Prescott Deininger

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. ncbi request reprint Mobile elements and mammalian genome evolution
    Prescott L Deininger
    Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Curr Opin Genet Dev 13:651-8. 2003
  2. pmc Diverse cis factors controlling Alu retrotransposition: what causes Alu elements to die?
    Matthew S Comeaux
    Tulane Cancer Center and Dept of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Genome Res 19:545-55. 2009
  3. pmc Somatic expression of LINE-1 elements in human tissues
    Victoria P Belancio
    Department of Structural and Cellular Biology, Tulane School of Medicine and Tulane Center for Aging, Tulane University, New Orleans, LA 70112, USA
    Nucleic Acids Res 38:3909-22. 2010
  4. pmc LINE-1 RNA splicing and influences on mammalian gene expression
    Victoria P Belancio
    Tulane Cancer Center, SL66 and Department of Epidemiology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Nucleic Acids Res 34:1512-21. 2006
  5. pmc Inferring the expression variability of human transposable element-derived exons by linear model analysis of deep RNA sequencing data
    Wensheng Zhang
    Department of Computer Science, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA
    BMC Genomics 14:584. 2013
  6. pmc Alu elements: know the SINEs
    Prescott Deininger
    Tulane Cancer Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Genome Biol 12:236. 2011
  7. pmc Meeting report for mobile DNA 2010
    George Chaconas
    Department of Genetics, Cell Biology and Development, The University of Minnesota, Minneapolis, MN 55455, USA
    Mob DNA 1:20. 2010
  8. pmc LINE dancing in the human genome: transposable elements and disease
    Victoria P Belancio
    Department of Structural and Cellular Biology, School of Medicine, Tulane Cancer Center and Tulane Center for Aging, Tulane University, SL 49 1430 Tulane Ave, New Orleans, LA 70112, USA
    Genome Med 1:97. 2009
  9. pmc Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics
    Nicholas A Wallace
    Tulane Cancer Center and the Department of Epidemiology, Tulane University, New Orleans, LA 70112, USA
    Mob DNA 1:22. 2010
  10. ncbi request reprint Mammalian retroelements
    Prescott L Deininger
    Tulane Cancer Center, Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Genome Res 12:1455-65. 2002

Research Grants

  1. Sine Retrotransposition
    Prescott L Deininger; Fiscal Year: 2010
  2. Mentoring a Cancer Genetics Program
    Prescott Deininger; Fiscal Year: 2007
  3. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2006
  4. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2007
  5. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2005
  6. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2004
  7. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2003
  8. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2002
  9. HUMAN DIMORPHISMS BY SINE MASTER GENES
    Prescott Deininger; Fiscal Year: 2001
  10. HUMAN DIMORPHISMS BY SINE MASTER GENES
    Prescott Deininger; Fiscal Year: 2000

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Mobile elements and mammalian genome evolution
    Prescott L Deininger
    Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Curr Opin Genet Dev 13:651-8. 2003
    ....
  2. pmc Diverse cis factors controlling Alu retrotransposition: what causes Alu elements to die?
    Matthew S Comeaux
    Tulane Cancer Center and Dept of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Genome Res 19:545-55. 2009
    ....
  3. pmc Somatic expression of LINE-1 elements in human tissues
    Victoria P Belancio
    Department of Structural and Cellular Biology, Tulane School of Medicine and Tulane Center for Aging, Tulane University, New Orleans, LA 70112, USA
    Nucleic Acids Res 38:3909-22. 2010
    ..These findings have potential consequences for the whole organism in the form of cancer and mammalian aging...
  4. pmc LINE-1 RNA splicing and influences on mammalian gene expression
    Victoria P Belancio
    Tulane Cancer Center, SL66 and Department of Epidemiology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Nucleic Acids Res 34:1512-21. 2006
    ..Such contribution of functional splice sites by L1 may result in disruption of normal gene expression or formation of alternative mRNA transcripts...
  5. pmc Inferring the expression variability of human transposable element-derived exons by linear model analysis of deep RNA sequencing data
    Wensheng Zhang
    Department of Computer Science, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA
    BMC Genomics 14:584. 2013
    ..Existing knowledge of the retention patterns of TE exons in mRNAs were mainly established by the analysis of Expressed Sequence Tag (EST) data and microarray data...
  6. pmc Alu elements: know the SINEs
    Prescott Deininger
    Tulane Cancer Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Genome Biol 12:236. 2011
    ..Alu elements are primate-specific repeats and comprise 11% of the human genome. They have wide-ranging influences on gene expression. Their contribution to genome evolution, gene regulation and disease is reviewed...
  7. pmc Meeting report for mobile DNA 2010
    George Chaconas
    Department of Genetics, Cell Biology and Development, The University of Minnesota, Minneapolis, MN 55455, USA
    Mob DNA 1:20. 2010
    ..Here we present highlights from the platform sessions with a focus on talks presented by the invited speakers...
  8. pmc LINE dancing in the human genome: transposable elements and disease
    Victoria P Belancio
    Department of Structural and Cellular Biology, School of Medicine, Tulane Cancer Center and Tulane Center for Aging, Tulane University, SL 49 1430 Tulane Ave, New Orleans, LA 70112, USA
    Genome Med 1:97. 2009
    ..Here, we focus on the most recent advances in understanding of the impact of the active human TEs on the stability of the human genome and its relevance to human disease...
  9. pmc Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics
    Nicholas A Wallace
    Tulane Cancer Center and the Department of Epidemiology, Tulane University, New Orleans, LA 70112, USA
    Mob DNA 1:22. 2010
    ..Therefore, L1 expression has the potential to be a source of chronic DSBs and thus bring about the changes in cellular environment that could ultimately restrict its own retrotransposition...
  10. ncbi request reprint Mammalian retroelements
    Prescott L Deininger
    Tulane Cancer Center, Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Genome Res 12:1455-65. 2002
    ....
  11. pmc Alu distribution and mutation types of cancer genes
    Wensheng Zhang
    Department of Computer Science, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA
    BMC Genomics 12:157. 2011
    ..As of yet, little has been done to quantitatively assess the association between Alu distribution and genes that are causally implicated in oncogenesis...
  12. pmc miRNA-mediated relationships between Cis-SNP genotypes and transcript intensities in lymphocyte cell lines
    Wensheng Zhang
    Department of Computer Science, Xavier University of Louisiana, New Orleans, Louisiana, United States of America
    PLoS ONE 7:e31429. 2012
    ..These results provide concrete in silico evidence for the proposed hypothesis. The discovered modules warrant additional follow-up in independent laboratory studies...
  13. ncbi request reprint RNA truncation by premature polyadenylation attenuates human mobile element activity
    Victoria Perepelitsa-Belancio
    Tulane Cancer Center, SL66, and Department of Environmental Health Sciences, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, Louisiana 70112, USA
    Nat Genet 35:363-6. 2003
    ..This attenuation lowers the rate of retrotransposition in assays using HeLa cells. It probably also increases the negative effects of LINE-1 insertions into genes...
  14. ncbi request reprint Requirements for polyadenylation at the 3' end of LINE-1 elements
    Victoria P Belancio
    Tulane Cancer Center, SL66, and Department of Epidemiology, Tulane University Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, United States
    Gene 390:98-107. 2007
    ....
  15. ncbi request reprint Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health
    Victoria P Belancio
    Tulane Cancer Center and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Genome Res 18:343-58. 2008
    ..We consider their potential impact on host biology as well as their ultimate implications for the nature of the TE-host relationship...
  16. pmc Breaking the computational barrier: a divide-conquer and aggregate based approach for Alu insertion site characterisation
    Kun Zhang
    Department of Computer Science, Xavier University of Louisiana, New Orleans, Louisiana 70125, USA
    Int J Comput Biol Drug Des 2:302-22. 2009
    ..The proposed method is general enough that can be also applied to other sequence detection problems, such as microRNA target prediction...
  17. ncbi request reprint Molecular effects of volume expansion on the renal sodium phosphate cotransporter
    Jules B Puschett
    Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Am J Med Sci 326:1-8. 2003
    ..In recent experiments, Sprague-Dawley rats were subjected to the same short term VE. For both control and VE animals, brush border membrane vesicles (BBMV) were obtained...
  18. ncbi request reprint Non-traditional Alu evolution and primate genomic diversity
    Astrid M Roy-Engel
    Department of Environmental Health Sciences, Tulane Cancer Center SL 66, Tulane University Medical Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    J Mol Biol 316:1033-40. 2002
    ..This study suggests that the majority of Alu insertions in primate genomes are the products of unique evolutionary events...
  19. ncbi request reprint Predicting mammalian SINE subfamily activity from A-tail length
    Guy L Odom
    Tulane Cancer Center, and Department of Epidemiology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Mol Biol Evol 21:2140-8. 2004
    ..We suggest that these interruptions stabilize the length of the A-tails and contribute to the activity of these subfamilies. We present a model in which the dynamics of the 3' A-tail may be a central controlling factor in SINE activity...
  20. ncbi request reprint Abasic sites and survival in resected patients with non-small cell lung cancer
    Hua Zhao
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA
    Cancer Lett 246:47-53. 2007
    ..We postulate that an intact BER mechanism may reduce the accumulation of oxidative DNA damage that are thought to contribute to the tumor's malignant potential and therefore the risk of death...
  21. ncbi request reprint Potential for retroposition by old Alu subfamilies
    Karla Johanning
    Tulane Cancer Center SL 66, Department of Environmental Health Sciences, Tulane University Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Mol Evol 56:658-64. 2003
    ..The presence of few conserved Alu Sx elements and the dynamic expansion/contraction of the A-tail suggests that some of these older subfamilies may still be active at very low levels or in a few individuals...
  22. ncbi request reprint The USH1C 216G-->A splice-site mutation results in a 35-base-pair deletion
    Jennifer Lentz
    Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA
    Hum Genet 116:225-7. 2005
    ..Thus, the instability of the USH1C mRNA is explained by the 216G-->A out-of-frame splice site mutation...
  23. ncbi request reprint Structure, diversity, and evolution of the 45-bp VNTR in intron 5 of the USH1C gene
    Sevtap Savas
    Department of Genetics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA
    Genomics 83:439-44. 2004
    ..However, the 9-repeat VNTR(t,t) and 6-repeat VNTR(t) alleles shared the same haplotype, suggesting an expansion from 6(t) to 9(t,t)...
  24. pmc Characterization of pre-insertion loci of de novo L1 insertions
    Stephen L Gasior
    Tulane Cancer Center and Department of Epidemiology, Tulane University Health Sciences Center SL 66, 1430 Tulane Ave, New Orleans, LA 70112, United States
    Gene 390:190-8. 2007
    ....
  25. pmc ERCC1/XPF limits L1 retrotransposition
    Stephen L Gasior
    Tulane Cancer Center and Department of Epidemiology, SL66, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    DNA Repair (Amst) 7:983-9. 2008
    ..These results demonstrate for the first time that DNA repair enzymes act to limit non-LTR retrotransposition and may provide insight into the genetic instability phenotypes of ercc1 and xpf individuals...
  26. pmc Active Alu element "A-tails": size does matter
    Astrid M Roy-Engel
    Tulane Cancer Center, SL 66, Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Genome Res 12:1333-44. 2002
    ..On the basis of these observations, a model is presented for the role of A-tail length in determining which Alu elements are active...
  27. ncbi request reprint Alu repeats and human genomic diversity
    Mark A Batzer
    Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, Louisiana 70803, USA
    Nat Rev Genet 3:370-9. 2002
    ..Alu-insertion polymorphisms are a boon for the study of human population genetics and primate comparative genomics because they are neutral genetic markers of identical descent with known ancestral states...
  28. pmc Emergence of primate genes by retrotransposon-mediated sequence transduction
    Jinchuan Xing
    Department of Biological Sciences, Biological Computation and Visualization Center, Center for BioModular Multi Scale Systems, Louisiana State University, Baton Rouge, LA 70803, USA
    Proc Natl Acad Sci U S A 103:17608-13. 2006
    ..The duplication of entire genes and the creation of previously undescribed gene families through retrotransposon-mediated sequence transduction represent an important mechanism by which mobile elements impact their host genomes...
  29. ncbi request reprint Evolution of a hypervariable region of the low density lipoprotein receptor (LDLR) gene in humans and other hominoids
    David H Kass
    Department of Biology, Eastern Michigan University, Ypsilanti, MI 48197, USA
    Genetica 121:187-93. 2004
    ..The mechanism for the hypervariability in mutation rates is unclear, but may be accelerated as a result of Alu-mediated gene conversion in the human lineage...
  30. ncbi request reprint Introduction for the Gene special issue dedicated to the meeting "Genomic impact of eukaryotic transposable elements" at Asilomar
    Mark A Batzer
    Gene 390:1-2. 2007

Research Grants16

  1. Sine Retrotransposition
    Prescott L Deininger; Fiscal Year: 2010
    ..These studies will help to shed light on the reasons why some genetic loci are particularly prone to this form of recombination and whether we can better predict regions of genetic instability in the genome. ..
  2. Mentoring a Cancer Genetics Program
    Prescott Deininger; Fiscal Year: 2007
    ....
  3. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2006
    ..This system will allow a detailed analysis of the factors with influence the SINE retroposition process. ..
  4. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2007
    ..These studies will help to shed light on the reasons why some genetic loci are particularly prone to this form of recombination and whether we can better predict regions of genetic instability in the genome. ..
  5. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2005
    ..This system will allow a detailed analysis of the factors with influence the SINE retroposition process. ..
  6. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2004
    ..This system will allow a detailed analysis of the factors with influence the SINE retroposition process. ..
  7. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2003
    ..This system will allow a detailed analysis of the factors with influence the SINE retroposition process. ..
  8. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2002
    ..This system will allow a detailed analysis of the factors with influence the SINE retroposition process. ..
  9. HUMAN DIMORPHISMS BY SINE MASTER GENES
    Prescott Deininger; Fiscal Year: 2001
    ..To use this system to study the environmental, genetic and physiological factors that influence SINE mobility. ..
  10. HUMAN DIMORPHISMS BY SINE MASTER GENES
    Prescott Deininger; Fiscal Year: 2000
    ..To use this system to study the environmental, genetic and physiological factors that influence SINE mobility. ..
  11. HUMAN DIMORPHISMS BY SINE MASTER GENES
    Prescott Deininger; Fiscal Year: 1999
    ..To use this system to study the environmental, genetic and physiological factors that influence SINE mobility. ..
  12. Sine Retrotransposition
    Prescott Deininger; Fiscal Year: 2009
    ..These studies will help to shed light on the reasons why some genetic loci are particularly prone to this form of recombination and whether we can better predict regions of genetic instability in the genome. ..