KAILASH PANDEY

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint Dynamics of internalization and sequestration of guanylyl cyclase/atrial natriuretic peptide receptor-A
    K N Pandey
    Department of Physiology, Tulane University School of Medicine Health Sciences Center, New Orleans, LA 70112, USA
    Can J Physiol Pharmacol 79:631-9. 2001
  2. pmc The functional genomics of guanylyl cyclase/natriuretic peptide receptor-A: perspectives and paradigms
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    FEBS J 278:1792-807. 2011
  3. pmc Small peptide recognition sequence for intracellular sorting
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA
    Curr Opin Biotechnol 21:611-20. 2010
  4. doi request reprint Ligand-mediated endocytosis and intracellular sequestration of guanylyl cyclase/natriuretic peptide receptors: role of GDAY motif
    Kailash N Pandey
    Department of Physiology, Tulane University School of Medicine, SL 39 1430 Tulane Ave, New Orleans, LA 70112, USA
    Mol Cell Biochem 334:81-98. 2010
  5. doi request reprint Regulation of cardiac angiotensin-converting enzyme and angiotensin AT1 receptor gene expression in Npr1 gene-disrupted mice
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    Clin Exp Pharmacol Physiol 37:e70-7. 2010
  6. pmc Functional roles of short sequence motifs in the endocytosis of membrane receptors
    Kailash N Pandey
    Health Sciences Center, Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Front Biosci 14:5339-60. 2009
  7. pmc Guanylyl cyclase / atrial natriuretic peptide receptor-A: role in the pathophysiology of cardiovascular regulation
    Kailash N Pandey
    Department of Physiology, SL 39 Tulane University Health Sciences Center, School of Medicine, 1430 Tulane Avenue, LA 70112, New Orleans, USA
    Can J Physiol Pharmacol 89:557-73. 2011
  8. ncbi request reprint Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Peptides 26:985-1000. 2005
  9. ncbi request reprint Biology of natriuretic peptides and their receptors
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Peptides 26:901-32. 2005
  10. ncbi request reprint Ligand-regulated internalization, trafficking, and down-regulation of guanylyl cyclase/atrial natriuretic peptide receptor-A in human embryonic kidney 293 cells
    Kailash N Pandey
    Department of Physiology, Tulane University School of Medicine and Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 277:4618-27. 2002

Research Grants

Collaborators

  • LUIS NAVAR
  • Oliver Smithies
  • Nobuyo Maeda
  • Di Zhao
  • Prerna Kumar
  • Elangovan Vellaichamy
  • Renu Garg
  • Kiran K Arise
  • Gevoni Bolden
  • Shang Jin Shi
  • Guru Dutt Sharma
  • Stephen T Krazit
  • Naveen Somanna
  • Kiran Kaur
  • Madan L Khurana
  • Jude Fink
  • Naveen K Sommana
  • So Yeon Chin
  • Thomas Von Geldern
  • Paula M Oliver
  • Alexander S Antonov
  • Huong T Nguyen
  • Ross G Gerrity

Detail Information

Publications29

  1. ncbi request reprint Dynamics of internalization and sequestration of guanylyl cyclase/atrial natriuretic peptide receptor-A
    K N Pandey
    Department of Physiology, Tulane University School of Medicine Health Sciences Center, New Orleans, LA 70112, USA
    Can J Physiol Pharmacol 79:631-9. 2001
    ....
  2. pmc The functional genomics of guanylyl cyclase/natriuretic peptide receptor-A: perspectives and paradigms
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    FEBS J 278:1792-807. 2011
    ..Overall, this review attempts to provide insights and to delineate the current concepts in the field of functional genomics and signaling of GC-A/NPRA in hypertension and cardiovascular disease states at the molecular level...
  3. pmc Small peptide recognition sequence for intracellular sorting
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, USA
    Curr Opin Biotechnol 21:611-20. 2010
    ..Here a particular emphasis has been given to the functions of short-sequence signal motifs responsible for the itinerary and destination of membrane receptors and proteins moving into subcellular compartments...
  4. doi request reprint Ligand-mediated endocytosis and intracellular sequestration of guanylyl cyclase/natriuretic peptide receptors: role of GDAY motif
    Kailash N Pandey
    Department of Physiology, Tulane University School of Medicine, SL 39 1430 Tulane Ave, New Orleans, LA 70112, USA
    Mol Cell Biochem 334:81-98. 2010
    ....
  5. doi request reprint Regulation of cardiac angiotensin-converting enzyme and angiotensin AT1 receptor gene expression in Npr1 gene-disrupted mice
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    Clin Exp Pharmacol Physiol 37:e70-7. 2010
    ....
  6. pmc Functional roles of short sequence motifs in the endocytosis of membrane receptors
    Kailash N Pandey
    Health Sciences Center, Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Front Biosci 14:5339-60. 2009
    ....
  7. pmc Guanylyl cyclase / atrial natriuretic peptide receptor-A: role in the pathophysiology of cardiovascular regulation
    Kailash N Pandey
    Department of Physiology, SL 39 Tulane University Health Sciences Center, School of Medicine, 1430 Tulane Avenue, LA 70112, New Orleans, USA
    Can J Physiol Pharmacol 89:557-73. 2011
    ..We are now just at the initial stage of molecular therapeutics and pharmacogenomic advancement of the natriuretic peptides. More investigations should be undertaken and ongoing ones be extended in this important field...
  8. ncbi request reprint Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Peptides 26:985-1000. 2005
    ..The discussion is afforded to address the experimental insights into the mechanisms that cells utilize in modulating the delivery and metabolic processing of ligand-bound NPRA into the cell interior...
  9. ncbi request reprint Biology of natriuretic peptides and their receptors
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Peptides 26:901-32. 2005
    ....
  10. ncbi request reprint Ligand-regulated internalization, trafficking, and down-regulation of guanylyl cyclase/atrial natriuretic peptide receptor-A in human embryonic kidney 293 cells
    Kailash N Pandey
    Department of Physiology, Tulane University School of Medicine and Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 277:4618-27. 2002
    ..It is envisioned that the endocytotic pathway of ligand-receptor complexes of ANP-NPRA would lead to termination and/or diminished responsiveness of ANP in target cells...
  11. ncbi request reprint Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments
    Kailash N Pandey
    Department of Physiology, Tulane University School of Medicine and Health Sciences Center, New Orleans, LA 70112, USA
    Mol Cell Biochem 230:61-72. 2002
    ....
  12. pmc Internalization and trafficking of guanylyl (guanylate) cyclase/natriuretic peptide receptor A is regulated by an acidic tyrosine-based cytoplasmic motif GDAY
    Kailash N Pandey
    Department of Physiology, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Biochem J 388:103-13. 2005
    ..The current results provide new evidence for a dual role of the GDAY sequence motif in ligand-mediated internalization, recycling and down-regulation of a single-transmembrane receptor protein NPRA...
  13. ncbi request reprint Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy
    Elangovan Vellaichamy
    Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Physiol Genomics 31:193-202. 2007
    ..The results of the present study indicate that disruption of NPRA/cGMP signaling leads to the augmented expression of cardiac RAS pathways that promote the development of cardiac hypertrophy and remodeling...
  14. ncbi request reprint Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion
    Shang Jin Shi
    Department of Physiology, Tulane University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 285:F694-702. 2003
    ..01) and RPF (P < 0.01) compared with 2-copy wild-type mice. These results establish that NPRA activation is the predominant mechanism mediating the natriuretic, diuretic, and renal hemodynamic responses to acute blood volume expansion...
  15. ncbi request reprint Involvement of the NF-kappa B/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A
    Elangovan Vellaichamy
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    J Biol Chem 280:19230-42. 2005
    ....
  16. ncbi request reprint Transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-A gene
    Prerna Kumar
    Department of Physiology, SL 39, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Peptides 27:1762-9. 2006
    ..Collectively, the present results demonstrate that Ets-1 greatly stimulates Npr1 gene promoter activity, implicating its critical role in the regulation and function of NPRA at the molecular level...
  17. ncbi request reprint Guanylyl cyclase/natriuretic peptide receptor-A gene disruption causes increased adrenal angiotensin II and aldosterone levels
    Di Zhao
    Dept of Physiology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 293:F121-7. 2007
    ..Increased adrenal ANG II and Aldo levels may play an important role in elevated arterial blood pressure and progressive hypertension, leading to renal and vascular injury in Npr1 gene-disrupted mice...
  18. pmc Enhanced activation of pro-inflammatory cytokines in mice lacking natriuretic peptide receptor-A
    Elangovan Vellaichamy
    Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Peptides 28:893-9. 2007
    ..The present findings provide direct evidence that ablation of NPRA/cGMP signaling activates inflammatory cytokines, probably via NF-kappaB mediated signaling pathway, and is associated with hypertrophic growth of null mutant mice hearts...
  19. ncbi request reprint Reduced cGMP signaling activates NF-kappaB in hypertrophied hearts of mice lacking natriuretic peptide receptor-A
    Elangovan Vellaichamy
    Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 327:106-11. 2005
    ..The present findings provide direct evidence that ablation of NPRA/cGMP signaling activates NF-kappaB binding activity associated with hypertrophic growth of mutant mice hearts...
  20. ncbi request reprint Expression of atrial natriuretic peptide receptor-A antagonizes the mitogen-activated protein kinases (Erk2 and P38MAPK) in cultured human vascular smooth muscle cells
    Guru Dutt Sharma
    Department of Physiology, Tulane University Health Sciences Center, and School of Medicine New Orleans, LA 70112, USA
    Mol Cell Biochem 233:165-73. 2002
    ..Our results identify a signal transduction pathway in HVSMC that could contribute to vascular remodeling and structural changes in human hypertension...
  21. pmc ANP-mediated inhibition of distal nephron fractional sodium reabsorption in wild-type and mice overexpressing natriuretic peptide receptor
    Di Zhao
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center School of Medicine, New Orleans, Louisiana 70112, USA
    Am J Physiol Renal Physiol 298:F103-8. 2010
    ....
  22. pmc Cooperative activation of Npr1 gene transcription and expression by interaction of Ets-1 and p300
    Prerna Kumar
    Department of Physiology, Tulane University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    Hypertension 54:172-8. 2009
    ..The present findings should yield important insights into the molecular signaling governing Npr1 gene transcription, an important regulator in the control of hypertension and cardiovascular events...
  23. ncbi request reprint Genomic structure, organization, and promoter region analysis of murine guanylyl cyclase/atrial natriuretic peptide receptor-A gene
    Renu Garg
    Department of Physiology, Tulane University School of Medicine, Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 710112, USA
    Gene 291:123-33. 2002
    ..The analyses and characterization of the genomic structure of murine Npr1 gene should yield important insights into the species-specific regulation of this important gene family...
  24. ncbi request reprint Inhibition and down-regulation of gene transcription and guanylyl cyclase activity of NPRA by angiotensin II involving protein kinase C
    Kiran K Arise
    Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 349:131-5. 2006
    ..This is the first report to demonstrate that ANG II-dependent transcriptional repression of Npr1 gene promoter activity and down-regulation of GC activity of translated protein, NPRA is regulated by PKC pathways...
  25. pmc Regulation of natriuretic peptide receptor-A gene expression and stimulation of its guanylate cyclase activity by transcription factor Ets-1
    Prerna Kumar
    Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, LA 70112, U S A
    Biosci Rep 29:57-70. 2009
    ..Collectively, the present study demonstrates that Npr1 gene transcription and GC activity of the receptor are critically controlled by Ets-1 in target cells...
  26. ncbi request reprint Angiotensin II-mediated negative regulation of Npr1 promoter activity and gene transcription
    Renu Garg
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center and School of Medicine, New Orleans, LA 70112, USA
    Hypertension 41:730-6. 2003
    ..The present study thus reveals the presence of functional cis-regulatory elements in the promoter region of the murine Npr1 gene and its transcriptional downregulation by vasoactive peptide Ang II...
  27. ncbi request reprint Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression
    Renu Garg
    Department of Physiology, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Peptides 26:1009-23. 2005
    ....
  28. pmc Interactive roles of Ets-1, Sp1, and acetylated histones in the retinoic acid-dependent activation of guanylyl cyclase/atrial natriuretic peptide receptor-A gene transcription
    Prerna Kumar
    Department of Physiology, Tulane University Health Sciences Center and School of Medicine, New Orleans, Louisiana 70112, USA
    J Biol Chem 285:37521-30. 2010
    ..Collectively, the present results demonstrate that ATRA regulates Npr1 gene transcription and GC activity of the receptor by involving the interactive actions of Ets-1, Sp1, and histone acetylation...
  29. ncbi request reprint Natriuretic peptides and their receptors
    Kailash N Pandey
    Peptides 26:899-900. 2005

Research Grants22

  1. ANP Receptor: Molecular approach of signaling mechanisms
    Kailash N Pandey; Fiscal Year: 2010
    ..Ultimately, this knowledge should yield new therapeutic molecular targets for the diagnosis, control, and treatment of hypertension and cardiovascular diseases. ..
  2. Study of ANP Receptor: Gene Targeting and Expression
    KAILASH PANDEY; Fiscal Year: 2007
    ..Overall, this project is expected to produce important new insights into the molecular mechanisms that underlie NPRA-dependent blood pressure regulation, kidney function, and cardiovascular pathophysiology in general. ..
  3. ANP Receptor:Molecular approach of signaling mechanisms
    KAILASH PANDEY; Fiscal Year: 2006
    ..The resulting knowledge should yield new therapeutic targets and novel loci for the control and treatment of hypertension and cardiovascular disorders ..
  4. ANP RECEPTOR--MOLECULAR APPROACH OF SIGNALING MECHANISMS
    KAILASH PANDEY; Fiscal Year: 1999
    ....
  5. ANP RECEPTOR GENE--TARGETING AND EXPRESSION
    KAILASH PANDEY; Fiscal Year: 2001
    ..The resulting knowledge should yield new therapeutic targets for the treatment of hypertension and prevention of hypertension-related cardiovascular disorders. ..
  6. Study of ANP Receptor: Gene Targeting and Expression
    Kailash N Pandey; Fiscal Year: 2010
    ..Ultimately, this knowledge should yield new molecular therapeutic targets for the control and treatment of hypertension and cardiovascular diseases. ..