-205. 2005
    ..In this short review, the chronic diarrhea is presented from the perspective of the non-human primate or simian model of AIDS (SAIDS), and its most common opportunistic and pathogenic co-infections...
  7. ncbi Variability among Cryptosporidium parvum genotype 1 and 2 immunodominant surface glycoproteins
    K Sestak
    Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA, USA
    Parasite Immunol 24:213-9. 2002
    ..parvum genotype 1 and 2 isolates at the level of gp15. We contemplate that gp15 surface glycoprotein plays an important role in the biology of C. parvum as a potent inducer of immune response and a possible virulence factor...
  8. ncbi Quantitative evaluation of Enterocytozoon bieneusi infection in simian immunodeficiency virus-infected rhesus monkeys
    K Sestak
    Tufts University School of Veterinary Medicine, North Grafton, MA, USA
    J Med Primatol 32:74-81. 2003
    ..bieneusi DNA in feces (> or =100 spores/g) for at least three consecutive months. Increased number of E. bieneusi in feces was accompanied by decreased counts of circulating CD4+ T lymphocytes and increased SIV plasma viral load...
  9. ncbi Epidemiology of microsporidiosis: sources and modes of transmission
    E S Didier
    Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Vet Parasitol 126:145-66. 2004
    ..Strategies to capture and disinfect microsporidia in water are being developed and include filtration, coagulation, chlorination, gamma-irradiation, and ozonation...
  10. ncbi Visualizing cytokine-secreting cells in situ in the rhesus macaque model of chronic gut inflammation
    Geeta Ramesh
    Division of Comparative Pathology, Tulane National Primate Research Center and Tulane University Health Science Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    Clin Diagn Lab Immunol 12:192-7. 2005
    ....
  11. ncbi Infectious agent and immune response characteristics of chronic enterocolitis in captive rhesus macaques
    Karol Sestak
    Division of Microbiology and Immunolgy, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    Infect Immun 71:4079-86. 2003
    ..The data also suggest that chronic colitis in rhesus macaques may have potential as a model of inflammatory bowel disease in humans...
  12. ncbi A decline in CCL3-5 chemokine gene expression during primary simian-human immunodeficiency virus infection
    Wei Zhao
    Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 2:e726. 2007
    ....
  13. ncbi Single epitope mucosal vaccine delivered via immuno-stimulating complexes induces low level of immunity against simian-HIV
    Bapi Pahar
    Tulane National Primate Research Center, Covington, LA 70433, USA
    Vaccine 24:6839-49. 2006
    ..We predict that if coadministered with additional epitopes and/or more efficacious mucosal delivery system or route, HIV/SIV-derived peptide vaccines may have potential to elicit heterologous protection...
  14. ncbi Development of a rotavirus-shedding model in rhesus macaques, using a homologous wild-type rotavirus of a new P genotype
    Monica M McNeal
    Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    J Virol 79:944-54. 2005
    ..Therefore, TUCH infection of macaques provides a useful nonhuman primate model for studies on rotavirus protection...
  15. ncbi Summary of the animal homologue section of HLDA8
    Armin Saalmuller
    Clinical Immunology, Veterinary University of Vienna, Vienna, Austria
    Cell Immunol 236:51-8. 2005
    ..Our results suggest the suitability of crossreactive mAb for the animal model studies. Moreover, these findings contribute to our understanding of the evolution of the immune system...
  16. ncbi A non-human primate model for gluten sensitivity
    Michael T Bethune
    Department of Biochemistry, Stanford University, Stanford, California, USA
    PLoS ONE 3:e1614. 2008
    ..There is a growing need in fundamental and translational research for animal models that exhibit aspects of human gluten sensitivity...
  17. ncbi Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques
    Michael T Bethune
    Department of Biochemistry, Stanford University, Stanford, California, United States of America
    PLoS ONE 3:e1857. 2008
    ....
  18. ncbi Characterization of a rhesus monkey calicivirus representing a new genus of Caliciviridae
    Tibor Farkas
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Virol 82:5408-16. 2008
    ..Although the pathogenicity of TV in rhesus macaques remains to be elucidated, the likelihood of TV causing intestinal infection and the availability of a tissue culture system make this virus a valuable surrogate for human CVs...
  19. ncbi Recovery of infectious virus by transfection of in vitro-generated RNA from tulane calicivirus cDNA
    Chao Wei
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol 82:11429-36. 2008
    ..The availability of the complete genomic sequence and the reverse genetics system described herein make TV a valuable model for studying calicivirus pathogenesis and replication...
  20. ncbi Characterization of cytolethal distending toxin of campylobacter species isolated from captive macaque monkeys
    Rohana P Dassanayake
    Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA
    J Clin Microbiol 43:641-9. 2005
    ..We concluded that cytolethal distending toxin activity is a characteristic of C. jejuni. Our C. jejuni cdtB gene-specific PCR assay might be of assistance for differentiating toxigenic C. jejuni from C. coli in clinical laboratories...

Research Grants7

  1. HIV and the Mucosal Immune System:New Vaccine Strategies
    Karol Sestak; Fiscal Year: 2006
    ..Moreover, this proposed study might identify important correlates of protective immune responses that will be useful in designing effective therapeutic strategies. ..
  2. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2010
    ..We have partially characterized a model of GSE in non-human primates. We believe that such a model will be extremely useful for studies of the immunopathogenesis and treatment of CD. ..
  3. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2009
    ..We have partially characterized a model of GSE in non-human primates. We believe that such a model will be extremely useful for studies of the immunopathogenesis and treatment of CD. ..
  4. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2010
    ..abstract_text> ..