S Michal Jazwinski
Affiliation: Tulane University
Zaman S, Choudhury M, Jiang J, Srivastava P, Mohanty B, Danielson C, et al
. Mechanism of Regulation of Intrachromatid Recombination and Long-Range Chromosome Interactions in Saccharomyces cerevisiae. Mol Cell Biol. 2016;36:1451-63 pubmed publisher
..We show further that long-range Fob1-mediated Ter-Ter interactions in trans are downregulated by Sir2. These regulatory mechanisms control intrachromatid recombination and the replicative life span (RLS). ..
Jiang J, Stumpferl S, Jazwinski S. Dual roles of mitochondrial fusion gene FZO1 in yeast age asymmetry and in longevity mediated by a novel ATG32-dependent retrograde response. Biogerontology. 2018;: pubmed publisher
..MDARR can be masked by the operation of the 'classic' retrograde response. ..
Jazwinski S. Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging. Ageing Res Rev. 2015;23:67-74 pubmed publisher
..The retrograde response and ceramide are essential components of a lifespan maintenance process that likely evolved as a cytoprotective mechanism to defend the organism from diverse stressors. ..
Jazwinski S, Kim S, Dai J, Li L, Bi X, Jiang J, et al
. HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging. Aging Cell. 2010;9:698-708 pubmed publisher
..The interaction between the three genes described here suggests new models for cellular and molecular mechanisms underlying exceptional survival and healthy aging that involve lipotoxicity. ..
Jazwinski S. The retrograde response: when mitochondrial quality control is not enough. Biochim Biophys Acta. 2013;1833:400-9 pubmed publisher
..This article is part of a Special Issue entitled: Protein Import and Quality Control in Mitochondria and Plastids. ..
Jiang J, Stumpferl S, Tiwari A, Qin Q, Rodríguez Quiñones J, Jazwinski S. Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae. Genetics. 2016;204:659-673 pubmed
..The finding that this gene is PHO84 opens up a new set of questions about the mechanisms involved, as this gene is known to have pleiotropic effects. ..
Jazwinski S, Jiang J, Kim S. Adaptation to metabolic dysfunction during aging: Making the best of a bad situation. Exp Gerontol. 2018;107:87-90 pubmed publisher
..Thus, the theme of mitochondria-nucleus communication as an adaptive response during aging appears very widespread. ..