Laura Schrader

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint The other half of Hebb: K+ channels and the regulation of neuronal excitability in the hippocampus
    Laura A Schrader
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurobiol 25:51-66. 2002
  2. ncbi request reprint ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit
    Laura A Schrader
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    Am J Physiol Cell Physiol 290:C852-61. 2006
  3. pmc Kv4.2 is a locus for PKC and ERK/MAPK cross-talk
    Laura A Schrader
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Biochem J 417:705-15. 2009
  4. ncbi request reprint PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex
    Laura A Schrader
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:10123-33. 2002
  5. ncbi request reprint Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents
    Andrew W Varga
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:3643-54. 2004
  6. pmc Cage mate separation in pair-housed male rats evokes an acute stress corticosterone response
    Chantelle L Ferland
    Neuroscience Program, Tulane University, New Orleans, LA 70118, USA
    Neurosci Lett 489:154-8. 2011
  7. ncbi request reprint Regulation of surface localization of the small conductance Ca2+-activated potassium channel, Sk2, through direct phosphorylation by cAMP-dependent protein kinase
    Yajun Ren
    Cain Foundation Laboratories, Department of Pediatrics, Department of Neurology, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, 77030, USA
    J Biol Chem 281:11769-79. 2006
  8. ncbi request reprint In vivo regulation of an Aplysia glutamate transporter, ApGT1, during long-term memory formation
    Maria Sol Collado
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5001, USA
    J Neurochem 100:1315-28. 2007
  9. pmc Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells
    Carmel M McDermott
    Department of Cell and Molecular Biology, Tulane University, 6400 Freret St, New Orleans, LA 70118, USA
    J Physiol 589:3517-32. 2011
  10. pmc The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning
    Jon C Alexander
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 16:167-77. 2009

Research Grants

  1. Mechanisms of K+ Channel Modulation in Plasticity
    Laura Schrader; Fiscal Year: 2007

Collaborators

  • Mark R Bowlby
  • Li Lian Yuan
  • Hiroaki Misonou
  • A E Anderson
  • Carmel M McDermott
  • Jon C Alexander
  • J David Sweatt
  • Chantelle L Ferland
  • Maria Sol Collado
  • Yajun Ren
  • Andrew W Varga
  • Riichi Shibata
  • Claire Stelly
  • Debra Karhson
  • Vicky Rands
  • Tumay Tunur
  • W Frank An
  • Lisa C Lyons
  • Juan D Pita-Almenar
  • Omar Khabour
  • Arnold Eskin
  • Jonathan M Levenson
  • John P Adelman
  • Paul J Pfaffinger
  • Lyndon F Barnwell
  • Farah D Lubin
  • Daniel Johnston
  • Gang Yi Wu
  • Jennifer R Gatchel
  • James S Trimmer
  • Kenneth J Rhodes
  • Claire R Campomanes
  • Lisa C Doliveira
  • Karen I Carroll

Detail Information

Publications11

  1. ncbi request reprint The other half of Hebb: K+ channels and the regulation of neuronal excitability in the hippocampus
    Laura A Schrader
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurobiol 25:51-66. 2002
    ..In conclusion, we provide a model for an alternative form of coincidence detection through K+ channels in the hippocampus...
  2. ncbi request reprint ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit
    Laura A Schrader
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    Am J Physiol Cell Physiol 290:C852-61. 2006
    ..Overall these studies provide new insights into the structure-function relationships for MAPK regulation of membrane ion channels...
  3. pmc Kv4.2 is a locus for PKC and ERK/MAPK cross-talk
    Laura A Schrader
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Biochem J 417:705-15. 2009
    ..2 C-terminal sequence. We found that phosphorylation of Kv4.2 by PKC enhanced ERK phosphorylation of the channel in vitro. These findings suggest the possibility that Kv4.2 is a locus for PKC and ERK cross-talk...
  4. ncbi request reprint PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex
    Laura A Schrader
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:10123-33. 2002
    ..2-encoded A channels by PKA. Overall, our studies indicate that PKA must of necessity act on a supramolecular complex of pore-forming alpha-subunits plus ancillary subunits to alter channel properties...
  5. ncbi request reprint Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents
    Andrew W Varga
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:3643-54. 2004
    ..Thus CaMKII can directly modulate neuronal excitability by increasing cell-surface expression of A-type K(+) channels...
  6. pmc Cage mate separation in pair-housed male rats evokes an acute stress corticosterone response
    Chantelle L Ferland
    Neuroscience Program, Tulane University, New Orleans, LA 70118, USA
    Neurosci Lett 489:154-8. 2011
    ..The results of this study demonstrate that separation can induce an acute stress response in the remaining cage mate measured by increased CORT and should be considered in molecular, behavioral, and electrophysiological studies...
  7. ncbi request reprint Regulation of surface localization of the small conductance Ca2+-activated potassium channel, Sk2, through direct phosphorylation by cAMP-dependent protein kinase
    Yajun Ren
    Cain Foundation Laboratories, Department of Pediatrics, Department of Neurology, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, 77030, USA
    J Biol Chem 281:11769-79. 2006
    ..Thus, our findings suggest that PKA phosphorylation of these three sites is necessary for PKA-mediated reorganization of SK2 surface expression...
  8. ncbi request reprint In vivo regulation of an Aplysia glutamate transporter, ApGT1, during long-term memory formation
    Maria Sol Collado
    Department of Biology and Biochemistry, University of Houston, Houston, TX 77204 5001, USA
    J Neurochem 100:1315-28. 2007
    ..These results suggest that an increase in levels of ApGT1 is responsible, at least in part, for the long-term increase in glutamate uptake associated with long-term memory...
  9. pmc Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells
    Carmel M McDermott
    Department of Cell and Molecular Biology, Tulane University, 6400 Freret St, New Orleans, LA 70118, USA
    J Physiol 589:3517-32. 2011
    ..2 subunit protein at the cell surface. These results are consistent with an increase in cell excitability in response to KOR activation and may reflect new possibilities for additional opioid functions...
  10. pmc The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning
    Jon C Alexander
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 16:167-77. 2009
    ..These data suggest a role for regulation of gene expression by KChIP3/DREAM/calsenilin in consolidation of contextual fear conditioning memories...
  11. ncbi request reprint A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels
    Riichi Shibata
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 278:36445-54. 2003
    ..2 hydrophobic domain. These studies point to an essential role for KChIPs in determining both the biophysical and molecular characteristics of Kv4 channels and provide a molecular basis for the dramatic phenotype of KChIP knockout mice...

Research Grants1

  1. Mechanisms of K+ Channel Modulation in Plasticity
    Laura Schrader; Fiscal Year: 2007
    ..In addition, we will study their modulation in hippocampal neurons, assayed by biochemical and immunohistochemical techniques. ..