Monica E Embers

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc Pharmacokinetic analysis of oral doxycycline in rhesus macaques
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Med Primatol 42:57-61. 2013
  2. pmc Dynamic longitudinal antibody responses during Borrelia burgdorferi infection and antibiotic treatment of rhesus macaques
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, USA
    Clin Vaccine Immunol 19:1218-26. 2012
  3. pmc Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection
    Monica E Embers
    Divisions of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America
    PLoS ONE 7:e29914. 2012
  4. doi request reprint Characterization of a Moraxella species that causes epistaxis in macaques
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA, USA
    Vet Microbiol 147:367-75. 2011
  5. ncbi request reprint Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    FEMS Immunol Med Microbiol 50:421-9. 2007
  6. pmc The failure of immune response evasion by linear plasmid 28-1-deficient Borrelia burgdorferi is attributable to persistent expression of an outer surface protein
    Monica E Embers
    Divisions of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 76:3984-91. 2008
  7. pmc Dominant epitopes of the C6 diagnostic peptide of Borrelia burgdorferi are largely inaccessible to antibody on the parent VlsE molecule
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 14:931-6. 2007
  8. pmc Borrelia burgdorferi spirochetes that harbor only a portion of the lp28-1 plasmid elicit antibody responses detectable with the C6 test for Lyme disease
    Monica E Embers
    Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 14:90-3. 2007
  9. ncbi request reprint Survival strategies of Borrelia burgdorferi, the etiologic agent of Lyme disease
    Monica E Embers
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    Microbes Infect 6:312-8. 2004
  10. pmc Vaccination against Lyme disease: past, present, and future
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center Covington, LA, USA
    Front Cell Infect Microbiol 3:6. 2013

Detail Information

Publications10

  1. pmc Pharmacokinetic analysis of oral doxycycline in rhesus macaques
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Covington, LA 70433, USA
    J Med Primatol 42:57-61. 2013
    ..The most relevant pharmacodynamic property of a bacteriostatic antibiotic such as doxycycline is the minimum inhibitory concentration (MIC), whereas pharmacokinetics may include rates of absorption and elimination from blood...
  2. pmc Dynamic longitudinal antibody responses during Borrelia burgdorferi infection and antibiotic treatment of rhesus macaques
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, USA
    Clin Vaccine Immunol 19:1218-26. 2012
    ..burgdorferi OppA-2 antigenicity in nonhuman primates. The combination of DbpA, OspC, OspA, and OppA-2 with the C6 diagnostic peptide has the potential to detect infection throughout all disease phases...
  3. pmc Persistence of Borrelia burgdorferi in rhesus macaques following antibiotic treatment of disseminated infection
    Monica E Embers
    Divisions of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana, United States of America
    PLoS ONE 7:e29914. 2012
    ..This finding raises important questions about the pathogenicity of antibiotic-tolerant persisters and whether or not they can contribute to symptoms post-treatment...
  4. doi request reprint Characterization of a Moraxella species that causes epistaxis in macaques
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA, USA
    Vet Microbiol 147:367-75. 2011
    ..The nasopharyngeal isolates in this study appear uniquely adapted to a macaque host and, though they share many of the phenotypic characteristics of M. catarrhalis, appear to form a genotypically distinct species...
  5. ncbi request reprint Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    FEMS Immunol Med Microbiol 50:421-9. 2007
    ..These observations, together with the recovery of cultivable spirochetes from tissue of one animal at 98 weeks postinoculation, challenge the notion that the rabbit cannot harbour a long-term B. burgdorferi infection...
  6. pmc The failure of immune response evasion by linear plasmid 28-1-deficient Borrelia burgdorferi is attributable to persistent expression of an outer surface protein
    Monica E Embers
    Divisions of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 76:3984-91. 2008
    ..These findings indicate that incomplete repression of OspC by lp28-1(-) organisms renders them susceptible to immune-mediated clearance. The lp28-1 plasmid must harbor one or more genes involved in OspC downregulation...
  7. pmc Dominant epitopes of the C6 diagnostic peptide of Borrelia burgdorferi are largely inaccessible to antibody on the parent VlsE molecule
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 14:931-6. 2007
    ..5%. These findings indicate that IR6 epitopes are largely concealed from the VlsE molecular surface and that full-length VlsE-based diagnosis likely detects antibodies to conformational and/or variable region epitopes...
  8. pmc Borrelia burgdorferi spirochetes that harbor only a portion of the lp28-1 plasmid elicit antibody responses detectable with the C6 test for Lyme disease
    Monica E Embers
    Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    Clin Vaccine Immunol 14:90-3. 2007
    ..These findings demonstrate that diagnosis by C6 ELISA remains effective for infection with all B. burgdorferi genotypes, including those with incomplete lp28-1 plasmids...
  9. ncbi request reprint Survival strategies of Borrelia burgdorferi, the etiologic agent of Lyme disease
    Monica E Embers
    Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, LA 70433, USA
    Microbes Infect 6:312-8. 2004
    ..Here we critically review the supporting evidence for possible stratagems utilized by Borrelia burgdorferi, the spirochete that causes Lyme disease, to persist in the mammalian host...
  10. pmc Vaccination against Lyme disease: past, present, and future
    Monica E Embers
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center Covington, LA, USA
    Front Cell Infect Microbiol 3:6. 2013
    ..We present the correlates of protection for this infectious disease, the pros and cons of past vaccination strategies, and new paradigms for future vaccine design that would include elements of both the vector and the pathogen...