Melanie Ehrlich

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint DNA methylation in cancer: too much, but also too little
    Melanie Ehrlich
    Human Genetics Program SL31, Department of Biochemistry, Tulane Medical School, New Orleans, Louisiana, LA 70122, USA
    Oncogene 21:5400-13. 2002
  2. pmc Epigenetics of a tandem DNA repeat: chromatin DNaseI sensitivity and opposite methylation changes in cancers
    Koji Tsumagari
    Human Genetics Program and Department of Biochemistry and Tulane Cancer Center, Tulane Medical School, Department of Mathematics, Tulane University, New Orleans, LA 70112, USA
    Nucleic Acids Res 36:2196-207. 2008
  3. ncbi request reprint Hemimethylation footprints of DNA demethylation in cancer
    Chunbo Shao
    Hayward Human Genetics Center, Tulane Medical School, New Orleans, LA 70112, USA
    Epigenetics 4:165-75. 2009
  4. pmc DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2
    Xueqing Xu
    Human Genetics Program and Department of Biochemistry and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
    Nucleic Acids Res 37:7381-93. 2009
  5. pmc Both hypomethylation and hypermethylation in a 0.2-kb region of a DNA repeat in cancer
    Rie Nishiyama
    Human Genetics Program, Department of Biochemistry, and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
    Mol Cancer Res 3:617-26. 2005
  6. pmc Gene expression during normal and FSHD myogenesis
    Koji Tsumagari
    Human Genetics Program, Tulane Medical School, New Orleans, LA, USA
    BMC Med Genomics 4:67. 2011
  7. ncbi request reprint Satellite DNA hypomethylation in karyotyped Wilms tumors
    Melanie Ehrlich
    Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, LA, USA
    Cancer Genet Cytogenet 141:97-105. 2003
  8. ncbi request reprint A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others
    Rie Nishiyama
    Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA
    Cancer Biol Ther 4:440-8. 2005
  9. pmc Early de novo DNA methylation and prolonged demethylation in the muscle lineage
    Koji Tsumagari
    Program in Human Genetics and Tulane Cancer Center, Tulane Health Sciences Center, New Orleans, LA, USA
    Epigenetics 8:317-32. 2013
  10. ncbi request reprint DNA hypomethylation is prevalent even in low-grade breast cancers
    Kesmic Jackson
    Department of Biochemistry, Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA
    Cancer Biol Ther 3:1225-31. 2004

Collaborators

Detail Information

Publications32

  1. ncbi request reprint DNA methylation in cancer: too much, but also too little
    Melanie Ehrlich
    Human Genetics Program SL31, Department of Biochemistry, Tulane Medical School, New Orleans, Louisiana, LA 70122, USA
    Oncogene 21:5400-13. 2002
    ..Inducing DNA hypomethylation may have short-term anticancer effects, but might also help speed tumor progression from cancer cells surviving the DNA demethylation chemotherapy...
  2. pmc Epigenetics of a tandem DNA repeat: chromatin DNaseI sensitivity and opposite methylation changes in cancers
    Koji Tsumagari
    Human Genetics Program and Department of Biochemistry and Tulane Cancer Center, Tulane Medical School, Department of Mathematics, Tulane University, New Orleans, LA 70112, USA
    Nucleic Acids Res 36:2196-207. 2008
    ..This subregion contains runs of G that form G-quadruplexes in vitro. Unusual DNA structures might contribute to topological constraints that link short 4q D4Z4 arrays to FSHD and make long ones phenotypically neutral...
  3. ncbi request reprint Hemimethylation footprints of DNA demethylation in cancer
    Chunbo Shao
    Hayward Human Genetics Center, Tulane Medical School, New Orleans, LA 70112, USA
    Epigenetics 4:165-75. 2009
    ..Constitutive heterochromatin may be especially suitable for providing a snapshot of demethylation intermediates because hemimethylation might be more long-lived in heterochromatin due to its highly condensed state...
  4. pmc DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2
    Xueqing Xu
    Human Genetics Program and Department of Biochemistry and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
    Nucleic Acids Res 37:7381-93. 2009
    ..Their selective occurrence in cells derived from mesoderm suggests functionality. Our findings indicate that the gene desert regions of 4q35.2 may have functional significance, possibly also to FSHD, despite their paucity of known genes...
  5. pmc Both hypomethylation and hypermethylation in a 0.2-kb region of a DNA repeat in cancer
    Rie Nishiyama
    Human Genetics Program, Department of Biochemistry, and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
    Mol Cancer Res 3:617-26. 2005
    ..NBL2 is an attractive candidate for an epigenetic cancer marker and for elucidating the nature of epigenetic changes in cancer...
  6. pmc Gene expression during normal and FSHD myogenesis
    Koji Tsumagari
    Human Genetics Program, Tulane Medical School, New Orleans, LA, USA
    BMC Med Genomics 4:67. 2011
    ..Within each repeat unit is a gene, DUX4, that can encode a protein containing two homeodomains. A DUX4 transcript derived from the last repeat unit in a contracted array is associated with pathogenesis but it is unclear how...
  7. ncbi request reprint Satellite DNA hypomethylation in karyotyped Wilms tumors
    Melanie Ehrlich
    Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, LA, USA
    Cancer Genet Cytogenet 141:97-105. 2003
    ....
  8. ncbi request reprint A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others
    Rie Nishiyama
    Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA
    Cancer Biol Ther 4:440-8. 2005
    ....
  9. pmc Early de novo DNA methylation and prolonged demethylation in the muscle lineage
    Koji Tsumagari
    Program in Human Genetics and Tulane Cancer Center, Tulane Health Sciences Center, New Orleans, LA, USA
    Epigenetics 8:317-32. 2013
    ..They also suggest that, in muscle, TET1 or TET2 are involved in active demethylation and in formation of stable 5-hmC residues...
  10. ncbi request reprint DNA hypomethylation is prevalent even in low-grade breast cancers
    Kesmic Jackson
    Department of Biochemistry, Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA
    Cancer Biol Ther 3:1225-31. 2004
    ....
  11. pmc ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation
    Melanie Ehrlich
    Hayward Human Genetics Program, Tulane Medical School, New Orleans, LA 70112, USA
    Autoimmunity 41:253-71. 2008
    ....
  12. ncbi request reprint Cytogenetic and immuno-FISH analysis of the 4q subtelomeric region, which is associated with facioscapulohumeral muscular dystrophy
    Fan Yang
    Human Genetics Program and Department of Biochemistry, Tulane Medical School, New Orleans, LA 70112, USA
    Chromosoma 112:350-9. 2004
    ..2 regions of FSHD myoblasts did not behave differently than those of control myoblasts. Other models for how D4Z4 array contraction causes long-distance regulation of gene expression in cis need to be tested...
  13. doi request reprint DNA methylation and cancer-associated genetic instability
    Melanie Ehrlich
    Tulane Cancer Center, Department of Biochemistry, Tulane Medical School, New Orleans, Louisiana 70112, USA
    Adv Exp Med Biol 570:363-92. 2005
  14. ncbi request reprint Imatinib (ST1571) provides only limited selectivity for CML cells and treatment might be complicated by silent BCR-ABL genes
    Guanchao Jiang
    Tulane Cancer Center and Humon Genetics Program, Tulane Medical School, New Orleans, Lousiana 70112, USA
    Cancer Biol Ther 2:103-8. 2003
    ..Our results indicate that IM is only partially specific for CML progenitor cells compared to normal hematopoietic progenitor cells and suggest that some CML cells may have a silent BCR-ABL oncogene that could interfere with therapy...
  15. pmc Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF)
    Melanie Ehrlich
    Human Genetics Program, Tulane University Health Sciences Center 1430 Tulane Ave, New Orleans, LA 70112, USA
    Orphanet J Rare Dis 1:2. 2006
    ..Treatment almost always includes regular infusions of immunoglobulins, mostly intravenously. Recently, bone marrow transplantation has been tried...
  16. pmc Deciphering transcription dysregulation in FSH muscular dystrophy
    Melanie Ehrlich
    Human Genetics Program and Center for Bioinformatics and Genomics, Tulane Cancer Center, Tulane University, New Orleans, LA 70122, USA
    J Hum Genet 57:477-84. 2012
    ..The Majority Rules model is the simpler explanation of findings about FSHD-associated gene expression and the DUX4-encoded homeodomain-type protein...
  17. pmc DNA hypomethylation in cancer cells
    Melanie Ehrlich
    Hayward Genetics Program, Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, 1430 TulaneAvenue, New Orleans, LA 70112, USA
    Epigenomics 1:239-59. 2009
    ..Evidence is accumulating for the biological significance and clinical relevance of DNA hypomethylation in cancer, and for cancer-linked demethylation and de novo methylation being highly dynamic processes...
  18. ncbi request reprint Testing the position-effect variegation hypothesis for facioscapulohumeral muscular dystrophy by analysis of histone modification and gene expression in subtelomeric 4q
    Guanchao Jiang
    Human Genetics Program and Department of Biochemistry, Tulane Medical School, New Orleans, LA 70112, USA
    Hum Mol Genet 12:2909-21. 2003
    ..3 kb repeat...
  19. pmc Hybridization analysis of D4Z4 repeat arrays linked to FSHD
    Melanie Ehrlich
    Program in Human Genetics and Department of Biochemistry, Tulane Medical School, New Orleans, LA, USA
    Chromosoma 116:107-16. 2007
    ..Furthermore, we show that the D4Z4-like sequences present elsewhere in the genome are not tandemly arranged, like those at 4q35 and 10q26...
  20. ncbi request reprint Histone modification in constitutive heterochromatin versus unexpressed euchromatin in human cells
    Guanchao Jiang
    Human Genetics Program and Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, New Orleans, Louisiana 70112, USA
    J Cell Biochem 93:286-300. 2004
    ....
  21. doi request reprint Modeling dependence in methylation patterns with application to ovarian carcinomas
    Michelle R Lacey
    Tulane University, USA
    Stat Appl Genet Mol Biol 8:Article 40. 2009
    ....
  22. doi request reprint DNA hypomethylation and hemimethylation in cancer
    Melanie Ehrlich
    Human Genetics Program, Tulane University, New Orleans, LA 70122, USA
    Adv Exp Med Biol 754:31-56. 2013
    ....
  23. ncbi request reprint Expression of various genes is controlled by DNA methylation during mammalian development
    Melanie Ehrlich
    Program in Human Genetics, Department of Biochemistry, and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
    J Cell Biochem 88:899-910. 2003
    ..Also, I discuss previously established and newly hypothesized mechanisms for this epigenetic control...
  24. ncbi request reprint The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease
    Melanie Ehrlich
    Human Genetics Program and Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
    Clin Immunol 109:17-28. 2003
    ..Comparisons of ICF and control lymphoblastoid cell lines and ICF patients' symptoms suggest an involvement of DNA methylation in the late stages of lymphocyte maturation...
  25. ncbi request reprint Hypomethylation and hypermethylation of DNA in Wilms tumors
    Melanie Ehrlich
    Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana, LA 70112, USA
    Oncogene 21:6694-702. 2002
    ..This suggests that the DNA hypomethylation contributes independently to oncogenesis or tumor progression...
  26. ncbi request reprint DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements
    Melanie Ehrlich
    Tulane Medical School, New Orleans, LA 70112, USA
    J Nutr 132:2424S-2429S. 2002
    ..Microarray gene expression analysis on ICF and normal lymphoblastoid cell lines suggests that this hypomethylation also may affect gene expression elsewhere in the genome...
  27. pmc Will the transcription control elements in chromatin please stand up?
    Melanie Ehrlich
    Epigenetics 3:179-80. 2008
  28. ncbi request reprint DNA hypomethylation and ovarian cancer biology
    Martin Widschwendter
    Department of Obstetrics and Gynecology, Medical University Innsbruck, Innsbruck, Austria
    Cancer Res 64:4472-80. 2004
    ....
  29. pmc RNAPol-ChIP analysis of transcription from FSHD-linked tandem repeats and satellite DNA
    Vassilios Alexiadis
    Genpathway, Inc, San Diego, CA 92121, USA
    Biochim Biophys Acta 1769:29-40. 2007
    ..In addition, our results do not support the previously hypothesized disease-linked differential transcription of D4Z4 sequences in short, FSHD-linked arrays...
  30. ncbi request reprint Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer
    Christoph Grunau
    Institut de Genetique Humaine, CNRS UPR 1142, Montpellier, France
    Genes Chromosomes Cancer 43:11-24. 2005
    ..Consequently, we propose BAGE hypomethylation as a new, highly informative epigenetic biomarker for the diagnosis of cancer, whose hypomethylation in cancer may be causally related to that of juxtacentromeric satellite DNA...
  31. pmc Analysis of repetitive element DNA methylation by MethyLight
    Daniel J Weisenberger
    Department of Surgery, Keck School of Medicine, USC Norris Comprehensive Cancer Center, University of Southern California Los Angeles, CA, USA
    Nucleic Acids Res 33:6823-36. 2005
    ....
  32. ncbi request reprint Interphase chromosomal abnormalities and mitotic missegregation of hypomethylated sequences in ICF syndrome cells
    David Gisselsson
    Department of Clinical Genetics, University Hospital, 22185 Lund, Sweden
    Chromosoma 114:118-26. 2005
    ..This can help explain why specific types of 1qh and 16qh rearrangements are not present at high frequencies in ICF lymphoid cells despite diverse 1qh and 16qh aberrations continuously being generated...