Research Topics
| Ivona V PandreaSummaryAffiliation: Tulane University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Distinct expression profiles of TGF-beta1 signaling mediators in pathogenic SIVmac and non-pathogenic SIVagm infectionsMickaël J Y Ploquin
Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France
Retrovirology 3:37. 2006..We therefore compared the very early expression dynamics of pro- and anti-inflammatory markers as well as of factors involved in the TGF-beta1 signaling pathway in SIV-infected AGMs and MACs...- Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulenceIvona V Pandrea
Divisions of Comparative Pathology and Microbiology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Immunol 179:3035-46. 2007.... - Simian immunodeficiency virus SIVagm dynamics in African green monkeysIvona Pandrea
Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 82:3713-24. 2008.... - Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hostsIvona Pandrea
Tulane National Primate Research Center, Covington, LA 70433, USA
Blood 109:1069-76. 2007..Beneficial effects of low CCR5 expression on CD4+ T cells may include the reduction of target cells for viral replication and a decreased homing of activated CD4+ T cells to inflamed tissue... 
Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: common patterns and species-specific differencesIvona Pandrea
Tulane National Primate Research Center, Covington, LA 70433, USA
J Med Primatol 35:194-201. 2006....- Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hostsIvona Pandrea
Tulane National Primate Research Center, Covington, LA 70433, USA
J Virol 80:4858-67. 2006..sab92018). Due to these similarities, we conclude that Caribbean AGMs are a useful alternative to AGMs of African origin as a model for the study of SIV infection in natural African hosts... - Cutting edge: Experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletionIvona Pandrea
Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
J Immunol 181:6687-91. 2008.... - AIDS in african nonhuman primate hosts of SIVs: a new paradigm of SIV infectionIvona Pandrea
Divisions of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA
Curr HIV Res 7:57-72. 2009.... - Limited ability of humoral immune responses in control of viremia during infection with SIVsmmD215 strainThaidra Gaufin
Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
Blood 113:4250-61. 2009..Our data suggest that a deficiency of Ab responses did not markedly affect viral replication or disease progression and that they may be compensated by more robust cellular responses... - In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaquesRajeev Gautam
Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
Virology 362:257-70. 2007..In vivo, SIVsmm isolates replicated at high levels in all SIVsmm-infected Rh. The poor in vitro replication of primary SIVsmm isolates in Rh cells did not correlate with in vivo replication, emphasizing the value of in vivo studies... - Effect of B-cell depletion on viral replication and clinical outcome of simian immunodeficiency virus infection in a natural hostThaidra Gaufin
Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
J Virol 83:10347-57. 2009..Our results, although obtained with a limited number of animals, suggest that humoral immune responses play only a minor role in the control of SIV viral replication during acute and chronic SIV infection in natural hosts... - Simian immunodeficiency virus SIVrcm, a unique CCR2-tropic virus, selectively depletes memory CD4+ T cells in pigtailed macaques through expanded coreceptor usage in vivoRajeev Gautam
Tulane National Primate Research Center, Covington, LA 70433, USA
J Virol 83:7894-908. 2009..Taken together, these findings emphasize the importance of understanding the selective forces driving viral adaptation to a new host... - Classic AIDS in a sooty mangabey after an 18-year natural infectionBinhua Ling
Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
J Virol 78:8902-8. 2004..Therefore, the results also suggest that SMs have a special mechanism for resisting AIDS development... - Experimental depletion of CD8+ cells in acutely SIVagm-infected African Green Monkeys results in increased viral replicationThaidra Gaufin
Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
Retrovirology 7:42. 2010..To assess the role of cellular immune responses in the control of SIV replication in natural hosts, we investigated the impact of CD8+ cell depletion during acute SIV infection in AGMs... - Paucity of CD4+ CCR5+ T cells may prevent transmission of simian immunodeficiency virus in natural nonhuman primate hosts by breast-feedingIvona Pandrea
Departement de Virologie, Tulane National Primate Research Center, Tulane University Health Science Center, Covington, Louisiana 70433, USA
J Virol 82:5501-9. 2008.... - Impact of viral factors on very early in vivo replication profiles in simian immunodeficiency virus SIVagm-infected African green monkeysIvona Pandrea
Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 79:6249-59. 2005..sab92018 and for SIVagm.ver644. In conclusion, our study showed that the extent of virus replication during the primary infection is primarily dependent on viral determinants... - Immune responses induced by intranasal imiquimod and implications for therapeutics in rhinovirus infectionsSanda Clejan
Department of Pathology and Laboratory Medicine, Tulane University School of Medicine and the General Clinical Research Center, New Orleans, LA, 70112 2699, USA
J Cell Mol Med 9:457-61. 2005..We think that this work will encourage a number of double blind clinical trials to confirm the effectiveness of the intranasal treatment of the common cold with imiquimod... - Into the wild: simian immunodeficiency virus (SIV) infection in natural hostsIvona Pandrea
Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
Trends Immunol 29:419-28. 2008..Immunologic features observed during natural SIV infections suggest approaches for designing new strategies for producing novel second-generation vaccines and therapeutic approaches to inhibit disease progression in HIV-infected humans... - Decreased CCR5 expression on CD4+ T cells of SIV-infected sooty mangabeysRonald Veazey
National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
AIDS Res Hum Retroviruses 19:227-33. 2003.... - Simian immunodeficiency virus infection in neonatal macaquesRonald S Veazey
Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
J Virol 77:8783-92. 2003.... - Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeysCristian Apetrei
Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 81:7913-23. 2007..Taken together, this systematic analysis of the subtype-specific features of SIV(smm) infection in natural SM hosts identifies subtype-specific differences in the pathogenicity of SIV(smm) infection... - Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus extinctionCristian Apetrei
Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA
J Infect Dis 202:S371-6. 2010..Thus, down‐regulation of CD4 and CCR5 expression on CD4+ T cells may effectively control human immunodeficiency virus acquisition and result in SIV extinction... - Kuru experiments triggered the emergence of pathogenic SIVmacCristian Apetrei
Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
AIDS 20:317-21. 2006 - Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstmCristian Apetrei
Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
J Virol 79:8991-9005. 2005..The genetic variability of SIVsm strains among PCs may influence the diagnosis and monitoring of SIVsm infection and, consequently, may bias the results of pathogenesis studies... - Dynamics of Simian immunodeficiency virus-specific cytotoxic T-cell responses in tissuesRonald S Veazey
Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
J Med Primatol 32:194-200. 2003..These data suggest that while high CTL responses develop at a similar rate, and magnitude in both peripheral and mucosal lymphoid tissues in primary SIV infection, mucosal CTL responses may predominate later in the course of the disease... - Direct inoculation of simian immunodeficiency virus from sooty mangabeys in black mangabeys (Lophocebus aterrimus): first evidence of AIDS in a heterologous African species and different pathologic outcomes of experimental infectionCristian Apetrei
Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
J Virol 78:11506-18. 2004..Finally, this case of AIDS in an African monkey suggests that the dogma of SIV nonpathogenicity in African NHP hosts should be reconsidered... - HIV type 1 diversity in northeastern Romania in 200-2001 based on phylogenic analysis of pol sequences from patient failing antiretroviral therapyCristian Apetrei
Virology Laboratory, Pathology Laboratory and Infectious diseases Clinic, School of Medicine, Gr T Popa University of Iasi, Romania
AIDS Res Hum Retroviruses 19:1155-1161. 2003..The circulation of subtype F1 in Romania has the potential to be a source of this HIV-1 subtype in Europe.... - HIV genetic diversity: biological and public health consequencesIsolde F Butler
Tulane National Primate Research Center, Covington, LA 70433, USA
Curr HIV Res 5:23-45. 2007..Here we discuss the distribution of these divergent viral forms worldwide and the potential consequences of such a tremendous viral diversity for diagnostic, monitoring, treatment and the development of an effective vaccine... - Phylogenetic relationships of methionine aminopeptidase 2 among Encephalitozoon species and genotypes of microsporidiaIvona Pandrea
Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
Mol Biochem Parasitol 140:141-52. 2005.... - Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesisShari N Gordon
University of Pennsylvania School of Medicine, 705 Stellar Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19143, USA
J Virol 82:3725-35. 2008.... - Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeysShari N Gordon
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Immunol 179:3026-34. 2007....
Research Grants
- Pathogenesis of SIV in African green monkeysIvona Pandrea; Fiscal Year: 2009..Combined, these aims are designed to determine the viral and/or host factors responsible for resistance to AIDS. ..