Siddhartha Hazari

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc Free fatty acids induce ER stress and block antiviral activity of interferon alpha against hepatitis C virus in cell culture
    Feyza Gunduz
    Department of Medicine, Gastroenterology and Hepatology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Virol J 9:143. 2012
  2. pmc Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1
    Sibnarayan Datta
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA
    Virol J 8:351. 2011
  3. pmc Impaired antiviral activity of interferon alpha against hepatitis C virus 2a in Huh-7 cells with a defective Jak-Stat pathway
    Sidhartha Hazari
    Department of Pathology and Laboratory Medicine, Tulane University of Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Virol J 7:36. 2010
  4. pmc Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone
    Partha K Chandra
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Virol J 7:118. 2010
  5. pmc Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in hepatitis C virus replicon
    Sidhartha Hazari
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, USA
    Virol J 4:89. 2007
  6. pmc Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication
    Bret Poat
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Virol J 7:265. 2010
  7. pmc Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis
    Yanfang Wang
    Department of Biochemistry and Molecular Biology, Stanley Scott Cancer Center, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Mol Cancer 10:84. 2011

Collaborators

Detail Information

Publications7

  1. pmc Free fatty acids induce ER stress and block antiviral activity of interferon alpha against hepatitis C virus in cell culture
    Feyza Gunduz
    Department of Medicine, Gastroenterology and Hepatology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Virol J 9:143. 2012
    ..We investigated the effect of hepatocellular steatosis on hepatitis C virus (HCV) replication and IFN-α antiviral response in a cell culture model...
  2. pmc Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1
    Sibnarayan Datta
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA
    Virol J 8:351. 2011
    ..The results of this study suggest that expression of cell surface IFNAR1 is critical for the response of HCV to exogenous IFN-α...
  3. pmc Impaired antiviral activity of interferon alpha against hepatitis C virus 2a in Huh-7 cells with a defective Jak-Stat pathway
    Sidhartha Hazari
    Department of Pathology and Laboratory Medicine, Tulane University of Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Virol J 7:36. 2010
    ..The molecular mechanisms explaining the differences in IFN-alpha responsiveness between HCV 1 and other genotypes have not been elucidated...
  4. pmc Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone
    Partha K Chandra
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Virol J 7:118. 2010
    ..This study was performed further to explore the mechanism of action of this recombinant antibody and to determine whether or not this antibody inhibits replication and infectivity of a highly efficient JFH1 HCV 2a virus clone...
  5. pmc Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in hepatitis C virus replicon
    Sidhartha Hazari
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, USA
    Virol J 4:89. 2007
    ..The mechanisms of IFN-resistance are unclear. The aim of this study was to determine the contribution of host cell factors to the mechanisms of interferon resistance using replicon cell lines...
  6. pmc Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication
    Bret Poat
    Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Virol J 7:265. 2010
    ....
  7. pmc Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis
    Yanfang Wang
    Department of Biochemistry and Molecular Biology, Stanley Scott Cancer Center, LSU Health Sciences Center, New Orleans, LA 70112, USA
    Mol Cancer 10:84. 2011
    ..The importance of integrins in cell migration and cell invasion was examined by in vitro assays. Further the effect of integrins on metastasis was investigated by in vivo experimental metastasis assays using mouse models...