M T Philipp

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc A decline in C6 antibody titer occurs in successfully treated patients with culture-confirmed early localized or early disseminated Lyme Borreliosis
    Mario T Philipp
    Department of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    Clin Diagn Lab Immunol 12:1069-74. 2005
  2. ncbi request reprint Antibody response to IR6, a conserved immunodominant region of the VlsE lipoprotein, wanes rapidly after antibiotic treatment of Borrelia burgdorferi infection in experimental animals and in humans
    M T Philipp
    Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    J Infect Dis 184:870-8. 2001
  3. pmc Serologic evaluation of patients from Missouri with erythema migrans-like skin lesions with the C6 Lyme test
    Mario T Philipp
    Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 13:1170-1. 2006
  4. ncbi request reprint Experimental infection of rhesus macaques with Streptococcus pneumoniae: a possible model for vaccine assessment
    Mario T Philipp
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    J Med Primatol 35:113-22. 2006
  5. ncbi request reprint The outer surface protein A (OspA) vaccine against Lyme disease: efficacy in the rhesus monkey
    M T Philipp
    Tulane University Medical Center, Tulane Regional Primate Research Center, Covington, LA, USA
    Vaccine 15:1872-87. 1997
  6. pmc C6 test as an indicator of therapy outcome for patients with localized or disseminated lyme borreliosis
    Mario T Philipp
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    J Clin Microbiol 41:4955-60. 2003
  7. pmc C-terminal invariable domain of VlsE may not serve as target for protective immune response against Borrelia burgdorferi
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 69:1337-43. 2001
  8. pmc C-terminal invariable domain of VlsE is immunodominant but its antigenicity is scarcely conserved among strains of Lyme disease spirochetes
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 69:3224-31. 2001
  9. pmc Characterization of a Borrelia burgdorferi VlsE invariable region useful in canine Lyme disease serodiagnosis by enzyme-linked immunosorbent assay
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    J Clin Microbiol 38:4160-6. 2000
  10. pmc Borrelia burgdorferi antigens that are targeted by antibody-dependent, complement-mediated killing in the rhesus monkey
    M K Aydintug
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Medical Center, Covington, Louisiana 70433
    Infect Immun 62:4929-37. 1994

Collaborators

Detail Information

Publications48

  1. pmc A decline in C6 antibody titer occurs in successfully treated patients with culture-confirmed early localized or early disseminated Lyme Borreliosis
    Mario T Philipp
    Department of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    Clin Diagn Lab Immunol 12:1069-74. 2005
    ..0001). These results indicate that a decline in anti-C(6) antibody titer coincides with effective antimicrobial therapy in patients with early localized or early disseminated Lyme borreliosis...
  2. ncbi request reprint Antibody response to IR6, a conserved immunodominant region of the VlsE lipoprotein, wanes rapidly after antibiotic treatment of Borrelia burgdorferi infection in experimental animals and in humans
    M T Philipp
    Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    J Infect Dis 184:870-8. 2001
    ..burgdorferi infection has been eliminated...
  3. pmc Serologic evaluation of patients from Missouri with erythema migrans-like skin lesions with the C6 Lyme test
    Mario T Philipp
    Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 13:1170-1. 2006
    ..The C6 test is negative in patients with STARI, providing further evidence that B. burgdorferi is not the etiologic agent of this disease...
  4. ncbi request reprint Experimental infection of rhesus macaques with Streptococcus pneumoniae: a possible model for vaccine assessment
    Mario T Philipp
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    J Med Primatol 35:113-22. 2006
    ..We explored the possibility of using normal adult rhesus macaques for the preclinical assessment of safety, immunogenicity, and efficacy of newly developed vaccines against Streptococcus pneumoniae infection of the lung...
  5. ncbi request reprint The outer surface protein A (OspA) vaccine against Lyme disease: efficacy in the rhesus monkey
    M T Philipp
    Tulane University Medical Center, Tulane Regional Primate Research Center, Covington, LA, USA
    Vaccine 15:1872-87. 1997
    ..The post-mortem immunohistochemical and polymerase chain reaction analyses, however, suggest that these monkeys may have undergone a low-level infection that was transient...
  6. pmc C6 test as an indicator of therapy outcome for patients with localized or disseminated lyme borreliosis
    Mario T Philipp
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    J Clin Microbiol 41:4955-60. 2003
    ..0003). These results suggest that a change in the anti-C(6) antibody titer may serve as an indicator of therapy outcome for patients with localized or disseminated Lyme borreliosis...
  7. pmc C-terminal invariable domain of VlsE may not serve as target for protective immune response against Borrelia burgdorferi
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 69:1337-43. 2001
    ..We concluded that the C-terminal invariable domain was exposed at the antigen's surface but not at the surface of either cultured or in vivo spirochetes and thus cannot elicit protection against B. burgdorferi infection...
  8. pmc C-terminal invariable domain of VlsE is immunodominant but its antigenicity is scarcely conserved among strains of Lyme disease spirochetes
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 69:3224-31. 2001
    ..In contrast, antibody to the more conserved invariable region IR(6) of VlsE was present in all of these dog and human serum samples...
  9. pmc Characterization of a Borrelia burgdorferi VlsE invariable region useful in canine Lyme disease serodiagnosis by enzyme-linked immunosorbent assay
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    J Clin Microbiol 38:4160-6. 2000
    ..Therefore, this C(6) ELISA was both sensitive and specific for the serodiagnosis of canine Lyme disease and could be used with vaccinated dogs...
  10. pmc Borrelia burgdorferi antigens that are targeted by antibody-dependent, complement-mediated killing in the rhesus monkey
    M K Aydintug
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Medical Center, Covington, Louisiana 70433
    Infect Immun 62:4929-37. 1994
    ..First, both OspA and OspB are targeted by the ADCK mechanism in the rhesus monkey. Second, one or more B. burgdorferi surface antigens that are neither OspA nor OspB also participate in ADCK...
  11. pmc Analysis of Borrelia burgdorferi vlsE gene expression and recombination in the tick vector
    K J Indest
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 69:7083-90. 2001
    ..burgdorferi clones derived from a mouse that was infected with B31-5A3 capillary-fed nymphs showed considerable recombination. It follows that vlsE recombination does not occur in the tick vector...
  12. ncbi request reprint Pathogenesis of Lyme neuroborreliosis: mitogen-activated protein kinases Erk1, Erk2, and p38 in the response of astrocytes to Borrelia burgdorferi lipoproteins
    Geeta Ramesh
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Neurosci Lett 384:112-6. 2005
    ..MAPK inhibition thus may be considered as a strategy to control inflammation and apoptosis in Lyme neuroborreliosis...
  13. pmc Autocrine and exocrine regulation of interleukin-10 production in THP-1 cells stimulated with Borrelia burgdorferi lipoproteins
    Guillermo H Giambartolomei
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 70:1881-8. 2002
    ..Moreover, the regulation of its production with lipoprotein as a stimulant is indistinguishable from that observed when LPS acts as a stimulant...
  14. pmc Killing of Borrelia burgdorferi by antibody elicited by OspA vaccine is inefficient in the absence of complement
    J M Nowling
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Medical Center, Covington, Louisiana 70433, USA
    Infect Immun 67:443-5. 1999
    ..The relative inefficiency of the complement-independent killing mechanism by anti-OspA antibody may explain why OspA vaccine efficacy is critically dependent on antibody titer...
  15. pmc Cryptic and exposed invariable regions of VlsE, the variable surface antigen of Borrelia burgdorferi sl
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Medical Center, Covington, Louisiana 70433, USA
    J Bacteriol 182:3597-601. 2000
    ..However, negative surface immunofluorescence and in vitro antibody-mediated killing results indicated that none of the IRs were accessible to antibody at the spirochetal surface in vitro...
  16. pmc Borrelia burgdorferi escape mutants that survive in the presence of antiserum to the OspA vaccine are killed when complement is also present
    M Sole
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Medical Center, Covington, Louisiana 70433, USA
    Infect Immun 66:2540-6. 1998
    ..On the other hand, if the killing of B. burgdorferi with anti-OspA antibody also takes place within the human host, then our results indicate that chimeric/deletion escape mutants will be killed as well...
  17. ncbi request reprint Borrelia burgdorferi stimulates in vitro a selective expansion of CD3-CD4-CD8- (triple negative) autoreactive cells in naive rhesus monkey lymphocytes
    F Ganapamo
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Infect Dis 183:1221-8. 2001
    ..These cells both proliferated and produced IL-6 when cocultured with APCs alone. The possible relevance of these cells to Lyme disease pathogenesis remains to be determined...
  18. pmc Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis
    Geeta Ramesh
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA
    Am J Pathol 173:1415-27. 2008
    ..burgdorferi. These results provide proof of concept for our hypothesis that B. burgdorferi produces inflammatory mediators in the central nervous system, accompanied by glial and neuronal apoptosis...
  19. pmc An immune evasion mechanism for spirochetal persistence in Lyme borreliosis
    Fang Ting Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Exp Med 195:415-22. 2002
    ..OspC-expressing spirochetes reappeared in SCID mice after the anti-OspC antibody was eliminated. We submit that selection of surface-antigen nonexpressers is an immune evasion mechanism that contributes to spirochetal persistence...
  20. ncbi request reprint Pathogenesis of Lyme neuroborreliosis: Borrelia burgdorferi lipoproteins induce both proliferation and apoptosis in rhesus monkey astrocytes
    Geeta Ramesh
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    Eur J Immunol 33:2539-50. 2003
    ..Our results provide proof of the principle that spirochetal lipoproteins could be key virulence factors in Lyme neuroborreliosis, and that astrogliosis might contribute to neuroborreliosis pathogenesis...
  21. pmc The failure of immune response evasion by linear plasmid 28-1-deficient Borrelia burgdorferi is attributable to persistent expression of an outer surface protein
    Monica E Embers
    Divisions of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 76:3984-91. 2008
    ..These findings indicate that incomplete repression of OspC by lp28-1(-) organisms renders them susceptible to immune-mediated clearance. The lp28-1 plasmid must harbor one or more genes involved in OspC downregulation...
  22. pmc Toll-like receptors: insights into their possible role in the pathogenesis of lyme neuroborreliosis
    Andrea L F Bernardino
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University, Covington, Louisiana 70433, USA
    Infect Immun 76:4385-95. 2008
    ..burgdorferi. The proinflammatory molecules elicited by these TLR-mediated responses could be a significant factor in the pathogenesis of Lyme neuroborreliosis...
  23. pmc A rhesus macaque model of Streptococcus pneumoniae carriage
    M T Philipp
    Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA
    J Med Primatol 41:60-6. 2012
    ..Elucidation of procedures to prevent or eradicate nasopharyngeal carriage in a model akin to the human would help to diminish the incidence of both pneumonia and invasive pneumococcal disease...
  24. ncbi request reprint Borrelia burgdorferi possesses a collagenolytic activity
    D J Grab
    Department of Parasitology, Tulane Regional Primate Research Center TRPRC, Covington, LA USA
    FEMS Microbiol Lett 144:39-45. 1996
    ..We propose that the collagenolytic activity of B. burgdorferi has a role in invasion, in the pathogenesis of Lyme arthritis, and perhaps also in other manifestations of Lyme borreliosis...
  25. pmc Dominant epitopes of the C6 diagnostic peptide of Borrelia burgdorferi are largely inaccessible to antibody on the parent VlsE molecule
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 14:931-6. 2007
    ..5%. These findings indicate that IR6 epitopes are largely concealed from the VlsE molecular surface and that full-length VlsE-based diagnosis likely detects antibodies to conformational and/or variable region epitopes...
  26. ncbi request reprint Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    FEMS Immunol Med Microbiol 50:421-9. 2007
    ..These observations, together with the recovery of cultivable spirochetes from tissue of one animal at 98 weeks postinoculation, challenge the notion that the rabbit cannot harbour a long-term B. burgdorferi infection...
  27. pmc Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppressors of cytokine signaling 1 and 3
    Vida A Dennis
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    Infect Immun 74:5780-9. 2006
    ..Our data are evidence to suggest that expression of SOCS is part of the mechanism of IL-10-mediated inhibition of inflammatory cytokines elicited by B. burgdorferi and its lipoproteins...
  28. pmc Live Borrelia burgdorferi spirochetes elicit inflammatory mediators from human monocytes via the Toll-like receptor signaling pathway
    Vida A Dennis
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    Infect Immun 77:1238-45. 2009
    ..burgdorferi spirochetes and furthermore suggest that the TLR-dependent interaction between these cells and live spirochetes is mediated by spirochetal lipoproteins but not by flagellin...
  29. pmc The antibiotics doxycycline and minocycline inhibit the inflammatory responses to the Lyme disease spirochete Borrelia burgdorferi
    Andrea L F Bernardino
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA
    J Infect Dis 199:1379-88. 2009
    ..Functionally, phosphorylation of IkappaBalpha and binding of NF-kappaB to target DNA were both reduced in these cells. Our results suggest that tetracyclines may have a dual therapeutic effect in Lyme disease...
  30. ncbi request reprint Differential acquired immune responsiveness to bacterial lipoproteins in Lyme disease-resistant and -susceptible mouse strains
    Frédéric Ganapamo
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Eur J Immunol 33:1934-40. 2003
    ..An investigation of the determinants of these two phenomena could be used as a blueprint to elucidate the pathogenesis of Lyme disease in humans...
  31. pmc Possible role of glial cells in the onset and progression of Lyme neuroborreliosis
    Geeta Ramesh
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Covington, LA, USA
    J Neuroinflammation 6:23. 2009
    ..This inflammatory context could potentiate glial and neuronal apoptosis...
  32. pmc Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells
    Tereance A Myers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Louisiana, United States of America
    PLoS Pathog 5:e1000659. 2009
    ..If, as we hypothesized, neuronal apoptosis is the key pathogenic event in Lyme neuroborreliosis, then targeting microglial responses may be a significant therapeutic approach for the treatment of this form of Lyme disease...
  33. doi request reprint Characterization of a Moraxella species that causes epistaxis in macaques
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA, USA
    Vet Microbiol 147:367-75. 2011
    ..The nasopharyngeal isolates in this study appear uniquely adapted to a macaque host and, though they share many of the phenotypic characteristics of M. catarrhalis, appear to form a genotypically distinct species...
  34. pmc Borrelia burgdorferi spirochetes that harbor only a portion of the lp28-1 plasmid elicit antibody responses detectable with the C6 test for Lyme disease
    Monica E Embers
    Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 14:90-3. 2007
    ..These findings demonstrate that diagnosis by C6 ELISA remains effective for infection with all B. burgdorferi genotypes, including those with incomplete lp28-1 plasmids...
  35. ncbi request reprint CD19(+) cells produce IFN-gamma in mice infected with Borrelia burgdorferi
    F Ganapamo
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    Eur J Immunol 31:3460-8. 2001
    ..We discuss this novel phenomenon in terms of its possible underlying mechanisms and its relevance, both in the context of the immunology of Lyme disease and that of other infectious diseases...
  36. ncbi request reprint Ixodes scapularis ticks (Acari: Ixodidae) from Louisiana are competent to transmit Borrelia burgdorferi, the agent of Lyme borreliosis
    Mary B Jacobs
    Division of Bacteriology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Med Entomol 40:964-7. 2003
    ..The resulting engorged larvae harbored spirochetes. We have demonstrated that the I. scapularis ticks found in Louisiana are fully competent to carry and transmit B. burgdorferi infection...
  37. ncbi request reprint Survival strategies of Borrelia burgdorferi, the etiologic agent of Lyme disease
    Monica E Embers
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    Microbes Infect 6:312-8. 2004
    ..Here we critically review the supporting evidence for possible stratagems utilized by Borrelia burgdorferi, the spirochete that causes Lyme disease, to persist in the mammalian host...
  38. pmc Assessment of the nasopharyngeal bacterial flora of rhesus macaques: moraxella, Neisseria, haemophilus, and other genera
    Lisa C Bowers
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana GlaxoSmithKline Biologicals, Rixensart, Belgium
    J Clin Microbiol 40:4340-2. 2002
    ..Moreover, in view of the susceptibility of macaques to organisms of the Haemophilus and Neisseria genera, it is possible that these animals may also accurately model nontypeable H. influenzae and N. meningitidis infections...
  39. pmc Infectivity of the highly transformable BBE02- lp56- mutant of Borrelia burgdorferi, the Lyme disease spirochete, via ticks
    Mary B Jacobs
    Division of Bacteriology, Veterinary Medicine, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 74:3678-81. 2006
    ..Importantly, however, the absence of lp56 and BBE02 did not detectably influence infectivity to mice via ticks...
  40. pmc Closing the phenotypic gap between transformed neuronal cell lines in culture and untransformed neurons
    Tereance A Myers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Neurosci Methods 174:31-41. 2008
    ..These results demonstrate that a 3D culture approach narrows the phenotypic gap between neuronal cell lines and primary neurons. The resulting cells may readily be used for in vitro research of neuronal pathogenesis...
  41. pmc Evaluation of the C6 peptide enzyme-linked immunosorbent assay for individuals vaccinated with the recombinant OspA vaccine
    Adriana R Marques
    Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Microbiol 40:2591-3. 2002
    ..The C6 peptide ELISA can be used to diagnose Lyme disease in patients who have received the OspA vaccine...
  42. ncbi request reprint Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates
    Rendi Murphree Bacon
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    J Infect Dis 187:1187-99. 2003
    ..burgdorferi in patients with acute erythema migrans. In later stages of Lyme disease, the sensitivities of the in parallel tests and 2-tiered testing were high and statistically equivalent...
  43. pmc Tripalmitoyl-S-glyceryl-cysteine-dependent OspA vaccination of toll-like receptor 2-deficient mice results in effective protection from Borrelia burgdorferi challenge
    Alyson Yoder
    Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA
    Infect Immun 71:3894-900. 2003
    ..These findings indicate that the Pam(3)Cys modification of bacterial lipoprotein has adjuvant properties independent of TLR2 signaling...
  44. pmc Detection of immune complexes is not independent of detection of antibodies in Lyme disease patients and does not confirm active infection with Borrelia burgdorferi
    Adriana R Marques
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1888, USA
    Clin Diagn Lab Immunol 12:1036-40. 2005
    ..burgdorferi in PEG-IC preparations is not more likely to reflect active infection than testing in unprocessed serum and should not be used in individuals who received the OspA vaccine...
  45. ncbi request reprint Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus
    Guillermo H Giambartolomei
    Instituto de Estudios de la Inmunidad Humoral Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    J Immunol 173:4635-42. 2004
    ..We submit that LPS is not the cause of inflammation in brucellosis; rather, lipoproteins of this organism trigger the production of proinflammatory cytokines, and TLR2 is involved in this process...
  46. pmc Dogs vaccinated with common Lyme disease vaccines do not respond to IR6, the conserved immunodominant region of the VlsE surface protein of Borrelia burgdorferi
    Thomas P O'Connor
    Department of Research and Development, IDEXX Laboratories, One IDEXX Dr, Westbrook, ME 04092, USA
    Clin Diagn Lab Immunol 11:458-62. 2004
    ..All serum specimens were uniformly nonreactive in the C(6) peptide immunoenzyme procedures at all time points throughout the study...
  47. pmc Borrelia burgdorferi transcriptome in the central nervous system of non-human primates
    Sukanya Narasimhan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:15953-8. 2003
    ..burgdorferi gene expression in vivo. The results provide a global snapshot of the spirochetal transcriptome in the CNS and should spur the design of experiments aimed at understanding the molecular basis of neuroborreliosis...
  48. pmc Induction of Plasmodium falciparum transmission-blocking antibodies in nonhuman primates by a combination of DNA and protein immunizations
    Cevayir Coban
    Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, The Johns Hopkins University Bloomberg School of Public Health, Baltimore 21205, USA
    Infect Immun 72:253-9. 2004
    ....