Affiliation: Tulane University
- The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infectionBinhua Ling
Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
J Infect Dis 202:1846-54. 2010....
- Nonpathogenic CCR2-tropic SIVrcm after serial passage and its effect on SIVmac infection of Indian rhesus macaquesBinhua Ling
Division of Comparative Pathology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
Virology 379:38-44. 2008..These results suggest that SIVrcm is nonpathogenic and may be useful for examining effective immune responses in SIV infection...
- Control of viremia and maintenance of intestinal CD4(+) memory T cells in SHIV(162P3) infected macaques after pathogenic SIV(MAC251) challengeBapi Pahar
Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA
Virology 387:273-84. 2009..These results suggest that protection against pathogenic lentiviral infection or disease progression is indeed possible, and may correlate with preservation of mucosal CD4(+) T cells...
- Early restoration of mucosal CD4 memory CCR5 T cells in the gut of SIV-infected rhesus predicts long term non-progressionBinhua Ling
Tulane National Primate Research Center, Covington, Louisianna, USA
AIDS 21:2377-85. 2007..The key questions addressed were whether or not LTNP experience an early and rapid loss of mucosal CD4 T cells during the acute infection and the mechanisms by which they maintain the LTNP state...
- Classic AIDS in a sooty mangabey after an 18-year natural infectionBinhua Ling
Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
J Virol 78:8902-8. 2004..Therefore, the results also suggest that SMs have a special mechanism for resisting AIDS development...
- Detection and partial characterization of simian immunodeficiency virus SIVsm strains from bush meat samples from rural Sierra LeoneCristian Apetrei
Microbiology Division, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
J Virol 79:2631-6. 2005..In spite of the fact that our study doubles the number of known SIVsm strains from wild SMs, none of the simian strains were close to the groups in which HIV-2 was epidemic (groups A and B)...
- SIV(mac) pathogenesis in rhesus macaques of Chinese and Indian origin compared with primary HIV infections in humansBinhua Ling
Tulane University Health Sciences Center, Department of Tropical Medicine and the Tulane Regional Primate Research Center, Covington, Louisiana 70433, USA
AIDS 16:1489-96. 2002..The Ch Rh subspecies is a suitable AIDS model and may have advantages over the rapid and highly pathogenic Ind Rh model. Moreover, Ind Rh supplies are limited and use of Ch Rh provides a new resource...
- The level of monocyte turnover predicts disease progression in the macaque model of AIDSAtsuhiko Hasegawa
Division of Immunology, Tulane National Primate Research Center, Tulane University Health Science Center, Covington, LA 70433, USA
Blood 114:2917-25. 2009..Our results show the importance of monocyte/macrophages in the pathogenesis of AIDS and suggest the dynamic changes of the monocyte/macrophages as a new marker for AIDS progression...
- A link between SIVsm in sooty mangabeys (SM) in wild-living monkeys in Sierra Leone and SIVsm in an American-based SM colonyBinhua Ling
Tulane National Primate Research Center, Covington, Louisiana 70433, USA
AIDS Res Hum Retroviruses 20:1348-51. 2004..The discovery of this strain in a wild-living SM also indicates that noninvasive methods can be used for SIV detection from monkey feces collected in the field...
- Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challengeRonald S Veazey
Tulane National Primate Research Center, Covington, Louisiana, USA
J Infect Dis 199:1525-7. 2009..These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline...
- Decreased CCR5 expression on CD4+ T cells of SIV-infected sooty mangabeysRonald Veazey
National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
AIDS Res Hum Retroviruses 19:227-33. 2003....
- Noninvasive detection of new simian immunodeficiency virus lineages in captive sooty mangabeys: ability to amplify virion RNA from fecal samples correlates with viral load in plasmaBinhua Ling
Aaron Diamond AIDS Research Center, New York, New York 10016, USA
J Virol 77:2214-26. 2003..These assays will be useful for studying the phylogeny and epidemiology of SIVsm infections in the wild, and they hold promise as tools for investigating natural SIV infections in endangered nonhuman primates...
- Boosting of SIV-specific T cell responses in rhesus macaques that resist repeated intravaginal challenge with SIVmac251Barbara L Shacklett
Gladstone Institute of Virology and Immunology, University of California-San Francisco, San Francisco, California 94103, USA
AIDS Res Hum Retroviruses 18:1081-8. 2002..These results support a protective role for SIVmac-specific T cells in repeatedly exposed, persistently seronegative rhesus macaques...