W Pan

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide
    Weihong Pan
    Veterans Affairs Medical Center and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Exp Biol Med (Maywood) 227:609-15. 2002
  2. ncbi request reprint Interactions of cytokines with the blood-brain barrier: implications for feeding
    Weihong Pan
    Departments of Medicine and Neuroscience, Tulane University School of Medicine and the VA Medical Center Research Service, New Orleans, Louisiana, USA
    Curr Pharm Des 9:827-31. 2003
  3. ncbi request reprint Increased hippocampal uptake of tumor necrosis factor alpha and behavioral changes in mice
    Weihong Pan
    Tulane University School of Medicine and Veterans Affairs Medical Center, New Orleans, LA 70112, USA
    Exp Brain Res 149:195-9. 2003
  4. ncbi request reprint Bradykinin antagonist decreases early disruption of the blood-spinal cord barrier after spinal cord injury in mice
    W Pan
    VA Medical Center and Department of Medicine, Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112, USA
    Neurosci Lett 307:25-8. 2001
  5. ncbi request reprint Selected contribution: circadian rhythm of tumor necrosis factor-alpha uptake into mouse spinal cord
    Weihong Pan
    Department of Medicine, Tulane University and the Veterans Affairs Medical Center, New Orleans, Louisiana 70112 1262, USA
    J Appl Physiol 92:1357-62; discussion 1356. 2002
  6. ncbi request reprint TNFalpha transport across the blood-brain barrier is abolished in receptor knockout mice
    Weihong Pan
    VA Medical Center and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, 70112 1262, USA
    Exp Neurol 174:193-200. 2002
  7. ncbi request reprint Upregulation of p55 and p75 receptors mediating TNF-alpha transport across the injured blood-spinal cord barrier
    Weihong Pan
    Department of Medicine, Tulane University Health Science Center and the VA Medical Center, New Orleans, Louisiana 70112 1262, USA
    J Mol Neurosci 21:173-84. 2003
  8. ncbi request reprint Upregulation of the transport system for TNFalpha at the blood-brain barrier
    W Pan
    VA Medical Center and Tulane University School of Medicine, New Orleans, LA 70112 1262, USA
    Arch Physiol Biochem 109:350-3. 2001
  9. ncbi request reprint Selective increase in TNF alpha permeation across the blood-spinal cord barrier after SCI
    Weihong Pan
    Department of Medicine and Neuroscience Program, Tulane University School of Medicine and VA Medical Center, New Orleans, LA 70112 1262, USA
    J Neuroimmunol 134:111-7. 2003
  10. ncbi request reprint Changing the chemokine gradient: CINC1 crosses the blood-brain barrier
    W Pan
    Department of Medicine, Tulane University School of Medicine and the VA Medical Center, New Orleans, LA 70112, USA
    J Neuroimmunol 115:64-70. 2001

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide
    Weihong Pan
    Veterans Affairs Medical Center and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Exp Biol Med (Maywood) 227:609-15. 2002
    ..The presence of mAbmc1 also caused significant reduction of the influx of Abeta into the brain after perfusion. Therefore, effective antibodies to Abeta can reduce the influx of Abeta(1-40) into the brain...
  2. ncbi request reprint Interactions of cytokines with the blood-brain barrier: implications for feeding
    Weihong Pan
    Departments of Medicine and Neuroscience, Tulane University School of Medicine and the VA Medical Center Research Service, New Orleans, Louisiana, USA
    Curr Pharm Des 9:827-31. 2003
    ..Our understanding of cytokines interacting with the BBB is still growing; not only are more cytokines being studied, but also more details of the nature of the transport systems and how they affect feeding behavior are being explored...
  3. ncbi request reprint Increased hippocampal uptake of tumor necrosis factor alpha and behavioral changes in mice
    Weihong Pan
    Tulane University School of Medicine and Veterans Affairs Medical Center, New Orleans, LA 70112, USA
    Exp Brain Res 149:195-9. 2003
    ..Although no causal relationship can be established at this time, the behavioral changes might be related to the increased TNF alpha transport after trauma...
  4. ncbi request reprint Bradykinin antagonist decreases early disruption of the blood-spinal cord barrier after spinal cord injury in mice
    W Pan
    VA Medical Center and Department of Medicine, Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112, USA
    Neurosci Lett 307:25-8. 2001
    ..This indicates the therapeutic potential of bradykinin antagonists in ameliorating tissue damage induced by SCI...
  5. ncbi request reprint Selected contribution: circadian rhythm of tumor necrosis factor-alpha uptake into mouse spinal cord
    Weihong Pan
    Department of Medicine, Tulane University and the Veterans Affairs Medical Center, New Orleans, Louisiana 70112 1262, USA
    J Appl Physiol 92:1357-62; discussion 1356. 2002
    ..The circadian rhythm of the influx of TNF-alpha into this region of the CNS suggests a functional role for the spinal cord in the physiological actions of TNF-alpha...
  6. ncbi request reprint TNFalpha transport across the blood-brain barrier is abolished in receptor knockout mice
    Weihong Pan
    VA Medical Center and Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, 70112 1262, USA
    Exp Neurol 174:193-200. 2002
    ....
  7. ncbi request reprint Upregulation of p55 and p75 receptors mediating TNF-alpha transport across the injured blood-spinal cord barrier
    Weihong Pan
    Department of Medicine, Tulane University Health Science Center and the VA Medical Center, New Orleans, Louisiana 70112 1262, USA
    J Mol Neurosci 21:173-84. 2003
    ..Knowledge of receptor-mediated regulation could facilitate effective therapeutic manipulation of BSCB permeation of vascular cytokines important to CNS regeneration...
  8. ncbi request reprint Upregulation of the transport system for TNFalpha at the blood-brain barrier
    W Pan
    VA Medical Center and Tulane University School of Medicine, New Orleans, LA 70112 1262, USA
    Arch Physiol Biochem 109:350-3. 2001
    ..Exogenous TNFalpha has biphasic effects in modulating functional scores. The BBB, a dynamically regulated barrier, is actively involved in disease processes...
  9. ncbi request reprint Selective increase in TNF alpha permeation across the blood-spinal cord barrier after SCI
    Weihong Pan
    Department of Medicine and Neuroscience Program, Tulane University School of Medicine and VA Medical Center, New Orleans, LA 70112 1262, USA
    J Neuroimmunol 134:111-7. 2003
    ..We conclude that SCI by lumbar hemisection activates the transport system for TNF alpha at the BBB and suggest that selective permeation of TNF alpha may facilitate functional recovery...
  10. ncbi request reprint Changing the chemokine gradient: CINC1 crosses the blood-brain barrier
    W Pan
    Department of Medicine, Tulane University School of Medicine and the VA Medical Center, New Orleans, LA 70112, USA
    J Neuroimmunol 115:64-70. 2001
    ..Thus, the influx of CINC1 may alter the "chemokine gradient" across the BBB and therefore affect inflammatory reactions involving the CNS...
  11. ncbi request reprint Polypeptide delivery across the blood-brain barrier
    Weihong Pan
    Department of Medicine and Neuroscience Program, Tulane University and the VA Medical Center, New Orleans, Louisiana, USA
    Curr Drug Targets CNS Neurol Disord 3:131-6. 2004
    ..Better understanding of the BBB will provide insight and direction for future research in the treatment of CNS disorders...
  12. ncbi request reprint Diurnal variation of leptin entry from blood to brain involving partial saturation of the transport system
    W Pan
    Tulane University School of Medicine and VA Medical Center, New Orleans, LA, USA
    Life Sci 68:2705-14. 2001
    ..Together, the results show that the BBB is actively involved in the neuroendocrine regulation of feeding behavior...
  13. ncbi request reprint Transport of brain-derived neurotrophic factor across the blood-brain barrier
    W Pan
    VA Medical Center, New Orleans, LA 70112 1262, USA
    Neuropharmacology 37:1553-61. 1998
    ..Therefore, we conclude that intact BDNF in the peripheral circulation crosses the BBB by a high-capacity, saturable transport system...
  14. ncbi request reprint Saturable entry of ciliary neurotrophic factor into brain
    W Pan
    Department of Medicine, VA Medical Center and Tulane University School of Medicine, New Orleans, LA 70112 1262, USA
    Neurosci Lett 263:69-71. 1999
    ..The Ki was reduced more than 3-fold by addition of excess unlabeled CNTF. The results indicate that CNTF is saturably transported across the BBB from blood to brain...
  15. ncbi request reprint Adrenomedullin and the blood-brain barrier
    A J Kastin
    VA Medical Center and Tulane University School of Medicine, New Orleans, LA 70112-1262, USA
    Horm Metab Res 33:19-25. 2001
    ..This suggests a function for ADM at the cerebral blood vessels, such as altering cerebral blood flow and perfusion, without disruption of the BBB...
  16. ncbi request reprint Permeability of the blood-brain barrier to neurotrophins
    W Pan
    VA Medical Center, New Orleans, LA 70146, USA
    Brain Res 788:87-94. 1998
    ..The results suggest that peripheral administration of neurotrophins could have therapeutic effects within the CNS...
  17. ncbi request reprint Interactions of IGF-1 with the blood-brain barrier in vivo and in situ
    W Pan
    VA Medical Center and Department of Medicine and Neuroscience Program, Tulane University School of Medicine, New Orleans, LA, USA
    Neuroendocrinology 72:171-8. 2000
    ..We conclude that IGF-1 enters the CNS by a saturable transport system at the BBB, which functions in synchrony with IGF binding proteins in the periphery to regulate the availability of IGF-1 to the CNS...
  18. ncbi request reprint Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls
    A J Kastin
    VA Medical Center and Tulane University School of Medicine, New Orleans LA 70112-1262, USA
    Peptides 22:2127-36. 2001
    ..Thus, with additional considerations such as stability and interactions with the vasculature, multiple-time regression analysis is sensitive and selective for study of the penetration of peptides across the BBB...
  19. ncbi request reprint Increase in TNFalpha transport after SCI is specific for time, region, and type of lesion
    W Pan
    Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112-1262, USA
    Exp Neurol 170:357-63. 2001
    ....
  20. ncbi request reprint Tumor necrosis factor-alpha: a neuromodulator in the CNS
    W Pan
    Department of Medicine, Tulane University School of Medicine, New Orleans, LA, USA
    Neurosci Biobehav Rev 21:603-13. 1997
    ..It could induce growth-promoting cytokines and neurotrophins, or it could increase the production of antiproliferative cytokines, nitric oxide, and free radicals, thereby contributing to apoptosis...
  21. ncbi request reprint Entry of EGF into brain is rapid and saturable
    W Pan
    VA Medical Center and Tulane University School of Medicine, New Orleans, LA 70112 1262, USA
    Peptides 20:1091-8. 1999
    ..Thus, EGF has a saturable transport system at the BBB for rapid, unidirectional influx. The transport system does not require the entire EGF receptor and is susceptible to possible therapeutic manipulation...
  22. ncbi request reprint Effect of middle cerebral artery occlusion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat
    A Somogyvari-Vigh
    Tulane University Department of Medicine, New Orleans, LA 70112, USA
    Regul Pept 91:89-95. 2000
    ..These findings imply the necessity of adjusting the dose of intravenously administered PACAP38 in order to maximize its therapeutic effect on the brain damage resulting from focal ischemia..
  23. ncbi request reprint Feeding peptides interact in several ways with the blood-brain barrier
    A J Kastin
    VA Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112 1262, USA
    Curr Pharm Des 9:789-94. 2003
    ....
  24. ncbi request reprint Saturable entry of leukemia inhibitory factor from blood to the central nervous system
    W Pan
    VA Medical Center and Tulane University School of Medicine, New Orleans, LA 70112, USA
    J Neuroimmunol 106:172-80. 2000
    ..Our results show that peripherally administered LIF readily enters the brain and spinal cord by a saturable transport system across the BBB that may have biological implications...
  25. doi request reprint Quercetin induced tissue-type plasminogen activator expression is mediated through Sp1 and p38 mitogen-activated protein kinase in human endothelial cells
    W Pan
    The Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 34194 2170, USA
    J Thromb Haemost 6:976-85. 2008
    ..However, the regulatory elements and signaling pathways involved in this regulation are unknown...
  26. ncbi request reprint Effects of peptides: a cross-listing of peptides and their central actions published in the journal Peptides from 1994 through 1998
    W Pan
    VA Medical Center and Tulane University School of Medicine, Neuroscience Training Program and Department of Medicine, New Orleans, LA 70112 1262, USA
    Peptides 20:1127-38. 1999
    ..In the second table, the central nervous system effects are arranged alphabetically. No longer can there be any doubt that peptides affect the central nervous system, sometimes in several ways...
  27. ncbi request reprint Involving AP-2 transcription factor in connexin 26 up-regulation during pregnancy and lactation
    Z J Tu
    Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Reprod Dev 59:17-24. 2001
    ..These data infer that AP-2, along with previously reported Sp transcription factors, is involved in the up-regulation of Cx26 gene during pregnancy and lactation...
  28. pmc Differential endothelial cell gene expression by African Americans versus Caucasian Americans: a possible contribution to health disparity in vascular disease and cancer
    P Wei
    Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Med 9:2. 2011
    ....
  29. pmc Blood-brain barrier and feeding: regulatory roles of saturable transport systems for ingestive peptides
    Abba J Kastin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Pharm Des 14:1615-9. 2008
    ..Thus, the gatekeeper function of the BBB can be expanded to a primary governing role, especially for entry of ingestive peptides subject to their respective saturable transport systems...
  30. ncbi request reprint Soluble receptor inhibits leptin transport
    Hong Tu
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Cell Physiol 214:301-5. 2008
    ..Instead, these soluble receptors inhibited surface binding and endocytosis of leptin. Thus, we provide novel direct evidence both in vivo and in vitro that soluble receptors of leptin serve as antagonists of the transport of leptin...
  31. pmc Adipokines and the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, United States
    Peptides 28:1317-30. 2007
    ..Still others, like interleukin-6, may reach the brain but are rapidly degraded. This review summarizes current knowledge and recent findings of the rapidly growing family of adipokines and their interactions with the BBB...
  32. ncbi request reprint Convergent trafficking pattern of leptin after endocytosis mediated by ObRa-ObRd
    Hong Tu
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Cell Physiol 212:215-22. 2007
    ..This stability was further enhanced by inhibition of lysosomal activity. Thus, the intracellular pool of intact leptin may allow prolonged biological functions for this adipokine...
  33. pmc TNFalpha trafficking in cerebral vascular endothelial cells
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Neuroimmunol 185:47-56. 2007
    ..The vesicular trafficking of TNFalpha reflects the immunomodulatory potential of peripheral cytokines for the CNS...
  34. ncbi request reprint Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin
    Hong Tu
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Mol Endocrinol 21:700-11. 2007
    ..We conclude that both CRHR1 and CRHR2 play a facilitatory role in the non-clathrin-, non-caveolae-mediated endocytosis and intracellular signal transduction of this potent peptide...
  35. ncbi request reprint Gamma glutamyl transpeptidase is a dynamic indicator of endothelial response to stroke
    Chuanhui Yu
    Blood Brain Barrier Group, PBRC, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Exp Neurol 203:116-22. 2007
    ..With the co-existence of inflammation and hypoxia in the brain after ischemic stroke, dynamic changes of gammaGT activity reflect evolving changes of endothelial function...
  36. ncbi request reprint Permeation of hepatocyte growth factor across the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, LSU System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Exp Neurol 201:99-104. 2006
    ..The amount of HGF that crossed the BBB in intact form was substantial and could be physiologically important in the CNS...
  37. ncbi request reprint Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity?
    Abba J Kastin
    Pennington Biomedical Research Center Baton Rouge, Louisiana 70808, USA
    Endocrinology 147:2086-7. 2006
  38. ncbi request reprint Differential role of TNF receptors in cellular trafficking of intact TNF
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Cell Physiol Biochem 20:559-68. 2007
    ..Accordingly, we determined the differential role of the two receptors for tumor necrosis factor alpha (TNFR1, TNFR2) on cellular transcytosis...
  39. ncbi request reprint Opposing effects of proteasomes and lysosomes on LIFR: modulation by TNF
    Chuanhui Yu
    The Blood Brain Barrier Group, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    J Mol Neurosci 32:80-9. 2007
    ..The novel opposite effects of proteasomes and lysosomes in controlling receptor expression shows the functional implications and interactions of circulating inflammatory cytokines in acutely modulating BBB activity...
  40. pmc Neuroinflammation facilitates LIF entry into brain: role of TNF
    Weihong Pan
    Blood Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Physiol Cell Physiol 294:C1436-42. 2008
    ..The results show that neuroinflammation by LPS induces endothelial signaling and enhances cytokine transport across the BBB...
  41. doi request reprint Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Neurochem 106:313-9. 2008
    ..The results suggest that the BBB is an interface for blood-borne IL15 to interact with the CNS in the basal state and during inflammation...
  42. pmc Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice
    Weihong Pan
    Blood Brain Barrier Group, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Endocrinology 149:2798-806. 2008
    ....
  43. ncbi request reprint Cytokine transport across the injured blood-spinal cord barrier
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Pharm Des 14:1620-4. 2008
    ..The increased transport of TNF and LIF after SCI remains saturable and does not coincide with generalized BBB disruption, highlighting a pivotal regulatory role for the blood-spinal cord barrier...
  44. pmc Developmental changes of leptin receptors in cerebral microvessels: unexpected relation to leptin transport
    Weihong Pan
    Blood Brain Barrier Group, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 149:877-85. 2008
    ..Overall, the developmental changes observed for leptin receptors unexpectedly failed to correlate with the entry of leptin into brain, and this may indicate different functions of the receptors in neonates and adults...
  45. ncbi request reprint Urocortin trafficking in cerebral microvessel endothelial cells
    Hong Tu
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Mol Neurosci 31:171-81. 2007
    ..Thus, urocortin endocytosis is a saturable process leading to vesicular intracellular transport that can be enhanced by cell-surface leptin...
  46. ncbi request reprint TNF activates P-glycoprotein in cerebral microvascular endothelial cells
    Chuanhui Yu
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Cell Physiol Biochem 20:853-8. 2007
    ..Many chemotherapeutic agents, anti-epileptics, anti-HIV drugs, and opiates are substrates for MDRs. Therefore, understanding the regulation of MDRs in the endothelial cells composing the blood-brain barrier has therapeutic implications...
  47. ncbi request reprint Nesfatin-1 crosses the blood-brain barrier without saturation
    Weihong Pan
    Blood Brain Barrier Group, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 28:2223-8. 2007
    ..Thus, the limited penetration under physiological conditions does not limit the pharmacological delivery of this satiety peptide as a potential therapeutic agent...
  48. pmc Tumor necrosis factor and stroke: role of the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, United States
    Prog Neurobiol 83:363-74. 2007
    ..As we better understand how peripheral TNFalpha affects its own transport and modulates neuroregeneration, we may be in a better position to pharmacologically manipulate its regulatory transport system to treat stroke...
  49. ncbi request reprint Reciprocal interactions of insulin and insulin-like growth factor I in receptor-mediated transport across the blood-brain barrier
    Yongmei Yu
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 147:2611-5. 2006
    ..The redundancy of their transport systems illustrates the regulatory function of the blood-brain barrier and reflects the importance of blood-borne insulin and IGF-I in the central nervous system...
  50. ncbi request reprint Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin
    Weihong Pan
    The BBB Group, Pennington Biomedical Research Center, LSU System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 27:911-6. 2006
    ..The differential interactions of obestatin, adiponectin, and ghrelin with the BBB illustrate their distinctive physiological interactions with the CNS...
  51. ncbi request reprint Why study transport of peptides and proteins at the neurovascular interface
    Weihong Pan
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res Brain Res Rev 46:32-43. 2004
    ..Better understanding of the nature and regulation of the transport systems at the BBB will provide a new direction to enhance the interactions of peripheral peptides and proteins with the CNS...
  52. ncbi request reprint Modulation of feeding-related peptide/protein signals by the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Neurochem 90:455-61. 2004
    ..Thus, sites of action of leptin, urocortin, and TNFalpha exist not only in the brain but also at the BBB where they each control the flow of other ingestive signals to CNS targets...
  53. ncbi request reprint Brain proteome of mice lacking the receptors for tumor necrosis factor alpha
    Vojislav Pejovic
    Tulane Medical School, VAMC, New Orleans, LA 70112, USA
    Proteomics 4:1461-4. 2004
    ..This is the first time that some of them have been associated with TNF alpha signaling pathways...
  54. ncbi request reprint Neuregulin-1-beta1 enters brain and spinal cord by receptor-mediated transport
    Abba J Kastin
    Veterans Affairs Medical Center and Tulane University Health Sciences Center, New Orleans, Louisiana 70112 1262, USA
    J Neurochem 88:965-70. 2004
    ..The results indicate that NRG-1-beta1 enters spinal cord and brain by a saturable receptor-mediated mechanism, which provides the opportunity for possible therapeutic manipulation at the BBB level...
  55. ncbi request reprint Peptide transport across the blood-brain barrier
    Abba J Kastin
    VA Medical Center and Tulane University School of Medicine, New Orleans, LA 70112 1262, USA
    Prog Drug Res 61:79-100. 2003
  56. ncbi request reprint Circulating TGF-beta1 does not cross the intact blood-brain barrier
    Abba J Kastin
    VA Medical Center and Tulane University School of Medicine, New Orleans, LA 70112 1262, USA
    J Mol Neurosci 21:43-8. 2003
    ..Thus, the therapeutic potential of TGF-beta1 administered in blood is probably limited to situations in which the BBB has been disrupted...
  57. ncbi request reprint Different mechanisms influencing permeation of PDGF-AA and PDGF-BB across the blood-brain barrier
    Abba J Kastin
    VA Medical Center, New Orleans, Louisiana 70112 1262, USA
    J Neurochem 87:7-12. 2003
    ..Information from these studies could be useful in the design of analogues for delivery of PDGF as a therapeutic agent...
  58. ncbi request reprint Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier
    Abba J Kastin
    VA Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112 1262, USA
    Brain Res Mol Brain Res 114:168-71. 2003
    ..We show that 125I-IL-10 is stable in circulating blood but does not cross the intact BBB after intravenous delivery. Thus, peripheral IL-10 probably can serve as a CNS therapeutic only when the BBB is disrupted...
  59. ncbi request reprint Glial cell line-derived neurotrophic factor does not enter normal mouse brain
    Abba J Kastin
    VA Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112 1262, USA
    Neurosci Lett 340:239-41. 2003
    ....
  60. ncbi request reprint Novel peptide-peptide cooperation may transform feeding behavior
    Abba J Kastin
    Veterans Affairs Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70112 1262, USA
    Peptides 23:2189-96. 2002
    ..Such a novel interaction between two peptides at the BBB opens new approaches for general study of the dynamic regulatory role of the BBB in brain-body communication as well as the specific study of obesity...
  61. ncbi request reprint Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
    Abba J Kastin
    VA Medical Center, New Orleans, LA, USA
    J Mol Neurosci 18:7-14. 2002
    ..Therefore, we conclude that [Ser8]GLP-1 and the endogenous peptide GLP-1 can gain access to the brain from the periphery by simple diffusion and thus contribute to the regulation of feeding...
  62. ncbi request reprint Endomorphins exit the brain by a saturable efflux system at the basolateral surface of cerebral endothelial cells
    Aniko Somogyvari-Vigh
    Tulane University Department of Medicine and VA Medical Center, 1601 Perdido Street, 8F165, New Orleans, LA 70112, USA
    Exp Brain Res 156:224-30. 2004
    ..As endormorphins are mainly produced in the CNS, the presence of the efflux system at the BBB could play an important role in pain modulation and neuroendocrine control...
  63. ncbi request reprint Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge 70808, USA
    J Cell Sci 117:5071-8. 2004
    ..These studies suggest that RAP may provide a novel means of protein-based drug delivery to the brain...
  64. ncbi request reprint Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Neuroimmunol 174:119-25. 2006
    ..This enhanced transport correlated with increased expression of LIFRalpha shown by immunofluorescent staining and Western blot. Therefore, LIFR at the BBB provides an important target for therapeutic intervention...
  65. ncbi request reprint Stroke upregulates TNFalpha transport across the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Exp Neurol 198:222-33. 2006
    ..Given the known multiple modulatory effects of TNFalpha after stroke, the results indicate that the TNFalpha transport system at the BBB facilitates neuroplasticity and plays an important role in stroke recovery...
  66. ncbi request reprint Selective tissue uptake of agouti-related protein(82-131) and its modulation by fasting
    Weihong Pan
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, 70808, USA
    Endocrinology 146:5533-9. 2005
    ..Thus, the differential uptake of AgRP by peripheral organs could be a regulated process that is modulated by food deprivation...
  67. ncbi request reprint Permeation of growth hormone across the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 146:4898-904. 2005
    ..The central nervous system effects of peripheral GH can be attributed to permeation of the BBB despite the absence of a specific transport system...
  68. doi request reprint Peptides and hormesis
    Abba J Kastin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Crit Rev Toxicol 38:629-31. 2008
    ..Hopefully, hormesis will be routinely considered in the design of research projects and the discovery of pharmaceutical agents...
  69. ncbi request reprint Effects of peptides, with emphasis on feeding, pain, and behavior A 5-year (1999-2003) review of publications in Peptides
    Yongmei Yu
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 25:2257-89. 2004
    ..By presenting in condensed form the effects of peptides which are essential for systems biology, we hope that this summary of existing knowledge will encourage additional novel research to be presented in Peptides...
  70. ncbi request reprint Novel cytosine deaminase fusion gene enhances the effect of radiation on breast cancer in bone by reducing tumor burden, osteolysis, and skeletal fracture
    Michael Goblirsch
    Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 12:3168-76. 2006
    ..Painful breast carcinoma metastases in bone are a common manifestation of malignant disease. Eradication of these tumors can be evasive, and as a result, skeletal morbidity increases with disease progression...
  71. ncbi request reprint Strategies to create a regenerating environment for the injured spinal cord
    Shulin Xiang
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Pharm Des 11:1267-77. 2005
    ..Overall, insights arising from the experimental results may eventually lead to better therapeutic intervention so as to lessen the functional disability and enhance the quality of life in patients with SCI...
  72. ncbi request reprint Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment
    Lee J Quinton
    Department of Physiology, Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA 70112
    Am J Physiol Lung Cell Mol Physiol 286:L465-72. 2004
    ..Our results show that CINC, in contrast to MIP-2, is selectively transported from the lung to the systemic circulation, where it promotes neutrophil migration into the lung in response to a chemotactic stimulus...
  73. pmc The fasting polypeptide FGF21 can enter brain from blood
    Hung Hsuchou
    Blood Brain Barrier Group, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 28:2382-6. 2007
    ..Efflux, which occurred at the same rate as the bulk reabsorption of cerebrospinal fluid, also was not saturable. In summary, FGF21 shows significant, non-saturable, unidirectional influx across the BBB...
  74. ncbi request reprint Targeting neurite growth inhibitors to induce CNS regeneration
    Abba J Kastin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Pharm Des 11:1247-53. 2005
    ..Thus, there are several therapeutic approaches to overcome the actions of endogenous neurite growth inhibitors so as to promote CNS regeneration...
  75. pmc Neural plasticity after spinal cord injury
    Yuemin Ding
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Pharm Des 11:1441-50. 2005
    ..Thus, further understanding of the mechanisms of plasticity could lead to better ways of promoting useful reorganization and preventing undesirable consequences...
  76. ncbi request reprint Unexpected amplification of leptin-induced Stat3 signaling by urocortin: implications for obesity
    Weihong Pan
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    J Mol Neurosci 33:232-8. 2007
    ..By unexpectedly potentiating leptin signaling through Stat, urocortin amplifies the cellular response of leptin. This novel phenomenon suggests that urocortin can play an important compensatory role during leptin resistance in obesity...
  77. ncbi request reprint TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression
    Chuanhui Yu
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Cell Physiol 213:161-6. 2007
    ..Thus, TNF stimulation results in decreased responsiveness of RBE4 cells to LIF, indicating complex regulatory interactions of cytokines at the BBB...
  78. ncbi request reprint Analysis of distinct tartrate-resistant acid phosphatase promoter regions in transgenic mice
    Weihong Pan
    Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 280:4888-93. 2005
    ..6-kb C portion of the (TRAP) promoter, it is likely that transcription binding sites outside of the 2.2-kb region will have profound effects on regulation of the gene in vivo and in vitro...
  79. ncbi request reprint Increased leptin permeation across the blood-brain barrier after chronic alcohol ingestion
    Weihong Pan
    Blood Brain Barrier Lab, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Neuropsychopharmacology 33:859-66. 2008
    ..The results showing increased leptin permeation across the BBB lead to the speculation that leptin may serve as a homeostatic feeding signal in these mice...
  80. ncbi request reprint From MIF-1 to endomorphin: the Tyr-MIF-1 family of peptides
    Weihong Pan
    Blood Brain Barrier Group, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 28:2411-34. 2007
    ..These peptides clearly illustrate that the name of a peptide restricts neither its actions nor its conceptual implications...