Research Topics
Genomes and Genes | S Michal JazwinskiSummaryAffiliation: Tulane University Country: USA Publications
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Publications
The retrograde response: when mitochondrial quality control is not enoughS Michal Jazwinski
Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Biochim Biophys Acta 1833:400-9. 2013..This article is part of a Special Issue entitled: Protein Import and Quality Control in Mitochondria and Plastids...- Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signalingYong Yu Liu
Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA
Mol Cancer 9:145. 2010..Understanding the molecular mechanisms underlying MDR1 overexpression and how it interacts with GCS may find effective approaches to reverse drug resistance... 
The Retrograde ResponseRetrograde Response and Other Pathways of Interorganelle CommunicationInterorganelle Communication in Yeast Replicative AgingS Michal Jazwinski
Department of Medicine, Tulane University Health Sciences Center, Tulane Center for Aging, Tulane University, New Orleans, LA, 70112, USA
Subcell Biochem 57:79-100. 2012..The impact of these varied physiological responses on yeast replicative aging remains to be assessed...- HRAS1 and LASS1 with APOE are associated with human longevity and healthy agingS Michal Jazwinski
Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Aging Cell 9:698-708. 2010..The interaction between the three genes described here suggests new models for cellular and molecular mechanisms underlying exceptional survival and healthy aging that involve lipotoxicity... 
A novel role of peroxin PEX6: suppression of aging defects in mitochondriaJae Gu Seo
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Aging Cell 6:405-13. 2007..The novel function of Pex6p described here may provide insights into peroxisomal and mitochondrial disorders and into metabolic diseases in general...- Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3Jian Chen
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Mech Ageing Dev 131:29-37. 2010..These results suggest a model in which IGFBP3, leptin and T3 act as non-immune factors to maintain a larger pool of naïve CD8 T cells in healthy nonagenarians... - Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevitySangkyu Kim
Tulane Center for Aging, New Orleans, LA 70112, USA
Biogerontology 13:119-31. 2012..Given the differences between this gene and XRCC6, they point to the distinct impact that alternate pathways of telomere maintenance may have on aging and exceptional survival... - The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast agingS Michal Jazwinski
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, Box P7 2, New Orleans, LA 70112, USA
Gene 354:22-7. 2005..Gene regulatory phenomena akin to the retrograde response also operate in human cells, which display both common and cell-type specific changes in gene expression on loss of mitochondrial function... - Nuclear gene expression changes due to mitochondrial dysfunction in ARPE-19 cells: implications for age-related macular degenerationMichael V Miceli
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Invest Ophthalmol Vis Sci 46:1765-73. 2005.... - Natural genetic variation in yeast longevityStefan W Stumpferl
Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Genome Res 22:1963-73. 2012..This study provides a glimpse of the complex genetic architecture of replicative lifespan in yeast and of the potential role of genetic variation hitherto unsampled in the laboratory... - Gene regulatory changes in yeast during life extension by nutrient limitationJinqing Wang
Department of Medicine and the Tulane Center for Aging, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
Exp Gerontol 45:621-31. 2010..These gene regulatory events portend an increase in the generation of biosynthetic intermediates necessary for the production of daughter cells, which is the measure of yeast replicative life span... - Yeast longevity and aging--the mitochondrial connectionS Michal Jazwinski
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
Mech Ageing Dev 126:243-8. 2005..Common threads weave their way through the studies of aging in yeast and in other model organisms. This suggests conserved features of aging across phyla... - Necessary role for the Lag1p motif in (dihydro)ceramide synthase activityStefka Spassieva
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 281:33931-8. 2006.... - The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevitySangkyu Kim
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Biogerontology 5:305-16. 2004..Rtg2p and Gcn5p in the SLIK complex link metabolism to stress responses, chromatin-dependent gene regulation, and genome stability in yeast aging... - Development of a serum profile for healthy agingLauri O Byerley
Physiology Department, Louisiana State University Health Science Center, 1901 Perdido St, New Orleans, LA 70112, USA
Age (Dordr) 32:497-507. 2010..These preliminary results show that the proteomics approach can be used to identify potential proteins or markers that may be involved in the aging process and/or be important determinants of longevity... - Rtg2 protein: at the nexus of yeast longevity and agingS Michal Jazwinski
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido St, P O Box P7 2, New Orleans, LA 70112, USA
FEMS Yeast Res 5:1253-9. 2005..Phenomena that resemble the retrograde response appear to exist in human cells, with both common and cell type-specific gene expression changes as the output... - A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiaeChi-Yung Lai
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
Genetics 162:73-87. 2002..We propose, more generally, that age asymmetry depends on partition of active and undamaged cellular components to the progeny and that this "filter" breaks down with age... - Yeast replicative life span--the mitochondrial connectionS Michal Jazwinski
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7-2, New Orleans, LA 70112, USA
FEMS Yeast Res 5:119-25. 2004..In sum, it is clear that mitochondria lie at the nexus of yeast longevity and aging... - The association between flow-mediated dilation and physical function in older menMichael A Welsch
Louisiana State University, Baton Rouge, LA, USA
Med Sci Sports Exerc 40:1237-43. 2008..The probability that an individual is able to live independently decreases sharply below the threshold score of 57 units on the physical functional performance (PFP-10) test... - Biological aging research today: potential, peeves, and problemsS Michal Jazwinski
Department of Biochemistry and Molecular Biology and Center for Healthy Aging, Louisiana State University Health Sciences Center, 1901 Perdido Street, Box P7 2, New Orleans, LA 70112, USA
Exp Gerontol 37:1141-6. 2002..However, this will require the development of indices of frailty and of healthy aging. In the end, we may be able to 'cure' aging, but only in a statistical sense which is measured at the level of the population... - Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespanMichael V Miceli
Tulane Center for Aging and Department of Medicine, Tulane University Health Sciences Center New Orleans, LA, USA
Front Genet 2:102. 2011..We conclude that a decrease in MMP is the signal that initiates the retrograde response and leads to increased RLS... - CD8 T-cell immune phenotype of successful agingHui-Chen Hsu
The University of Alabama at Birmingham, Department of Medicine, Division of Clinical Immunology Rheumatology, 701 South 19th Street, LHRB 473, Birmingham, AL 35294, USA
Mech Ageing Dev 127:231-9. 2006..Increased AICD may result in enhanced rejuvenation capacity of T cells and limit the impact of aging on T cell function in nonagenarians... - Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthaseVineet Gupta
Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA, USA
J Lipid Res 51:866-74. 2010..These data indicate that this cell-based fluorescent method is direct, reproducible, and simple for assessing ceramide glycosylation. It is applicable to validate GCS activity in drug-resistant cancers and in other disorders... - LAG1 puts the focus on ceramide signalingS Michal Jazwinski
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1901 Perdido Street, PO Box P7 2, New Orleans, LA 70112, USA
Int J Biochem Cell Biol 34:1491-5. 2002..This provides a wide range of physiologic processes through which Lag 1 p may impinge upon life span... - Common and cell type-specific responses of human cells to mitochondrial dysfunctionMichael V Miceli
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Exp Cell Res 302:270-80. 2005..These expression changes may help explain the response of different tissues to the loss of mitochondrial function due to aging or disease...
Research Grants
- NUTRITIONAL AND METABOLIC MECHANISMS OF AGINGS Michal Jazwinski; Fiscal Year: 2006..The results of the proposed research have important implications for aging, diabetes, and cancer. ..