Affiliation: Tulane University
Li M, Hansen J, Huang L, Keyser B, Taylor J. Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. Cardiovasc Drug Rev. 2005;23:173-96 pubmed
..We conclude that NNC 55-0396, by virtue of its modified structure, does not produce the metabolite that causes inhibition of L-type Ca2+ channel channels, thus rendering it more selective to T-type Ca2+ channels. ..
Taylor J, Zeng X, Pottle J, Lee K, Wang A, Yi S, et al
. Calcium signaling and T-type calcium channels in cancer cell cycling. World J Gastroenterol. 2008;14:4984-91 pubmed
..Since T-type Ca(2+) channels are not expressed in epithelial cells, selective T-type Ca(2+) channel blockers may be useful in the treatment of certain types of cancers. ..
Huang L, Bhattacharjee A, Taylor J, Zhang M, Keyser B, Marrero L, et al
. [Ca2+]i regulates trafficking of Cav1.3 (alpha1D Ca2+ channel) in insulin-secreting cells. Am J Physiol Cell Physiol. 2004;286:C213-21 pubmed
..These results suggest that Cav1.3 channel trafficking is involved in glucose desensitization of pancreatic beta-cells. ..