Chang Han

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin
    Jinqiang Zhang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Gastroenterology 143:246-56.e8. 2012
  2. pmc Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth
    Chang Han
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Hepatology 52:644-55. 2010
  3. pmc Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells
    Kyoungsub Song
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
    Hepatology 58:1681-92. 2013
  4. pmc 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins
    Dongdong Lu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Biol Chem 288:19484-502. 2013
  5. pmc miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF)
    Jinqiang Zhang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Pathol 182:1629-39. 2013
  6. pmc miR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth
    Lu Lu
    Authors Affiliation Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Mol Cancer Res 12:890-900. 2014
  7. pmc Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
    Ying Wang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA
    Hepatology 58:995-1010. 2013
  8. pmc Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression
    Dongdong Lu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Gastroenterology 140:2084-94. 2011

Collaborators

Detail Information

Publications8

  1. pmc MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin
    Jinqiang Zhang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Gastroenterology 143:246-56.e8. 2012
    ..MicroRNAs (miRNAs) have been implicated in the development and progression of human cancers. We investigated the roles and mechanisms of miR-26a in human cholangiocarcinoma...
  2. pmc Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth
    Chang Han
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Hepatology 52:644-55. 2010
    ..Therefore, regulation of TGF-beta signaling by cPLA(2)alpha and PPAR-gamma may represent an important mechanism for control of hepatic cell growth and hepatocarcinogenesis...
  3. pmc Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells
    Kyoungsub Song
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
    Hepatology 58:1681-92. 2013
    ....
  4. pmc 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins
    Dongdong Lu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Biol Chem 288:19484-502. 2013
    ..These findings disclose a novel 15-PGDH-mediated 15-keto-PGE2 signaling cascade that interacts with PPAR-γ, Smad2/3, and TAP63. ..
  5. pmc miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF)
    Jinqiang Zhang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Pathol 182:1629-39. 2013
    ..This study established a novel tumor-suppressor role of miR-101 in cholangiocarcinoma and it suggests the possibility of targeting miR-101 and related signaling pathways for future therapy...
  6. pmc miR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth
    Lu Lu
    Authors Affiliation Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Mol Cancer Res 12:890-900. 2014
    ..In parallel, cyclooxygenase-2 (COX2) overexpression and PGE2 treatment increased miR-21 levels and enhanced miR-21 promoter activity in human cholangiocarcinoma cells...
  7. pmc Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
    Ying Wang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA
    Hepatology 58:995-1010. 2013
    ..Therefore, the status of autophagy is a key factor that determines the therapeutic response to Hh-targeted therapies...
  8. pmc Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression
    Dongdong Lu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Gastroenterology 140:2084-94. 2011
    ..Although COX-2 is involved in the development and progression of various human cancers, the role of mPGES-1 in carcinogenesis has not been determined. We investigated the role of mPGES-1 in human cholangiocarcinoma growth...