Khalid Matrougui

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity
    Sabry M Shaarawy
    Department of Cancer Biology, National Research Institute, Cairo University, Cairo, Egypt
    Int J Biol Sci 5:549-57. 2009
  2. ncbi request reprint A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus
    Maria Galán
    Department of Physiology, Hypertension, and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Hypertension 60:71-80. 2012
  3. pmc Natural regulatory T cells control coronary arteriolar endothelial dysfunction in hypertensive mice
    Khalid Matrougui
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, Louisiana 70112, USA
    Am J Pathol 178:434-41. 2011
  4. pmc Diabetes and microvascular pathophysiology: role of epidermal growth factor receptor tyrosine kinase
    Khalid Matrougui
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Diabetes Metab Res Rev 26:13-6. 2010
  5. pmc Chronic inhibition of epidermal growth factor receptor tyrosine kinase and extracellular signal-regulated kinases 1 and 2 (ERK1/2) augments vascular response to limb ischemia in type 2 diabetic mice
    Soo Kyoung Choi
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, Louisiana 70112, USA
    Am J Pathol 180:410-8. 2012
  6. ncbi request reprint Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice
    Ali Amin
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    J Pathol 227:165-74. 2012
  7. pmc Mechanisms of myogenic tone of coronary arteriole: Role of down stream signaling of the EGFR tyrosine kinase
    Ali H Amin
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Microvasc Res 81:135-42. 2011
  8. pmc Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension
    Ali Amin
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Pflugers Arch 464:583-92. 2012
  9. pmc Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alphavbeta3-integrin, and TGF-beta1 in response to ANG II and high glucose
    Souad Belmadani
    Dept of Physiology, Hypertension and Renal Center of Excellence, Tulane Univ, School of Medicine, Health Sciences Center, New Orleans, Louisana, USA
    Am J Physiol Heart Circ Physiol 295:H69-76. 2008
  10. doi request reprint Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice
    Modar Kassan
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, LA 70112, USA
    Arterioscler Thromb Vasc Biol 32:1652-61. 2012

Collaborators

Detail Information

Publications32

  1. pmc Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity
    Sabry M Shaarawy
    Department of Cancer Biology, National Research Institute, Cairo University, Cairo, Egypt
    Int J Biol Sci 5:549-57. 2009
    ..The present study was conducted to investigate the chemopreventive effects of garlic extract and silymarin on N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl(4))-induced hepatotoxicity in male albino rats...
  2. ncbi request reprint A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus
    Maria Galán
    Department of Physiology, Hypertension, and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Hypertension 60:71-80. 2012
    ..This study unveiled novel roles for enhanced EGFRtk phosphorylation and its downstream ER stress in cardiac fibrosis and microvascular endothelial dysfunction in type 1 diabetes mellitus...
  3. pmc Natural regulatory T cells control coronary arteriolar endothelial dysfunction in hypertensive mice
    Khalid Matrougui
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, Louisiana 70112, USA
    Am J Pathol 178:434-41. 2011
    ..These results suggest a new direction in the investigation of vascular disease in hypertension and could lead to a therapeutic strategy that involves immune system modulation using Tregs...
  4. pmc Diabetes and microvascular pathophysiology: role of epidermal growth factor receptor tyrosine kinase
    Khalid Matrougui
    Department of Physiology, and Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Diabetes Metab Res Rev 26:13-6. 2010
    ..In this review, we discuss the link between the EGFR transactivation and microvascular dysfunction that occurs in type 2 diabetes...
  5. pmc Chronic inhibition of epidermal growth factor receptor tyrosine kinase and extracellular signal-regulated kinases 1 and 2 (ERK1/2) augments vascular response to limb ischemia in type 2 diabetic mice
    Soo Kyoung Choi
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, Louisiana 70112, USA
    Am J Pathol 180:410-8. 2012
    ..Thus, EGFRtk and ERK1/2 could be possible targets to protect from ischemia-induced vascular pathology in type 2 diabetes...
  6. ncbi request reprint Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice
    Ali Amin
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    J Pathol 227:165-74. 2012
    ..Thus, ER stress and inflammation could be potential targets for a novel therapeutic approach to prevent impaired ischaemia-induced vascular pathology in type II diabetes...
  7. pmc Mechanisms of myogenic tone of coronary arteriole: Role of down stream signaling of the EGFR tyrosine kinase
    Ali H Amin
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Microvasc Res 81:135-42. 2011
    ..Thus, we hypothesized that GRB2-SOS, Akt, JAK and STAT3 are downstream signaling of the EGFR and play role in myogenic tone...
  8. pmc Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension
    Ali Amin
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Pflugers Arch 464:583-92. 2012
    ..Our findings indicate that SN therapy rescues the neovascularization and blood flow recovery in the ischemic hind limb of sham and HT mice likely through the Akt/NO/cGMP and VEGFR pathways...
  9. pmc Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alphavbeta3-integrin, and TGF-beta1 in response to ANG II and high glucose
    Souad Belmadani
    Dept of Physiology, Hypertension and Renal Center of Excellence, Tulane Univ, School of Medicine, Health Sciences Center, New Orleans, Louisana, USA
    Am J Physiol Heart Circ Physiol 295:H69-76. 2008
    ..This pathway could be a potential target for overcoming small artery complications in diabetes and hypertension...
  10. doi request reprint Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice
    Modar Kassan
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, LA 70112, USA
    Arterioscler Thromb Vasc Biol 32:1652-61. 2012
    ..In the present study, we explored the beneficial therapeutic effect of endoplasmic reticulum (ER) stress inhibition on cardiac damage and vascular dysfunction in hypertension...
  11. pmc Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice
    Ali H Amin
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, LA 70112, USA
    Lab Invest 90:985-96. 2010
    ..Our novel study data provide evidence that in type II diabetes, stimulated MSCs with EGF enhance the recovery of blood flow and angiogenesis...
  12. ncbi request reprint Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction
    Maria Galán
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Biochim Biophys Acta 1843:1063-75. 2014
    ..In this study we aimed to elucidate the mechanisms by which ER stress induction and oxidative stress impair vascular endothelial function...
  13. ncbi request reprint Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice
    Modar Kassan
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, Louisiana
    Am J Physiol Heart Circ Physiol 306:H972-80. 2014
    ..Therefore, p22(phox) could be an important target to improve vascular function in diabetes. ..
  14. pmc Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice
    Jun Su
    Department of Pharmacology, Tulane University, 1430 Tulane Ave, New Orleans LA 70112, USA
    Arterioscler Thromb Vasc Biol 28:1432-8. 2008
    ..Type 2 diabetes is associated with increased advanced glycation end product (AGE) formation and vasculopathy. We hypothesized that AGEs contribute to resistance artery dysfunction...
  15. pmc Role of elevated EGFR phosphorylation in the induction of structural remodelling and altered mechanical properties of resistance artery from type 2 diabetic mice
    Desiree I Palen
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, 1430 Tulane Ave, New Orleans LA 70112, USA
    Diabetes Metab Res Rev 24:651-6. 2008
    ..We hypothesized that the sustained elevated EGFR phosphorylation produces structural wall remodelling and altered mechanical properties of mesenteric resistance artery (MRA) in type 2 diabetes...
  16. pmc Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus
    Soo Kyoung Choi
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, LA 70112, USA
    Hypertension 59:1060-8. 2012
    ..We provide evidence that T2DM impairs microvascular function by an enhanced PARP-1 activity-dependent mechanism. Therefore, PARP-1 could be a potential target for overcoming diabetic microvascular complications...
  17. pmc High-fat diet induces lung remodeling in ApoE-deficient mice: an association with an increase in circulatory and lung inflammatory factors
    Amarjit S Naura
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Lab Invest 89:1243-51. 2009
    ..These results suggest that hypercholesterolemia may promote chronic inflammatory conditions in lungs that are conducive to lung remodeling potentially through TNF-alpha-mediated processes...
  18. pmc Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice
    Souad Belmadani
    Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Diabetes 57:1629-37. 2008
    ..Type 2 diabetes is associated with microvascular complications. We hypothesized that elevated EGFR phosphorylation contributes to resistance artery dysfunction in type 2 diabetes...
  19. pmc Interleukin-10 released by CD4(+)CD25(+) natural regulatory T cells improves microvascular endothelial function through inhibition of NADPH oxidase activity in hypertensive mice
    Modar Kassan
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, LA 70112, USA
    Arterioscler Thromb Vasc Biol 31:2534-42. 2011
    ..However, the underlying mechanism by which Tregs regulate vascular endothelial function remains unknown...
  20. ncbi request reprint CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension
    Modar Kassan
    aDepartment of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia bDepartment of Pharmacology, Tulane University, New Orleans, Louisiana cCollege of Nanoscale Science and Engineering, University at Albany, Albany, New York, USA
    J Hypertens 31:1939-43. 2013
    ..In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction. ..
  21. pmc Enhanced NF-κB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes
    Modar Kassan
    Department of Physiology, Hypertension and Renal Center of Excellence, Tulane University, New Orleans, Louisiana, USA
    Diabetes 62:2078-87. 2013
    ..Therefore, NF-κB could be a potential target to overcome diabetes-induced vascular dysfunction...
  22. pmc Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content
    Chetan P Hans
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Pharmacol Exp Ther 329:150-8. 2009
    ..In accordance, PARP inhibition may prove beneficial not only in preventing atherogenesis but also in promoting regression of preexisting plaques...
  23. pmc Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy
    Chetan P Hans
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Cardiovasc Pathol 20:e57-68. 2011
    ....
  24. pmc Amplification of coronary arteriogenic capacity of multipotent stromal cells by epidermal growth factor
    Souad Belmadani
    Department of Physiology, LSUHSC, New Orleans, LA, USA
    Arterioscler Thromb Vasc Biol 29:802-8. 2009
    ..We determined whether increasing adherence of multipotent stromal cells (MSCs) would amplify their effects on coronary collateral growth (CCG)...
  25. pmc Role of ACE/AT2R complex in the control of mesenteric resistance artery contraction induced by ACE/AT1R complex activation in response to Ang I
    Jun Su
    Department of Pharmacology, LSU Health Sciences Center, Tulane University, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Mol Cell Biochem 311:1-7. 2008
    ....
  26. ncbi request reprint Hydrogen peroxide acts as relaxing factor in human vascular smooth muscle cells independent of map-kinase and nitric oxide
    Desiree I Palen
    Department of Pharmacology, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Front Biosci 11:2526-34. 2006
    ..The relaxation induced by H2O2 is independent of BKCa, ERK1/2 MAP-Kinase and NOS pathways. The relaxing effect to H2O2 changes to contracting effect when the potassium channels are compromised...
  27. pmc Involvement of tumor necrosis factor-alpha in natriuretic response to systemic infusion of nitric oxide synthase inhibitor in anesthetized mice
    Mohd Shahid
    Department of Physiology and Tulane Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 299:F217-24. 2010
    ..These data demonstrate that L-NAME-induced natriuresis is mediated, at least in part, by concomitant generation of TNF-alpha during NO blockade...
  28. ncbi request reprint Mice lacking the gene encoding for MMP-9 and resistance artery reactivity
    Jun Su
    Department of Pharmacology, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Biochem Biophys Res Commun 349:1177-81. 2006
    ....
  29. ncbi request reprint Role of SHP-1, Kv.1.2, and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells
    Desiree I Palen
    Department of Pharmacology, LSU Health Sciences Center at New Orleans, LA 70112, USA
    Cardiovasc Res 68:268-77. 2005
    ..In this study we determined the mechanisms that lead to ERK1/2 MAP kinase dephosphorylation in response to NO...
  30. ncbi request reprint Survivin is not only a death encounter but also a survival protein for invading tumor cells
    Allal Ouhtit
    Department of Pathology, Stanley S Scott Cancer Center, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    Front Biosci 12:1260-70. 2007
    ..In this report, in addition to reviewing the SVV known functions, we discuss the newly proposed mechanisms by which SVV might serve as a survival tool for invading tumor cells...
  31. doi request reprint Chronic escitalopram treatment induces erectile dysfunction by decreasing nitric oxide bioavailability mediated by increased nicotinamide adenine dinucleotide phosphate oxidase activity and reactive oxygen species production
    Modar Kassan
    Department of Physiology, Tulane University School of Medicine, New Orleans, LA
    Urology 82:1188.e1-7. 2013
    ..To investigate the effects of escitalopram, a selective serotonin reuptake inhibitor, on erectile and penile vascular function in the rat...
  32. ncbi request reprint Involvement of metalloproteinases 2/9 in epidermal growth factor receptor transactivation in pressure-induced myogenic tone in mouse mesenteric resistance arteries
    Pamela A Lucchesi
    Department of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, USA
    Circulation 110:3587-93. 2004
    ..The present study used mouse mesenteric resistance arteries (MRAs) to investigate the role of EGFR transactivation under pressure-induced myogenic tone (MT)...

Research Grants2

  1. Mechanisms of Coronary Arteriolar Dysfunction in Type 2 Diabetes
    Khalid Matrougui; Fiscal Year: 2010
    ..The goal of our studies is to determine how increased Epidermal Growth Factor Receptor tyrosine kinase activity compromises coronary arteriolar function in type 2 diabetes. ..
  2. Mechanisms of Coronary Arteriolar Dysfunction in Type 2 Diabetes
    Khalid Matrougui; Fiscal Year: 2011
    ..The goal of our studies is to determine how increased Epidermal Growth Factor Receptor tyrosine kinase activity compromises coronary arteriolar function in type 2 diabetes. ..