Research Topics
| Melanie EhrlichSummaryAffiliation: Tulane University Country: USA Publications
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Detail Information
Publications
DNA methylation in cancer: too much, but also too littleMelanie Ehrlich
Human Genetics Program SL31, Department of Biochemistry, Tulane Medical School, New Orleans, Louisiana, LA 70122, USA
Oncogene 21:5400-13. 2002..Inducing DNA hypomethylation may have short-term anticancer effects, but might also help speed tumor progression from cancer cells surviving the DNA demethylation chemotherapy...
Epigenetics of a tandem DNA repeat: chromatin DNaseI sensitivity and opposite methylation changes in cancersKoji Tsumagari
Human Genetics Program and Department of Biochemistry and Tulane Cancer Center, Tulane Medical School, Department of Mathematics, Tulane University, New Orleans, LA 70112, USA
Nucleic Acids Res 36:2196-207. 2008..This subregion contains runs of G that form G-quadruplexes in vitro. Unusual DNA structures might contribute to topological constraints that link short 4q D4Z4 arrays to FSHD and make long ones phenotypically neutral...- Hemimethylation footprints of DNA demethylation in cancerChunbo Shao
Hayward Human Genetics Center, Tulane Medical School, New Orleans, LA 70112, USA
Epigenetics 4:165-75. 2009..Constitutive heterochromatin may be especially suitable for providing a snapshot of demethylation intermediates because hemimethylation might be more long-lived in heterochromatin due to its highly condensed state... - DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2Xueqing Xu
Human Genetics Program and Department of Biochemistry and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
Nucleic Acids Res 37:7381-93. 2009..Their selective occurrence in cells derived from mesoderm suggests functionality. Our findings indicate that the gene desert regions of 4q35.2 may have functional significance, possibly also to FSHD, despite their paucity of known genes... - Both hypomethylation and hypermethylation in a 0.2-kb region of a DNA repeat in cancerRie Nishiyama
Human Genetics Program, Department of Biochemistry, and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
Mol Cancer Res 3:617-26. 2005..NBL2 is an attractive candidate for an epigenetic cancer marker and for elucidating the nature of epigenetic changes in cancer... - Gene expression during normal and FSHD myogenesisKoji Tsumagari
Human Genetics Program, Tulane Medical School, New Orleans, LA, USA
BMC Med Genomics 4:67. 2011..Within each repeat unit is a gene, DUX4, that can encode a protein containing two homeodomains. A DUX4 transcript derived from the last repeat unit in a contracted array is associated with pathogenesis but it is unclear how... - A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in othersRie Nishiyama
Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA
Cancer Biol Ther 4:440-8. 2005.... - Satellite DNA hypomethylation in karyotyped Wilms tumorsMelanie Ehrlich
Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, LA, USA
Cancer Genet Cytogenet 141:97-105. 2003.... - ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulationMelanie Ehrlich
Hayward Human Genetics Program, Tulane Medical School, New Orleans, LA 70112, USA
Autoimmunity 41:253-71. 2008.... - Cytogenetic and immuno-FISH analysis of the 4q subtelomeric region, which is associated with facioscapulohumeral muscular dystrophyFan Yang
Human Genetics Program and Department of Biochemistry, Tulane Medical School, New Orleans, LA 70112, USA
Chromosoma 112:350-9. 2004..2 regions of FSHD myoblasts did not behave differently than those of control myoblasts. Other models for how D4Z4 array contraction causes long-distance regulation of gene expression in cis need to be tested... - DNA hypomethylation is prevalent even in low-grade breast cancersKesmic Jackson
Department of Biochemistry, Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana 70112, USA
Cancer Biol Ther 3:1225-31. 2004.... - DNA methylation and cancer-associated genetic instabilityMelanie Ehrlich
Tulane Cancer Center, Department of Biochemistry, Tulane Medical School, New Orleans, Louisiana 70112, USA
Adv Exp Med Biol 570:363-92. 2005 - Imatinib (ST1571) provides only limited selectivity for CML cells and treatment might be complicated by silent BCR-ABL genesGuanchao Jiang
Tulane Cancer Center and Humon Genetics Program, Tulane Medical School, New Orleans, Lousiana 70112, USA
Cancer Biol Ther 2:103-8. 2003..Our results indicate that IM is only partially specific for CML progenitor cells compared to normal hematopoietic progenitor cells and suggest that some CML cells may have a silent BCR-ABL oncogene that could interfere with therapy... - Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF)Melanie Ehrlich
Human Genetics Program, Tulane University Health Sciences Center 1430 Tulane Ave, New Orleans, LA 70112, USA
Orphanet J Rare Dis 1:2. 2006..Treatment almost always includes regular infusions of immunoglobulins, mostly intravenously. Recently, bone marrow transplantation has been tried... - DNA hypomethylation in cancer cellsMelanie Ehrlich
Hayward Genetics Program, Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, 1430 TulaneAvenue, New Orleans, LA 70112, USA
Epigenomics 1:239-59. 2009..Evidence is accumulating for the biological significance and clinical relevance of DNA hypomethylation in cancer, and for cancer-linked demethylation and de novo methylation being highly dynamic processes... - Hybridization analysis of D4Z4 repeat arrays linked to FSHDMelanie Ehrlich
Program in Human Genetics and Department of Biochemistry, Tulane Medical School, New Orleans, LA, USA
Chromosoma 116:107-16. 2007..Furthermore, we show that the D4Z4-like sequences present elsewhere in the genome are not tandemly arranged, like those at 4q35 and 10q26... - Testing the position-effect variegation hypothesis for facioscapulohumeral muscular dystrophy by analysis of histone modification and gene expression in subtelomeric 4qGuanchao Jiang
Human Genetics Program and Department of Biochemistry, Tulane Medical School, New Orleans, LA 70112, USA
Hum Mol Genet 12:2909-21. 2003..3 kb repeat... - Histone modification in constitutive heterochromatin versus unexpressed euchromatin in human cellsGuanchao Jiang
Human Genetics Program and Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, New Orleans, Louisiana 70112, USA
J Cell Biochem 93:286-300. 2004.... 
Modeling dependence in methylation patterns with application to ovarian carcinomasMichelle R Lacey
Tulane University, USA
Stat Appl Genet Mol Biol 8:Article 40. 2009....- DNA hypomethylation and hemimethylation in cancerMelanie Ehrlich
Human Genetics Program, Tulane University, New Orleans, LA 70122, USA
Adv Exp Med Biol 754:31-56. 2013.... - Expression of various genes is controlled by DNA methylation during mammalian developmentMelanie Ehrlich
Program in Human Genetics, Department of Biochemistry, and Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
J Cell Biochem 88:899-910. 2003..Also, I discuss previously established and newly hypothesized mechanisms for this epigenetic control... - The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency diseaseMelanie Ehrlich
Human Genetics Program and Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA
Clin Immunol 109:17-28. 2003..Comparisons of ICF and control lymphoblastoid cell lines and ICF patients' symptoms suggest an involvement of DNA methylation in the late stages of lymphocyte maturation... - DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangementsMelanie Ehrlich
Tulane Medical School, New Orleans, LA 70112, USA
J Nutr 132:2424S-2429S. 2002..Microarray gene expression analysis on ICF and normal lymphoblastoid cell lines suggests that this hypomethylation also may affect gene expression elsewhere in the genome... - Hypomethylation and hypermethylation of DNA in Wilms tumorsMelanie Ehrlich
Tulane Cancer Center and Human Genetics Program, Tulane Medical School, New Orleans, Louisiana, LA 70112, USA
Oncogene 21:6694-702. 2002..This suggests that the DNA hypomethylation contributes independently to oncogenesis or tumor progression... - Deciphering transcription dysregulation in FSH muscular dystrophyMelanie Ehrlich
Human Genetics Program and Center for Bioinformatics and Genomics, Tulane Cancer Center, Tulane University, New Orleans, LA 70122, USA
J Hum Genet 57:477-84. 2012..The Majority Rules model is the simpler explanation of findings about FSHD-associated gene expression and the DUX4-encoded homeodomain-type protein... - DNA hypomethylation and ovarian cancer biologyMartin Widschwendter
Department of Obstetrics and Gynecology, Medical University Innsbruck, Innsbruck, Austria
Cancer Res 64:4472-80. 2004.... - Will the transcription control elements in chromatin please stand up?Melanie Ehrlich
Epigenetics 3:179-80. 2008 - Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancerChristoph Grunau
Institut de Genetique Humaine, CNRS UPR 1142, Montpellier, France
Genes Chromosomes Cancer 43:11-24. 2005..Consequently, we propose BAGE hypomethylation as a new, highly informative epigenetic biomarker for the diagnosis of cancer, whose hypomethylation in cancer may be causally related to that of juxtacentromeric satellite DNA... - RNAPol-ChIP analysis of transcription from FSHD-linked tandem repeats and satellite DNAVassilios Alexiadis
Genpathway, Inc, San Diego, CA 92121, USA
Biochim Biophys Acta 1769:29-40. 2007..In addition, our results do not support the previously hypothesized disease-linked differential transcription of D4Z4 sequences in short, FSHD-linked arrays... - Analysis of repetitive element DNA methylation by MethyLightDaniel J Weisenberger
Department of Surgery, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California Los Angeles, CA, USA
Nucleic Acids Res 33:6823-36. 2005.... - Interphase chromosomal abnormalities and mitotic missegregation of hypomethylated sequences in ICF syndrome cellsDavid Gisselsson
Department of Clinical Genetics, University Hospital, 22185 Lund, Sweden
Chromosoma 114:118-26. 2005..This can help explain why specific types of 1qh and 16qh rearrangements are not present at high frequencies in ICF lymphoid cells despite diverse 1qh and 16qh aberrations continuously being generated...