Research Topics
Species | Lyndsay V RhodesSummaryAffiliation: Tulane University Country: USA Publications
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Detail Information
Publications
Effects of SDF-1-CXCR4 signaling on microRNA expression and tumorigenesis in estrogen receptor-alpha (ER-α)-positive breast cancer cellsLyndsay V Rhodes
Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
Exp Cell Res 317:2573-81. 2011..These findings represent future potential therapeutic targets for the treatment of hormone-independent and endocrine-resistant breast cancer...- Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalkLyndsay V Rhodes
Department of Medicine, Section of Haematology and Medical Oncology, Tulane University Health Science Centre, New Orleans, Louisiana, USA
Mol Cancer 9:295. 2010..Therefore, we set out to investigate the impact of hMSCs on the oestrogen receptor positive, hormone-dependent breast carcinoma cell line MCF-7... - Endocrine disruptor regulation of microRNA expression in breast carcinoma cellsSyreeta L Tilghman
Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana, United States of America
PLoS ONE 7:e32754. 2012..Given the important implications of EDC-regulated ER function, we sought to define the effects of BPA and DDT on microRNA regulation and expression levels in estrogen-responsive human breast cancer cells... 
Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancerJames W Antoon
Tulane Department of Pharmacology Section of Hematology and Medical Oncology, Tulane Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, SL 83, New Orleans, Louisiana 70112, USA
J Mol Endocrinol 46:205-16. 2011..This inhibitor binds the ER directly in the antagonist ligand-binding domain. Taken together, our results suggest that SKIs have the ability to act as novel ER signaling inhibitors in breast carcinoma...- Targeting triple-negative breast cancer cells with the histone deacetylase inhibitor panobinostatChandra R Tate
Department of Medicine, Section of Hematology and Medical Oncology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
Breast Cancer Res 14:R79. 2012..Here, we investigate the ability of the histone deacetylase inhibitor panobinostat (LBH589) to selectively target triple-negative breast cancer (TNBC) cell proliferation and survival in vitro and tumorigenesis in vivo... - Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistanceJames W Antoon
Departments of Pharmacology, Tulane University School of Medicine, Tulane Avenue, New Orleans, LA, USA
Sci Rep 2:539. 2012..This first report identifying specific mechanisms underlying acquired resistance to TNF could lead to a better understanding of the progression of breast cancer in response to chemotherapy treatment... - Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cellsQuan Jiang
Department of Chemistry, Xavier University of Louisiana, New Orleans, Louisiana 70125, USA
J Med Chem 53:6153-63. 2010..The most effective analogue, 2, was found to reduce in vivo estrogen stimulated MCF-7 cell tumorigenesis using a xenograft mouse model... - Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migrationChanghua Zhou
Department of Chemistry, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA
Breast Cancer Res 14:R45. 2012..This study was undertaken to investigate the global proteomic alterations in a tamoxifen resistant MCF-7 breast cancer cell line obtained by long term treatment of the wild type MCF-7 cell line with 4-hydroxytamoxifen (4-OH Tam)... - The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cellsLyndsay V Rhodes
Department of Medicine, Section of Hematology and Medical Oncology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Oncol Rep 27:10-6. 2012..This activity is correlated with TSA alteration of microRNA expression profiles indicative of a less aggressive phenotype... - Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancerLyndsay V Rhodes
Department of Medicine, Section of Hematology and Medical Oncology, Center for Bioenvironmental Research, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Cancer Res 71:603-13. 2011..Our findings highlight CXCR4 signaling as a rational therapeutic target for the treatment of ER-positive, estrogen-independent breast carcinomas needing improved clinical management... - Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640James W Antoon
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
Endocrinology 151:5124-35. 2010.... - Insulin-like growth factor-1 signaling regulates miRNA expression in MCF-7 breast cancer cell lineElizabeth C Martin
Department of Medicine Section of Hematology and Medical Oncology, Tulane University, New Orleans, LA, USA
PLoS ONE 7:e49067. 2012..Taken together, these data give new insights into mechanisms governing IGF-1 signaling in breast cancer... - Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independenceLyndsay V Rhodes
Department of Medicine, Section of Hematology and Medical Oncology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Breast Cancer Res Treat 121:293-300. 2010..This tumor stroma-cell interaction may provide a novel target for the treatment of estrogen receptor-positive, hormone-independent, and endocrine-resistant breast carcinoma... - Phytoalexins, miRNAs and breast cancer: a review of phytochemical-mediated miRNA regulation in breast cancerSyreeta L Tilghman
Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA
J Health Care Poor Underserved 24:36-46. 2013..This review will discuss how dietary intake of natural products, by regulating specific miRNAs, contribute to the prevention and treatment of breast cancer... - In vitro and in vivo evaluation of novel anticancer agents in triple negative breast cancer modelsKiTani Parker Johnson
Division of Basic Pharmaceutical Sciences, Xavier University of Louisiana, School of Pharmacy, 1 Drexel Drive, New Orleans, LA 70125, USA
J Health Care Poor Underserved 24:104-11. 2013..DJ52 at 50 mg/kg caused significant decrease in tumor volume (p value <.05) by nearly 50% compared with the control with vehicle alone. These data suggest that DJ52 has merit for further evaluation as a novel anticancer agent... - Inhibition of p38 mitogen-activated protein kinase alters microRNA expression and reverses epithelial-to-mesenchymal transitionJames W Antoon
Department of Medicine, Section of Hematology and Medical Oncology, Tulane University School of Medicine, New Orleans, LA 70112, USA
Int J Oncol 42:1139-50. 2013.... - Human uterine smooth muscle and leiomyoma cells differ in their rapid 17beta-estradiol signaling: implications for proliferationErica N Nierth-Simpson
Center for Bioenvironmental Research, Tulane University, New Orleans, Louisiana, USA
Endocrinology 150:2436-45. 2009..These studies demonstrate that rapid E2-signaling pathways contribute to the promotion of leiomyomas...