Andrew A Lackner

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction
    Mahesh Mohan
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 7:e34561. 2012
  2. pmc Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of SIV infection
    Mahesh Mohan
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 8:e60122. 2013
  3. pmc HIV pathogenesis: the host
    A A Lackner
    Tulane National Primate Research Center, Tulane University Health Science Center, Covington, LA 70443, USA
    Cold Spring Harb Perspect Med 2:a007005. 2012
  4. pmc SIV antigen immunization induces transient antigen-specific T cell responses and selectively activates viral replication in draining lymph nodes in retroviral suppressed rhesus macaques
    Haitao Hu
    Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, USA
    Retrovirology 8:57. 2011
  5. ncbi request reprint Current concepts in AIDS pathogenesis: insights from the SIV/macaque model
    Andrew A Lackner
    Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    Annu Rev Med 58:461-76. 2007
  6. pmc Control of viremia and maintenance of intestinal CD4(+) memory T cells in SHIV(162P3) infected macaques after pathogenic SIV(MAC251) challenge
    Bapi Pahar
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA
    Virology 387:273-84. 2009
  7. pmc Simian immunodeficiency virus selectively infects proliferating CD4+ T cells in neonatal rhesus macaques
    Xiaolei Wang
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA, USA
    Blood 116:4168-74. 2010
  8. pmc The level of monocyte turnover predicts disease progression in the macaque model of AIDS
    Atsuhiko Hasegawa
    Division of Immunology, Tulane National Primate Research Center, Tulane University Health Science Center, Covington, LA 70433, USA
    Blood 114:2917-25. 2009
  9. ncbi request reprint Early restoration of mucosal CD4 memory CCR5 T cells in the gut of SIV-infected rhesus predicts long term non-progression
    Binhua Ling
    Tulane National Primate Research Center, Covington, Louisianna, USA
    AIDS 21:2377-85. 2007
  10. pmc MCP-3/CCL7 production by astrocytes: implications for SIV neuroinvasion and AIDS encephalitis
    Nicole A Renner
    Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Neurovirol 17:146-52. 2011

Detail Information

Publications83

  1. pmc Focused examination of the intestinal lamina propria yields greater molecular insight into mechanisms underlying SIV induced immune dysfunction
    Mahesh Mohan
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 7:e34561. 2012
    ..Consequently GI disease, a major complication of HIV/SIV infection can facilitate translocation of lumenal bacterial products causing localized/systemic immune activation leading to AIDS progression...
  2. pmc Focused examination of the intestinal epithelium reveals transcriptional signatures consistent with disturbances in enterocyte maturation and differentiation during the course of SIV infection
    Mahesh Mohan
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 8:e60122. 2013
    ....
  3. pmc HIV pathogenesis: the host
    A A Lackner
    Tulane National Primate Research Center, Tulane University Health Science Center, Covington, LA 70443, USA
    Cold Spring Harb Perspect Med 2:a007005. 2012
    ..This article draws from data derived from both human and nonhuman primate studies...
  4. pmc SIV antigen immunization induces transient antigen-specific T cell responses and selectively activates viral replication in draining lymph nodes in retroviral suppressed rhesus macaques
    Haitao Hu
    Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, USA
    Retrovirology 8:57. 2011
    ..Animals were immunized on contralateral sides with SIV gag and RhCMV pp65 encoding plasmids, which allowed lymph nodes draining each antigen to be obtained at the same time from the same animal for direct comparison...
  5. ncbi request reprint Current concepts in AIDS pathogenesis: insights from the SIV/macaque model
    Andrew A Lackner
    Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    Annu Rev Med 58:461-76. 2007
    ..The nonhuman primate model of AIDS has been used extensively to fill these gaps in our understanding of AIDS pathogenesis...
  6. pmc Control of viremia and maintenance of intestinal CD4(+) memory T cells in SHIV(162P3) infected macaques after pathogenic SIV(MAC251) challenge
    Bapi Pahar
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA
    Virology 387:273-84. 2009
    ..These results suggest that protection against pathogenic lentiviral infection or disease progression is indeed possible, and may correlate with preservation of mucosal CD4(+) T cells...
  7. pmc Simian immunodeficiency virus selectively infects proliferating CD4+ T cells in neonatal rhesus macaques
    Xiaolei Wang
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA, USA
    Blood 116:4168-74. 2010
    ..Eventual failure of CD4(+) T-cell turnover in intestinal tissues may indicate a poorer prognosis for HIV-infected infants...
  8. pmc The level of monocyte turnover predicts disease progression in the macaque model of AIDS
    Atsuhiko Hasegawa
    Division of Immunology, Tulane National Primate Research Center, Tulane University Health Science Center, Covington, LA 70433, USA
    Blood 114:2917-25. 2009
    ..Our results show the importance of monocyte/macrophages in the pathogenesis of AIDS and suggest the dynamic changes of the monocyte/macrophages as a new marker for AIDS progression...
  9. ncbi request reprint Early restoration of mucosal CD4 memory CCR5 T cells in the gut of SIV-infected rhesus predicts long term non-progression
    Binhua Ling
    Tulane National Primate Research Center, Covington, Louisianna, USA
    AIDS 21:2377-85. 2007
    ..The key questions addressed were whether or not LTNP experience an early and rapid loss of mucosal CD4 T cells during the acute infection and the mechanisms by which they maintain the LTNP state...
  10. pmc MCP-3/CCL7 production by astrocytes: implications for SIV neuroinvasion and AIDS encephalitis
    Nicole A Renner
    Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Neurovirol 17:146-52. 2011
    ....
  11. ncbi request reprint Kuru experiments triggered the emergence of pathogenic SIVmac
    Cristian Apetrei
    Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    AIDS 20:317-21. 2006
  12. pmc The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection
    Binhua Ling
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    J Infect Dis 202:1846-54. 2010
    ....
  13. ncbi request reprint Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines
    Bapi Pahar
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA
    Eur J Immunol 36:583-92. 2006
    ..Finally, these intestinal DP T cells may be important target cells for HIV infection and replication due to their activation, memory phenotype and high expression of CCR5...
  14. pmc Gastrointestinal disease in simian immunodeficiency virus-infected rhesus macaques is characterized by proinflammatory dysregulation of the interleukin-6-Janus kinase/signal transducer and activator of transcription3 pathway
    Mahesh Mohan
    Division of Comparative Pathology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    Am J Pathol 171:1952-65. 2007
    ..Despite high SOCS-3 expression, STAT3 remained constitutively active, providing a possible explanation for persistent intestinal inflammation and immune activation that may favor viral replication and disease pro-gression...
  15. pmc The stress-response factor SigH modulates the interaction between Mycobacterium tuberculosis and host phagocytes
    Noton K Dutta
    Divisions of Bacteriology and Parasitology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 7:e28958. 2012
    ..The SigH regulon appears to be required to modulate innate immune responses directed against Mtb...
  16. pmc CCAAT/enhancer binding protein beta is a major mediator of inflammation and viral replication in the gastrointestinal tract of simian immunodeficiency virus-infected rhesus macaques
    Mahesh Mohan
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    Am J Pathol 173:106-18. 2008
    ..More importantly, these data provide a molecular mechanism for persistent inflammation and immune activation leading to increased SIV burden and GIT pathology in SIV-infected macaques and perhaps HIV-infected individuals...
  17. pmc Virus-specific T cell responses in macaques acutely infected with SHIV(sf162p3)
    Bapi Pahar
    Division of Immunology, Tulane National Primate Research Center, Tulane University School of Medicine, 18703 Three Rivers Road, Covington, LA 70433, USA
    Virology 363:36-47. 2007
    ..Although some animals had strong virus-specific cellular immune responses, many had weak or minimal responses that did not correlate with the post peak decline in plasma viremia...
  18. pmc Association of FAK activation with lentivirus-induced disruption of blood-brain barrier tight junction-associated ZO-1 protein organization
    Nathan S Ivey
    Tulane Primate Center, Pathology, Covington, LA 70433, USA
    J Neurovirol 15:312-23. 2009
    ..Inhibition of FAK activation is sufficient to prevent tight junction disruption. Thus, it may be possible to inhibit the development of HIVE by using inhibitors of FAK...
  19. pmc Intestinal double-positive CD4+CD8+ T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIVMAC251 infection
    Xiaolei Wang
    Divisions of Comparative Pathology, Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA, USA
    Blood 112:4981-90. 2008
    ..Collectively, these findings demonstrate that intestinal DP T cells of neonates are proliferating, activated memory cells and are likely involved in regulating immune responses, in contrast to immature DP T cells in the thymus...
  20. pmc Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression
    Huanbin Xu
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA
    J Immunol 185:7340-8. 2010
    ..Blockade of this pathway may have therapeutic implications for HIV-infected patients...
  21. pmc Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts
    Ivona Pandrea
    Tulane National Primate Research Center, Covington, LA 70433, USA
    J Virol 80:4858-67. 2006
    ..sab92018). Due to these similarities, we conclude that Caribbean AGMs are a useful alternative to AGMs of African origin as a model for the study of SIV infection in natural African hosts...
  22. pmc A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T cells
    Matthew W Breed
    Tulane National Primate Research Center, Covington, Louisiana, USA
    J Virol 87:13048-52. 2013
    ..This suggests that the GYxxØ motif and S727P each contribute to SIV's targeting to mucosal tissues. ..
  23. pmc Cutting edge: Experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion
    Ivona Pandrea
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Immunol 181:6687-91. 2008
    ....
  24. pmc Simian immunodeficiency virus infection in rhesus macaques induces selective tissue specific B cell defects in double positive CD21+CD27+ memory B cells
    Arpita Das
    Division of Microbiology, Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA
    Clin Immunol 140:223-8. 2011
    ..Our findings demonstrate that SIV infection may induce selective defective responses in specific tissues, by suppressing memory B cell proliferation in tissues...
  25. pmc Neurokinin-1 receptor (NK1-R) expression in the brains of SIV-infected rhesus macaques: implications for substance P in NK1-R immune cell trafficking into the CNS
    Heather Vinet-Oliphant
    Tulane National Primate Research Center, Division of Comparative Pathology, Covington, LA 70433, USA
    Am J Pathol 177:1286-97. 2010
    ..Moreover, pretreatment with SP enhanced both SP- and CCL5-mediated chemotaxis. All of these findings suggest that SP and NK1-R are important in SIV infection of macrophages and the development of SIVE lesions...
  26. ncbi request reprint Single epitope mucosal vaccine delivered via immuno-stimulating complexes induces low level of immunity against simian-HIV
    Bapi Pahar
    Tulane National Primate Research Center, Covington, LA 70433, USA
    Vaccine 24:6839-49. 2006
    ..We predict that if coadministered with additional epitopes and/or more efficacious mucosal delivery system or route, HIV/SIV-derived peptide vaccines may have potential to elicit heterologous protection...
  27. pmc Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression
    Matthew W Breed
    Tulane National Primate Research Center, Covington, Louisiana, USA
    J Virol 87:1528-43. 2013
    ....
  28. pmc Microglia activation by SIV-infected macrophages: alterations in morphology and cytokine secretion
    Nicole A Renner
    Tulane National Primate Research Center, Tulane University, New Orleans, LA, USA
    J Neurovirol 18:213-21. 2012
    ..This response is triggered by incubation with macrophages, irrespective of whether or not they are infected with SIV, indicating a rapid, generalized immune response when infiltrating macrophages entering the brain...
  29. pmc The Mycobacterium tuberculosis stress response factor SigH is required for bacterial burden as well as immunopathology in primate lungs
    Smriti Mehra
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Infect Dis 205:1203-13. 2012
    ..Infection of macrophages with the Δ-sigH mutant generates more potent innate immune response than does infection with Mtb. The mutant is attenuated for pathology in mice...
  30. pmc CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood-brain barrier
    Juan T Borda
    Division of Comparative Pathology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Am J Pathol 172:725-37. 2008
    ....
  31. pmc Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence
    Ivona V Pandrea
    Divisions of Comparative Pathology and Microbiology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Immunol 179:3035-46. 2007
    ....
  32. pmc Clinical and immunopathologic alterations in rhesus macaques affected with globoid cell leukodystrophy
    Juan T Borda
    DVM, PhD, Division of Comparative Pathology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Am J Pathol 172:98-111. 2008
    ..Collectively, these data suggest that dysregulation of monocyte/macrophage/microglia and up-regulation of certain cytokines may contribute to the pathogenesis of Krabbe's disease...
  33. pmc Visualizing cytokine-secreting cells in situ in the rhesus macaque model of chronic gut inflammation
    Geeta Ramesh
    Division of Comparative Pathology, Tulane National Primate Research Center and Tulane University Health Science Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    Clin Diagn Lab Immunol 12:192-7. 2005
    ....
  34. pmc CD8 down-regulation and functional impairment of SIV-specific cytotoxic T lymphocytes in lymphoid and mucosal tissues during SIV infection
    Huanbin Xu
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Leukoc Biol 93:943-50. 2013
    ....
  35. pmc Divergent kinetics of proliferating T cell subsets in simian immunodeficiency virus (SIV) infection: SIV eliminates the "first responder" CD4+ T cells in primary infection
    Xiaolei Wang
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA
    J Virol 87:7032-8. 2013
    ....
  36. pmc Granuloma correlates of protection against tuberculosis and mechanisms of immune modulation by Mycobacterium tuberculosis
    Smriti Mehra
    Division of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Infect Dis 207:1115-27. 2013
    ..Hence, new antituberculosis vaccines are needed. Correlates of protection against tuberculosis are not known. We studied the effects of BCG vaccination on gene expression in tuberculosis granulomas using macaques...
  37. pmc Distinct expression patterns of CD69 in mucosal and systemic lymphoid tissues in primary SIV infection of rhesus macaques
    Xiaolei Wang
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, United States of America
    PLoS ONE 6:e27207. 2011
    ..Combined, these results indicate CD69+CD4+ T cells are a major early target for viral infection, and their rapid loss by direct infection may have profound effects on intestinal immune regulation in HIV infected patients...
  38. pmc Massive infection and loss of CD4+ T cells occurs in the intestinal tract of neonatal rhesus macaques in acute SIV infection
    Xiaolei Wang
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA
    Blood 109:1174-81. 2007
    ..The results in dicate that "activated" central memory CD4+ T cells are the major target for early SIV infection and CD4+ T cell depletion in neonatal macaques...
  39. pmc Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts
    Ivona Pandrea
    Tulane National Primate Research Center, Covington, LA 70433, USA
    Blood 109:1069-76. 2007
    ..Beneficial effects of low CCR5 expression on CD4+ T cells may include the reduction of target cells for viral replication and a decreased homing of activated CD4+ T cells to inflamed tissue...
  40. pmc Interaction of the Lyme disease spirochete Borrelia burgdorferi with brain parenchyma elicits inflammatory mediators from glial cells as well as glial and neuronal apoptosis
    Geeta Ramesh
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA
    Am J Pathol 173:1415-27. 2008
    ..burgdorferi. These results provide proof of concept for our hypothesis that B. burgdorferi produces inflammatory mediators in the central nervous system, accompanied by glial and neuronal apoptosis...
  41. pmc Direct inoculation of simian immunodeficiency virus from sooty mangabeys in black mangabeys (Lophocebus aterrimus): first evidence of AIDS in a heterologous African species and different pathologic outcomes of experimental infection
    Cristian Apetrei
    Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    J Virol 78:11506-18. 2004
    ..Finally, this case of AIDS in an African monkey suggests that the dogma of SIV nonpathogenicity in African NHP hosts should be reconsidered...
  42. pmc Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstm
    Cristian Apetrei
    Division of Microbiology and Immunology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Virol 79:8991-9005. 2005
    ..The genetic variability of SIVsm strains among PCs may influence the diagnosis and monitoring of SIVsm infection and, consequently, may bias the results of pathogenesis studies...
  43. pmc Acquired immunodeficiency syndrome and the blood-brain barrier
    Nathan S Ivey
    Tulane National Primate Research Center, Covington, LA 70433, USA
    J Neurovirol 15:111-22. 2009
    ..We then discuss the ways in which HIV/SIV affects the BBB, largely through infection of monocytes/macrophages, and how infected macrophages crossing the BBB ultimately results in breakdown of the barrier...
  44. doi request reprint Locally infiltrative ameloblastic fibroma in a rhesus macaque (Macaca mulatta) with characterizations of its proliferating activity and biological behavior
    David X Liu
    Divisions of Comparative Pathology, Tulane National Primate Research Center, 18733 Three Rivers Road, Covington, LA 70433, USA
    J Vet Diagn Invest 24:630-5. 2012
    ..Based on the clinical, histologic, and immunophenotypic features, the tumor was identified as a locally infiltrative ameloblastic fibroma...
  45. pmc Kinetics of liver macrophages (Kupffer cells) in SIV-infected macaques
    Muhammad H Ahsan
    Tulane National Primate Research Center, Tulane University School of Medicine, 18703 Three Rivers Road, Covington, LA 70433, USA
    Virology 446:77-85. 2013
    ....
  46. pmc Rapid down-regulation of γc on T cells in early SIV infection correlates with impairment of T-cell function
    Huanbin Xu
    Tulane National Primate Research Center, Division of Comparative Pathology, 18703 Three Rivers Rd, Covington, LA 70433, USA
    FASEB J 26:2294-305. 2012
    ..Down-regulation of γ(c) during early HIV/SIV infection may inhibit T-cell function, particularly of CD8(+) T cells, and, may be linked with immune failure and loss of viral containment...
  47. pmc Acute and chronic T cell dynamics in the livers of simian immunodeficiency virus-infected macaques
    Muhammad H Ahsan
    Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, USA
    J Virol 86:5244-52. 2012
    ..These data suggest that the liver is a major source of antigenic stimulation for promoting CD8(+) T cells and possibly a source for early CD4(+) T cell infection and destruction...
  48. ncbi request reprint Dynamics of Simian immunodeficiency virus-specific cytotoxic T-cell responses in tissues
    Ronald S Veazey
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    J Med Primatol 32:194-200. 2003
    ..These data suggest that while high CTL responses develop at a similar rate, and magnitude in both peripheral and mucosal lymphoid tissues in primary SIV infection, mucosal CTL responses may predominate later in the course of the disease...
  49. pmc Differential cross-reactivity of monoclonal antibody OPD4 (anti-CD45RO) in macaques
    Xiaolei Wang
    Division of Comparative Pathology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Dev Comp Immunol 32:859-68. 2008
    ....
  50. pmc Simian immunodeficiency virus infection in neonatal macaques
    Ronald S Veazey
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    J Virol 77:8783-92. 2003
    ....
  51. pmc Dynamics of cytokine/chemokine responses in intestinal CD4+ and CD8+ T Cells during Acute Simian Immunodeficiency Virus Infection
    Carys S Kenway-Lynch
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana, USA
    J Virol 87:11916-23. 2013
    ..Additionally, both CD4(+) and CD8(+) T cells showed upregulation of macrophage migration inhibition factor (MIF) and basic fibroblast growth factor (FGF-basic) cytokines that have been linked to HIV disease progression. ..
  52. pmc Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus
    Smriti Mehra
    Divisions of Bacteriology and Parasitology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Med Primatol 40:233-43. 2011
    ..Annually, ∼11 million people are coinfected with HIV and Mycobacterium tuberculosis (Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation...
  53. pmc Classic AIDS in a sooty mangabey after an 18-year natural infection
    Binhua Ling
    Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    J Virol 78:8902-8. 2004
    ..Therefore, the results also suggest that SMs have a special mechanism for resisting AIDS development...
  54. ncbi request reprint SIV-induced activation of the blood-brain barrier requires cell-associated virus and is not restricted to endothelial cell activation
    Andrew G MacLean
    Tulane National Primate Research Center, Covington, LA, USA
    J Med Primatol 33:236-42. 2004
    ....
  55. pmc The gastrointestinal tract and AIDS pathogenesis
    Andrew A Lackner
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    Gastroenterology 136:1965-78. 2009
    ..This article draws extensively on work done in the nonhuman primate model of AIDS to fill gaps in our understanding of AIDS in humans...
  56. pmc Hematologic abnormalities associated with simian immunodeficieny virus (SIV) infection mimic those in HIV infection
    Amy F Gill
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Med Primatol 41:214-24. 2012
    ..A retrospective data analysis of simian immunodeficieny virus (SIV)-infected rhesus macaques (RM) of Indian origin was performed to determine the prevalence of hematologic abnormalities free of these confounds...
  57. pmc Cell tropism of simian immunodeficiency virus in culture is not predictive of in vivo tropism or pathogenesis
    Juan T Borda
    Tulane National Primate Research Center, Tulane University, Covington, LA 70433, USA
    Am J Pathol 165:2111-22. 2004
    ..These data combined with the absence of macrophage-associated lesions in SIVmac239/316-infected animals indicate that in vitro cell tropism is not predictive of in vivo tropism or disease pathogenesis...
  58. ncbi request reprint Distribution and immunophenotype of DC-SIGN-expressing cells in SIV-infected and uninfected macaques
    Annette J Schwartz
    Division of Comparative Pathology, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    AIDS Res Hum Retroviruses 18:1021-9. 2002
    ..DC-SIGN(+) cells were consistently CD68(+), but fascin(-) and HLA-DR(-). The absence of intraepithelial DC-SIGN-positive cells in mucosal tissues suggests that DC-SIGN does not play a significant role in transmucosal passage of HIV/SIV...
  59. pmc Impact of antiretroviral therapy on intestinal lymphoid tissues in HIV infection
    Ronald S Veazey
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United Statesof America
    PLoS Med 3:e515. 2006
  60. ncbi request reprint Persistent babesiosis in a Rhesus macaque (Macaca mulatta) infected with a simian-human immunodeficiency virus
    David X Liu
    Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA
    J Med Primatol 43:206-8. 2014
    ..A rhesus macaque developed chronic anemia, lymphocytic leukocytopenia, fever, and anorexia while immunodeficient following inoculation with a simian-human immunodeficiency virus...
  61. ncbi request reprint Vaginal CD4+ T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection
    Ronald S Veazey
    Tulane National Primate Research Center, Health Sciences Center, Tulane University, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Infect Dis 187:769-76. 2003
    ..This demonstrates that large numbers of CD4(+) T cells expressing high levels of CCR5 reside within the vagina and that these cells are preferentially targeted for elimination by SIV infection...
  62. ncbi request reprint Systemic arteriopathy in SIV-infected rhesus macaques (Macaca mulatta)
    Tokuma Yanai
    Division of Comparative Pathology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA, USA
    J Med Primatol 35:106-12. 2006
    ..These animals developed clinical signs of AIDS, including lymphadenopathy, weight loss, diarrhea and collapse...
  63. doi request reprint Comparison of the vaginal environment of Macaca mulatta and Macaca nemestrina throughout the menstrual cycle
    Sarah V Hadzic
    Tulane National Primate Research Center, Covington, LA, USA
    Am J Reprod Immunol 71:322-9. 2014
    ..However, comparative studies to explore the reasons for these differences are lacking...
  64. doi request reprint Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy
    Eric R Snook
    Division of Regenerative Medicine, Tulane National Primate Research Center, Covington, Louisiana
    Am J Pathol 184:382-96. 2014
    ....
  65. pmc Infectious agent and immune response characteristics of chronic enterocolitis in captive rhesus macaques
    Karol Sestak
    Division of Microbiology and Immunolgy, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
    Infect Immun 71:4079-86. 2003
    ..The data also suggest that chronic colitis in rhesus macaques may have potential as a model of inflammatory bowel disease in humans...
  66. pmc Getting to the guts of HIV pathogenesis
    Ronald S Veazey
    Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    J Exp Med 200:697-700. 2004
    ..Here we discuss the important implications of these papers for our understanding of HIV pathogenesis, treatment, and vaccine design...
  67. pmc Genetic requirements for the survival of tubercle bacilli in primates
    Noton K Dutta
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Infect Dis 201:1743-52. 2010
    ..It is imperative to delineate the mechanisms employed by Mycobacterium tuberculosis to successfully infect and persist in mammalian lungs...
  68. ncbi request reprint Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity
    Gui bo Yang
    Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Neuroimmunol 146:46-9. 2004
    ..These results provide morphological evidence to suggest interactions between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa. This further supports a possible role of 5-HT in mucosal immune responses...
  69. pmc Elicitation of simian immunodeficiency virus-specific cytotoxic T lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination
    Jamal Baig
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 76:11484-90. 2002
    ..These studies therefore suggest that systemic delivery of potent HIV immunogens may suffice to elicit substantial mucosal CTL responses...
  70. pmc Decreased levels of recent thymic emigrants in peripheral blood of simian immunodeficiency virus-infected macaques correlate with alterations within the thymus
    Donald L Sodora
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Virol 76:9981-90. 2002
    ..SIV infection of macaques will be a useful model system to elucidate the mechanisms responsible for the thymic dysfunction observed in HIV-infected patients...
  71. ncbi request reprint Relationships between astrogliosis and 1H MR spectroscopic measures of brain choline/creatine and myo-inositol/creatine in a primate model
    John P Kim
    Massachusetts General Hospital, A A Martinos Center for Biomedical Imaging and Neuroradiology Division, Charlestown, USA
    AJNR Am J Neuroradiol 26:752-9. 2005
    ..We tested the hypotheses that in vivo Cho/Cr and/or MI/Cr levels are correlated with glial fibrillary acidic protein (GFAP) immunostains and that the changes are water-soluble metabolites...
  72. ncbi request reprint Simian immunodeficiency virus encephalitis: analysis of envelope sequences from individual brain multinucleated giant cells and tissue samples
    Elena V Ryzhova
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Virology 297:57-67. 2002
    ..The survival of archival sequences and their activation presumably by the fusion of productively and quiescently infected macrophages/microglia identify the central nervous system as a possible anatomical reservoir for latent infection...
  73. pmc Enteric ganglionitis in rhesus macaques infected with simian immunodeficiency virus
    Marlene S Orandle
    Department of Pathobiological Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, LA 70803, USA
    J Virol 81:6265-75. 2007
    ..This study provides evidence that the ENS may be playing a role in the pathogenesis of GI disease and enteropathy in HIV-infected people...
  74. pmc Both mucosal and systemic routes of immunization with the live, attenuated NYVAC/simian immunodeficiency virus SIV(gpe) recombinant vaccine result in gag-specific CD8(+) T-cell responses in mucosal tissues of macaques
    Liljana Stevceva
    Basic Research Laboratory, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Virol 76:11659-76. 2002
    ..We conclude that immunization with a live vector vaccine results in the appearance of CD8(+) T-cell responses at mucosal sites even when the vaccine is delivered by nonmucosal routes...
  75. pmc Enhanced expression of proinflammatory cytokines in the central nervous system is associated with neuroinvasion by simian immunodeficiency virus and the development of encephalitis
    Marlene S Orandle
    New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    J Virol 76:5797-802. 2002
    ..These observations provide evidence that cytokines produced by activated inflammatory macrophages are an important element in the pathogenesis of SIVE...
  76. pmc Characterization of an in vitro rhesus macaque blood-brain barrier
    Andrew G MacLean
    New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772 9102, USA
    J Neuroimmunol 131:98-103. 2002
    ..We believe that this model is highly relevant for examining immunological events at the blood-brain barrier and demonstrate its potential usefulness for examining early events in AIDS neuropathogenesis...
  77. ncbi request reprint In vivo 1H MRS of brain injury and repair during acute SIV infection in the macaque model of neuroAIDS
    Jane B Greco
    Massachusetts General Hospital NMR Center and Neuroradiology Division, Charlestown, Massachusetts, USA
    Magn Reson Med 51:1108-14. 2004
    ..Similar events are likely to occur in acutely HIV-infected people, and may explain the neurobehavioral symptoms associated with acute HIV infection...
  78. ncbi request reprint Quantitative neuropathologic correlates of changes in ratio of N-acetylaspartate to creatine in macaque brain
    Margaret R Lentz
    NMR Center and Neuroradiology Division, Massachusetts General Hospital, 55 Fruit St, GRB 285, Boston, MA 02114 2696, USA
    Radiology 235:461-8. 2005
    ....
  79. ncbi request reprint Functional simian immunodeficiency virus Gag-specific CD8+ intraepithelial lymphocytes in the mucosae of SIVmac251- or simian-human immunodeficiency virus KU2-infected macaques
    Liljana Stevceva
    Basic Research Laboratory, National Cancer Institute, 41 D804, Bethesda, MD 20892 5055, USA
    Virology 319:190-200. 2004
    ..Direct staining of tetramers also revealed their presence in intact tissue. These Gag-specific IELs expressed the activation marker CD69 and produced IFN-gamma, suggesting an active immune response in this locale...
  80. pmc A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS
    Robert A Fuller
    Massachusetts General Hospital NMR Center and Neuroradiology Division, Harvard Medical School, Charlestown, MA, USA
    BMC Neurosci 5:10. 2004
    ..Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo 1H MRS study of the SIV/macaque model of neuroAIDS...
  81. ncbi request reprint HIV swiftly guts the immune system
    Ronald S Veazey
    Nat Med 11:469-70. 2005
  82. pmc Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection
    Dan Huang
    Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine at Chicago, 909 S Wolcott Ave, Chicago, IL 60612, USA
    Infect Immun 76:426-36. 2008
    ..Thus, clonally expanded Vgamma2Vdelta2 T cells appeared to undergo trans-endothelial migration, interstitial localization, and granuloma infiltration as immune responses to M. tuberculosis infection...
  83. pmc Measurement of plasma-derived substance P: biological, methodological, and statistical considerations
    Donald E Campbell
    Division of Allergy and Immunology, Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104, USA
    Clin Vaccine Immunol 13:1197-203. 2006
    ..These results further emphasize the need for careful consideration in the selection of methods for SP quantitation, as well as caution in the interpretation and comparison of data reported in the literature...