ZUBAIDA R SAIFUDEEN
Affiliation: Tulane University
El Dahr S, Saifudeen Z. Epigenetic regulation of renal development. Semin Cell Dev Biol. 2018;: pubmed publisher
..These technological advances will provide an unprecedented view of the enhancer landscape during cell fate commitment and help in defining the complex transcriptional networks governing kidney development and disease. ..
Li Y, Liu J, Li W, Brown A, Baddoo M, Li M, et al
. p53 Enables metabolic fitness and self-renewal of nephron progenitor cells. Development. 2015;142:1228-41 pubmed publisher
..In summary, our data indicate a novel role for p53 in enabling the metabolic fitness and self-renewal of nephron progenitors. ..
Saifudeen Z, Dipp S, Stefkova J, Yao X, Lookabaugh S, El Dahr S. p53 regulates metanephric development. J Am Soc Nephrol. 2009;20:2328-37 pubmed publisher
..In summary, our data lend support for a restrictive role for p53 activity in UB outgrowth from the WD. ..
Saifudeen Z, Liu J, Dipp S, Yao X, Li Y, McLaughlin N, et al
. A p53-Pax2 pathway in kidney development: implications for nephrogenesis. PLoS ONE. 2012;7:e44869 pubmed publisher
..We propose that the cross-talk between p53 and Pax2 provides a transcriptional platform that promotes nephrogenesis, thus contributing to nephron endowment. ..
Saifudeen Z. Tissue-Specific Functions of p53 During Kidney Development. Results Probl Cell Differ. 2017;60:111-136 pubmed publisher
..Defining the molecular networks targeted by p53 in the NPC may well provide new targets not only for regenerative medicine but also for cancer treatment. ..
Liu J, Edgington Giordano F, Dugas C, Abrams A, Katakam P, Satou R, et al
. Regulation of Nephron Progenitor Cell Self-Renewal by Intermediary Metabolism. J Am Soc Nephrol. 2017;28:3323-3335 pubmed publisher
..Our findings suggest that glycolysis is a pivotal, cell-intrinsic determinant of NPC fate, with a high glycolytic flux supporting self-renewal and inhibition of glycolysis stimulating differentiation. ..