Wayne Jg Hellstrom

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint Update on drug interactions with phosphodiesterase-5 inhibitors prescribed as first-line therapy for patients with erectile dysfunction or pulmonary hypertension
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Curr Drug Metab 14:265-9. 2013
  2. ncbi request reprint Udenafil, a long-acting PDE5 inhibitor for erectile dysfunction
    Emad A Salem
    Tulane University Health Sciences Center, Department of Urology, Section of Andrology, New Orleans, LA 70112, USA
    Curr Opin Investig Drugs 7:661-9. 2006
  3. pmc Emerging treatments for premature ejaculation: focus on dapoxetine
    Wayne Jg Hellstrom
    Chief, Section of Andrology, Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA
    Neuropsychiatr Dis Treat 5:37-46. 2009
  4. ncbi request reprint Review of erectile dysfunction in diabetic animal models
    Serap Gur
    Department of Urology, 1430 Tulane Avenue, SL 42, New Orleans, LA 70112, USA
    Curr Diabetes Rev 10:61-73. 2014
  5. doi request reprint Bother and distress associated with Peyronie's disease: validation of the Peyronie's disease questionnaire
    Wayne J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, 70112, USA
    J Urol 190:627-34. 2013
  6. doi request reprint A phase II, single-blind, randomized, crossover evaluation of the safety and efficacy of avanafil using visual sexual stimulation in patients with mild to moderate erectile dysfunction
    Wayne J G Hellstrom
    Department of Urology, Tulane University Medical Center, New Orleans, LA 70112, USA
    BJU Int 111:137-47. 2013
  7. doi request reprint Sexual dysfunction following radical prostatectomy
    Cooper R Benson
    Department of Urology, Louisiana State University, New Orleans, Louisiana 70112, USA
    J Androl 33:1143-54. 2012
  8. ncbi request reprint PDE5 inhibitor treatment options for urologic and non-urologic indications: 2012 update
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Curr Pharm Des 18:5590-606. 2012
  9. doi request reprint Importance of hypogonadism and testosterone replacement therapy in current urologic practice: a review
    Wayne J G Hellstrom
    Department of Urology, Tulane University, Health Sciences Center, 1430 Tulane Avenue, SL 42, New Orleans, LA 70112, USA
    Int Urol Nephrol 44:61-70. 2012
  10. doi request reprint Update on treatments for premature ejaculation
    W J G Hellstrom
    Department of Urology, Tulane University, New Orleans, LA 70112, USA
    Int J Clin Pract 65:16-26. 2011

Detail Information

Publications94

  1. ncbi request reprint Update on drug interactions with phosphodiesterase-5 inhibitors prescribed as first-line therapy for patients with erectile dysfunction or pulmonary hypertension
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Curr Drug Metab 14:265-9. 2013
    ..This review discusses relevant PDE5i drug interactions, including those with CYP 450 inhibitors and inducers which are frequently used during the treatment of ED and PH...
  2. ncbi request reprint Udenafil, a long-acting PDE5 inhibitor for erectile dysfunction
    Emad A Salem
    Tulane University Health Sciences Center, Department of Urology, Section of Andrology, New Orleans, LA 70112, USA
    Curr Opin Investig Drugs 7:661-9. 2006
    ..A phase IIa clinical trial for ED is currently underway in the US, and phase III trials are planned for 2006...
  3. pmc Emerging treatments for premature ejaculation: focus on dapoxetine
    Wayne Jg Hellstrom
    Chief, Section of Andrology, Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA
    Neuropsychiatr Dis Treat 5:37-46. 2009
    ..The most common adverse events with dapoxetine included nausea, diarrhea, headache, dizziness, and somnolence...
  4. ncbi request reprint Review of erectile dysfunction in diabetic animal models
    Serap Gur
    Department of Urology, 1430 Tulane Avenue, SL 42, New Orleans, LA 70112, USA
    Curr Diabetes Rev 10:61-73. 2014
    ..Preclinical studies using the diabetic animal model will likely provide further insight for intervention and prevention strategies for diabetic ED treatment...
  5. doi request reprint Bother and distress associated with Peyronie's disease: validation of the Peyronie's disease questionnaire
    Wayne J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, 70112, USA
    J Urol 190:627-34. 2013
    ..auxilium.com/PDQ), a 15-question self-reported survey that measures the impact and severity of Peyronie's disease symptoms in 3 domains, including 1) psychological and physical symptoms, 2) penile pain and 3) symptom bother...
  6. doi request reprint A phase II, single-blind, randomized, crossover evaluation of the safety and efficacy of avanafil using visual sexual stimulation in patients with mild to moderate erectile dysfunction
    Wayne J G Hellstrom
    Department of Urology, Tulane University Medical Center, New Orleans, LA 70112, USA
    BJU Int 111:137-47. 2013
    ....
  7. doi request reprint Sexual dysfunction following radical prostatectomy
    Cooper R Benson
    Department of Urology, Louisiana State University, New Orleans, Louisiana 70112, USA
    J Androl 33:1143-54. 2012
    ..The aim of this review is to discuss the most recent literature regarding post-RP sexual dysfunctions...
  8. ncbi request reprint PDE5 inhibitor treatment options for urologic and non-urologic indications: 2012 update
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Curr Pharm Des 18:5590-606. 2012
    ..In this review, potential applications of PDE5-Is on urologic, cardiovascular, gastrointestinal, and central nervous system disorders will be updated...
  9. doi request reprint Importance of hypogonadism and testosterone replacement therapy in current urologic practice: a review
    Wayne J G Hellstrom
    Department of Urology, Tulane University, Health Sciences Center, 1430 Tulane Avenue, SL 42, New Orleans, LA 70112, USA
    Int Urol Nephrol 44:61-70. 2012
    ..The administration of exogenous testosterone is not a means of reversing the aging process in men with normal testosterone levels, but it may offer considerable benefit for those with hypogonadism...
  10. doi request reprint Update on treatments for premature ejaculation
    W J G Hellstrom
    Department of Urology, Tulane University, New Orleans, LA 70112, USA
    Int J Clin Pract 65:16-26. 2011
    ..Coupled with efficient diagnosis, it is hoped that these newer agents will improve the quality of life for patients who suffer from PE...
  11. ncbi request reprint Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers
    Wayne J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 176:1529-33. 2006
    ..We assessed the effect of acute administration of tamsulosin, alfuzosin and placebo on ejaculate volume and sperm concentration in post-ejaculate urine, and addressed the mechanism of action of tamsulosin and alfuzosin on ejaculation...
  12. doi request reprint Implants, mechanical devices, and vascular surgery for erectile dysfunction
    Wayne J G Hellstrom
    Tulane University School of Medicine, Department of Urology, New Orleans, LA 70112, USA
    J Sex Med 7:501-23. 2010
    ..Aim. To develop an evidence-based, state-of-the-art consensus report on the treatment of erectile dysfunction by implants, mechanical devices, and vascular surgery...
  13. ncbi request reprint Vardenafil in patients with erectile dysfunction: achieving treatment optimization
    Wayne J G Hellstrom
    Tulane University Medical Center, Department of Urology, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Androl 26:604-9. 2005
    ....
  14. ncbi request reprint Semen and sperm reference ranges for men 45 years of age and older
    Wayne J G Hellstrom
    Department of Urology, SL 42, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, Louisiana 70112, USA
    J Androl 27:421-8. 2006
    ..The observation that less than half the men in this study met all 4 WHO reference values for measured semen and sperm parameters underscores the need for age-specific reference ranges...
  15. ncbi request reprint Single-blind, multicenter, placebo controlled, parallel study to assess the safety and efficacy of intralesional interferon alpha-2B for minimally invasive treatment for Peyronie's disease
    Wayne J G Hellstrom
    Department of Urology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Urol 176:394-8. 2006
    ..We investigated the efficacy and safety of intralesional interferon alpha-2b for the treatment of Peyronie's disease...
  16. ncbi request reprint An evaluation of semen characteristics in men 45 years of age or older after daily dosing with tadalafil 20mg: results of a multicenter, randomized, double-blind, placebo-controlled, 9-month study
    Wayne J G Hellstrom
    Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Eur Urol 53:1058-65. 2008
    ..Assess the effects on spermatogenesis of daily tadalafil 20mg over three spermatogenesis cycles in men >or= 45 yr...
  17. ncbi request reprint Clinical applications of centrally acting agents in male sexual dysfunction
    W J G Hellstrom
    Tulane University Medical Center, New Orleans, LA 70112, USA
    Int J Impot Res 20:S17-23. 2008
    ..Bremelanotide, a melanocortin agonist, has been tested in men with ED and may prove to be one of the first centrally acting agents to have clinical utility in male sexual dysfunction...
  18. ncbi request reprint Current safety and tolerability issues in men with erectile dysfunction receiving PDE5 inhibitors
    W J G Hellstrom
    Section of Andrology and Male Infertility, Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Int J Clin Pract 61:1547-54. 2007
    ..We conducted an electronic literature review of data concerning the safety and tolerability issues of men with ED receiving PDE5 inhibitors...
  19. doi request reprint Medical management of Peyronie's disease
    Wayne J G Hellstrom
    Tulane University School of Medicine, Department of Urology, 1430 Tulane Ave, New Orleans, LA 70112 2699, USA
    J Androl 30:397-405. 2009
    ..Ongoing basic research in PD will likely identify future targets for medical exploitation...
  20. doi request reprint Effects of alfuzosin and tamsulosin on sperm parameters in healthy men: results of a short-term, randomized, double-blind, placebo-controlled, crossover study
    Wayne J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, 1430 Tulane Avenue SL 42, New Orleans, LA 70112, USA
    J Androl 30:469-74. 2009
    ..The results suggest that tamsulosin has a negative effect on sperm in healthy men. Studies on the effects of alpha(1)-adrenergic blockers on sperm in men with BPH are warranted...
  21. ncbi request reprint Treatment of premature ejaculation: new drugs and treatment strategies
    Wayne J G Hellstrom
    Tulane University Medical Center, Department of Urology, 1430 Tulane Avenue, New Orleans, LA 701120 2632, USA
    Curr Urol Rep 7:473-8. 2006
    ..PE is a treatable condition, and new drugs in development may provide benefits over those available...
  22. ncbi request reprint Ejaculatory dysfunction and its association with lower urinary tract symptoms of benign prostatic hyperplasia and BPH treatment
    Wayne J G Hellstrom
    Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Urology 74:15-21. 2009
    ....
  23. ncbi request reprint Current and future pharmacotherapies of premature ejaculation
    Wayne J G Hellstrom
    Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    J Sex Med 3:332-41. 2006
    ..There are currently no oral or topical agents approved by government regulation agencies for the management of premature ejaculation (PE)...
  24. doi request reprint Introduction: centrally acting agents in male sexual dysfunction
    W J G Hellstrom
    Tulane University Medical Center, New Orleans, LA 70112, USA
    Int J Impot Res 20:S1-2. 2008
  25. ncbi request reprint Testosterone replacement therapy
    Wayne J G Hellstrom
    Tulane University Medical Center, New Orleans, LA, USA
    ScientificWorldJournal 4:142-9. 2004
  26. ncbi request reprint Three-piece inflatable penile prosthesis components (surgical pearls on reservoirs, pumps, and rear-tip extenders)
    W J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Int J Impot Res 15:S136-8. 2003
    ..Therefore, a better understanding of the techniques used for placement of the penile prosthesis is necessary. The following review will discuss the techniques and a few clinical pearls in the placements of inflatable penile prostheses...
  27. doi request reprint Available and future therapies for premature ejaculation
    W J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Drugs Today (Barc) 46:507-21. 2010
    ..Together with a recent, evidence-based definition of PE, these novel therapies should improve sexual function and quality of life in men suffering from PE...
  28. ncbi request reprint Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones
    Wayne J G Hellstrom
    Department of Urology SL 42, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Urol 170:887-91. 2003
    ..We assessed the effects on spermatogenesis of placebo vs 10 or 20 mg tadalafil administered daily for 6 months to healthy men and men with mild erectile dysfunction...
  29. ncbi request reprint Vardenafil: a new approach to the treatment of erectile dysfunction
    Wayne J G Hellstrom
    Department of Urology, Tulane University Medical Center, 1430 Tulane Avenue, SL 42, New Orleans, LA 70112, USA
    Curr Urol Rep 4:479-87. 2003
    ..Vardenafil may be associated with transient reductions in blood pressure and commensurate increases in heart rate, with the overall incidence of cardiovascular-related adverse events similar to that of placebo...
  30. ncbi request reprint Sustained efficacy and tolerability of vardenafil, a highly potent selective phosphodiesterase type 5 inhibitor, in men with erectile dysfunction: results of a randomized, double-blind, 26-week placebo-controlled pivotal trial
    Wayne J G Hellstrom
    Department of Urology, Tulane University Medical Center, New Orleans, Louisiana 70112, USA
    Urology 61:8-14. 2003
    ..Vardenafil was well tolerated. These results demonstrate that vardenafil provides sustained efficacy with reduced incidence of nuisance side effects over time. High resolution video, medium resolution video, low resolution video...
  31. ncbi request reprint Feline penile erection induced by topical glans penis application of combination alprostadil and SEPA (Topiglan)
    M F Usta
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Int J Impot Res 16:73-7. 2004
    ..Topical PGE(1) application to the glans penis may become an important treatment option in selected patients suffering from erectile dysfunction...
  32. ncbi request reprint Antimicrobial activity of antibiotic-soaked, Resist-coated Bioflex
    W J G Hellstrom
    Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Int J Impot Res 15:18-21. 2003
    ..This effect, and the anti-adherence properties of Resist, may prevent adhesion and colonization of some microorganisms to penile implants and reduce chances for infection...
  33. ncbi request reprint Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial
    Wayne J G Hellstrom
    Department of Urology, Tulane University Medical Center, New Orleans, Louisiana 70112, USA
    J Androl 23:763-71. 2002
  34. ncbi request reprint The molecular basis of erectile physiology: from bench to bedside
    Wayne J G Hellstrom
    Department of Urology, Tulane University, New Orleans, Louisiana 70112, USA
    J Androl 23:S3-4. 2002
  35. ncbi request reprint Androgen deficiency in the aging male: pathophysiology, diagnosis, and treatment alternatives
    V Flynn
    Department of Urology, SL 42, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Curr Urol Rep 2:473-9. 2001
    ..This communication reviews the clinical manifestations and diagnosis of androgen deficiency, the inherent risks and benefits of androgen replacement, and the options of testosterone replacement currently available...
  36. ncbi request reprint Benign prostatic hyperplasia, sexual function, and overall evaluation of the male patient
    Wayne J G Hellstrom
    Section of Andrology and Male Infertility, Department of Urology, Tulane University Health Sciences Center, 1430 Tulane Ave, SL 42, New Orleans, LA 70112, USA
    J Am Osteopath Assoc 104:S5-10. 2004
    ..This presentation reviews the role of LUTS and ED in aging men and noninvasive and invasive treatment modalities for BPH...
  37. ncbi request reprint Surgical approaches for advanced Peyronie's disease patients
    W J G Hellstrom
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Int J Impot Res 15:S121-4. 2003
    ..When patients with Peyronie's disease have both penile deformity and ED, penile prosthesis implantation with or without excision or incision of the tunica is the current standard of care...
  38. ncbi request reprint Intranasal apomorphine. Nastech Pharmaceutical
    Muammer Kendirci
    Section of Andrology and Male Infertility, Department of Urology, Tulane University, Health Sciences Center, 1430 Tulane Avenue SL 4, New Orleans, LA 70112, USA
    IDrugs 7:483-8. 2004
    ..Nastech Pharmaceutical Co Inc is developing a nasal formulation of apomorphine for the potential treatment of erectile dysfunction and female sexual dysfunction...
  39. doi request reprint Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation
    Serap Gur
    Tulane University Health Sciences Center, Departments of Urology and Pharmacology, New Orleans, LA 70112, USA
    Expert Opin Drug Saf 12:81-90. 2013
    ..Treatment with 5-alpha reductase inhibitors (5ARI) is commonly utilized for the treatment of benign prostatic hyperplasia (BPH). The true prevalence of sexual side effects with 5ARI treatment is currently unknown...
  40. ncbi request reprint Vardenafil: a novel type 5 phosphodiesterase inhibitor for the treatment of erectile dysfunction
    Muammer Kendirci
    Tulane University Health Sciences Center, Department of Urology, New Orleans, LA 70112, USA
    Expert Opin Pharmacother 5:923-32. 2004
    ....
  41. ncbi request reprint Intralesional interferon-alpha-2B injections for the treatment of Peyronie's disease
    Gerald Dang
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    South Med J 97:42-6. 2004
    ..Intralesional therapies provide an alternative to surgical treatment of Peyronie's disease (PD). This study examines the efficacy of intraplaque injections of interferon-alpha-2B (IFN-alpha-2B) in the treatment of PD...
  42. ncbi request reprint Patient and partner satisfaction and long-term results after surgical treatment for Peyronie's disease
    Mustafa F Usta
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Urology 62:105-9. 2003
    ..To assess the long-term functional outcome, patient and partner satisfaction, and predictive factors for unfavorable results in men treated with a surgical approach for severe Peyronie's disease...
  43. ncbi request reprint Stratification of penile vascular pathologies in patients with Peyronie's disease and in men with erectile dysfunction according to age: a comparative study
    Mustafa F Usta
    Section of Andrology, Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Urol 172:259-62. 2004
    ..Erectile dysfunction (ED) occurs in 20% to 54% of men with Peyronie's disease (PD). We investigated the role of vascular status in the pathophysiology of ED in patients with PD...
  44. doi request reprint Alfuzosin attenuates erectile dysfunction in rats with partial bladder outlet obstruction
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    BJU Int 102:1651-7. 2008
    ....
  45. ncbi request reprint Chronic inhibition of nitric-oxide synthase induces hypertension and erectile dysfunction in the rat that is not reversed by sildenafil
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    BJU Int 106:78-83. 2010
    ....
  46. ncbi request reprint Optimizing nitric oxide production by time dependent L-arginine administration in isolated human corpus cavernosum
    Serap Gur
    Department of Urology, Tulane Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 178:1543-8. 2007
    ..We investigated the relaxant effects of repetitive administration of L-arginine, the substrate for nitric oxide, at hourly intervals and elucidated its mechanism of action in human corpus cavernosum...
  47. ncbi request reprint The penile implant for erectile dysfunction
    John J Mulcahy
    Department of Urology, Indiana University, Indianapolis, IN, USA
    J Sex Med 1:98-109. 2004
    ..Although they are the least chosen and most invasive treatment option, they have the highest satisfaction rate of all available ED options and provide a predictable and reliable result...
  48. ncbi request reprint The impact of intralesional interferon alpha-2b injection therapy on penile hemodynamics in men with Peyronie's disease
    Muammer Kendirci
    Department of Urology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Sex Med 2:709-15. 2005
    ..PDDU may be used to monitor objectively changes in penile vascular parameters in men who undergo treatment for Peyronie's disease (PD), including intralesional interferon alpha-2b (IFN alpha-2b)...
  49. ncbi request reprint Pharmacological Management of Peyronie's Disease
    Landon W Trost
    Department of Urology, Tulane Health Sciences Center, New Orleans, Louisiana 70112, USA
    Drugs 67:527-45. 2007
    ..Further basic scientific research in Peyronie's disease is likely to identify additional targets for future pharmacotherapy...
  50. ncbi request reprint 5-alpha reductase inhibitors and erectile dysfunction: the connection
    Fikret Erdemir
    Tulane University Department of Urology, New Orleans, LA, USA
    J Sex Med 5:2917-24. 2008
    ..5ARI use has been associated with adverse sexual outcomes, including erectile dysfunction (ED), ejaculatory dysfunction (EjD), and decreased libido...
  51. ncbi request reprint Central nervous system agents in the treatment of erectile dysfunction
    Muammer Kendirci
    Department of Urology, Tulane University, Health Sciences Center, SL 42, New Orleans, LA 70112, USA
    Urol Clin North Am 32:487-501, vii. 2005
    ..Clinical research with apomorphine has demonstrated efficacy in men who have a range of ED. Recent interest has focused on other centrally acting agents for ED treatment, including the melanocortin receptor agonists...
  52. ncbi request reprint Poly(Adenosine diphosphate-ribose) polymerase inhibition preserves erectile function in rats after cavernous nerve injury
    Muammer Kendirci
    Department of Urology, School of Medicine, Tulane University, New Orleans, Louisiana, USA
    J Urol 174:2054-9. 2005
    ..Beverly, Massachusetts) in a bilateral cavernous nerve crush injury (BCNCI) model in rats...
  53. ncbi request reprint Gene transfer of extracellular SOD to the penis reduces O2-* and improves erectile function in aged rats
    Trinity J Bivalacqua
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Am J Physiol Heart Circ Physiol 284:H1408-21. 2003
    ..formation. Gene-transfer of EC-SOD reduces superoxide formation and restores age-associated erectile function and may represent a novel therapeutic target for the treatment of erectile dysfunction...
  54. ncbi request reprint Localization of peripheral dopamine D1 and D2 receptors in rat and human seminal vesicles
    Jae Seog Hyun
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Androl 23:114-20. 2002
    ....
  55. doi request reprint Phosphodiesterase type 5 (PDE5) inhibitors for the treatment of erectile dysfunction
    Philip Dorsey
    Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Expert Opin Pharmacother 11:1109-22. 2010
    ..Recently, investigators have noted the potential benefits of this class of medication in the treatment of various urologic and non-urologic conditions, and novel agents in this class are in late-stage trials...
  56. doi request reprint Incision and grafting for severe Peyronie's disease (CME)
    Brian Richardson
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    J Sex Med 6:2084-7; quiz 2088. 2009
    ..A 59-year-old man with a history of untreated penile trauma who presented with a 6-year history of worsening penile curvature that interfered with sexual functioning and resulted in associated erectile dysfunction...
  57. doi request reprint Management of erectile function by penile purinergic p2 receptors in the diabetic rat
    Serap Gur
    Department of Urology and Pharmacology, Tulane Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 181:2375-82. 2009
    ..We determined the role of purine and pyrimidine nucleotides in erectile function in diabetic rats...
  58. pmc Purinergic contraction of the rat vas deferens in L-NAME-induced hypertension: effect of sildenafil
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Asian J Androl 12:415-21. 2010
    ..The VD contractile response may be mediated more by the purinergic system than the adrenergic system, and sildenafil may alter the ejaculatory response in men with PE...
  59. ncbi request reprint Central regulation of ejaculation and the therapeutic role of serotonergic agents in premature ejaculation
    Kush Patel
    Tulane University, Department of Urology, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Curr Opin Investig Drugs 10:681-90. 2009
    ..With a range of centrally acting treatment options, treatment should be tailored to meet the needs and preferences of individual patients...
  60. ncbi request reprint Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress
    Serap Gur
    Tulane University Health Sciences Center, Department of Urology, 1430 Tulane Avenue, SL 42, New Orleans, LA 70112, USA
    Expert Opin Investig Drugs 17:855-64. 2008
    ..The phophodiesterase-5 (PDE5) inhibitors still remain ineffective in 15 - 57% of impotent men...
  61. ncbi request reprint Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum
    Somboon Leungwattanakij
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    J Androl 24:239-45. 2003
    ..In theory, cavernous fibrosis may be reduced by employing various vasoactive agents or interventions that increase oxygenation to the corporal tissues during the postoperative period...
  62. ncbi request reprint The relationship between the type of penile abnormality and penile vascular status in patients with peyronie's disease
    Muammer Kendirci
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 174:632-5; discussion 635. 2005
    ..We evaluated penile vascular status using penile duplex Doppler ultrasound (PDDU) according to the type of abnormality in men with Peyronie's disease (PD)...
  63. ncbi request reprint Critical analysis of surgery for Peyronie's disease
    Muammer Kendirci
    Department of Urology, Section of Andrology, Tulane University Health Sciences Center, 1430 Tulane Avenue, SL 42 New Orleans, LA 70112, USA
    Curr Opin Urol 14:381-8. 2004
    ..This review focuses on the surgical management of Peyronie's disease in the light of recent published reports from 2003 and 2004...
  64. ncbi request reprint Synchronous prosthetic implantation through a transscrotal incision: an outcome analysis
    Muammer Kendirci
    Department of Urology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Urol 175:2218-22. 2006
    ..A multi-institutional evaluation of dual prosthesis implantation was performed to determine the overall efficacy, safety and long-term success of this innovative approach...
  65. ncbi request reprint The effect of vascular risk factors on penile vascular status in men with erectile dysfunction
    Muammer Kendirci
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Urol 178:2516-20; discussion 2520. 2007
    ..This study evaluates the relationship between penile hemodynamic parameters and vascular risk factors in men with erectile dysfunction...
  66. ncbi request reprint Current concepts in the management of erectile dysfunction in men with prostate cancer
    Muammer Kendirci
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Clin Prostate Cancer 3:87-92. 2004
    ..Hopefully, these efforts will improve quality of life for patients with prostate cancer. The aim of this article is to review the current modalities of ED management for men with prostate cancer...
  67. ncbi request reprint The protective effect of aminoguanidine on erectile function in diabetic rats is not related to the timing of treatment
    Mustafa F Usta
    Department of Urology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    BJU Int 94:429-32. 2004
    ....
  68. ncbi request reprint Gene therapy techniques for the delivery of endothelial nitric oxide synthase to the corpora cavernosa for erectile dysfunction
    Trinity J Bivalacqua
    Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, LA, USA
    Methods Mol Biol 279:173-85. 2004
    ....
  69. pmc RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction
    Trinity J Bivalacqua
    Department of Urology, Tulane Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 101:9121-6. 2004
    ..Importantly, these data imply that inhibition of RhoA/Rho-kinase improves eNOS protein content and activity thus restoring erectile function in diabetes...
  70. ncbi request reprint Diabetes mellitus is associated with severe Peyronie's disease
    Muammer Kendirci
    Tulane University, Urology, New Orleans, LA, USA
    BJU Int 99:383-6. 2007
    ..To evaluate the severity of penile deformity and penile blood flow variables in men with Peyronie's disease (PD) and diabetes mellitus (DM), and those with no risk factors...
  71. ncbi request reprint Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats
    Trinity J Bivalacqua
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    J Urol 169:1911-7. 2003
    ..We determined whether adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis of streptozotocin induced diabetic rats could improve the impaired erectile response...
  72. ncbi request reprint Premature ejaculation: current and future treatments
    Levent Gurkan
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Asian J Androl 10:102-9. 2008
    ..This review focuses on current and emerging treatment options and medications for PE. Advantages and limitations of each treatment option are discussed in the light of current published peer-reviewed literature...
  73. ncbi request reprint Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease
    Trinity J Bivalacqua
    Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Androl 24:S17-37. 2003
  74. ncbi request reprint The hydrophilic-coated inflatable penile prosthesis: 1-year experience
    Christopher E Wolter
    Department of Urology, Secion of Andrology and Male Infertility, Tulane University, School of Medicine, New Orleans, LA 70112, USA
    J Sex Med 1:221-4. 2004
    ..The Titan device was introduced to the American market in September 2002. This study reports the 1-year experience in the U.S. with the Titan and compares infection rates with the noncoated Alpha-1 IPP made by Mentor...
  75. doi request reprint Robot-assisted vessel harvesting for penile revascularization
    Mathew C Raynor
    Department of Urology, Tulane Health Sciences Center, New Orleans, Louisiana, USA
    J Sex Med 7:293-7. 2010
    ..We report our experience with robot-assisted epigastric vessel harvesting for use in penile revascularization procedures...
  76. ncbi request reprint Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use
    Muammer Kendirci
    Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Eur Urol 52:555-63. 2007
    ..To evaluate the peripheral mechanisms of erectile dysfunction (ED) in a rat model of triple-binge cocaine administration...
  77. doi request reprint A critical appraisal of erectile function in animal models of diabetes mellitus
    Serap Gur
    Department of Urology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Int J Androl 32:93-114. 2009
    ..We are optimistic that novel prevention and treatment strategies for diabetic ED are on the horizon...
  78. ncbi request reprint Endothelial nitric oxide synthase gene therapy for erectile dysfunction
    Trinity J Bivalacqua
    Department of Urology, Tulane Health Sciences Center, 1430 Tulane Avenue SL42, New Orleans, LA 70112, USA
    Curr Pharm Des 11:4059-67. 2005
    ..Putative gene therapy interventions to restore eNOS expression and subsequent endothelial function may represent an exciting new therapeutic strategy for the future treatment of ED...
  79. ncbi request reprint Exploring the potential of NO-independent stimulators and activators of soluble guanylate cyclase for the medical treatment of erectile dysfunction
    Serap Gur
    Department of Urology and Pharmacology, Health Sciences Center, Tulane University, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Curr Pharm Des 16:1619-33. 2010
    ..This novel drug therapy approach for the treatment of ED shows promise...
  80. ncbi request reprint Vardenafil provides reliable efficacy over time in men with erectile dysfunction
    Francesco Montorsi
    Instituto San Raffaele, Milan, Italy
    Urology 64:1187-95. 2004
    ..To evaluate the reliability of vardenafil efficacy and tolerability within 12 weeks in a broad population of men with erectile dysfunction (ED)...
  81. ncbi request reprint Penetration and maintenance of erection with vardenafil: a time-from-dosing analysis
    Luc Valiquette
    Service d Urologie, CHUM Hopital St Luc, Montreal, Quebec, Canada
    Can J Urol 12:2687-98; discussion 2699. 2005
    ....
  82. ncbi request reprint Visual field defect and intracerebral hemorrhage associated with use of vardenafil (Levitra)
    Wayne J G Hellstrom
    Neurology 66:293-4; author reply 293-4. 2006
  83. ncbi request reprint Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase
    Trinity J Bivalacqua
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 292:H1340-51. 2007
    ..Inhibition of the arginase pathway improves endothelial function in the aging penile circulation, suggesting that the arginase pathway may be exploited to improve erectile dysfunction associated with aging...
  84. doi request reprint The pharmacological treatment of premature ejaculation
    Francois Giuliano
    Department of Physical Medicine andRehabilitation, AP HP, Raymond Poincare Hospital, Garches, France
    BJU Int 102:668-75. 2008
    ..Phosphodiesterase-5 inhibitors have also been evaluated for treating PE, as have topical anaesthetics and the narcotic analgesic tramadol...
  85. ncbi request reprint Management of sildenafil treatment failures
    Muammer Kendirci
    Department of Urology, Sisli Etfal Training and Research Hospital, Istanbul 34280, Turkey
    Curr Opin Urol 16:449-59. 2006
    ..This communication reviews the management of sildenafil failures in light of recent advances...
  86. ncbi request reprint Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials
    Jon L Pryor
    University of Minnesota, Minneapolis, MN 55455, USA
    Lancet 368:929-37. 2006
    ..No drugs are approved for treatment of premature ejaculation. Our aim was to determine the efficacy and tolerability of on-demand dapoxetine in patients with severe premature ejaculation...
  87. ncbi request reprint Update on erectile dysfunction in prostate cancer patients
    Muammer Kendirci
    Department of Urology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
    Curr Opin Urol 16:186-95. 2006
    ..The aim of this communication is to review recent initiatives in erectile dysfunction restoration after prostate cancer therapy...
  88. ncbi request reprint Gene therapy for erectile dysfunction: fact or fiction?
    Muammer Kendirci
    Department of Urology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
    Eur Urol 50:1208-22. 2006
    ....
  89. ncbi request reprint Evaluation of corporal fibrosis in cadaveric pericardium and vein grafts for tunica albuginea substitution in rats
    Somboon Leungwattanakij
    Department of Urology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Asian J Androl 5:295-9. 2003
    ..To evaluate the degree of corporal fibrosis in rats with cadaveric pericardium or vein as grafting materials for tunica albuginea substitution...
  90. ncbi request reprint Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy
    Trinity J Bivalacqua
    Johns Hopkins Hospital, Brady Urological Institute, Baltimore, MD, USA
    J Sex Med 2:187-97; discussion 197-8. 2005
    ....
  91. doi request reprint An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation
    Chris G McMahon
    Australian Center for Sexual Health, Sydney, Australia
    J Sex Med 5:1590-606. 2008
    ....
  92. ncbi request reprint Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction
    Trinity J Bivalacqua
    Brady Urological Institute, Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Physiol Heart Circ Physiol 292:H1278-90. 2007
    ..These data highlight the potential clinical use of adult stem cell-based therapy for the treatment of ED...