Research Topics
Genomes and GenesSpecies | Prescott DeiningerSummaryAffiliation: Tulane University Country: USA Publications
Research Grants
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Detail Information
Publications
Diverse cis factors controlling Alu retrotransposition: what causes Alu elements to die?Matthew S Comeaux
Tulane Cancer Center and Dept of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Genome Res 19:545-55. 2009....- Alu elements: know the SINEsPrescott Deininger
Tulane Cancer Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
Genome Biol 12:236. 2011..Alu elements are primate-specific repeats and comprise 11% of the human genome. They have wide-ranging influences on gene expression. Their contribution to genome evolution, gene regulation and disease is reviewed... - Meeting report for mobile DNA 2010George Chaconas
Department of Genetics, Cell Biology and Development, The University of Minnesota, Minneapolis, MN 55455, USA
Mob DNA 1:20. 2010..Here we present highlights from the platform sessions with a focus on talks presented by the invited speakers... - LINE dancing in the human genome: transposable elements and diseaseVictoria P Belancio
Department of Structural and Cellular Biology, School of Medicine, Tulane Cancer Center and Tulane Center for Aging, Tulane University, SL 49 1430 Tulane Ave, New Orleans, LA 70112, USA
Genome Med 1:97. 2009..Here, we focus on the most recent advances in understanding of the impact of the active human TEs on the stability of the human genome and its relevance to human disease... - Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kineticsNicholas A Wallace
Tulane Cancer Center and the Department of Epidemiology, Tulane University, New Orleans, LA 70112, USA
Mob DNA 1:22. 2010..Therefore, L1 expression has the potential to be a source of chronic DSBs and thus bring about the changes in cellular environment that could ultimately restrict its own retrotransposition... 
Mammalian retroelementsPrescott L Deininger
Tulane Cancer Center, Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Genome Res 12:1455-65. 2002....- Mobile elements and mammalian genome evolutionPrescott L Deininger
Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Curr Opin Genet Dev 13:651-8. 2003.... 
Mammalian non-LTR retrotransposons: for better or worse, in sickness and in healthVictoria P Belancio
Tulane Cancer Center and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Genome Res 18:343-58. 2008..We consider their potential impact on host biology as well as their ultimate implications for the nature of the TE-host relationship...- Requirements for polyadenylation at the 3' end of LINE-1 elementsVictoria P Belancio
Tulane Cancer Center, SL66, and Department of Epidemiology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, United States
Gene 390:98-107. 2007.... - Alu distribution and mutation types of cancer genesWensheng Zhang
Department of Computer Science, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA
BMC Genomics 12:157. 2011..As of yet, little has been done to quantitatively assess the association between Alu distribution and genes that are causally implicated in oncogenesis... - Somatic expression of LINE-1 elements in human tissuesVictoria P Belancio
Department of Structural and Cellular Biology, Tulane School of Medicine and Tulane Center for Aging, Tulane University, New Orleans, LA 70112, USA
Nucleic Acids Res 38:3909-22. 2010..These findings have potential consequences for the whole organism in the form of cancer and mammalian aging... - Abasic sites and survival in resected patients with non-small cell lung cancerHua Zhao
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
Cancer Lett 246:47-53. 2007..We postulate that an intact BER mechanism may reduce the accumulation of oxidative DNA damage that are thought to contribute to the tumor's malignant potential and therefore the risk of death... - Molecular effects of volume expansion on the renal sodium phosphate cotransporterJules B Puschett
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA
Am J Med Sci 326:1-8. 2003..In recent experiments, Sprague-Dawley rats were subjected to the same short term VE. For both control and VE animals, brush border membrane vesicles (BBMV) were obtained... - Non-traditional Alu evolution and primate genomic diversityAstrid M Roy-Engel
Department of Environmental Health Sciences, Tulane Cancer Center SL-66, Tulane University Medical Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
J Mol Biol 316:1033-40. 2002..This study suggests that the majority of Alu insertions in primate genomes are the products of unique evolutionary events... - Predicting mammalian SINE subfamily activity from A-tail lengthGuy L Odom
Tulane Cancer Center, and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
Mol Biol Evol 21:2140-8. 2004..We suggest that these interruptions stabilize the length of the A-tails and contribute to the activity of these subfamilies. We present a model in which the dynamics of the 3' A-tail may be a central controlling factor in SINE activity... - LINE-1 RNA splicing and influences on mammalian gene expressionVictoria P Belancio
Tulane Cancer Center, SL66 and Department of Epidemiology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
Nucleic Acids Res 34:1512-21. 2006..Such contribution of functional splice sites by L1 may result in disruption of normal gene expression or formation of alternative mRNA transcripts... - Breaking the computational barrier: a divide-conquer and aggregate based approach for Alu insertion site characterisationKun Zhang
Department of Computer Science, Xavier University of Louisiana, New Orleans, Louisiana 70125, USA
Int J Comput Biol Drug Des 2:302-22. 2009..The proposed method is general enough that can be also applied to other sequence detection problems, such as microRNA target prediction... - Potential for retroposition by old Alu subfamiliesKarla Johanning
Tulane Cancer Center SL-66, Department of Environmental Health Sciences, Tulane University Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
J Mol Evol 56:658-64. 2003..The presence of few conserved Alu Sx elements and the dynamic expansion/contraction of the A-tail suggests that some of these older subfamilies may still be active at very low levels or in a few individuals... - The USH1C 216G-->A splice-site mutation results in a 35-base-pair deletionJennifer Lentz
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA
Hum Genet 116:225-7. 2005..Thus, the instability of the USH1C mRNA is explained by the 216G-->A out-of-frame splice site mutation... - ERCC1/XPF limits L1 retrotranspositionStephen L Gasior
Tulane Cancer Center and Department of Epidemiology, SL66, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
DNA Repair (Amst) 7:983-9. 2008..These results demonstrate for the first time that DNA repair enzymes act to limit non-LTR retrotransposition and may provide insight into the genetic instability phenotypes of ercc1 and xpf individuals... - Structure, diversity, and evolution of the 45-bp VNTR in intron 5 of the USH1C geneSevtap Savas
Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA
Genomics 83:439-44. 2004..However, the 9-repeat VNTR(t,t) and 6-repeat VNTR(t) alleles shared the same haplotype, suggesting an expansion from 6(t) to 9(t,t)... - Characterization of pre-insertion loci of de novo L1 insertionsStephen L Gasior
Tulane Cancer Center and Department of Epidemiology, Tulane University Health Sciences Center SL 66, 1430 Tulane Ave, New Orleans, LA 70112, United States
Gene 390:190-8. 2007.... - Active Alu element "A-tails": size does matterAstrid M Roy-Engel
Tulane Cancer Center, SL-66, Department of Environmental Health Sciences, Tulane University-Health Sciences Center, New Orleans, Louisiana 70112, USA
Genome Res 12:1333-44. 2002..On the basis of these observations, a model is presented for the role of A-tail length in determining which Alu elements are active... - Emergence of primate genes by retrotransposon-mediated sequence transductionJinchuan Xing
Department of Biological Sciences, Biological Computation and Visualization Center, Center for BioModular Multi Scale Systems, Louisiana State University, Baton Rouge, LA 70803, USA
Proc Natl Acad Sci U S A 103:17608-13. 2006..The duplication of entire genes and the creation of previously undescribed gene families through retrotransposon-mediated sequence transduction represent an important mechanism by which mobile elements impact their host genomes... - Alu repeats and human genomic diversityMark A Batzer
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA
Nat Rev Genet 3:370-9. 2002..Alu-insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states... - Evolution of a hypervariable region of the low density lipoprotein receptor (LDLR) gene in humans and other hominoidsDavid H Kass
Department of Biology, Eastern Michigan University, Ypsilanti, MI 48197, USA
Genetica 121:187-93. 2004..The mechanism for the hypervariability in mutation rates is unclear, but may be accelerated as a result of Alu-mediated gene conversion in the human lineage... - Introduction for the Gene special issue dedicated to the meeting "Genomic impact of eukaryotic transposable elements" at AsilomarMark A Batzer
Gene 390:1-2. 2007
Research Grants
- Sine RetrotranspositionPrescott Deininger; Fiscal Year: 2009..These studies will help to shed light on the reasons why some genetic loci are particularly prone to this form of recombination and whether we can better predict regions of genetic instability in the genome. ..
- Mentoring a Cancer Genetics ProgramPrescott Deininger; Fiscal Year: 2007....
- Sine RetrotranspositionPrescott Deininger; Fiscal Year: 2006..This system will allow a detailed analysis of the factors with influence the SINE retroposition process. ..
- Sine RetrotranspositionPrescott Deininger; Fiscal Year: 2007..These studies will help to shed light on the reasons why some genetic loci are particularly prone to this form of recombination and whether we can better predict regions of genetic instability in the genome. ..
- HUMAN DIMORPHISMS BY SINE MASTER GENESPrescott Deininger; Fiscal Year: 2001..To use this system to study the environmental, genetic and physiological factors that influence SINE mobility. ..
- Sine RetrotranspositionPrescott L Deininger; Fiscal Year: 2010..These studies will help to shed light on the reasons why some genetic loci are particularly prone to this form of recombination and whether we can better predict regions of genetic instability in the genome. ..