Laura Levy

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR
    Samantha L Finstad
    Department of Microbiology and Immunology, Program in Molecular and Cellular Biology and Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Virol J 1:3. 2004
  2. pmc Matrix attachment regions as targets for retroviral integration
    Chassidy N Johnson
    Department of Microbiology and Immunology, Tulane Cancer Center, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Virol J 2:68. 2005
  3. pmc Distinctive receptor binding properties of the surface glycoprotein of a natural feline leukemia virus isolate with unusual disease spectrum
    Lisa L Bolin
    Department of Microbiology and Immunology and Tulane Cancer Center, Tulane University School of Medicine, 1430 Tulane Avenue SL 38, New Orleans, LA 70112, USA
    Retrovirology 8:35. 2011
  4. pmc Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-beta1 and IL-6
    Kristin R Ruff
    Department of Microbiology and Immunology and Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    BMC Cancer 7:35. 2007
  5. pmc Advances in understanding molecular determinants in FeLV pathology
    Laura S Levy
    Department of Microbiology and Immunology and Tulane Cancer Center, Tulane University School of Medicine, 1430 Tulane Avenue SL 38, New Orleans, LA 70112, USA
    Vet Immunol Immunopathol 123:14-22. 2008
  6. pmc Unique long terminal repeat and surface glycoprotein gene sequences of feline leukemia virus as determinants of disease outcome
    Chandtip Chandhasin
    Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave SL 38, New Orleans, LA 70112, USA
    J Virol 79:5278-87. 2005
  7. pmc Subtle mutational changes in the SU protein of a natural feline leukemia virus subgroup A isolate alter disease spectrum
    Chandtip Chandhasin
    Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave SL 38, New Orleans, LA 70112, USA
    J Virol 79:1351-60. 2005
  8. pmc Substitution of feline leukemia virus long terminal repeat sequences into murine leukemia virus alters the pattern of insertional activation and identifies new common insertion sites
    Chassidy Johnson
    Department of Microbiology and Immunology and Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Virol 79:57-66. 2005
  9. pmc The frequency of occurrence and nature of recombinant feline leukemia viruses in the induction of multicentric lymphoma by infection of the domestic cat with FeLV-945
    Shamim Ahmad
    Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA
    Virology 403:103-10. 2010
  10. pmc Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells
    Samantha L Finstad
    Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue SL 38, New Orleans, LA 70112, USA
    J Virol 81:7274-9. 2007

Research Grants

  1. SELECTIVE FORCES OPERATIVE IN FELV INFECTION
    Laura S Levy; Fiscal Year: 2010
  2. SELECTIVE FORCES OPERATIVE IN FELV INFECTION
    Laura Levy; Fiscal Year: 2006
  3. Pathobiology of SAIDS-Associated Lymphomas
    Laura Levy; Fiscal Year: 2006
  4. IMMUNOBIOLOGY OF SIV-ASSOCIATED LYMPHOMAS
    Laura Levy; Fiscal Year: 1999
  5. SELECTIVE FORCES OPERATIVE IN FELV INFECTION
    Laura Levy; Fiscal Year: 2009

Collaborators

Detail Information

Publications13

  1. pmc Regulation of FeLV-945 by c-Myb binding and CBP recruitment to the LTR
    Samantha L Finstad
    Department of Microbiology and Immunology, Program in Molecular and Cellular Biology and Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Virol J 1:3. 2004
    ..The objective of the present study was to examine the molecular mechanism by which the 21-bp triplication exerts its influence and the selective advantage responsible for its precise conservation...
  2. pmc Matrix attachment regions as targets for retroviral integration
    Chassidy N Johnson
    Department of Microbiology and Immunology, Tulane Cancer Center, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Virol J 2:68. 2005
    ..The objective was to assess whether integration near MARs may be a factor for integration site selection...
  3. pmc Distinctive receptor binding properties of the surface glycoprotein of a natural feline leukemia virus isolate with unusual disease spectrum
    Lisa L Bolin
    Department of Microbiology and Immunology and Tulane Cancer Center, Tulane University School of Medicine, 1430 Tulane Avenue SL 38, New Orleans, LA 70112, USA
    Retrovirology 8:35. 2011
    ..The present studies demonstrate that FeLV-945 SU confers distinctive properties of binding to the cell surface receptor...
  4. pmc Growth regulation of simian and human AIDS-related non-Hodgkin's lymphoma cell lines by TGF-beta1 and IL-6
    Kristin R Ruff
    Department of Microbiology and Immunology and Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    BMC Cancer 7:35. 2007
    ....
  5. pmc Advances in understanding molecular determinants in FeLV pathology
    Laura S Levy
    Department of Microbiology and Immunology and Tulane Cancer Center, Tulane University School of Medicine, 1430 Tulane Avenue SL 38, New Orleans, LA 70112, USA
    Vet Immunol Immunopathol 123:14-22. 2008
    ..Together, these observations indicate that the distinctive LTR and SU gene of FeLV-945 mediate a rapid pathogenesis with distinctive clinical features and oncogenic mechanisms...
  6. pmc Unique long terminal repeat and surface glycoprotein gene sequences of feline leukemia virus as determinants of disease outcome
    Chandtip Chandhasin
    Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave SL 38, New Orleans, LA 70112, USA
    J Virol 79:5278-87. 2005
    ..Since the TM genes of FeLV-945 and FeLV-A/61E are nearly identical but the SU genes differ significantly, FeLV-945 SU is implicated in the outcome. These findings identify the FeLV-945 LTR and SU gene as determinants of disease...
  7. pmc Subtle mutational changes in the SU protein of a natural feline leukemia virus subgroup A isolate alter disease spectrum
    Chandtip Chandhasin
    Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Ave SL 38, New Orleans, LA 70112, USA
    J Virol 79:1351-60. 2005
    ....
  8. pmc Substitution of feline leukemia virus long terminal repeat sequences into murine leukemia virus alters the pattern of insertional activation and identifies new common insertion sites
    Chassidy Johnson
    Department of Microbiology and Immunology and Tulane Cancer Center, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Virol 79:57-66. 2005
    ..Finally, the findings demonstrate the utility of novel recombinant retroviruses such as MoFe2 to contribute new genes potentially relevant to the induction of lymphoid malignancy...
  9. pmc The frequency of occurrence and nature of recombinant feline leukemia viruses in the induction of multicentric lymphoma by infection of the domestic cat with FeLV-945
    Shamim Ahmad
    Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA
    Virology 403:103-10. 2010
    ..The results confirmed the frequent association of FeLV-B with thymic lymphoma but showed infrequent generation, low levels and lack of infectivity of FeLV-B in non-T-cell diseases including multicentric lymphoma...
  10. pmc Diminished potential for B-lymphoid differentiation after murine leukemia virus infection in vivo and in EML hematopoietic progenitor cells
    Samantha L Finstad
    Department of Microbiology and Immunology, Tulane University School of Medicine, 1430 Tulane Avenue SL 38, New Orleans, LA 70112, USA
    J Virol 81:7274-9. 2007
    ..This reduction in viability may confer a selective advantage on undifferentiated lymphoid progenitors in the bone marrow of gammaretrovirus-infected animals and thereby contribute to the establishment of a premalignant state...
  11. pmc Disruption of hematopoiesis and thymopoiesis in the early premalignant stages of infection with SL3-3 murine leukemia virus
    Karen Rulli
    Department of Microbiology and Immunology, School of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Virol 76:2363-74. 2002
    ..A model in which disrupted bone marrow hematopoiesis and thymopoiesis contribute to the development of lymphoma in the SL3-infected animal is discussed...
  12. ncbi request reprint Feline leukaemia virus LTR variation and disease association in a geographical and temporal cluster
    Chandtip Chandhasin
    Department of Microbiology and Immunology, Tulane University Health Sciences Center, 1430 Tulane Avenue SL 38, New Orleans, LA, USA
    J Gen Virol 85:2937-42. 2004
    ..While the length and termini of enhancer duplications were variable, the 21 bp repeat unit was invariant. Triplication of the 21 bp repeat conferred the optimal replicative advantage in feline cells...
  13. ncbi request reprint Retrospective analysis of clinical and laboratory factors associated with lymphoma in simian AIDS
    Ilana S Fortgang
    Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Leuk Lymphoma 45:161-9. 2004
    ..The results contribute to an understanding of the etiology of SAIDS-NHL and to the future development of useful predictors of SAIDS- or AIDS-related lymphoma...

Research Grants19

  1. SELECTIVE FORCES OPERATIVE IN FELV INFECTION
    Laura S Levy; Fiscal Year: 2010
    ..Further, the proposed work is important for understanding the early stages of the induction of malignancy by examining the process in an animal model. ..
  2. SELECTIVE FORCES OPERATIVE IN FELV INFECTION
    Laura Levy; Fiscal Year: 2006
    ..This possibility will be tested using a novel single-cycle infection assay. The results will be considered in the context of the range of FeLV variation in natural multicentric lymphomas. ..
  3. Pathobiology of SAIDS-Associated Lymphomas
    Laura Levy; Fiscal Year: 2006
    ..A clear understanding of the mechanisms by which these cytokines effect positive and negative growth regulation of 1) lymphoma cells could contribute to the development of therapeutic agents that modulate their action. ..
  4. IMMUNOBIOLOGY OF SIV-ASSOCIATED LYMPHOMAS
    Laura Levy; Fiscal Year: 1999
    ..The genetic alterations in these lymphomas, the role of rhEBV (an EBV-like virus), and perturbation of various cytokines will be studied. ..
  5. SELECTIVE FORCES OPERATIVE IN FELV INFECTION
    Laura Levy; Fiscal Year: 2009
    ..Further, the proposed work is important for understanding the early stages of the induction of malignancy by examining the process in an animal model. ..