S Michal Jazwinski

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, Box P7 2, New Orleans, LA 70112, USA
    Gene 354:22-7. 2005
  2. pmc Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan
    Michael V Miceli
    Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center New Orleans, LA, USA
    Front Genet 2:102. 2011
  3. pmc The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction
    S Michal Jazwinski
    Department of Medicine, Tulane Center for Aging, Tulane University Health Sciences Center New Orleans, LA, USA
    Front Physiol 3:139. 2012
  4. pmc The retrograde response: when mitochondrial quality control is not enough
    S Michal Jazwinski
    Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Biochim Biophys Acta 1833:400-9. 2013
  5. pmc Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling
    Yong Yu Liu
    Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA
    Mol Cancer 9:145. 2010
  6. doi request reprint The Retrograde ResponseRetrograde Response and Other Pathways of Interorganelle CommunicationInterorganelle Communication in Yeast Replicative Aging
    S Michal Jazwinski
    Department of Medicine, Tulane University Health Sciences Center, Tulane Center for Aging, Tulane University, New Orleans, LA, 70112, USA
    Subcell Biochem 57:79-100. 2012
  7. pmc HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging
    S Michal Jazwinski
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Aging Cell 9:698-708. 2010
  8. ncbi request reprint A novel role of peroxin PEX6: suppression of aging defects in mitochondria
    Jae Gu Seo
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Aging Cell 6:405-13. 2007
  9. pmc Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3
    Jian Chen
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mech Ageing Dev 131:29-37. 2010
  10. pmc An elevation of resting metabolic rate with declining health in nonagenarians may be associated with decreased muscle mass and function in women and men, respectively
    Sangkyu Kim
    Department of Medicine, Tulane Center for Aging, Tulane University Health Sciences Center, New Orleans, Louisiana
    J Gerontol A Biol Sci Med Sci 69:650-6. 2014

Research Grants

  1. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2000
  2. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2001
  3. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2002
  4. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2003
  5. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2004
  6. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2006

Detail Information

Publications29

  1. ncbi request reprint The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, Box P7 2, New Orleans, LA 70112, USA
    Gene 354:22-7. 2005
    ..Gene regulatory phenomena akin to the retrograde response also operate in human cells, which display both common and cell-type specific changes in gene expression on loss of mitochondrial function...
  2. pmc Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan
    Michael V Miceli
    Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center New Orleans, LA, USA
    Front Genet 2:102. 2011
    ..We conclude that a decrease in MMP is the signal that initiates the retrograde response and leads to increased RLS...
  3. pmc The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction
    S Michal Jazwinski
    Department of Medicine, Tulane Center for Aging, Tulane University Health Sciences Center New Orleans, LA, USA
    Front Physiol 3:139. 2012
    ..Further research will be needed to disentangle the pro-aging from the anti-aging effects of NFκB. Interestingly, this is also a challenge for the complete understanding of the yeast retrograde response...
  4. pmc The retrograde response: when mitochondrial quality control is not enough
    S Michal Jazwinski
    Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Biochim Biophys Acta 1833:400-9. 2013
    ..This article is part of a Special Issue entitled: Protein Import and Quality Control in Mitochondria and Plastids...
  5. pmc Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling
    Yong Yu Liu
    Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA
    Mol Cancer 9:145. 2010
    ..Understanding the molecular mechanisms underlying MDR1 overexpression and how it interacts with GCS may find effective approaches to reverse drug resistance...
  6. doi request reprint The Retrograde ResponseRetrograde Response and Other Pathways of Interorganelle CommunicationInterorganelle Communication in Yeast Replicative Aging
    S Michal Jazwinski
    Department of Medicine, Tulane University Health Sciences Center, Tulane Center for Aging, Tulane University, New Orleans, LA, 70112, USA
    Subcell Biochem 57:79-100. 2012
    ..The impact of these varied physiological responses on yeast replicative aging remains to be assessed...
  7. pmc HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging
    S Michal Jazwinski
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Aging Cell 9:698-708. 2010
    ..The interaction between the three genes described here suggests new models for cellular and molecular mechanisms underlying exceptional survival and healthy aging that involve lipotoxicity...
  8. ncbi request reprint A novel role of peroxin PEX6: suppression of aging defects in mitochondria
    Jae Gu Seo
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Aging Cell 6:405-13. 2007
    ..The novel function of Pex6p described here may provide insights into peroxisomal and mitochondrial disorders and into metabolic diseases in general...
  9. pmc Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3
    Jian Chen
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mech Ageing Dev 131:29-37. 2010
    ..These results suggest a model in which IGFBP3, leptin and T3 act as non-immune factors to maintain a larger pool of naïve CD8 T cells in healthy nonagenarians...
  10. pmc An elevation of resting metabolic rate with declining health in nonagenarians may be associated with decreased muscle mass and function in women and men, respectively
    Sangkyu Kim
    Department of Medicine, Tulane Center for Aging, Tulane University Health Sciences Center, New Orleans, Louisiana
    J Gerontol A Biol Sci Med Sci 69:650-6. 2014
    ....
  11. pmc Association of healthy aging with parental longevity
    Sangkyu Kim
    Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Ave, SL 12, New Orleans, LA, 70112, USA
    Age (Dordr) 35:1975-82. 2013
    ..Variation in the FI34 is, in part, due to genetic variation; thus, the FI34 can be a phenotypic measure suitable for genetic analyses of healthy aging...
  12. pmc Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
    Sangkyu Kim
    Tulane Center for Aging, New Orleans, LA 70112, USA
    Biogerontology 13:119-31. 2012
    ..Given the differences between this gene and XRCC6, they point to the distinct impact that alternate pathways of telomere maintenance may have on aging and exceptional survival...
  13. ncbi request reprint Nuclear gene expression changes due to mitochondrial dysfunction in ARPE-19 cells: implications for age-related macular degeneration
    Michael V Miceli
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
    Invest Ophthalmol Vis Sci 46:1765-73. 2005
    ..To measure changes in nuclear gene expression resulting from mitochondrial dysfunction in retinal pigment epithelial cells...
  14. ncbi request reprint Left atrial enlargement and reduced physical function during aging
    Andrew A Pellett
    Dept of Cardiopulmonary Science, Louisiana State University Health Sciences Center, New Orleans, LA
    J Aging Phys Act 21:417-32. 2013
    ..59; p = .0005) correlated with the total CS-PFP-10 score. Increased left atrial volume index may be a marker of impaired performance of activities of daily living in older individuals. ..
  15. pmc Natural genetic variation in yeast longevity
    Stefan W Stumpferl
    Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Genome Res 22:1963-73. 2012
    ..This study provides a glimpse of the complex genetic architecture of replicative lifespan in yeast and of the potential role of genetic variation hitherto unsampled in the laboratory...
  16. pmc Gene regulatory changes in yeast during life extension by nutrient limitation
    Jinqing Wang
    Department of Medicine and the Tulane Center for Aging, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Exp Gerontol 45:621-31. 2010
    ..These gene regulatory events portend an increase in the generation of biosynthetic intermediates necessary for the production of daughter cells, which is the measure of yeast replicative life span...
  17. ncbi request reprint Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity
    Stefka Spassieva
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:33931-8. 2006
    ....
  18. ncbi request reprint Yeast longevity and aging--the mitochondrial connection
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
    Mech Ageing Dev 126:243-8. 2005
    ..Common threads weave their way through the studies of aging in yeast and in other model organisms. This suggests conserved features of aging across phyla...
  19. ncbi request reprint The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity
    Sangkyu Kim
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Biogerontology 5:305-16. 2004
    ..Rtg2p and Gcn5p in the SLIK complex link metabolism to stress responses, chromatin-dependent gene regulation, and genome stability in yeast aging...
  20. pmc Development of a serum profile for healthy aging
    Lauri O Byerley
    Physiology Department, Louisiana State University Health Science Center, 1901 Perdido St, New Orleans, LA 70112, USA
    Age (Dordr) 32:497-507. 2010
    ..These preliminary results show that the proteomics approach can be used to identify potential proteins or markers that may be involved in the aging process and/or be important determinants of longevity...
  21. ncbi request reprint Rtg2 protein: at the nexus of yeast longevity and aging
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, P O Box P7 2, New Orleans, LA 70112, USA
    FEMS Yeast Res 5:1253-9. 2005
    ..Phenomena that resemble the retrograde response appear to exist in human cells, with both common and cell type-specific gene expression changes as the output...
  22. pmc A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae
    Chi Yung Lai
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Genetics 162:73-87. 2002
    ..We propose, more generally, that age asymmetry depends on partition of active and undamaged cellular components to the progeny and that this "filter" breaks down with age...
  23. ncbi request reprint Yeast replicative life span--the mitochondrial connection
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
    FEMS Yeast Res 5:119-25. 2004
    ..In sum, it is clear that mitochondria lie at the nexus of yeast longevity and aging...
  24. pmc The association between flow-mediated dilation and physical function in older men
    Michael A Welsch
    Louisiana State University, Baton Rouge, LA, USA
    Med Sci Sports Exerc 40:1237-43. 2008
    ..The probability that an individual is able to live independently decreases sharply below the threshold score of 57 units on the physical functional performance (PFP-10) test...
  25. ncbi request reprint Common and cell type-specific responses of human cells to mitochondrial dysfunction
    Michael V Miceli
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Cell Res 302:270-80. 2005
    ..These expression changes may help explain the response of different tissues to the loss of mitochondrial function due to aging or disease...
  26. ncbi request reprint Biological aging research today: potential, peeves, and problems
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology and Center for Healthy Aging, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
    Exp Gerontol 37:1141-6. 2002
    ..However, this will require the development of indices of frailty and of healthy aging. In the end, we may be able to 'cure' aging, but only in a statistical sense which is measured at the level of the population...
  27. pmc Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase
    Vineet Gupta
    Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA, USA
    J Lipid Res 51:866-74. 2010
    ..These data indicate that this cell-based fluorescent method is direct, reproducible, and simple for assessing ceramide glycosylation. It is applicable to validate GCS activity in drug-resistant cancers and in other disorders...
  28. ncbi request reprint CD8 T-cell immune phenotype of successful aging
    Hui Chen Hsu
    The University of Alabama at Birmingham, Department of Medicine, Division of Clinical Immunology Rheumatology, 701 South 19th Street, LHRB 473, Birmingham, AL 35294, USA
    Mech Ageing Dev 127:231-9. 2006
    ..Increased AICD may result in enhanced rejuvenation capacity of T cells and limit the impact of aging on T cell function in nonagenarians...
  29. ncbi request reprint LAG1 puts the focus on ceramide signaling
    S Michal Jazwinski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, PO Box P7 2, New Orleans, LA 70112, USA
    Int J Biochem Cell Biol 34:1491-5. 2002
    ..This provides a wide range of physiologic processes through which Lag 1 p may impinge upon life span...

Research Grants7

  1. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2000
    ..The results of the proposed research have important implications for aging, diabetes, and cancer. ..
  2. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2001
    ..The results of the proposed research have important implications for aging, diabetes, and cancer. ..
  3. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2002
    ..The results of the proposed research have important implications for aging, diabetes, and cancer. ..
  4. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2003
    ..The results of the proposed research have important implications for aging, diabetes, and cancer. ..
  5. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2004
    ..The results of the proposed research have important implications for aging, diabetes, and cancer. ..
  6. NUTRITIONAL AND METABOLIC MECHANISMS OF AGING
    S Michal Jazwinski; Fiscal Year: 2006
    ..The results of the proposed research have important implications for aging, diabetes, and cancer. ..