Affiliation: Tulane University
Garagliano J, Katsurada A, Miyata K, Derbenev A, Zsombok A, Navar L, et al
. Advanced Glycation End Products Stimulate Angiotensinogen Production in Renal Proximal Tubular Cells. Am J Med Sci. 2018;: pubmed publisher
..AGE-induced AGT augmentation was attenuated by an ERK inhibitor. The findings indicate that AGE enhances proximal tubular AGT expression via ERK1/2, which can exacerbate the development of diabetic related kidney injury. ..
Satou R, Penrose H, Navar L. Inflammation as a Regulator of the Renin-Angiotensin System and Blood Pressure. Curr Hypertens Rep. 2018;20:100 pubmed publisher
..Specifically, regulation of angiotensinogen (AGT) production by pro-inflammatory cytokines in the liver and kidney is proposed as a key mechanism underlying the progression of Ang II-dependent hypertension. ..
O Leary R, Penrose H, Miyata K, Satou R. Macrophage-derived IL-6 contributes to ANG II-mediated angiotensinogen stimulation in renal proximal tubular cells. Am J Physiol Renal Physiol. 2016;310:F1000-7 pubmed publisher
..These results demonstrate that ANG II-induced IL-6 elevation in M? enhances activation of the JAK-STAT pathway and consequent AGT upregulation in PTCs, suggesting involvement of an immune response in driving intrarenal RAS activity. ..
Satou R, Miyata K, Gonzalez Villalobos R, Ingelfinger J, Navar L, Kobori H. Interferon-? biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells. FASEB J. 2012;26:1821-30 pubmed publisher
..Thus, IFN-? biphasically regulates AGT expression in RPTCs via STAT3 activity modulated by STAT1-SOCS1 axis, suggesting the STAT1-SOCS1 axis is important in IFN-?-induced activation of the intrarenal renin-angiotensin system. ..
Satou R, Kobori H, Katsurada A, Miyata K, Navar L. Quantification of intact plasma AGT consisting of oxidized and reduced conformations using a modified ELISA. Am J Physiol Renal Physiol. 2016;311:F1211-F1216 pubmed publisher
..Furthermore, the lower availability of plasma iAGT in mice suggests that it may serve as a limiting factor in ANG I formation in this species. ..