Ryousuke Satou

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells
    Ryousuke Satou
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    FASEB J 26:1821-30. 2012
  2. pmc Intrarenal mouse renin-angiotensin system during ANG II-induced hypertension and ACE inhibition
    Romer A Gonzalez-Villalobos
    Dept of Physiology, Tulane Univ Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 298:F150-7. 2010
  3. pmc Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients
    Hiroyuki Kobori
    Department of Medicine, Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112 2699, USA
    Hypertension 53:344-50. 2009
  4. pmc Activation of reactive oxygen species and the renin-angiotensin system in IgA nephropathy model mice
    Naro Ohashi
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Clin Exp Pharmacol Physiol 36:509-15. 2009
  5. pmc Role of activated intrarenal reactive oxygen species and renin-angiotensin system in IgA nephropathy model mice
    Naro Ohashi
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Clin Exp Pharmacol Physiol 36:750-5. 2009
  6. pmc IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells
    Ryousuke Satou
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Mol Cell Endocrinol 311:24-31. 2009
  7. pmc Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension
    Romer A Gonzalez-Villalobos
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112, USA
    Hypertension 53:351-5. 2009
  8. pmc Intrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice
    Romer A Gonzalez-Villalobos
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 295:F772-9. 2008
  9. pmc Determination of plasma and urinary angiotensinogen levels in rodents by newly developed ELISA
    Hiroyuki Kobori
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Am J Physiol Renal Physiol 294:F1257-63. 2008
  10. pmc Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis
    Maki Urushihara
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Hypertension 57:586-93. 2011

Collaborators

Detail Information

Publications24

  1. pmc Interferon-γ biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells
    Ryousuke Satou
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    FASEB J 26:1821-30. 2012
    ..Thus, IFN-γ biphasically regulates AGT expression in RPTCs via STAT3 activity modulated by STAT1-SOCS1 axis, suggesting the STAT1-SOCS1 axis is important in IFN-γ-induced activation of the intrarenal renin-angiotensin system...
  2. pmc Intrarenal mouse renin-angiotensin system during ANG II-induced hypertension and ACE inhibition
    Romer A Gonzalez-Villalobos
    Dept of Physiology, Tulane Univ Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 298:F150-7. 2010
    ....
  3. pmc Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients
    Hiroyuki Kobori
    Department of Medicine, Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112 2699, USA
    Hypertension 53:344-50. 2009
    ....
  4. pmc Activation of reactive oxygen species and the renin-angiotensin system in IgA nephropathy model mice
    Naro Ohashi
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Clin Exp Pharmacol Physiol 36:509-15. 2009
    ..4. The data suggest that both ROS and the RAS are activated at an early phase in IgA nephropathy model mice...
  5. pmc Role of activated intrarenal reactive oxygen species and renin-angiotensin system in IgA nephropathy model mice
    Naro Ohashi
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112 2699, USA
    Clin Exp Pharmacol Physiol 36:750-5. 2009
    ..4. These data suggest that intrarenal ROS and RAS activation play a pivotal role in the development of IgA nephropathy model mice, from the early phase, independent of blood pressure...
  6. pmc IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells
    Ryousuke Satou
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Mol Cell Endocrinol 311:24-31. 2009
    ..STAT3 phosphorylation (366+/-55% at 30min) and translocation were enhanced by IL-6. The AGT augmentation was attenuated by a STAT3 inhibitor. These data indicate that IL-6 increases AGT expression via STAT3 pathway in RPTEC...
  7. pmc Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension
    Romer A Gonzalez-Villalobos
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112, USA
    Hypertension 53:351-5. 2009
    ....
  8. pmc Intrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice
    Romer A Gonzalez-Villalobos
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 295:F772-9. 2008
    ....
  9. pmc Determination of plasma and urinary angiotensinogen levels in rodents by newly developed ELISA
    Hiroyuki Kobori
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Am J Physiol Renal Physiol 294:F1257-63. 2008
    ..The development of rodent angiotensinogen ELISA allows quantitative comparisons in mouse and rat angiotensinogen levels in models of hypertension and cardiovascular and kidney diseases...
  10. pmc Addition of angiotensin II type 1 receptor blocker to CCR2 antagonist markedly attenuates crescentic glomerulonephritis
    Maki Urushihara
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Hypertension 57:586-93. 2011
    ..Moreover, our results demonstrate that inhibition of the MCP-1/CCR2 pathway with a combination of ARB effectively reduces renal injury in anti-GBM nephritis...
  11. pmc Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice
    Hiroyuki Kobori
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112 2699, USA
    Am J Physiol Renal Physiol 293:F938-45. 2007
    ..These data indicate for the first time that the selective stimulation of intrarenal production of ANG II from hAGT augments endogenous intrarenal mAGT mRNA and protein expression...
  12. pmc Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion
    Romer A Gonzalez-Villalobos
    Departments of Physiology and Hypertension, Renal Center, Tulane University School of Medicine, New Orleans, Louisiana, USA
    J Am Soc Nephrol 22:449-59. 2011
    ..These findings suggest that intrarenal ACE-derived angiotensin II formation, even in the absence of systemic ACE, increases kidney angiotensin II levels and promotes the development of hypertension...
  13. pmc Tumor necrosis factor-{alpha} suppresses angiotensinogen expression through formation of a p50/p50 homodimer in human renal proximal tubular cells
    Ryousuke Satou
    Department of Medicine and Physiology, Molecular Core in Hypertension and Renal Center of Excellence, Tulane Univ Health Sciences Center, 1430 Tulane Ave, No SL39 M720, New Orleans, LA 70112, USA
    Am J Physiol Cell Physiol 299:C750-9. 2010
    ..These results indicate that TNF-α suppresses AGT expression through p50/p50 homodimer formation in human RPTCs, suggesting a possible counteracting mechanism that limits excessive intrarenal AGT production...
  14. pmc ROCK/NF-κB axis-dependent augmentation of angiotensinogen by angiotensin II in primary-cultured preglomerular vascular smooth muscle cells
    Kayoko Miyata
    Dept of Physiology and Hypertension and Renal Center of Excellence, Tulane Univ Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112 2699
    Am J Physiol Renal Physiol 306:F608-18. 2014
    ..These results indicate that ROCK is involved in NF-κB activation and the ROCK/NF-κB axis contributes to ANG II-induced AGT upregulation, leading to intracellular ANG II augmentation. ..
  15. pmc Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension
    L Gabriel Navar
    Department of Physiology and the Hypertension and Renal Center of Excellence, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, USA
    Curr Opin Pharmacol 11:180-6. 2011
    ..The catalytic actions of renin and prorenin are enhanced by prorenin receptors (PRRs) on the intercalated cells. The resultant increased intrarenal Ang II levels contribute to the genesis of chronic hypertension...
  16. pmc Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats
    Minolfa C Prieto
    Department of Physiology and Hypertension and Renal Center, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Am J Physiol Renal Physiol 300:F749-55. 2011
    ....
  17. pmc Costimulation with angiotensin II and interleukin 6 augments angiotensinogen expression in cultured human renal proximal tubular cells
    Ryousuke Satou
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Am J Physiol Renal Physiol 295:F283-9. 2008
    ..The present study indicates that IL-6 plays an important role in ANG II-mediated augmentation of AGT expression in human renal proximal tubular cells...
  18. pmc Glomerular angiotensinogen is induced in mesangial cells in diabetic rats via reactive oxygen species--ERK/JNK pathways
    Naro Ohashi
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Hypertens Res 33:1174-81. 2010
    ....
  19. pmc The sodium-activated sodium channel is expressed in the rat kidney thick ascending limb and collecting duct cells and is upregulated during high salt intake
    Lucienne S Lara
    Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 303:F105-9. 2012
    ....
  20. pmc Urinary angiotensinogen as a potential biomarker of severity of chronic kidney diseases
    Hiroyuki Kobori
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    J Am Soc Hypertens 2:349-54. 2008
    ..8801 +/- 0.0885 vs. 0.9417 +/- 0.1048; P = .0024). These data confirmed our earlier report and showed that a new ELISA assay is a valid approach for measuring urinary AGT...
  21. pmc Novel sandwich ELISA for human angiotensinogen
    Akemi Katsurada
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Ave, SL39, New Orleans, LA 70112 2699, USA
    Am J Physiol Renal Physiol 293:F956-60. 2007
    ..This hAGT ELISA will be a useful tool to investigate the relationship of U(AGT) and reactivity to antihypertensive drugs in hypertensive patients...
  22. pmc Contribution of a nuclear factor-kappaB binding site to human angiotensinogen promoter activity in renal proximal tubular cells
    Omar W Acres
    Department of Medicine and Physiology, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Hypertension 57:608-13. 2011
    ..DNA binding levels of NF-κB protein were reduced in M1. These data demonstrate the functional importance of an NF-κB binding site in the hAGT promoter region, which contributes to hAGT promoter activity in human RPTCs...
  23. pmc Enhanced intrarenal oxidative stress and angiotensinogen in IgA nephropathy patients
    Hiroyuki Kobori
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Biochem Biophys Res Commun 358:156-63. 2007
    ....