Roy C Orlando

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint Pathogenesis of gastroesophageal reflux disease
    Roy C Orlando
    Department of Medicine, Gastroenterology and Hepatology Section, Tulane University Health Sciences Center and New Orleans Veterans Administration Hospital, SL 35, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Gastroenterol Clin North Am 31:S35-44. 2002
  2. ncbi request reprint Pathogenesis of gastroesophageal reflux disease
    Roy C Orlando
    Department of Gastroenterology and Hepatology, Tulane University Health Sciences Center and New Orleans Veterans Administration Hospital, Louisiana, USA
    Am J Med Sci 326:274-8. 2003
  3. ncbi request reprint Current understanding of the mechanisms of gastro-oesophageal reflux disease
    Roy C Orlando
    Department of Medicine, Tulane University Medical School, New Orleans, Louisiana 70112, USA
    Drugs 66:1-5; discussion 29-33. 2006
  4. ncbi request reprint Pathogenesis of reflux esophagitis and Barrett's esophagus
    Roy C Orlando
    Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue SL 35, New Orleans, LA 70112, USA
    Med Clin North Am 89:219-41, vii. 2005
  5. doi request reprint The effect of tegaserod on esophageal submucosal glands bicarbonate and mucin secretion
    Solange Abdulnour-Nakhoul
    Southeast Louisiana Veterans Health Care Network, and Departments of Medicine and Physiology, Tulane University School of Medicine, c o Tulane Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112 2699, USA
    Dig Dis Sci 53:2366-72. 2008
  6. ncbi request reprint Characterization of esophageal submucosal glands in pig tissue and cultures
    Solange Abdulnour-Nakhoul
    Department of Medicine, SL 45, 1430 Tulane Avenue, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Dig Dis Sci 52:3054-65. 2007
  7. pmc Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease
    Biljana Jovov
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 106:1039-47. 2011
  8. doi request reprint Effect of amiloride on experimental acid-induced heartburn in non-erosive reflux disease
    William J Bulsiewicz
    Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Diseases and Swallowing Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Dig Dis Sci 58:1955-9. 2013
  9. doi request reprint Defective barrier function in neosquamous epithelium
    Biljana Jovov
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7032, USA
    Am J Gastroenterol 108:386-91. 2013
  10. doi request reprint Lateral cell membranes and shunt resistance in rabbit esophageal epithelium
    Nelia A Tobey
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7310, USA
    Dig Dis Sci 55:1856-65. 2010

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Pathogenesis of gastroesophageal reflux disease
    Roy C Orlando
    Department of Medicine, Gastroenterology and Hepatology Section, Tulane University Health Sciences Center and New Orleans Veterans Administration Hospital, SL 35, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Gastroenterol Clin North Am 31:S35-44. 2002
    ..In either case, the final common pathway is damage to the esophageal epithelium--damage that is reflected in the development of heartburn, esophageal necrosis and inflammation, or both...
  2. ncbi request reprint Pathogenesis of gastroesophageal reflux disease
    Roy C Orlando
    Department of Gastroenterology and Hepatology, Tulane University Health Sciences Center and New Orleans Veterans Administration Hospital, Louisiana, USA
    Am J Med Sci 326:274-8. 2003
    ..In either case, the final common pathway for the clinical expression of reflux esophagitis is by damage to the esophageal epithelium that is responsible for the development of heartburn and/or esophageal necrosis and inflammation...
  3. ncbi request reprint Current understanding of the mechanisms of gastro-oesophageal reflux disease
    Roy C Orlando
    Department of Medicine, Tulane University Medical School, New Orleans, Louisiana 70112, USA
    Drugs 66:1-5; discussion 29-33. 2006
    ..This article examines these concepts and how they shape our current understanding of GERD...
  4. ncbi request reprint Pathogenesis of reflux esophagitis and Barrett's esophagus
    Roy C Orlando
    Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue SL 35, New Orleans, LA 70112, USA
    Med Clin North Am 89:219-41, vii. 2005
    ....
  5. doi request reprint The effect of tegaserod on esophageal submucosal glands bicarbonate and mucin secretion
    Solange Abdulnour-Nakhoul
    Southeast Louisiana Veterans Health Care Network, and Departments of Medicine and Physiology, Tulane University School of Medicine, c o Tulane Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112 2699, USA
    Dig Dis Sci 53:2366-72. 2008
    ..5) plus pepsin. These results indicate that tegaserod stimulates SMG bicarbonate secretion, an effect that likely accounts for the observed protection against acid-pepsin injury to pig, but not rabbit, esophagus...
  6. ncbi request reprint Characterization of esophageal submucosal glands in pig tissue and cultures
    Solange Abdulnour-Nakhoul
    Department of Medicine, SL 45, 1430 Tulane Avenue, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Dig Dis Sci 52:3054-65. 2007
    ....
  7. pmc Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease
    Biljana Jovov
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Gastroenterol 106:1039-47. 2011
    ..E-cadherin is a junctional protein important in barrier function in EE. Therefore, defects in barrier function in EE were sought in GERD as well as whether their presence correlated with abnormalities in e-cadherin...
  8. doi request reprint Effect of amiloride on experimental acid-induced heartburn in non-erosive reflux disease
    William J Bulsiewicz
    Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Diseases and Swallowing Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Dig Dis Sci 58:1955-9. 2013
    ..Amiloride, a diuretic, is known to inhibit ASICs. For this reason, we sought a role for ASICs in mediating heartburn by determining whether amiloride could block heartburn in NERD induced by esophageal acid perfusion...
  9. doi request reprint Defective barrier function in neosquamous epithelium
    Biljana Jovov
    Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7032, USA
    Am J Gastroenterol 108:386-91. 2013
    ....
  10. doi request reprint Lateral cell membranes and shunt resistance in rabbit esophageal epithelium
    Nelia A Tobey
    Department of Medicine, University of North Carolina, Chapel Hill, NC 27599 7310, USA
    Dig Dis Sci 55:1856-65. 2010
    ....
  11. ncbi request reprint Chloride transport in rabbit esophageal epithelial cells
    Solange Abdulnour-Nakhoul
    Department of Medicine, Tulane University School of Medicine, and Veterans Administration Medical Center, New Orleans, Louisiana 70112 2699, USA
    Am J Physiol Gastrointest Liver Physiol 282:G663-75. 2002
    ..Transport of Cl(-) at the basolateral membrane is likely the dominant pathway for regulation of intracellular Cl(-)...
  12. ncbi request reprint Regulatory volume decrease in human esophageal epithelial cells
    Geraldine S Orlando
    Department of Medicine, Tulane University School of Medicine and Veterans Administration Medical Center, New Orleans, Louisiana 70112 2699, USA
    Am J Physiol Gastrointest Liver Physiol 283:G932-7. 2002
    ....
  13. pmc Safety and efficacy of endoscopic mucosal therapy with radiofrequency ablation for patients with neoplastic Barrett's esophagus
    William J Bulsiewicz
    Center for Esophageal Diseases and Swallowing, Department of Medicine, Division of Gastroenterology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7080, USA
    Clin Gastroenterol Hepatol 11:636-42. 2013
    ..The goal of radiofrequency ablation (RFA) for patients with Barrett's esophagus (BE) is to eliminate dysplasia and metaplasia. The efficacy and safety of RFA for patients with BE and neoplasia are characterized incompletely...
  14. doi request reprint Review: Experimental models for Barrett's esophagus and esophageal adenocarcinoma
    Katherine S Garman
    Division of Gastroenterology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Center, North Carolina, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1231-43. 2012
    ..This review describes several of the existing and potential model systems for BE and EAC with their benefits and disadvantages...
  15. ncbi request reprint The pathogenesis of heartburn in nonerosive reflux disease: a unifying hypothesis
    William J Barlow
    Tulane University Health Sciences Center, Department of Medicine SL 35, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Gastroenterology 128:771-8. 2005
    ....
  16. ncbi request reprint Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action
    Weijian Shao
    Department of Physiology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Cell Physiol 289:C248-56. 2005
    ..Stimulation of NSCC with BP is expected to cause membrane depolarization and may explain, in part, its mechanisms of action in inhibiting osteoclasts...
  17. ncbi request reprint Mechanisms of epithelial injury and inflammation in gastrointestinal diseases
    Roy C Orlando
    Section of Gastroenterology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Rev Gastroenterol Disord 2:S2-8. 2002
    ..Further, the basis for the link between inflammation and cancer risk in Barrett's esophagus and Crohn's disease is described...
  18. ncbi request reprint Nonerosive reflux disease: a pathophysiologic perspective
    John D Long
    Section of Gastroenterology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Gastroenterol Rep 10:200-7. 2008
    ....
  19. ncbi request reprint Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance
    Biljana Jovov
    Dept of Medicine, Univ of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1106-13. 2007
    ..We conclude that Cldn-18 is the dominant claudin in the TJ of SCE and propose that the change from a Cldn-18-deficient TJ in SqE to a Cldn-18-rich TJ in SCE contributes to the greater acid resistance of BE...
  20. ncbi request reprint Effect of acid perfusion on passive electrophysiological properties of rabbit esophagus in vivo
    Ingemar Jacobson
    Integrative Pharmacology, AstraZeneca R and D Molndal, Sweden
    Dig Dis Sci 47:1369-80. 2002
    ..The electrophysiological results were to some extent corroborated by light microscopic findings, although no large acid-induced change in mucosal appearance was observed...
  21. pmc Viscous topical is more effective than nebulized steroid therapy for patients with eosinophilic esophagitis
    Evan S Dellon
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Gastroenterology 143:321-4.e1. 2012
    ..OVB was more effective than NEB in reducing numbers of esophageal eosinophils in patients with EoE. OVB provided a significantly higher level of esophageal exposure to the therapeutic agent, which correlated with lower eosinophil counts...
  22. ncbi request reprint HCO3- secretion in the esophageal submucosal glands
    Solange Abdulnour-Nakhoul
    The VA Medical Center, Attn Research, Rm 5F151, 1601 Perdido St, New Orleans, LA 70112 2699, USA
    Am J Physiol Gastrointest Liver Physiol 288:G736-44. 2005
    ..HCO(3)(-) transport in these cells is dependent on cytosolic and serosal membrane-bound carbonic anhydrase. HCO(3)(-) secretion is also dependent on serosal Cl(-) and is mediated by DIDS-sensitive transporters, possibly NBC and AE2...
  23. ncbi request reprint Esophageal perception and noncardiac chest pain
    Roy C Orlando
    Tulane University Medical School, 1430 Tulane Avenue, New Orleans, LA 70112 2699, USA
    Gastroenterol Clin North Am 33:25-33. 2004
    ....
  24. ncbi request reprint Nonselective cation transport in native esophageal epithelia
    Mouhamed S Awayda
    Dept of Physiology, SL 39, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Am J Physiol Cell Physiol 287:C395-402. 2004
    ..Moreover, our data are consistent with a potential role of ENaC subunits in the formation of a native nonselective cation channel...
  25. doi request reprint Pathophysiology of gastroesophageal reflux disease
    Roy C Orlando
    University of North Carolina School of Medicine, Chapel Hill, NC 27599 7032, USA
    J Clin Gastroenterol 42:584-8. 2008
    ....
  26. ncbi request reprint Chronic hypergastrinemia: causes and consequences
    Lori A Orlando
    Duke University Center for Clinical Health Policy and Durham VA, Durham, North Carolina, USA
    Dig Dis Sci 52:2482-9. 2007
    ..For this reason, we present a concise overview of the origin, causes, and potential risks of chronic hypergastrinemia...